Differential functions of RhoGDI β in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure

CONCLUSIONS: These findings indicate that RhoGDIβ is likely to inhibit the transformation of human urothelial cells during the early phase of BBN exposure, whereas it promotes invasion of the transformed/progressed urothelial cells in the late stage of BBN exposure. The studies also suggest that RhoGDIβ may be a useful biomarker for evaluating the progression of human bladder cancers.PMID:37635218 | DOI:10.1186/s12915-023-01683-2
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research