Structural and Functional Amygdala Abnormalities in Hemifacial Spasm

Structural and Functional Amygdala Abnormalities in Hemifacial Spasm Hui Xu1,2,3, Chenguang Guo1, Haining Li1, Lin Gao2, Ming Zhang1* and Yuan Wang1* 1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, China 3Faculty of Dentistry, University of Toronto, Toronto, ON, Canada Background and Purpose: Hemifacial spasm (HFS) is a rare neuromuscular disorder characterized by unilateral, involuntary, and paroxysmal contractions of orofacial muscles. To elucidate the central neural mechanisms of HFS, we investigated brain gray matter and resting-state functional connectivity (rsFC) in HFS patients. Methods: Thirty patients with HFS and 30 age- and sex-matched healthy participants consented to the study. T1-weighted structural magnetic resonance imaging (MRI) and resting-state BOLD images were collected in all participants. Cortical gray matter thickness was assessed, and subcortical volumetric analysis was performed. Seed-based rsFC analysis was performed on structurally abnormal regions in HFS patients. Post hoc correlations with HFS severity and measures of mood (i.e., depression and anxiety) were performed to characterize rsFC alterations. Results: There were no significant differences in cortical thickness in HFS patients compared to healt...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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