Corrigendum to "Enhanced cancer cell killing by truncated E2F-1 used in combination with oncolytic adenovirus" [Virology 433 (2) (2012) 538-547]
Virology. 2024 Apr 6;595:110079. doi: 10.1016/j.virol.2024.110079. Online ahead of print.NO ABSTRACTPMID:38583304 | DOI:10.1016/j.virol.2024.110079 (Source: Virology)
Source: Virology - April 7, 2024 Category: Virology Authors: Jorge G Gomez-Gutierrez Xia-Mei Rao Heshan Sam Zhou Kelly M McMasters Source Type: research
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKC α-HuR axis in rheumatoid arthritis
In conclusion, our findings unveil a novel regulatory mechanism involved in the pathogenesis of RA and suggest that targeting TRPM7 might be a potential strategy for the prevention and treatment of RA.PMID:38581988 | DOI:10.1016/j.intimp.2024.111933 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yi Lin Yong Chen Weirong Hu Xingyu Liu Wenjuan Hao Jing Xing Jie Ding Yucai Xu Feng Yao Yingjie Zhao Ke Wang Shufang Li Qiuxia Yu Wei Hu Renpeng Zhou Source Type: research
Management strategies for common viral infections in pediatric renal transplant recipients
World J Transplant. 2024 Mar 18;14(1):89978. doi: 10.5500/wjt.v14.i1.89978.ABSTRACTViral infections have been considered as a major cause of morbidity and mortality after kidney transplantation in pediatric cohort. Children are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Hence, prevention, early detection, and prompt treatment of such infe ctions are of paramount importance. Among all viral infections, herpes viruses (herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cyto...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Randula Ranawaka Kavinda Dayasiri Erandima Sandamali Manoji Gamage Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells
CONCLUSIONS: LB can improve BDL-induced liver fibrosis by inhibiting the activation and proliferation of HSCs and is expected to be a promising antifibrotic drug.PMID:38580181 | DOI:10.1016/j.ejphar.2024.176552 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Wei-Yi Cheng Xi-Xi Zeng Ping Cheng Jin-Xiang Zhang Source Type: research
Management strategies for common viral infections in pediatric renal transplant recipients
World J Transplant. 2024 Mar 18;14(1):89978. doi: 10.5500/wjt.v14.i1.89978.ABSTRACTViral infections have been considered as a major cause of morbidity and mortality after kidney transplantation in pediatric cohort. Children are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Hence, prevention, early detection, and prompt treatment of such infe ctions are of paramount importance. Among all viral infections, herpes viruses (herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cyto...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Randula Ranawaka Kavinda Dayasiri Erandima Sandamali Manoji Gamage Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells
CONCLUSIONS: LB can improve BDL-induced liver fibrosis by inhibiting the activation and proliferation of HSCs and is expected to be a promising antifibrotic drug.PMID:38580181 | DOI:10.1016/j.ejphar.2024.176552 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Wei-Yi Cheng Xi-Xi Zeng Ping Cheng Jin-Xiang Zhang Source Type: research
Viruses, Vol. 16, Pages 567: Oncolytic Adenovirus for the Targeting of Paclitaxel-Resistant Breast Cancer Stem Cells
Davydova
Adjuvant systemic therapies effectively reduce the risk of breast cancer recurrence and metastasis, but therapy resistance can develop in some patients due to breast cancer stem cells (BCSCs). Oncolytic adenovirus (OAd) represents a promising therapeutic approach as it can specifically target cancer cells. However, its potential to target BCSCs remains unclear. Here, we evaluated a Cox-2 promoter-controlled, Ad5/3 fiber-modified OAd designed to encode the human sodium iodide symporter (hNIS) in breast cancer models. To confirm the potential of OAds to target BCSCs, we employed BCSC-enriched estrogen receptor...
Source: Viruses - April 5, 2024 Category: Virology Authors: Robert Roman Ortiz LaRocca Ostrander Davydova Tags: Article Source Type: research
Genetic control of MRI contrast using the manganese transporter Zip14
CONCLUSIONS: The flexibility of this system as an MRI-visible gene-expression reporter will enable many applications of serial, high-resolution imaging of gene expression for basic science and therapy development.PMID:38573932 | DOI:10.1002/mrm.29993 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 4, 2024 Category: Radiology Authors: Harikrishna Rallapalli Eleanor C McCall Alan P Koretsky Source Type: research
Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice
AbstractDiabetes-associated cognitive dysfunction (DACD) has ascended to become the second leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a pivotal rate-limiting enzyme in L-serine biosynthesis, has been documented to instigate the insulin signaling pathway through dephosphorylation. Concomitantly, CD38, acting as a mediator in mitochondrial transfer, is activated by the insulin pathway. Given that we have demonstrated the beneficial effects of exogenous mitochondrial supplementation on DACD, we further hypothesized whether astrocytic PSPH could contribute to improving DACD by promoti...
Source: Molecular Neurobiology - April 4, 2024 Category: Neurology Source Type: research
Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage
CONCLUSION: Neuritin alleviated EBI by restoring impaired autophagic flux after SAH through the regulation of the cGAS-STING pathway.PMID:38570154 | DOI:10.1016/j.brainres.2024.148909 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Hao Zhang Kunhao Ren Youjie Hu Bin Liu Yaowen He Hui Xu Ketao Ma Weidong Tian Linzhi Dai Dong Zhao Source Type: research
Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage
CONCLUSION: Neuritin alleviated EBI by restoring impaired autophagic flux after SAH through the regulation of the cGAS-STING pathway.PMID:38570154 | DOI:10.1016/j.brainres.2024.148909 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Hao Zhang Kunhao Ren Youjie Hu Bin Liu Yaowen He Hui Xu Ketao Ma Weidong Tian Linzhi Dai Dong Zhao Source Type: research
