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Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507)
The South West Oncology Group ’s 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) treatment.... (Source: BMC Urology)
Source: BMC Urology - November 24, 2023 Category: Urology & Nephrology Authors: Jake Tempo, Damien Bolton and Michael O ’Callaghan Tags: Comment Source Type: research

Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507)
BMC Urol. 2023 Nov 24;23(1):194. doi: 10.1186/s12894-023-01352-0.ABSTRACTThe South West Oncology Group's 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) treatment. The results were published when the efficacy of BCG immunotherapy maintenance was unclear.Randomisation produced two arms, each containing 192 patients assessed to be at high risk of recurrence following induction BCG therapy for NMIUC. The treatment arm went on to receive three successive weekly intravesical and percutaneous BCG administrations...
Source: Cancer Control - November 23, 2023 Category: Cancer & Oncology Authors: Jake Tempo Damien Bolton Michael O'Callaghan Source Type: research

Magnetic resonance imaging radiomics-based prediction of clinically significant prostate cancer in equivocal PI-RADS 3 lesions in the transitional zone
ConclusionThe machine learning XGboost model presented the best performance in predicting csPCa in PI-RADS 3 lesions within the transitional zone. However, the addition of radiomic classifiers did not display any significant enhancement over the compound model of clinical and radiological findings. The most exemplary and generalized option for quantitative prostate evaluation was Mean ADC+PSAD. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 23, 2023 Category: Cancer & Oncology Source Type: research

Morphological variants of the invasive urothelial cell carcinoma.
Orv Hetil. 2023 Oct 8;164(40):1567-1582. doi: 10.1556/650.2023.32881. Print 2023 Oct 8.ABSTRACTUrothelial cell carcinoma is the most common malignant tumor of the urinary tract, which develops in the renal pelvis, ureter, and bladder, and rarely it develops in the ureter. Histologically, urothelial cell carcinoma is categorized into non-invasive and invasive forms. Non-invasive urothelial cell carcinoma has papillary growth, it is usually well differentiated, and has a favorable outcome, while invasive urothelial cell carcinoma infiltratively spreads the organs of origin, it is typically poorly differentiated, and often as...
Source: Orvosi Hetilap - November 21, 2023 Category: General Medicine Authors: Bogl árka Pósfai Fanni S ánta Anna Schubert D ávid Semjén Alex Jenei Linda Varga Levente Kuthi Source Type: research

Gene expression profiles to analyze the anticancer and carcinogenic effects of arsenic in bladder cancer
CONCLUSION: Arsenic exerted carcinogenic and anticancer functions by altering the expression of crosstalk genes such as BDKRB2, FOS, NR4A1, PLAU, SH3BGRL, and F10, and these were due to arsenic binding proteins.PMID:37969188 | PMC:PMC10641365 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - November 16, 2023 Category: Research Authors: Xiaomin Han Tengteng Zhang Qiang Ma Ruyi Chang Siyuan Xin Qingzhen Yu Guojun Zhang Yukun Wang Source Type: research

Ambient particulate matter exposure and urologic cancer: a longitudinal nationwide cohort study
Am J Cancer Res. 2023 Oct 15;13(10):4755-4766. eCollection 2023.ABSTRACTIncreased particulate matter (PM) exposure is positively associated with increased incidence and mortality of many human malignancies. However, evidence of urologic cancer is limited. We aimed to evaluate the association between PM10 exposure and the relative risk of urologic cancer. This nationwide longitudinal cohort study included 231,997 participants who underwent a baseline health examination in 2008 from the National Health Information Database of Korea. The primary endpoint was newly diagnosed urologic cancer according to PM10 exposure. Of the t...
Source: Cell Research - November 16, 2023 Category: Cytology Authors: Jihwan Park Mi Jung Rho Yong Hyun Park Source Type: research