Regulator of Angiogenesis and Vascular Function: A 2019 Update of the Vasoinhibin Nomenclature

Regulator of Angiogenesis and Vascular Function: A 2019 Update of the Vasoinhibin Nomenclature Jakob Triebel1*, Juan Pablo Robles2, Magdalena Zamora2, Gonzalo Martínez de la Escalera2, Thomas Bertsch1 and Carmen Clapp2 1Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg and Paracelsus Medical University Nuremberg, Nuremberg, Germany 2Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico Proteolytic cleavage of prolactin (PRL), the human anterior pituitary hormone fundamental for lactation can generate vasoinhibin, a peptide-hormone with endocrine, paracrine, and autocrine effects not shared with its precursor. Vasoinhibin effects include the regulation of blood vessel growth, permeability, and dilation (1, 2), and non-vascular effects such as stimulation of vasopressin release (3), thrombolytic actions (4), inhibition of neurite outgrowth (5), and the stimulation of anxiety- and depression-related behaviors (6). Vasoinhibin signals through a still-unidentified receptor on endothelial cells distinct from the PRL-receptor and interacts with multiple binding partners (4, 7, 8). The role of vasoinhibin in biology and disease is evolving and its understanding requires the revision of its nomenclature, which is the purpose of this commentary (9). The regulation of vasoinhibin generation occurs at the hypothalamo, the pituitary, and the targ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research