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Optimal size threshold for PIRADSv2 category 5 upgrade and its positive predictive value: is it predictive of "very high" likelihood of clinically-significant cancer?
CONCLUSIONS: There is high correlation between MLD and LV with comparable discrimination of csPCA using each. PIRADSv2's 1.5 cm MLD threshold is near the optimal threshold for PIRADS 5 upgrade but has moderate PPV. A much higher threshold would be needed to increase its PPV, with significant sacrifice in sensitivity.PMID:37945438 | DOI:10.1016/j.crad.2023.10.008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - November 9, 2023 Category: Cancer & Oncology Authors: V Batheja M Osman M Wynne D Nemirovsky G Morcos J Riess B Shin M Whalen S Haji-Momenian Source Type: research

The First Report of Cytology of DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma on Fine-Needle Aspiration
AbstractDEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal malignancy defined by its unique translocation.DEK::AFF2 carcinomas may be deceptively monotonous and lack keratinization, resembling transitional epithelium. The lack of traditional cytological atypia presents diagnostic challenges. Our case describes the first report of fine-needle aspiration cytology of a lymph node involved byDEK::AFF2 carcinoma in a patient with previously resected sinonasal inverted papilloma with carcinomatous transformation six years prior to presentation. This aspirate consisted of a lymphoi...
Source: Head and Neck Pathology - November 8, 2023 Category: Pathology Source Type: research

The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy
CONCLUSION: Pathological features and prognosis of bladder cancer with variant histol- ogies are worse than those of pure urothelial bladder cancer. Overall survival and can- cer-specific survival are shorter in bladder cancer with variant histology than in pure urothelial bladder cancer. Following the diagnosis of variant histology in transurethral bladder tumor, poor prognosis must be considered in the treatment plan.PMID:37877826 | DOI:10.5152/tud.2023.22223 (Source: Cell Research)
Source: Cell Research - October 25, 2023 Category: Cytology Authors: Özgür Efiloğlu Mehmet Çağlar Çakıcı G özde Kır Ayberk İplikçi Turgay Turan G özde Ecem Cecikoğlu As ıf Yıldırım Source Type: research

Evaluating the Role of Morphological Parameters in the Prostate Transition Zone in PHI-Based Predictive Models for Detecting Gray Zone Prostate Cancer
CONCLUSION: Our data confirmed the value of prostate TZ morphological parameters and suggested a significant advantage for the TZ-adjusted PHI predictive model (PHI-TZD) compared with PHI and PHID in the early detection of gray zone csPCa under specific conditions.PMID:37869472 | PMC:PMC10588416 | DOI:10.1177/11795549231201122 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 23, 2023 Category: Cancer & Oncology Authors: Yu-Hang Qian Yun-Tian Shi Xu-Jun Sheng Hai-Hong Liao Hao-Jie Chen Bo-Wen Shi Yong-Jiang Yu Source Type: research