Title: Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential

Conclusions: Our multiplexed qHTS approach allowed us to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP. The use of structure-based clustering analysis allowed us to identify molecular features that are likely responsible for the observed activity.

Citation: Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. 2015. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect 123:49–56; http://dx.doi.org/10.1289/ehp.1408642
Address correspondence to M. Xia, National Institutes of Health, National Center for Advancing Translational Sciences, 9800 Medical Center Dr., Bethesda, MD 20892-3375 USA. Telephone: [phone]. E-mail: [e-mail]
We thank P. Shinn and M. Itkin for assistance with compound management.
This work was supported through interagency agreement IAG Y2-ES-7020-01 from the National Institute of Environmental Health Sciences (NIEHS)/Division of the National Toxicology Program to the National Center for Advancing Translational Sciences, NIH.
The views expressed in this paper are those of the authors and do not necessarily reflect the statements, opinions, views, conclusions, or policies of the U.S. EPA, the NIEHS, the National Center for Advancing Translational Sciences, the NIH, or ...

Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research