Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy

CONCLUSIONS: Paracrine and autocrine secretions of VEGF-B induce expansion of a specific endocardium-derived endothelial cell population with distinct angiogenic markers. However, autocrine VEGF-B signaling fails to promote VEGF-B-induced endothelial cell migration and contribution to myocardial capillaries, predisposing to septal defects and inducing a mismatch between angiogenesis and myocardial growth, which results in pathological cardiac hypertrophy.PMID:38655691 | DOI:10.1161/CIRCRESAHA.123.324136

Source: Circulation Research - April 24, 2024 Category: Cardiology Authors: Ibrahim Sultan Markus Ramste Pim Peletier Karthik Amudhala Hemanthakumar Deepak Ramanujam Annakaisa Tirronen Ylva von Wright Salli Antila Pipsa Saharinen Lauri Eklund Eero Mervaala Seppo Yl ä-Herttuala Stefan Engelhardt Riikka Kivel ä Kari Alitalo Source Type: research