Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Case of the Week 728
This week ' s case was donated by Drs. Meredith Kavalier, Megan Shaughnessy, and David Cartwright. The patient has a history of treated urothelial cell carcinoma and remote travel to Asia. The cytopathologist was concerned by the presence of the following structures seen in a routine screening urine sample. How would you interpret these findings? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - October 11, 2023 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Surveying Laboratory Tests From a Health IT Perspective
We read that “70% of today’s medical decisions depend on laboratory test results,” according to the CDC. This three-part series looks at modern tests from a health IT perspective. How can we make them more accurate and delivery faster results? Which ones can we move into the home? How do we eliminate wasteful, unnecessary tests? This first article offer an overview of tests and their context.
Overview of Testing
Gerry Miller, founder and CEO of Cloudticity, classifies the value of a test by several factors:
How easy is the test to acquire?
How complex is the test to administer?
How much does it cost?
Most im...
Source: EMR and HIPAA - June 7, 2023 Category: Information Technology Authors: Andy Oram Tags: Health IT Company Healthcare IT Interoperability CDC CLIA Cloudicity Direct to Consumer Lab Testing Dr. Yair Lewis Epstein Becker Green Gerry Miller Healthcare Interoperability IVD Laboratories Labs Navina Robert Hearn Sand Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Great Deal of Work Lies Ahead in the Development of In Vivo Reprogramming as a Therapy
Reprogramming of ordinary somatic cells into induced pluripotent stem cells (iPSCs) was initially thought to be a way to obtain all of the patient matched cells needed for tissue engineering or cell therapies. A great deal of work has gone towards realizing that goal over the past fifteen years or so; the research community isn't there yet, but meaningful progress has taken place. Of late, another line of work has emerged, in that it might be possible to use partial reprogramming as a basis for therapy, delivering reprogramming factors into animals and humans in order to improve tissue function, without turning large numbe...
Source: Fight Aging! - May 31, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Confronting Stigma From Opioid Use Disorder in Cancer Care
by Fitzgerald Jones, Ho, Sager, Rosielle and MerlinHave you ever been so distressed by a perspective piece that it kept you up at night? The type of rumination that fills you with so much angst that you have no choice but to act. This is exactly how we felt when we read theAAHPM Quarterly Winter 2020 Let ’s Think About It Again.1 (member paywall)The column, which is structured as a sort of written debate in which two authors argue a clinical question, describes a case of a 45-year-old man with severe substance use disorder (SUD) recently diagnosed with extensive-stage small-cell lung cancer. He was offered aggr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 30, 2021 Category: Palliative Care Tags: ftigerald jones ho merlin rosielle sager Source Type: blogs
Confronting Stigma From Opioid Use Diorder in Cancer Care
by Fitzgerald Jones, Ho, Sager, Rosielle and MerlinHave you ever been so distressed by a perspective piece that it kept you up at night? The type of rumination that fills you with so much angst that you have no choice but to act. This is exactly how we felt when we read theAAHPM Quarterly Winter 2020 Let ’s Think About It Again.1 (member paywall)The column, which is structured as a sort of written debate in which two authors argue a clinical question, describes a case of a 45-year-old man with severe substance use disorder (SUD) recently diagnosed with extensive-stage small-cell lung cancer. He was offered aggr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 30, 2021 Category: Palliative Care Tags: ftigerald jones ho merlin rosielle sager Source Type: blogs
How to Spot a Future Vegan
Given the rapid rise of veganism we’ve been seeing lately, which by some accounts has increased by a factor of 10 or more in recent years (at least in the USA), it seems clear that this explosive growth is going to continue for a while.
It stands to reason that many people who aren’t vegan today eventually will go vegan, perhaps sometime within the next few years.
I’ve had a lot of experience seeing people transition from non-vegan to vegan, including hundreds who’ve emailed or talked to me about this before, during, and/or after their transitions.
I’ve also seen people who’ve b...
Source: Steve Pavlina's Personal Development Blog - February 4, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Source Type: blogs
How to Spot a Future Vegan
Given the rapid rise of veganism we’ve been seeing lately, which by some accounts has increased by a factor of 10 or more in recent years (at least in the USA), it seems clear that this explosive growth is going to continue for a while.
It stands to reason that many people who aren’t vegan today eventually will go vegan, perhaps sometime within the next few years.
I’ve had a lot of experience seeing people transition from non-vegan to vegan, including hundreds who’ve emailed or talked to me about this before, during, and/or after their transitions.
I’ve also seen people who’ve b...
Source: Steve Pavlina's Personal Development Blog - February 4, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Source Type: blogs
How are hospitals supposed to reduce readmissions? Part III
By KIP SULLIVAN, JD
The
Medicare Payment Advisory Commission (MedPAC) and other proponents of the
Hospital Readmissions Reduction Program (HRRP) justified their support for the
HRRP with the claim that research had already demonstrated how hospitals could
reduce readmissions for all Medicare fee-for-service patients, not just
for groups of carefully selected patients. In this three-part series, I am
reviewing the evidence for that claim.
We saw in Part I and Part II that the research MedPAC cited in its 2007 report to Congress (the report Congress relied on in authorizing the HRRP) contained no studies supporting tha...
Source: The Health Care Blog - October 14, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Medicare health reform Hospital Readmissions Reduction Program HRRP Kip Sullivan MedPAC Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. Th...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Better Sleep . . . With Benefits
There are a handful of strategies that can augment or improve sleep quality while remaining consistent with the Wheat Belly lifestyle. Many people who banish all wheat and grains from their diet experience improvement in sleep duration and quality, further enhanced by our efforts to cultivate bowel flora. (Bowel flora metabolites have a major influence on sleep and dreams.) But, given life stress, transitional changes as you get further into this lifestyle, bad habits, and other factors sometimes make additional efforts necessary. But getting sufficient quality sleep can take you further down the path of health.
Melatonin ...
Source: Wheat Belly Blog - September 20, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates 5-Hydroxytrptophan Dr. Davis health melatonin Natural Sleep Aides oxytocin reuteri tryptophan undoctored wheat belly yogurt Source Type: blogs
