Isthmin-1 alleviates cardiac ischemia/reperfusion injury through cGMP-PKG signaling pathway
CONCLUSION: ISM1 can protect against cardiac I/R injury through cGMP-PKG signaling pathway, and it is a promising therapeutic and predictive target of cardiac I/R injury.PMID:38637328 | DOI:10.1093/cvr/cvae077 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Min Hu Xin Zhang Can Hu Zhen-Guo Ma Sha-Sha Wang Teng Teng Xiao-Feng Zeng Qi-Zhu Tang Source Type: research
Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways
In this study, we initiated an acute restraint stress (ARS)-induced anxious mouse model and identified heightened expression of IL-19 and IL-20Rα in the medial prefrontal cortex (mPFC) of ARS mice. Notably, IL-19 and IL-20Rα were predominantly present in the excitatory pyramidal neurons of the mPFC under both basal and ARS conditions. Utilizing the adeno-associated virus (AAV) strategy, we demonstrated that IL-19 overexpression in the mPFC induced anxiety-related behaviors and elevated stress susceptibility. Additionally, we observed decreased protein levels of brain-derived neurotrophic factor (BDNF) and postsynaptic de...
Source: Brain Research Bulletin - April 18, 2024 Category: Neurology Authors: Yuting Jiang Lihong Xu Yifan Cao Fantao Meng Shujun Jiang Mengyu Yang Ziteng Zheng Yi Zhang Lu Yang Meiqin Wang Guizhi Sun Jing Liu Chen Li Minghu Cui Source Type: research
Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways
In this study, we initiated an acute restraint stress (ARS)-induced anxious mouse model and identified heightened expression of IL-19 and IL-20Rα in the medial prefrontal cortex (mPFC) of ARS mice. Notably, IL-19 and IL-20Rα were predominantly present in the excitatory pyramidal neurons of the mPFC under both basal and ARS conditions. Utilizing the adeno-associated virus (AAV) strategy, we demonstrated that IL-19 overexpression in the mPFC induced anxiety-related behaviors and elevated stress susceptibility. Additionally, we observed decreased protein levels of brain-derived neurotrophic factor (BDNF) and postsynaptic de...
Source: Brain Research - April 18, 2024 Category: Neurology Authors: Yuting Jiang Lihong Xu Yifan Cao Fantao Meng Shujun Jiang Mengyu Yang Ziteng Zheng Yi Zhang Lu Yang Meiqin Wang Guizhi Sun Jing Liu Chen Li Minghu Cui Source Type: research
TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis
In this study, we aimed to investigate whether TRPC4 in PAECs has an aggravating effect on PH and elucidate the molecular mechanisms. We observed that hypoxia treatment promoted PAEC apoptosis through a caspase-12/endoplasmic reticulum stress (ERS)-dependent pathway. Knockdown of TRPC4 attenuated hypoxia-induced apoptosis and caspase-3/caspase-12 activity in PAECs. Accordingly, adeno-associated virus (AAV) serotype 6-mediated pulmonary endothelial TRPC4 silencing (AAV6-Tie-shRNA-TRPC4) or TRPC4 antagonist suppressed PH progression as evidenced by reduced right ventricular systolic pressure (RVSP), pulmonary vascular remode...
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Liu Yang Zeyu Peng Fanpeng Gong WenXin Yan Yi Shi Hanyi Li Chang Zhou Hong Yao Menglu Yuan Fan Yu Lei Feng Naifu Wan Guizhu Liu Source Type: research
TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis
In this study, we aimed to investigate whether TRPC4 in PAECs has an aggravating effect on PH and elucidate the molecular mechanisms. We observed that hypoxia treatment promoted PAEC apoptosis through a caspase-12/endoplasmic reticulum stress (ERS)-dependent pathway. Knockdown of TRPC4 attenuated hypoxia-induced apoptosis and caspase-3/caspase-12 activity in PAECs. Accordingly, adeno-associated virus (AAV) serotype 6-mediated pulmonary endothelial TRPC4 silencing (AAV6-Tie-shRNA-TRPC4) or TRPC4 antagonist suppressed PH progression as evidenced by reduced right ventricular systolic pressure (RVSP), pulmonary vascular remode...
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Liu Yang Zeyu Peng Fanpeng Gong WenXin Yan Yi Shi Hanyi Li Chang Zhou Hong Yao Menglu Yuan Fan Yu Lei Feng Naifu Wan Guizhu Liu Source Type: research
Erratum to "Immunogenicity of an adenovirus-vectored bivalent vaccine against wild type SARS-CoV-2 and Omicron variants in a murine model" [Vaccine 42(6) (2024) 1292-1299]
Vaccine. 2024 Apr 16:S0264-410X(24)00386-4. doi: 10.1016/j.vaccine.2024.03.069. Online ahead of print.NO ABSTRACTPMID:38631955 | DOI:10.1016/j.vaccine.2024.03.069 (Source: Vaccine)
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Yuanyuan Ji Xiuwen Sui Wei Miao Chang Wang Qing Wang Zhuojun Duan Bochao Wei Dan Wu Menghan Wei Juan Shao Xiuyu Zheng Tao Zhu Source Type: research
Erratum to "Immunogenicity of an adenovirus-vectored bivalent vaccine against wild type SARS-CoV-2 and Omicron variants in a murine model" [Vaccine 42(6) (2024) 1292-1299]
Vaccine. 2024 Apr 16:S0264-410X(24)00386-4. doi: 10.1016/j.vaccine.2024.03.069. Online ahead of print.NO ABSTRACTPMID:38631955 | DOI:10.1016/j.vaccine.2024.03.069 (Source: Vaccine)
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Yuanyuan Ji Xiuwen Sui Wei Miao Chang Wang Qing Wang Zhuojun Duan Bochao Wei Dan Wu Menghan Wei Juan Shao Xiuyu Zheng Tao Zhu Source Type: research
GSE229818 Meyoid-specific deficiency of Glutamine Synthetase Aggravates LPS/D-GalN-induced liver injury via the activation of monocyte-derived macrophages
In conclusion, this research validates the protective effect of Glul against ALI. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway
CONCLUSIONS: Our findings revealed that APOD had a chondroprotective role in OA progression by the PI3K/AKT/mTOR signaling pathway.PMID:38626543 | DOI:10.1016/j.intimp.2024.112005 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Gang Zhang Chao Huang Ren Wang Jiangrong Guo Yong Qin Songcen Lv Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: Am J Trop Med Hyg - April 16, 2024 Category: Infectious Diseases Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: Am J Trop Med Hyg - April 16, 2024 Category: Infectious Diseases Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
Effect of Non-Rotavirus Enteric Infections on Vaccine Efficacy in a ROTASIIL Clinical Trial
This study examined the relative proportion of enteric pathogens associated with severe gastroenteritis (GE) among children younger than 2 years in a phase III efficacy trial of the ROTASIIL® vaccine in India, evaluated the impact of co-infections on vaccine efficacy (VE), and characterized the association between specific pathogens and the clinical profile of severe GE. Stored stool samples collected from cases of severe GE in the phase III trial were tested by quantitative polymerase chain reaction using TaqMan™ Array Cards. Etiology was attributed by calculating the adjusted attributable fraction (AF) for each pathog...
Source: Am J Trop Med Hyg - April 16, 2024 Category: Infectious Diseases Authors: Dilip Abraham Prasanna Samuel Premkumar James A Platts-Mills Tushar Tewari Niranjan Bhat Revathi Rajendiran Hemavathi Gunalan Gagandeep Kang Source Type: research
