Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis
Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis Tania Rahman1,2†‡, Andrew S. Brown2‡, Elizabeth L. Hartland1‡, Ian R. van Driel2* and Ka Yee Fung1†‡ 1Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia 2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia We have examined the influence of depleting plasmacytoid dendritic cells (pDC) in mice on the immune response to the gut pathogen Citrobacter rodentium, an organism that is a model for human attaching effacing pathogens such as enterohaemorraghic E. coli. A significantly higher number of C. rodentium were found in mice depleted of pDC from 7 days after infection and pDC depleted mice showed increased gut pathology and higher levels of mRNA encoding inflammatory cytokines in the colon upon infection. pDC-depletion led to a compromising of the gut mucosal barrier that may have contributed to increased numbers of C. rodentium in systemic organs. pDC-depleted mice infected with C. rodentium suffered substantial weight loss necessitating euthanasia. A number of observations suggested that this was not simply the result of dysregulation of immunity in the colon as pDC-depleted mice infected intravenously with C. rodentium also exhibited exacerbated ...
Publication date: Available online 21 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): George Makedonas, Satish K. Mehta, Richard A. Scheuring, Robert Haddon, Brian E. Crucian
Publication date: Available online 20 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Chandra Vethody, Roger Yu, Jacob M. Keck, Michelle K. Onasch, Cosby A. Stone, Elizabeth J. Phillips
A new study has suggested that some patients who make this switch may experience"double immunosuppression" – very low levels of both T and B cells, and therefore be at increased risk for infection.Medscape Medical News
Publication date: Available online 20 September 2020Source: Materials Today: ProceedingsAuthor(s): Asmaa EL Mazyani, Mohammed Chafi, Mohamed Essahli
Presentation of CF, airway clearance regimens, diabetes in CF, and other highlights from the cystic fibrosis episode of The Cribsiders podcast.Medscape Pediatrics
Abstract Pulmonary comorbidities and ASA physical status class III and IV can significantly increase the rate of major complications after ISC placement. Patients with an underlying pulmonary comorbidity or lung disease (chronic obstructive pulmonary disease, asthma, or obstructive sleep apnea) have a 2.2-fold increased risk of having any complication and a 2.4-fold increased risk of having a major pulmonary complication compared to those without pulmonary comorbidities. Patients with pulmonary comorbidities may benefit from alternative pain management strategies to avoid complications in the early postoperative p...
The combination of lenvatinib and pembrolizumab may extend by more than 1 year the lives of patients with advanced melanoma who progress after immunotherapy, show'important'trial results.Medscape Medical News
I commend to your attentionthis essay by Hunter (somewhat lengthy in the context of today's short attention spans) and this by Lili Loofbourow (equally lengthy). They make somewhat similar points, with different framing, so pick the one you like. The version in a pistachio shell is that it's pointless to accuse Republicans of hypocrisy, or lying, because they aren't even pretending to actually believe anything they say. It's all bullshit, 100%. That also means it's pointless to try to have a discussion based on facts and logic, because neither of those words means anything to them and their followers. This is tr...
Publication date: Available online 20 September 2020Source: Journal of Theoretical BiologyAuthor(s): Ke Li, James M. McCaw, Pengxing Cao
Publication date: Available online 20 September 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Aref Abbasi Moud, Milad Kamkar, Amir Sanati-Nezhad, Seyed Hossein Hejazi, Uttandaraman Sundararaj
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