Chemoimmunotherapy combinations: translating basic knowledge into clinical successes
Genes & Immunity, Published online: 13 March 2024; doi:10.1038/s41435-024-00264-9While chemotherapeutic agents were long solely associated with immunosuppression, clinical data demonstrate that the combination of some chemotherapies with immunomodulators can be beneficial against cancer. Defining combinations featuring optimal anticancer activity along with minimal toxicity remains however a major challenge. Clinical evidence suggests that immune responses in patients treated with combination therapies are associated with progression-free survival. Progress in understanding the mechanisms responsible for anticancer imm...
Source: Genes and Immunity - March 13, 2024 Category: Genetics & Stem Cells Authors: Lionel Apetoh Source Type: research

Pivotal role of BCL11B in the immune, hematopoietic and nervous systems: a review of the BCL11B-associated phenotypes from the genetic perspective
Genes & Immunity, Published online: 12 March 2024; doi:10.1038/s41435-024-00263-wPivotal role of BCL11B in the immune, hematopoietic and nervous systems: a review of the BCL11B-associated phenotypes from the genetic perspective (Source: Genes and Immunity)
Source: Genes and Immunity - March 12, 2024 Category: Genetics & Stem Cells Authors: Jos é María García-Aznar Sara Alonso Alvarez Teresa Bernal del Castillo Source Type: research

RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma
Genes & Immunity, Published online: 12 March 2024; doi:10.1038/s41435-024-00265-8RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma (Source: Genes and Immunity)
Source: Genes and Immunity - March 12, 2024 Category: Genetics & Stem Cells Authors: Xinhui Li Shan Liu Laibin Zou Min Dai Chaobei Zhu Source Type: research

Intratumoral NK cell delivery combined with neutralization of the NKG2A pathway as treatment for solid cancer
Genes & Immunity, Published online: 09 March 2024; doi:10.1038/s41435-024-00267-6Intratumoral NK cell delivery combined with neutralization of the NKG2A pathway as treatment for solid cancer (Source: Genes and Immunity)
Source: Genes and Immunity - March 9, 2024 Category: Genetics & Stem Cells Authors: Ignacio Melero Carmen Molina Cristina Eguizabal Maite Alvarez Source Type: research

Getting under the skin: resident memory CD8+ T cells have a second residence in the draining lymph node
Genes & Immunity, Published online: 08 March 2024; doi:10.1038/s41435-024-00266-7Getting under the skin: resident memory CD8+ T cells have a second residence in the draining lymph node (Source: Genes and Immunity)
Source: Genes and Immunity - March 8, 2024 Category: Genetics & Stem Cells Authors: Teresa Neuwirth Azuah L. Gonzalez Emilie Fisher-Gupta Georg Stary Source Type: research

Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease
Genes & Immunity, Published online: 23 February 2024; doi:10.1038/s41435-024-00260-zCytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease (Source: Genes and Immunity)
Source: Genes and Immunity - February 23, 2024 Category: Genetics & Stem Cells Authors: Marisa Flook Elena Rojano Alvaro Gallego-Martinez Alba Escalera-Balsera Patricia Perez-Carpena M. del Carmen Moleon Rocio Gonzalez-Aguado Victoria Rivero de Jesus Emilio Dom ínguez-Durán Lidia Frejo Juan A. G. Ranea Jose Antonio Lopez-Escamez Source Type: research

Epigenetic reprogramming of CAR T cells for in vivo functional persistence against solid tumors
Genes & Immunity, Published online: 22 February 2024; doi:10.1038/s41435-024-00262-xEpigenetic reprogramming of CAR T cells for in vivo functional persistence against solid tumors (Source: Genes and Immunity)
Source: Genes and Immunity - February 22, 2024 Category: Genetics & Stem Cells Authors: Michael Saitakis Source Type: research

Correction: Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line
Genes & Immunity, Published online: 20 February 2024; doi:10.1038/s41435-024-00259-6Correction: Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line (Source: Genes and Immunity)
Source: Genes and Immunity - February 20, 2024 Category: Genetics & Stem Cells Authors: Maria Perez-Lanzon Maria Chiara Maiuri Carlos Lopez-Otin Guido Kroemer Source Type: research

CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study
Genes & Immunity, Published online: 17 February 2024; doi:10.1038/s41435-024-00258-7CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study (Source: Genes and Immunity)
Source: Genes and Immunity - February 17, 2024 Category: Genetics & Stem Cells Authors: Xinran Xue Zhihao Wen Xin Zhang Ying Yang Yifei Li Ruoxi Liao Qin Zheng Yang Fu Yu Liu Hongyan Liao Source Type: research

Navigating the thymic landscape through development: from cellular atlas to tissue cartography
Genes & Immunity, Published online: 10 February 2024; doi:10.1038/s41435-024-00257-8Navigating the thymic landscape through development: from cellular atlas to tissue cartography (Source: Genes and Immunity)
Source: Genes and Immunity - February 10, 2024 Category: Genetics & Stem Cells Authors: D örte Symmank Felix Clemens Richter Andr é F. Rendeiro Source Type: research

An immunogenomic exome landscape of triple positive primary antiphospholipid patients
Genes & Immunity, Published online: 24 January 2024; doi:10.1038/s41435-024-00255-wAn immunogenomic exome landscape of triple positive primary antiphospholipid patients (Source: Genes and Immunity)
Source: Genes and Immunity - January 24, 2024 Category: Genetics & Stem Cells Authors: A. Guffroy L. Jacquel Y. Seeleuthner N. Paul V. Poindron F. Maurier V. Delannoy A. C. Voegeli P. Zhang B. Nespola A. Molitor M. J. Apithy P. Soulas-Sprauel T. Martin R. E. Voll S. Bahram V. Gies J. L. Casanova A. Cobat B. Boisson R. Carapito A. S. Korgano Source Type: research

BCL2 inhibition stimulates dendritic cell function for improved anticancer immunotherapy
Genes & Immunity, Published online: 24 January 2024; doi:10.1038/s41435-024-00256-9BCL2 inhibition stimulates dendritic cell function for improved anticancer immunotherapy (Source: Genes and Immunity)
Source: Genes and Immunity - January 24, 2024 Category: Genetics & Stem Cells Authors: Peng Liu Liwei Zhao Guido Kroemer Oliver Kepp Source Type: research

Take my breath away—mitochondrial dysfunction drives CD8+ T cell exhaustion
Genes & Immunity, Published online: 22 January 2024; doi:10.1038/s41435-023-00233-8Take my breath away—mitochondrial dysfunction drives CD8+ T cell exhaustion (Source: Genes and Immunity)
Source: Genes and Immunity - January 22, 2024 Category: Genetics & Stem Cells Authors: Felix Clemens Richter Mariia Saliutina Ahmed N. Hegazy Andreas Bergthaler Source Type: research

Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Genes & Immunity, Published online: 22 January 2024; doi:10.1038/s41435-024-00254-xInterferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation (Source: Genes and Immunity)
Source: Genes and Immunity - January 22, 2024 Category: Genetics & Stem Cells Authors: Hao Zhang Di Zhang Yue Xu He Zhang Zijian Zhang Xiaopeng Hu Source Type: research

Same name, different game?—How ontogeny shapes classical monocyte phenotypes
Genes & Immunity, Published online: 20 January 2024; doi:10.1038/s41435-023-00248-1Same name, different game?—How ontogeny shapes classical monocyte phenotypes (Source: Genes and Immunity)
Source: Genes and Immunity - January 20, 2024 Category: Genetics & Stem Cells Authors: Lisabeth Pimenov Azuah Lucrecia Gonzalez Amanda C. Doran Sylvia Knapp Source Type: research