Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021-June 2023
We describe demographic and clinical characteristics, including potential involvement of adenovirus in development of acute hepatitis, of 8 fatally ill children who met reporting criteria. The children had diverse courses of illness. Two children were immunocompromised when initially brought for care. Four children tested positive for adenovirus in multiple specimen types, including 2 for whom typing was completed. One adenovirus-positive child had no known underlying conditions, supporting a potential relationship between adenovirus and acute hepatitis in previously healthy children. Our findings emphasize the importance ...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Olivia Almendares Julia M Baker David E Sugerman Umesh D Parashar Sarah Reagan-Steiner Hannah L Kirking Paul A Gasta ñaduy Jacqueline E Tate Hepatitis of Unknown Etiology Group2 Source Type: research
Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021-June 2023
We describe demographic and clinical characteristics, including potential involvement of adenovirus in development of acute hepatitis, of 8 fatally ill children who met reporting criteria. The children had diverse courses of illness. Two children were immunocompromised when initially brought for care. Four children tested positive for adenovirus in multiple specimen types, including 2 for whom typing was completed. One adenovirus-positive child had no known underlying conditions, supporting a potential relationship between adenovirus and acute hepatitis in previously healthy children. Our findings emphasize the importance ...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Olivia Almendares Julia M Baker David E Sugerman Umesh D Parashar Sarah Reagan-Steiner Hannah L Kirking Paul A Gasta ñaduy Jacqueline E Tate Hepatitis of Unknown Etiology Group2 Source Type: research
Adeno-associated virus genome quantification with amplification-free CRISPR-Cas12a
Gene Therapy, Published online: 25 March 2024; doi:10.1038/s41434-024-00449-xAdeno-associated virus genome quantification with amplification-free CRISPR-Cas12a (Source: Gene Therapy)
Source: Gene Therapy - March 25, 2024 Category: Genetics & Stem Cells Authors: Zach Hetzler Stella M. Marinakos Noah Lott Noor Mohammad Agnieszka Lass-Napiorkowska Jenna Kolbe Lauren Turrentine Delaney Fields Laurie Overton Helena Marie Angus Hucknall Oliver Rammo Henry George Qingshan Wei Source Type: research
Correction to: Efficacy and Safety of Adeno-Associated Virus-Based Clinical Gene Therapy for Hemophilia: A Systematic Review and Meta-Analysis, by Han et al. Hum Gene Ther 2024;35(3-4):93 –103; doi: 10.1089/hum.2023.208.
Human Gene Therapy, Ahead of Print. (Source: Human Gene Therapy)
Source: Human Gene Therapy - March 25, 2024 Category: Genetics & Stem Cells Source Type: research
Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain
Autophagy. 2024 Mar 24:1-18. doi: 10.1080/15548627.2024.2330038. Online ahead of print.ABSTRACTA large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired neuronal macroautophagy in the prelimbic cortical (PrL) subregion of the mPFC paralleled the occurrence of anxiety-like behaviors in rats with chronic spared nerve injury (SNI). Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos+ neuronal subpopulat...
Source: Autophagy - March 24, 2024 Category: Cytology Authors: Su Fu Haojie Sun Jiaxin Wang Shuaixin Gao Liu Zhu Kun Cui Shimeng Liu Xuetao Qi Rui Guan Xiaocen Fan Qingying Liu Wen Chen Li Su Shuang Cui Feifei Liao Fengyu Liu Catherine C L Wong Ming Yi You Wan Source Type: research
