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Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil
CONCLUSIONS: The cellular composition, spatial location, molecular and functional changes in PT and TDLN microenvironments along with NSCLC progression were deciphered, highlighting the immunoregulatory roles and evolutionary heterogeneity of TANs.PMID:37491740 | DOI:10.1002/ctm2.1340 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - July 26, 2023 Category: Cancer & Oncology Authors: Haoxin Peng Xiangrong Wu Shaopeng Liu Miao He Chenshuo Tang Yaokai Wen Chao Xie Ran Zhong Caichen Li Shan Xiong Jun Liu Hongbo Zheng Jianxing He Xu Lu Wenhua Liang Source Type: research

Outcomes of Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome
We report the outcomes of a phase I/II clinical trial in which 5 patients with severe WAS underwent GT using a self-inactivating lentiviral (SIN-LV) vector expressing the human WAS cDNA under the control of a 1.6kB fragment of the autologous promoter after busulfan and fludarabine conditioning. All subjects were alive and well with sustained multi-lineage vector gene marking (median follow-up: 7.6 years). Clinical improvement of eczema, infections and bleeding diathesis was universal. Immune function was consistently improved despite sub-physiological levels of transgenic WAS protein expression. Improvements in platelet co...
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Roxane Labrosse Julia Chu Myriam Armant John K Everett Danilo Pellin Niharika Kareddy Andrew L Frelinger Lauren A Henderson Amy E O'Connell Amlan Biswas Jet Coenen-van der Spek Alexandra Marina Miggelbrink Claudia Fiorini Hriju Adhikari Charles C Berry Vi Source Type: research

Effect of four fluoroquinolones on the viability of bladder cancer cells in 2D and 3D cultures
This study aimed to analyze the properties of 4 fluoroquinolones as potential candidates for supportive treatment of bladder cancer. MethodsComparative analyses were performed on the cytotoxic effects of norfloxacin, enrofloxacin, moxifloxacin, and ofloxacin on normal and cancer urothelial cell lines. In 2D culture, the cytotoxic properties of fluoroquinolones were evaluated using MTT assay, real-time cell growth analysis, fluorescence and light microscopy, flow cytometry, and molecular analysis. In 3D culture, the properties of fluoroquinolones were tested using luminescence assays and confocal microscopy.Results and Disc...
Source: Frontiers in Oncology - July 18, 2023 Category: Cancer & Oncology Source Type: research

Fluoranthene-terminated terpyridine ensemble for fluorescence light up and ratiometric chemical sensor for multi toxic metals
Anal Chim Acta. 2023 Sep 15;1274:341526. doi: 10.1016/j.aca.2023.341526. Epub 2023 Jun 23.ABSTRACTA novel π-electron rich fluoranthene embellished with a phenyl spacer and coupled with terpyridine (TS1) was developed through Diels-Alder reaction. Single crystal X-ray structure evidences the variations in dihedral angles between the fluoranthene and the phenyl unit responsible for development of non-coplanar interactions and stabilized by a wave-like molecular packing in the crystal lattice with weak π-π interaction of 4.125 Å. The peripheral terpyridine of TS1 endows an efficient binding with multiple metal ions by col...
Source: Analytica Chimica Acta - July 16, 2023 Category: Chemistry Authors: Kasthuri Selvaraj Prasanth Palanisamy Buthanapalli Ramakrishna Rajesh Pamanji Joseph Selvin Koigoora Srikanth Sohrab Nasiri Stepan Kment Venkatramaiah Nutalapati Source Type: research