Structural and Functional Amygdala Abnormalities in Hemifacial Spasm
Structural and Functional Amygdala Abnormalities in Hemifacial Spasm Hui Xu1,2,3, Chenguang Guo1, Haining Li1, Lin Gao2, Ming Zhang1* and Yuan Wang1* 1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, China 3Faculty of Dentistry, University of Toronto, Toronto, ON, Canada Background and Purpose: Hemifacial spasm (HFS) is a rare neuromuscular disorder characterized by unilateral, involuntary, and paroxysmal contractions of orofacial muscles. To elucidate the central neural mechanisms of HFS, we investigated brain gray matter and resting-state functional connectivity (rsFC) in HFS patients. Methods: Thirty patients with HFS and 30 age- and sex-matched healthy participants consented to the study. T1-weighted structural magnetic resonance imaging (MRI) and resting-state BOLD images were collected in all participants. Cortical gray matter thickness was assessed, and subcortical volumetric analysis was performed. Seed-based rsFC analysis was performed on structurally abnormal regions in HFS patients. Post hoc correlations with HFS severity and measures of mood (i.e., depression and anxiety) were performed to characterize rsFC alterations. Results: There were no significant differences in cortical thickness in HFS patients compared to healt...
Publication date: Available online 23 October 2019Source: Molecular and Cellular ProbesAuthor(s): Yi ChenAbstractCyclooxygenase-2 (COX-2) is an inducible enzyme that plays a key role in the inflammatory cascade through the generation of prostaglandins. Recent studies have found that COX-2 is closely related to the occurrence and development of tumors, angiogenesis and metastasis of tumors. Overexpressed COX-2 has become a predictive biomarker for progression of pre-malignant towards cancer in some tissues, which makes the detection of COX-2 of great value and clinical significance. This review highlights COX-2-specific flu...
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02129A, CommunicationYouping Tian, Yi Gong, Xiao-Si Hu, Jin-Sheng Yu, Ying Zhou, Jian Zhou A highly efficient metal-free aldol-type reaction of various acetals or ketals with fluorinated silyl enol ethers catalysed by less than 1 mol% HClO4 (70% wt., aq.) is developed. This provides... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01967G, PaperYi He, Thomas Narmon, Danjun WU, Zhenghua Li, Luc Van Meervelt, Erik V Van der Eycken A rapid approach for the diversity-oriented synthesis of complex bridged polycyclic N-heterocycles from readily available starting materials in two operational steps has been developed. This strategy firstly introduces molecular diversity... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02165E, PaperDengke Li, Jian Lei A method for the synthesis of 2-thiolated benzimidazoles is described starting from thiols and 1-azido-2-isocyanoarenes. The isocyano group works as acceptor of various thio radicals, followed by denitrogenative annulation of... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02138H, PaperChen Zhou, Chen Hu, Gang Hong, Yuchen He, Zhicong Tang, Limin Wang A highly efficient dehydrogenative reaction of a series of nucleophiles with 9-aryl-fluoren-9-ols has been realized by using only 2 mol % of Sc(OTf)3 as catalyst. The corresponding indole-containing 9,9-diarylfluorenes were... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02079A, PaperAdam Forman, Roland Pfoh, Alexander Eddenden, P. Lynne Howell, Mark Nitz Mono-de-N-acetylated β-(1→6)-N-acetyl-D-glucosamine penta- and hepta-saccharides were obtained using a convergent synthesis. The site of de-N-acetylation drives the selectivity of hydrolysis by PgaB. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02065A, PaperLaurent El Kaim, Mahanandaiah Kurva, Mansour Dol é Kerim, Rocío Gámez-Montaño The Ugi reaction of 2-nitrobenzoic acid derivatives has been used for a Diversity Oriented Synthesis of complex isoindolinones via a SNAr reaction involving the peptidyl position. When the cyclization is... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02095K, CommunicationXia Zhang, Jingchao Chen, Ruhima Khan, Guoli Shen, Zhenxiu He, Yongyun Zhou, Baomin Fan The rhodium-catalyzed transfer hydrogenation of quinoxalines with water as hydrogen source was reported. The reaction allowed the simple preparation of tetrahydroquinoxalines in mild conditions. The deuterium-labelling experiment confirmed that water... The content of this RSS Feed (c) The Royal Society of Chemistry
We report the synthesis of 4-thioferulic acid (TFA), a new ferulic acid (FA) derivative, and highlight the differences between the two compounds concerning rate and mechanism of radical scavenging activity,... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01858A, CommunicationJulie E. Laudenschlager, Logan A. Combee, Michael K. Hilinski Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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