Shank3 deficiency elicits autistic-like behaviors by activating p38 α in hypothalamic AgRP neurons

ConclusionsThese results demonstrate that theShank3 deficiency caused autistic-like behaviors by activating p38 α signaling in AgRP neurons, suggesting that p38α signaling in AgRP neurons is a potential therapeutic target forShank3 mutant-related autism.

http://link.springer.com/10.1186/s13229-024-00595-4

Source: Molecular Autism - April 3, 2024 Category: Molecular Biology Source Type: research