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A comprehensive pan-cancer analysis of CDH5 in immunological response
ConclusionIn summary, CDH5 was positively associated with a favorable prognosis and effective immune response in tumors, showing a great potential to serve as a novel tumor biomarker and immune checkpoint. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 21, 2023 Category: Allergy & Immunology Source Type: research

The Tao of copper metabolism: from physiology to pathology
We present a comprehensive overview of the Yin-Yang equilibrium in copper metabolism, particularly emphasising its pathophysiological alterations and their relevance to copper-related diseases and malignancies.PMID:37718523 | DOI:10.2174/0929867331666230915162405 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Shan Gao Mei Zhou Zhenchu Tang Source Type: research

Correlation between androgen and estrogen receptor expression and clinicopathologic features in carcinoma urinary bladder
CONCLUSION: Our study has the largest sample size conducted on Indian population with results differing from previous studies conducted on western population. Estrogen receptor beta expression was significantly associated with small unifocal tumours and better DFS. Estrogen receptor alpha and androgen receptor expression were not found to be associated with the clinicopathologic features of the study population.PMID:37668795 | DOI:10.1007/s00432-023-05348-z (Source: Cell Research)
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Nikita Shrivastava Rahul Jena Gautam Ram Choudhary Priyank Bhargava Vikarn Vishwajeet Poonam Elhence Mahendra Singh Deepak Prakash Bhirud Arjun Singh Sandhu Source Type: research

Resection of Solitary Lung Metastasis of Urinary Tract Transitional Cell Cancer Can Prolong Survival in Selected Patients
In this study, we examined the long-term outcome and the prognostic survival factors associated with pulmonary metastasectomy of urinary tract TCC, as based on our centre's 20-year experience. Between 2000 and 2020, curative pulmonary metastasectomy was performed in 18 patients (14 males and 4 females). Clinical, demographical and surgical data were retrospectively analysed. The disease-free interval between treatment of the primary tumour and pulmonary metastasectomy ranged from one to 48 months. Survival analysis was conducted with the Kaplan-Meier method and log-rank test. The 3- and 5-year survival rates were 84.7% and...
Source: Zentralblatt fur Chirurgie - September 5, 2023 Category: Surgery Authors: Benjamin Ehle Mohamed Hassan Uyen-Thao Le Bernward Passlick Konstantinos Grapatsas Source Type: research

Correlation between androgen and estrogen receptor expression and clinicopathologic features in carcinoma urinary bladder
CONCLUSION: Our study has the largest sample size conducted on Indian population with results differing from previous studies conducted on western population. Estrogen receptor beta expression was significantly associated with small unifocal tumours and better DFS. Estrogen receptor alpha and androgen receptor expression were not found to be associated with the clinicopathologic features of the study population.PMID:37668795 | DOI:10.1007/s00432-023-05348-z (Source: Cell Research)
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Nikita Shrivastava Rahul Jena Gautam Ram Choudhary Priyank Bhargava Vikarn Vishwajeet Poonam Elhence Mahendra Singh Deepak Prakash Bhirud Arjun Singh Sandhu Source Type: research

Resection of Solitary Lung Metastasis of Urinary Tract Transitional Cell Cancer Can Prolong Survival in Selected Patients
In this study, we examined the long-term outcome and the prognostic survival factors associated with pulmonary metastasectomy of urinary tract TCC, as based on our centre's 20-year experience. Between 2000 and 2020, curative pulmonary metastasectomy was performed in 18 patients (14 males and 4 females). Clinical, demographical and surgical data were retrospectively analysed. The disease-free interval between treatment of the primary tumour and pulmonary metastasectomy ranged from one to 48 months. Survival analysis was conducted with the Kaplan-Meier method and log-rank test. The 3- and 5-year survival rates were 84.7% and...
Source: Zentralblatt fur Chirurgie - September 5, 2023 Category: Surgery Authors: Benjamin Ehle Mohamed Hassan Uyen-Thao Le Bernward Passlick Konstantinos Grapatsas Source Type: research

Resection of Solitary Lung Metastasis of Urinary Tract Transitional Cell Cancer Can Prolong Survival in Selected Patients
In this study, we examined the long-term outcome and the prognostic survival factors associated with pulmonary metastasectomy of urinary tract TCC, as based on our centre's 20-year experience. Between 2000 and 2020, curative pulmonary metastasectomy was performed in 18 patients (14 males and 4 females). Clinical, demographical and surgical data were retrospectively analysed. The disease-free interval between treatment of the primary tumour and pulmonary metastasectomy ranged from one to 48 months. Survival analysis was conducted with the Kaplan-Meier method and log-rank test. The 3- and 5-year survival rates were 84.7% and...
Source: Zentralblatt fur Chirurgie - September 5, 2023 Category: Surgery Authors: Benjamin Ehle Mohamed Hassan Uyen-Thao Le Bernward Passlick Konstantinos Grapatsas Source Type: research

Resection of Solitary Lung Metastasis of Urinary Tract Transitional Cell Cancer Can Prolong Survival in Selected Patients
In this study, we examined the long-term outcome and the prognostic survival factors associated with pulmonary metastasectomy of urinary tract TCC, as based on our centre's 20-year experience. Between 2000 and 2020, curative pulmonary metastasectomy was performed in 18 patients (14 males and 4 females). Clinical, demographical and surgical data were retrospectively analysed. The disease-free interval between treatment of the primary tumour and pulmonary metastasectomy ranged from one to 48 months. Survival analysis was conducted with the Kaplan-Meier method and log-rank test. The 3- and 5-year survival rates were 84.7% and...
Source: Zentralblatt fur Chirurgie - September 5, 2023 Category: Surgery Authors: Benjamin Ehle Mohamed Hassan Uyen-Thao Le Bernward Passlick Konstantinos Grapatsas Source Type: research

Resection of Solitary Lung Metastasis of Urinary Tract Transitional Cell Cancer Can Prolong Survival in Selected Patients
In this study, we examined the long-term outcome and the prognostic survival factors associated with pulmonary metastasectomy of urinary tract TCC, as based on our centre's 20-year experience. Between 2000 and 2020, curative pulmonary metastasectomy was performed in 18 patients (14 males and 4 females). Clinical, demographical and surgical data were retrospectively analysed. The disease-free interval between treatment of the primary tumour and pulmonary metastasectomy ranged from one to 48 months. Survival analysis was conducted with the Kaplan-Meier method and log-rank test. The 3- and 5-year survival rates were 84.7% and...
Source: Zentralblatt fur Chirurgie - September 5, 2023 Category: Surgery Authors: Benjamin Ehle Mohamed Hassan Uyen-Thao Le Bernward Passlick Konstantinos Grapatsas Source Type: research

Resection of Solitary Lung Metastasis of Urinary Tract Transitional Cell Cancer Can Prolong Survival in Selected Patients
In this study, we examined the long-term outcome and the prognostic survival factors associated with pulmonary metastasectomy of urinary tract TCC, as based on our centre's 20-year experience. Between 2000 and 2020, curative pulmonary metastasectomy was performed in 18 patients (14 males and 4 females). Clinical, demographical and surgical data were retrospectively analysed. The disease-free interval between treatment of the primary tumour and pulmonary metastasectomy ranged from one to 48 months. Survival analysis was conducted with the Kaplan-Meier method and log-rank test. The 3- and 5-year survival rates were 84.7% and...
Source: Zentralblatt fur Chirurgie - September 5, 2023 Category: Surgery Authors: Benjamin Ehle Mohamed Hassan Uyen-Thao Le Bernward Passlick Konstantinos Grapatsas Source Type: research

The influence of anti-cancer therapies on lymphocyte subpopulations of lung cancer patients
ConclusionsIn conclusion, this study suggests that different types of anti-cancer therapies affect lymphocyte subpopulations of NSCLC patients. Further large-scale and multicentre studies are required to confirm our results and to evaluate the prognostic value of lymphocyte subpopulations. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - August 28, 2023 Category: Allergy & Immunology Source Type: research

Differential functions of RhoGDI β in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure
CONCLUSIONS: These findings indicate that RhoGDIβ is likely to inhibit the transformation of human urothelial cells during the early phase of BBN exposure, whereas it promotes invasion of the transformed/progressed urothelial cells in the late stage of BBN exposure. The studies also suggest that RhoGDIβ may be a useful biomarker for evaluating the progression of human bladder cancers.PMID:37635218 | DOI:10.1186/s12915-023-01683-2 (Source: Cancer Control)
Source: Cancer Control - August 27, 2023 Category: Cancer & Oncology Authors: Xiaohui Hua Ronghao Zou Xiaoyue Bai Yuyao Yang Juan Lu Chuanshu Huang Source Type: research

Cancers, Vol. 15, Pages 3921: Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience
Conclusions: Retreatment with cisplatin at the time of relapse may provide an advantage for some patients with hepatoblastoma. Multiply relapsed disease was not uncommon and not associated with a worse prognosis. Careful attention should be paid to cumulative therapy-induced toxicity while concurrently aiming to improve cure. (Source: Cancers)
Source: Cancers - August 1, 2023 Category: Cancer & Oncology Authors: Katherine M. Somers Rachel Bernstein Tabbouche Alexander Bondoc Alexander J. Towbin Sarangarajan Ranganathan Greg Tiao James I. Geller Tags: Article Source Type: research

Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil
CONCLUSIONS: The cellular composition, spatial location, molecular and functional changes in PT and TDLN microenvironments along with NSCLC progression were deciphered, highlighting the immunoregulatory roles and evolutionary heterogeneity of TANs.PMID:37491740 | DOI:10.1002/ctm2.1340 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - July 26, 2023 Category: Cancer & Oncology Authors: Haoxin Peng Xiangrong Wu Shaopeng Liu Miao He Chenshuo Tang Yaokai Wen Chao Xie Ran Zhong Caichen Li Shan Xiong Jun Liu Hongbo Zheng Jianxing He Xu Lu Wenhua Liang Source Type: research

A longitudinal study of transitions between smoking and smokeless tobacco use from the ITC Bangladesh Surveys: implications for tobacco control in the Southeast Asia region
This study tracks transitions of use among different product users (cigarettes, bidis, and SLT) in Bangladesh, one of the largest consumers of tobacco in the region, and examines factors related to transitions and cessation.METHODS: Four waves (2009-2015) of the International Tobacco Control (ITC) Bangladesh Survey with a cohort sample of 3245 tobacco users were analysed. Generalized Estimating Equations (GEE) models were used to explore the socioeconomic correlates of transitions from the exclusive use of cigarettes, bidis, or SLT to the use of other tobacco products or quitting over time.FINDINGS: Among exclusive cigaret...
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: Daniel Tzu-Hsuan Chen Nigar Nargis Geoffrey T Fong Syed Mahfuzul Huq Anne C K Quah Filippos T Filippidis Source Type: research