Transitional Cell Carcinoma Research Transitional Cell Carcinoma RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tumorigenesis of basal muscle invasive bladder cancer was mediated by PTEN protein degradation resulting from SNHG1 upregulation
CONCLUSIONS: Our findings, for the first time, demonstrate that overexpressed SNHG1 competes with USP8 for binding to HUR. This competition attenuates USP8 mRNA stability and protein expression, leading to PTEN protein degradation, consequently, this process drives urothelial cell malignant transformation and fosters BMIBC growth and primary BMIBC formation.PMID:38365726 | DOI:10.1186/s13046-024-02966-4 (Source: Cell Research)
Source: Cell Research - February 16, 2024 Category: Cytology Authors: Tengda Li Maowen Huang Ning Sun Xiaohui Hua Ruifan Chen Qipeng Xie Shirui Huang Mengxiang Du Yazhen Zhao Qianqian Lin Jiheng Xu Xiaoyun Han Yunping Zhao Zhongxian Tian Yu Zhang Wei Chen Xian Shen Chuanshu Huang Source Type: research

Myeloid-derived suppressor cells from tumour-bearing mice induce the population expansion of CD19 < sup > hi < /sup > Fc γRIIb < sup > hi < /sup > regulatory B cells via PD-L1
Immunology. 2024 Feb 8. doi: 10.1111/imm.13763. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) increase in number and gain immunosuppressive functions in tumours and many other pathological conditions. MDSCs are characterized by their strong T-cell immunosuppressive capacity. The effects that MDSCs may have on B cells, especially within the tumour microenvironment, are less well understood. Here, we report that either monocytic MDSCs or polymorphonuclear MDSCs can promote increases in interleukin (IL)-10-expressing CD19hi FcγRIIbhi regulatory B cells in vitro and in vivo. Splenic transitional-1, -2...
Source: Immunology - February 9, 2024 Category: Allergy & Immunology Authors: Wenyan Chen Xiaomin Ning Yang Liu Tingting Shen Mengru Liu Hui Yin Yue Ding Jingwen Zhou Rui Yin Liangliang Cai Yuhan Wu Li Qian Source Type: research

Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis
ConclusionsThis integrative analysis not only provides a comprehensive landscape of pancreatic cancer and fibroblast population, but also suggests a novel insight to the dynamic states of pancreatic cancer cells and unveils potential therapeutic targets.Graphical Abstract (Source: Genome Medicine)
Source: Genome Medicine - January 31, 2024 Category: Genetics & Stem Cells Source Type: research

Malignancy in the public life: the story of Hubert Humphrey ’s bladder cancer
Hubert Horatio Humphrey was the 38th Vice President of the United States and a political leader on the national scene for 30 years. In 1967 he developed hematuria and many years later was diagnosed with bladder cancer. He was treated with radiation, surgical resection and chemotherapy but died in 1978 from metastatic transitional cell carcinoma. This manuscript reviews Humphrey ’s political career, his medical history and how information about his medical condition was used in the lay press. (Source: Urology)
Source: Urology - January 30, 2024 Category: Urology & Nephrology Authors: Kostantinos E. Morris, Theodore N. Pappas Source Type: research

Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management
Curr Cancer Drug Targets. 2024 Jan 25. doi: 10.2174/0115680096281906231213055422. Online ahead of print.ABSTRACTExosomes are very small (nano-sized) vesicles participating in tumor development by involvement in intercellular communication mediated by transferring biocomponents. Exosomes appear to play vital roles in various cancer development, such as ovarian cancer, a common malignancy in women. Several hallmarks of ovarian cancer are reported to be affected by the exosome-- mediated cellular cross-talk, including modulating peritoneal dissemination and chemoresistance. Since the expression of some biomolecules, such as m...
Source: Current Cancer Drug Targets - January 29, 2024 Category: Cancer & Oncology Authors: Vahideh Keyvani Zari Naderi Ghale-Noie Samaneh Mollazadeh Reihaneh Alsadat Mahmoudian Elnaz Ghorbani Hamid Naderi Majid Khazaei Seyed Mahdi Hassanian Gordon A Ferns Amir Avan Kazem Anvari Source Type: research

A concept analysis of transitional care for people with cancer
This study aimed to analyse the concept of transitional care for people with cancer.DesignRodgers' evolutionary concept analysis.MethodsA systematic literature search was conducted on the databases of PubMed (including MEDLINE), EMBASE, Scopus and Web of Science to retrieve articles published between 2000 and 2022.ResultsTwenty-nine eligible articles were selected and their findings were classified in terms of related concepts and alternative terms, antecedents, attributes and consequences. Attributes included three main categories, namely ‘nurse-related attributes’, ‘organisation-related attributes’ and ‘patient...
Source: Nursing Open - January 23, 2024 Category: Nursing Authors: Abbas Mardani, Maryam Azizi, Farshid Alazmani  Noodeh, Azizeh Alizadeh, Maryam Maleki, Mojtaba Vaismoradi, Manela Glarcher Tags: CONCEPT Source Type: research

GSE244534 Spatial Transcriptomics of Pancreatic Tumors Reveal Distinct Compartmentalisation of Neutrophil Subsets [Spatial Transcriptomics]
Contributors : Melissa S Ng ; Immanuel Kwok ; Leonard Tan ; Yingrou Tan ; Shih Changming ; Mengwei Li ; Nicholas Ang ; Jinmiao Chen ; Laiguan NgSeries Type : OtherOrganism : Mus musculusNeutrophils are increasingly recognized as key players in the tumour immune response, and are associated with poor clinical outcomes. Multiple studies have characterised various neutrophil states within the tumor, with associated pro- and anti- tumoral functions. However, it is unknown if this heterogeneity of neutrophils is contributed by their surrounding tumor microenivironment. To answer this, we performed 10X Visium spatial tra...
Source: GEO: Gene Expression Omnibus - January 11, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research

Treatment of Oligometastatic GI Cancers
This article reviews existing data on the management of oligometastatic GI cancer, summarizes current state of knowledge for each disease state, and provides updates on ongoing studies in this space.PMID:38190577 | DOI:10.1200/EDBK_430152 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - January 8, 2024 Category: Cancer & Oncology Authors: Clayton T Marcinak Patrick B Schwartz Mustafa M Basree Newton Hurst Michael Bassetti Jeremy D Kratz Nataliya V Uboha Source Type: research

Alkaloids from Corydalis saxicola and their antiproliferative activity against cancer cells
Fitoterapia. 2023 Dec 28:105791. doi: 10.1016/j.fitote.2023.105791. Online ahead of print.ABSTRACTEight undescribed alkaloids named corydalisine D-K (1-7), including one isoquinoline benzopyranone alkaloid (1), one benzocyclopentanone alkaloid (2), four benzofuranone alkaloids (3, 4, and 5a/5b) and two protoberberine alkaloids (6 and 7), along with fourteen known ones, were isolated from the Corydalis saxicola. Their structures, including absolute configurations, were unambiguously identified using spectroscopic techniques, single-crystal X-ray diffraction and electron circular dichroism calculation. Compounds 2, 14 and 21...
Source: Fitoterapia - December 30, 2023 Category: Biochemistry Authors: Li Luo Jia-Zi Luo Xi-Xi Song Cai-Yi Wang De-Ming Tang Wen-Tao Sun Cai-Wen Fan Mei-Shan Li Heng-Shan Wang Source Type: research

Clinico-demographic Profile of Carcinoma Urinary Bladder —5-Year Experience from a Tertiary Care Centre of Eastern India
In this study, we analysed the clinico-demographic profile of patients with urinary bladder carcinoma, attending a tertiary care centre in Eastern India over the last 5  years. We analysed the database of Oncology OPD of a tertiary care centre in West Bengal in Eastern India and collected the demographic, clinical and treatment data of urinary bladder carcinoma patients who attended our OPD between 2017 and 2021. The objective was to assess the demographic and cli nical profile of these patients and compare them with those reported from other parts of India as well as the rest of the world. Majority of patients (70%) were...
Source: Indian Journal of Surgical Oncology - December 15, 2023 Category: Cancer & Oncology Source Type: research

Human polyomaviruses JCPyV and MCPyV in urothelial cell carcinoma: a single institution experience
ConclusionOur findings show the presence of JCPyV in the urine and UCC of immunocompetent patients. Moreover, MCPyV was detected in two UCC cases. In total, five UCC cases showed the presence of either JCPyV or MCPyV. The evidence here supports the hypothesis that these viruses might sporadically be associated with UCC. Further studies are needed to confirm the relevance of JCPyV or MCPyV as a possible risk factor for UCC development. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 13, 2023 Category: Cancer & Oncology Source Type: research

Transitional Epidemiology of Human Papillomavirus Infection in Iran: A Cross-Sectional Study and National Review
CONCLUSION: The hypothesis of the impact of behavioral and cultural changes in addition to population aging on general health indicates the need for national health promotion strategies. Additionally, it emphasizes the critical significance of conducting further investigational studies to obtain the actual and updated prevalence of HPV in Iran.PMID:38073753 | PMC:PMC10699225 | DOI:10.4103/abr.abr_396_21 (Source: Adv Data)
Source: Adv Data - December 11, 2023 Category: Epidemiology Authors: Malihe Hasanzadeh Saeid Amel Jamehdar Leila Mousavi Seresht Mohammad Taghi Shakeri Somaye Bolandi Source Type: research

Effects of a return to work program on the health and barriers to returning to work in head and neck cancer patients: A randomized controlled trial
CONCLUSIONS: The RTW program effectively improved perceived health status and psychosocial function in HNC patients. Survivorship care should include a transitional return-to-work program to help patients transition back to work.TRIAL REGISTRATION: NCT04322695.PMID:38059206 | PMC:PMC10696387 | DOI:10.1016/j.apjon.2023.100320 (Source: Cancer Control)
Source: Cancer Control - December 7, 2023 Category: Cancer & Oncology Authors: Ya-Lan Chang Bing-Shen Huang Chien-Yu Lin Ching-Fang Chung Shu-Ching Chen Source Type: research

Assessment of quantitative zonal parameters of prostate gland in discrimination of normal, benign, and malignant conditions: are these the more reliable parameters in the diagnosis of prostate cancer?
CONCLUSIONS: Quantitative DCE-MRI parameters may vary according to age, disease, and zonal anatomy. These differences may contribute to the diagnosis of clinically relevant prostate cancer.PMID:38039044 | DOI:10.26355/eurrev_202311_34482 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: L Karaca Z M Özdemir A Kahraman H Çelik S Kaya Source Type: research

Assessment of quantitative zonal parameters of prostate gland in discrimination of normal, benign, and malignant conditions: are these the more reliable parameters in the diagnosis of prostate cancer?
CONCLUSIONS: Quantitative DCE-MRI parameters may vary according to age, disease, and zonal anatomy. These differences may contribute to the diagnosis of clinically relevant prostate cancer.PMID:38039044 | DOI:10.26355/eurrev_202311_34482 (Source: Cancer Control)
Source: Cancer Control - December 1, 2023 Category: Cancer & Oncology Authors: L Karaca Z M Özdemir A Kahraman H Çelik S Kaya Source Type: research