Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice

CONCLUSIONS: This study provides a promising oncolytic virus treatment strategy for TNBC based on targeting dysregulated cholesterol metabolism. It also establishes a basis for subsequent clinical trials of ADV-ApoA1 in the treatment of TNBC.PMID:38566092 | DOI:10.1186/s13046-024-03011-0

Source: Clinical Genitourinary Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Jie Dong Lingkai Kong Shiqun Wang Mao Xia Yenan Zhang Jingyi Wu Fuming Yang Shuguang Zuo Jiwu Wei Source Type: research