Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research

Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: Am J Pathol)
Source: Am J Pathol - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research

Metabolome sequencing reveals that PRMT1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis
This study identified the metabolic type-related features and intermediate transition morphology of IMPC, and the identification of potential targets of PRMT1 is expected to provide a basis for the precise diagnosis and treatment of breast IMPC.PMID:37301537 | DOI:10.1016/j.ajpath.2023.05.010 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - June 10, 2023 Category: Pathology Authors: Kailiang Wu Weidong Li Hanjiao Liu Chen Niu Qianqian Shi Jingyue Zhang Guangshen Gao Hui Sun Fangfang Liu Li Fu Source Type: research

Cancers, Vol. 15, Pages 3086: The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model
Conclusions: Our findings highlight the potential of SHR-5 as an anti-aging agent for bladder cancer prevention through reshaping tumor metabolism via the inhibition of the mTOR signaling. Global metabolomics profiling provides a unique and efficient tool for studying the mechanisms of complex herb extracts’ action. (Source: Cancers)
Source: Cancers - June 7, 2023 Category: Cancer & Oncology Authors: Zhongbo Liu Noriko N Yokoyama Liankun Song Jun Xie Zhina Sadeghi Yi Xi Wu Sarah Yee Xue-Ru Wu Beverly Wang Edward Uchio Xiaolin Zi Tags: Article Source Type: research

High risk of non-cancer mortality in bladder cancer patients: evidence from SEER-Medicaid
CONCLUSIONS: Cardiovascular diseases are the leading non-cancer cause of death in BC patients, followed by respiratory disease, diabetes mellitus and infectious diseases. Physicians should pay attention to the risk of death from these non-cancer diseases. Also, physicians should encourage patients to engage in more proactive self-surveillance and follow up.PMID:37270459 | DOI:10.1007/s00432-023-04867-z (Source: Cell Research)
Source: Cell Research - June 3, 2023 Category: Cytology Authors: Shunde Wang Chengguo Ge Source Type: research

High risk of non-cancer mortality in bladder cancer patients: evidence from SEER-Medicaid
ConclusionsCardiovascular diseases are the leading non-cancer cause of death in BC patients, followed by respiratory disease, diabetes mellitus and infectious diseases. Physicians should pay attention to the risk of death from these non-cancer diseases. Also, physicians should encourage patients to engage in more proactive self-surveillance and follow up. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 3, 2023 Category: Cancer & Oncology Source Type: research

Single-cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal esophageal squamous cell carcinoma
GobioX BioTech, China; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, China; Shanghai Collaborative Innovation Center of Endoscopy, China; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, China. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - June 1, 2023 Category: Gastroenterology Authors: Xinyang Liu, YANBO LIU, Jia-Cheng Xu, Yi-Fei Zhang, Yuan-Yuan Ruan, Yi Zhao, Lin-Feng Wu, Jian-Wei Hu, Zhen Zhang, Meng-Jiang He, Tianyin Chen, Xiaoyue Xu, Jing-Wei Zhang, Yi-Qun Zhang, Ping-Hong Zhou Tags: Esophagus 2 Monday, May 8, 2023 8:00 AM - 9:30 AM Source Type: research

Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization
Int J Mol Sci. 2023 May 9;24(10):8500. doi: 10.3390/ijms24108500.ABSTRACTMultiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promoting resistance to treatments. To date no studies have determined the impact of genetic variation in autophagy-related genes on MM risk. We perf...
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Esther Clavero Jos é Manuel Sanchez-Maldonado Angelica Macauda Rob Ter Horst Bel ém Sampaio-Marques Artur Jurczyszyn Alyssa Clay-Gilmour Angelika Stein Michelle A T Hildebrandt Niels Weinhold Gabriele Buda Ram ón García-Sanz Waldemar Tomczak Ulla Voge Source Type: research

< em > Nuclear Protein 1 < /em > Expression Is Associated with PPARG in Bladder Transitional Cell Carcinoma
CONCLUSIONS: The study findings indicate that Nuclear protein 1 is positively associated with the malignancy degree of BTCC and that Nuclear protein 1 expression is negatively correlated with PPARG.PMID:37197716 | PMC:PMC10185424 | DOI:10.1155/2023/6797694 (Source: PPAR Research)
Source: PPAR Research - May 17, 2023 Category: Genetics & Stem Cells Authors: Chao Lu Shenglin Gao Li Zhang Xiaokai Shi Yin Chen Shuzhang Wei Li Zuo Lifeng Zhang Source Type: research

< em > Nuclear Protein 1 < /em > Expression Is Associated with PPARG in Bladder Transitional Cell Carcinoma
CONCLUSIONS: The study findings indicate that Nuclear protein 1 is positively associated with the malignancy degree of BTCC and that Nuclear protein 1 expression is negatively correlated with PPARG.PMID:37197716 | PMC:PMC10185424 | DOI:10.1155/2023/6797694 (Source: Cell Research)
Source: Cell Research - May 17, 2023 Category: Cytology Authors: Chao Lu Shenglin Gao Li Zhang Xiaokai Shi Yin Chen Shuzhang Wei Li Zuo Lifeng Zhang Source Type: research

< em > Nuclear Protein 1 < /em > Expression Is Associated with PPARG in Bladder Transitional Cell Carcinoma
CONCLUSIONS: The study findings indicate that Nuclear protein 1 is positively associated with the malignancy degree of BTCC and that Nuclear protein 1 expression is negatively correlated with PPARG.PMID:37197716 | PMC:PMC10185424 | DOI:10.1155/2023/6797694 (Source: PPAR Research)
Source: PPAR Research - May 17, 2023 Category: Genetics & Stem Cells Authors: Chao Lu Shenglin Gao Li Zhang Xiaokai Shi Yin Chen Shuzhang Wei Li Zuo Lifeng Zhang Source Type: research

GSE215920 Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma [Bulk RNA-seq]
Contributors : Marzia Scortegagna ; Ze'ev A RonaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor microenvironment components, including T and myeloid cells, play important roles in lung adenocarcinoma (LADC) progression and response to therapy. Here, we identify a role for Siah1a/2 ubiquitin ligases in controlling alveolar macrophage (AM) differentiation and urethane-induced LADC. Genetic ablation of Siah1a/2 in AMs enriched their immature state, coinciding with increased pro-tumorigenic and inflammatory gene signatures and abundance of Siah1a/2 substrates NRF2 and B-catenin. U...
Source: GEO: Gene Expression Omnibus - May 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research