GSE242267 Kinetic chromatin openin profiles in mouse ApcDHep or wt hepatocytes
Contributor : Ang élique GougeletSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe analyzed chromatin opening in hepatocytes isolated from Apclox/loxlivers, after injection of adenovirus Ad5 -Cre-GFP and sorting on the basis of GFP signal at day 6, 15 and 21 post-injection. Our aims was to study the impact of an aberrant beta-catenin activation on chromatin opening in hepatocytes during the early steps of liver tumorigenesis. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Imaging of adeno-associated viral capsids for purposes of gene editing using CEST NMR/MRI
CONCLUSION: AAV2 viral capsids exhibit strong capacity as an endogenous CEST contrast agent and can potentially be used for monitoring and evaluation of AAV vector-mediated gene therapy protocols.PMID:38651648 | DOI:10.1002/mrm.30058 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Bonnie Lam Mark Velasquez Tomoko Ogiyama Kevin Godines Fan-Yun Szu A J Velasquez-Mao Wissam AlGhuraibawi Jingshen Wang Phillip B Messersmith Moriel H Vandsburger Source Type: research
Imaging of adeno-associated viral capsids for purposes of gene editing using CEST NMR/MRI
CONCLUSION: AAV2 viral capsids exhibit strong capacity as an endogenous CEST contrast agent and can potentially be used for monitoring and evaluation of AAV vector-mediated gene therapy protocols.PMID:38651648 | DOI:10.1002/mrm.30058 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Bonnie Lam Mark Velasquez Tomoko Ogiyama Kevin Godines Fan-Yun Szu A J Velasquez-Mao Wissam AlGhuraibawi Jingshen Wang Phillip B Messersmith Moriel H Vandsburger Source Type: research
Viruses, Vol. 16, Pages 658: Expanding the Scope of Adenoviral Vectors by Utilizing Novel Tools for Recombination and Vector Rescue
Ruzsics
Recombinant adenoviruses are widely used in clinical and laboratory applications. Despite the wide variety of available sero- and genotypes, only a fraction is utilized in vivo. As adenoviruses are a large group of viruses, displaying many different tropisms, immune epitopes, and replication characteristics, the merits of translating these natural benefits into vector applications are apparent. This translation, however, proves difficult, since while research has investigated the application of these viruses, there are no universally applicable rules in vector design for non-classical adenovirus types. In t...
Source: Viruses - April 23, 2024 Category: Virology Authors: Fischer Fedotova B ühler Darriba Schreiner Ruzsics Tags: Article Source Type: research
Immune reconstitution in children after haploidentical haematopoietic stem cell transplantation
CONCLUSION: Paediatric patients who undergo haploidentical HSCT with PTCy are likely to have delayed IR and an increased risk of viral reactivation/infection compared with HLA-matched HSCT. The addition of ATG to PTCy delayed T cell recovery and increased risk of BKV reactivation.PMID:38646695 | DOI:10.1111/ijlh.14290 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 22, 2024 Category: Hematology Authors: Saranthorn Apasuthirat Nopporn Apiwattanakul Usanarat Anurathapan Nintita Sripaiboonkij Thokanit Karan Paisooksantivatana Ekawat Pasomsub Suradej Hongeng Samart Pakakasama Source Type: research
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
CONCLUSIONS: The implementation of COVID-19 infection control measures reduced the incidence of cRV infection. However, CDI increased significantly and incidence rates of CPE and VRE remained unchanged in hematological patients after the pandemic. Infection control measures suitable for each type of HCAI, such as stringent hand washing for CDI and enough isolation capacities, should be implemented and maintained in future pandemics, especially in immunocompromised patients.PMID:38649159 | DOI:10.3904/kjim.2023.508 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Seohee Oh Yu-Sun Sung Mihee Jang Yong-Jin Kim Hyun-Wook Park Dukhee Nho Dong-Gun Lee Hyeon Woo Yim Sung-Yeon Cho Source Type: research
Correction: Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
Mol Biol Rep. 2024 Apr 22;51(1):565. doi: 10.1007/s11033-024-09489-3.NO ABSTRACTPMID:38649646 | DOI:10.1007/s11033-024-09489-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Alejandra G Martinez-Perez Rodolfo Garza-Morales Maria J de Loera-Arias Sheila A Villa-Cedillo Aracely Garcia-Garcia Humberto Rodriguez-Rocha Orlando E Flores-Maldonado Jesus Valdes Jose J Perez-Trujillo Odila Saucedo-Cardenas Source Type: research
Unlocking the potential of adeno-associated virus in neuroscience: a brief review
Mol Biol Rep. 2024 Apr 22;51(1):563. doi: 10.1007/s11033-024-09521-6.ABSTRACTAdeno-associated virus (AAV) has emerged as a pivotal tool in neuroscience research, owing to its remarkable versatility and efficiency in delivering genetic material to diverse cell types within the nervous system. This mini review aims to underscore the advanced applications of AAV vectors in neuroscience and their profound potential to revolutionize our understanding of brain function and therapeutic interventions for neurological disorders. By providing a concise overview of the latest developments and strategies employing AAV vectors, this re...
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Antea Minetti Source Type: research
Severe adenovirus infection outbreak in Colombia: Experience from a tertiary pediatric hospital in 2022
Conclusion. In 2022, there was an outbreak of severe adenovirus infections, affecting mainly children under five years of age, with higher-than-usual mortality.PMID:38648343 | DOI:10.7705/biomedica.7047 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - April 22, 2024 Category: International Medicine & Public Health Authors: Natalia V élez-Tirado Lina Casta ño-Jaramillo Sonia Restrepo-Gualteros Catalina Alcal á-Lozano Erika Ruge Carolina Puente Diana Li-Zeng Diego Chaparro-Arce Mar ía Camila Beltrán-Dimas Juan Francisco L ópez Miguel Luengas-Monroy Diego Galvis-Trujillo Source Type: research
Immune reconstitution in children after haploidentical haematopoietic stem cell transplantation
CONCLUSION: Paediatric patients who undergo haploidentical HSCT with PTCy are likely to have delayed IR and an increased risk of viral reactivation/infection compared with HLA-matched HSCT. The addition of ATG to PTCy delayed T cell recovery and increased risk of BKV reactivation.PMID:38646695 | DOI:10.1111/ijlh.14290 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 22, 2024 Category: Hematology Authors: Saranthorn Apasuthirat Nopporn Apiwattanakul Usanarat Anurathapan Nintita Sripaiboonkij Thokanit Karan Paisooksantivatana Ekawat Pasomsub Suradej Hongeng Samart Pakakasama Source Type: research
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
CONCLUSIONS: The implementation of COVID-19 infection control measures reduced the incidence of cRV infection. However, CDI increased significantly and incidence rates of CPE and VRE remained unchanged in hematological patients after the pandemic. Infection control measures suitable for each type of HCAI, such as stringent hand washing for CDI and enough isolation capacities, should be implemented and maintained in future pandemics, especially in immunocompromised patients.PMID:38649159 | DOI:10.3904/kjim.2023.508 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Seohee Oh Yu-Sun Sung Mihee Jang Yong-Jin Kim Hyun-Wook Park Dukhee Nho Dong-Gun Lee Hyeon Woo Yim Sung-Yeon Cho Source Type: research
Severe adenovirus infection outbreak in Colombia: Experience from a tertiary pediatric hospital in 2022
Conclusion. In 2022, there was an outbreak of severe adenovirus infections, affecting mainly children under five years of age, with higher-than-usual mortality.PMID:38648343 | DOI:10.7705/biomedica.7047 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - April 22, 2024 Category: International Medicine & Public Health Authors: Natalia V élez-Tirado Lina Casta ño-Jaramillo Sonia Restrepo-Gualteros Catalina Alcal á-Lozano Erika Ruge Carolina Puente Diana Li-Zeng Diego Chaparro-Arce Mar ía Camila Beltrán-Dimas Juan Francisco L ópez Miguel Luengas-Monroy Diego Galvis-Trujillo Source Type: research
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
CONCLUSIONS: The implementation of COVID-19 infection control measures reduced the incidence of cRV infection. However, CDI increased significantly and incidence rates of CPE and VRE remained unchanged in hematological patients after the pandemic. Infection control measures suitable for each type of HCAI, such as stringent hand washing for CDI and enough isolation capacities, should be implemented and maintained in future pandemics, especially in immunocompromised patients.PMID:38649159 | DOI:10.3904/kjim.2023.508 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Seohee Oh Yu-Sun Sung Mihee Jang Yong-Jin Kim Hyun-Wook Park Dukhee Nho Dong-Gun Lee Hyeon Woo Yim Sung-Yeon Cho Source Type: research
Severe adenovirus infection outbreak in Colombia: Experience from a tertiary pediatric hospital in 2022
Conclusion. In 2022, there was an outbreak of severe adenovirus infections, affecting mainly children under five years of age, with higher-than-usual mortality.PMID:38648343 | DOI:10.7705/biomedica.7047 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - April 22, 2024 Category: International Medicine & Public Health Authors: Natalia V élez-Tirado Lina Casta ño-Jaramillo Sonia Restrepo-Gualteros Catalina Alcal á-Lozano Erika Ruge Carolina Puente Diana Li-Zeng Diego Chaparro-Arce Mar ía Camila Beltrán-Dimas Juan Francisco L ópez Miguel Luengas-Monroy Diego Galvis-Trujillo Source Type: research
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
CONCLUSIONS: The implementation of COVID-19 infection control measures reduced the incidence of cRV infection. However, CDI increased significantly and incidence rates of CPE and VRE remained unchanged in hematological patients after the pandemic. Infection control measures suitable for each type of HCAI, such as stringent hand washing for CDI and enough isolation capacities, should be implemented and maintained in future pandemics, especially in immunocompromised patients.PMID:38649159 | DOI:10.3904/kjim.2023.508 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Seohee Oh Yu-Sun Sung Mihee Jang Yong-Jin Kim Hyun-Wook Park Dukhee Nho Dong-Gun Lee Hyeon Woo Yim Sung-Yeon Cho Source Type: research
