Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis Tania Rahman1,2†‡, Andrew S. Brown2‡, Elizabeth L. Hartland1‡, Ian R. van Driel2* and Ka Yee Fung1†‡ 1Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia 2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia We have examined the influence of depleting plasmacytoid dendritic cells (pDC) in mice on the immune response to the gut pathogen Citrobacter rodentium, an organism that is a model for human attaching effacing pathogens such as enterohaemorraghic E. coli. A significantly higher number of C. rodentium were found in mice depleted of pDC from 7 days after infection and pDC depleted mice showed increased gut pathology and higher levels of mRNA encoding inflammatory cytokines in the colon upon infection. pDC-depletion led to a compromising of the gut mucosal barrier that may have contributed to increased numbers of C. rodentium in systemic organs. pDC-depleted mice infected with C. rodentium suffered substantial weight loss necessitating euthanasia. A number of observations suggested that this was not simply the result of dysregulation of immunity in the colon as pDC-depleted mice infected intravenously with C. rodentium also exhibited exacerbated ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CrystEngComm, 2020, Accepted Manuscript DOI: 10.1039/D0CE00251H, PaperPrasanta Kumar Bhaumik, Abhisek Banerjee, Tamal Dutta, Sudipta Chatterjee, Antonio Frontera, Shouvik Chattopadhyay Two compartmental N2O4 donor Schiff bases, H2L1 [N,N-bis(3-methoxysalicylidene)-2,2-dimethylpropane-1,3-diamine] and H2L2 [N,N-bis(3-ethoxysalicylidene)-2,2-dimethylpropane-1,3-diamine], each having inner N2O2 and outer O4 compartments, have been used to prepare four hetero-trinuclear nickel(II) complexes [Ni(L1)Na(L1)Ni(NCS)] •H2O (1),... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 20 February 2020Source: MethodsXAuthor(s): O.J. Røtterud, G.E.N. Gravning, S.J. Hauge, O. AlvseikeAbstractThe Hygiene Performance Rating scheme is developed by Animalia in Norway. This unique auditing tool for assessment of slaughter hygiene has been used in Norwegian abattoirs for the last 10 years. The Hygiene Performance Rating scheme visually evaluates and documents each operation on the slaughter line, assessing the factors that can affect the slaughter hygiene. The protocol is based on a systematic evaluation of general hygienic practices of each operation, such as the operat...
Source: MethodsX - Category: Science Source Type: research
This study demonstrated that there was a higher abundance of sRNA in the pig farm WWTPs and 52 sRNAs were detected. The sRNAs were mainly present in Proteobacteria and Firmicutes, including the potential human pathogenic bacteria (HPB) (Escherichia, Shigella, Bordetella and Morganella), crop pathogen (Pectobacterium) and denitrifying bacteria (Zobellella). And the sRNAs were involved in the bacterial functional activities such as translation, transcription, drug resistance, membrane transport and amino acid metabolism. In addition, most sRNAs had a higher abundance in anoxic tanks which contained a higher abundance of the ...
Source: Journal of Environmental Sciences - Category: Environmental Health Source Type: research
In this study, an analysis of the potential mechanism underlying photocatalytic disinfection was performed based on integrated metabolic networks and transcriptional data. Two sets of RNA-seq data (wild type and a photocatalysis-resistant mutant mediated by titanium dioxide (TiO2)) were processed to constrain the genome scale metabolic models (GSMM) of E. coli. By analyzing the metabolic network, the differential metabolic flux of every reaction was computed in constrained GSMM, and several significantly differential metabolic fluxes in reactions were extracted and analyzed. Most of these reactions were involved in the tra...
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Publication date: March 2020Source: Journal of Phonetics, Volume 79Author(s): Jelena Krivokapić, Will Styler, Benjamin ParrellAbstractStudies examining articulatory characteristics of pauses have identified language-specific postures of the vocal tract in inter-utterance pauses and different articulatory patterns in grammatical and non-grammatical pauses. Pause postures—specific articulatory movements that occur during pauses at strong prosodic boundaries—have been identified for Greek and German. However, the cognitive function of these articulations has not been examined so far. We start addressing this ques...
Source: Journal of Phonetics - Category: Speech-Language Pathology Source Type: research
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This study aims to address how the 2008 Wenchuan Earthquake influenced knowledge generation and diffusion compared to the research stemming from the 1989 Loma Prieta Earthquake in the United States and the 1995 Hanshin Awaji Earthquake in Japan, for the three countries are exposed to high seismic risk. The findings show that (1) regarding research quantity, the influence of the Wenchuan Earthquake on disaster-related knowledge generation is just beginning compared with the gradual decreases in research on the other earthquakes; (2) regarding disciplinary development, the proportion of studies relating to the Wenchuan Earth...
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Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
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Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research
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