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Dielectric properties of urine in relation to bladder cancer
This study aims to investigate the dielectric properties of urine in relation to bladder cancer, which is safe and non-invasive to patients. 30 healthy subjects and 30 bladder cancer patients were recruited. Their urine samples were subjected to urinalysis and cytology assessment. A vector network analyzer was used to measure the dielectric constant (Ɛ') and loss factor (Ɛ″) at microwave frequencies of between 0.2 and 50 GHz at 25 °C, 30 °C and 37 °C. Significant differences in Ɛ' and Ɛ″ were observed between healthy subjects and patients, especially at frequencies of between 25 and 40 GHz at 25 °C. Bladder can...
Source: Health Physics - October 16, 2023 Category: Physics Authors: Chao-Zhe Zhu Hua-Nong Ting Kwan-Hoong Ng Kein-Seong Mun Teng-Aik Ong Source Type: research

Dielectric properties of urine in relation to bladder cancer
This study aims to investigate the dielectric properties of urine in relation to bladder cancer, which is safe and non-invasive to patients. 30 healthy subjects and 30 bladder cancer patients were recruited. Their urine samples were subjected to urinalysis and cytology assessment. A vector network analyzer was used to measure the dielectric constant ( Ɛ′) and loss factor (Ɛ″) at microwave frequencies of between 0.2 and 50 GHz at 25 °C, 30 °C and 37 °C. Significant differences in Ɛ′ and Ɛ″ were observed between healthy subjects and patients, especially at frequencies of between 25 and 40 GHz at 25 °C. ...
Source: Australasian Physical and Engineering Sciences in Medicine - October 16, 2023 Category: Biomedical Engineering Source Type: research

Cancers, Vol. 15, Pages 4886: Current and Emerging Strategies to Treat Urothelial Carcinoma
riscoll Urothelial cell carcinoma (UCC, bladder cancer, BC) remains a difficult-to-treat malignancy with a rising incidence worldwide. In the U.S., UCC is the sixth most incident neoplasm and ~90% of diagnoses are made in those &gt;55 years of age; it is ~four times more commonly observed in men than women. The most important risk factor for developing BC is tobacco smoking, which accounts for ~50% of cases, followed by occupational exposure to aromatic amines and ionizing radiation. The standard of care for advanced UCC includes platinum-based chemotherapy and programmed cell death (PD-1) or programmed cell de...
Source: Cancers - October 8, 2023 Category: Cancer & Oncology Authors: Berkha Rani James J. Ignatz-Hoover Priyanka S. Rana James J. Driscoll Tags: Review Source Type: research

Identification of hub genes in bladder transitional cell carcinoma through ceRNA network construction integrated with gene network analysis
J Cell Mol Med. 2023 Oct 5. doi: 10.1111/jcmm.17979. Online ahead of print.ABSTRACTBladder transitional cell carcinoma (BTCC) forms more than 90% of bladder cancer cases. It brings challenges to the early diagnosis and therapy of BTCC, due to lack of efficient screening biomarkers. We used weighted gene co-expression network analysis (WGCNA) combined competing endogenous RNA (ceRNA) network construction depending on TCGA datasets to investigate potential hub genes and regulatory pathways associated with occurrence and progression of BTCC. We further used real-time polymerase chain reaction (RT-PCR) to validate the relative...
Source: Molecular Medicine - October 5, 2023 Category: Molecular Biology Authors: Hai Wang Lei Gao Yin Chen Lei Zhang Yu Bai Cuiping Zhao Lifeng Zhang Li Zuo Heyun Sun Source Type: research

Identification of hub genes in bladder transitional cell carcinoma through ceRNA network construction integrated with gene network analysis
J Cell Mol Med. 2023 Oct 5. doi: 10.1111/jcmm.17979. Online ahead of print.ABSTRACTBladder transitional cell carcinoma (BTCC) forms more than 90% of bladder cancer cases. It brings challenges to the early diagnosis and therapy of BTCC, due to lack of efficient screening biomarkers. We used weighted gene co-expression network analysis (WGCNA) combined competing endogenous RNA (ceRNA) network construction depending on TCGA datasets to investigate potential hub genes and regulatory pathways associated with occurrence and progression of BTCC. We further used real-time polymerase chain reaction (RT-PCR) to validate the relative...
Source: J Cell Mol Med - October 5, 2023 Category: Molecular Biology Authors: Hai Wang Lei Gao Yin Chen Lei Zhang Yu Bai Cuiping Zhao Lifeng Zhang Li Zuo Heyun Sun Source Type: research

Diagnostic algorithm for subcentimeter hepatocellular carcinoma using alpha-fetoprotein and imaging features on gadoxetic acid –enhanced MRI
ConclusionIncluding AFP in the diagnostic algorithm may improve the diagnostic performance for subcentimeter HCC.Clinical relevance statementCombining imaging features on gadoxetic acid –enhanced MRI with alpha-fetoprotein may enhance the diagnostic performance for subcentimeter HCC in treatment-naïve patients with chronic hepatitis B.Key Points• The traditional diagnostic hallmark of HCC (arterial-phase hyperintensity and portal-phase hypointensity) shows modest diagnostic performance for subcentimeter HCC on EOB-MRI.• Serum alpha-fetoprotein> 13.7 ng/mL, arterial-phase hyperintensity, portal-phase hypointensity...
Source: European Radiology - October 4, 2023 Category: Radiology Source Type: research

The Association of P53, CK29, and FGFR3 Overexpression with the Characteristics of Urothelial Cell Carcinoma of the Bladder
CONCLUSION: The study findings indicate that the intensity and percentage of cell staining for P53 and CK20 in the UCC of the bladder can aid in differentiating the grading patterns. The tendency of tumor relapse can be predicted by demonstrating heterogeneous and non-papillary patterns.PMID:37774064 | DOI:10.31557/APJCP.2023.24.9.3125 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2023 Category: Cancer & Oncology Authors: Mojgan Asgari Faezeh Firouzi Maryam Abolhasani Mohammad Bahadoram Maedeh Barahman Zahra Madjd Mitra Mehrazam Shakiba Hassanzadeh Esma'il Akade Source Type: research

Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis
CONCLUSIONS: Taken together, our data highlight that extending the dosing interval of ocrelizumab does not lead to increased repopulation of effector B cells. We show that the increase of CD20 expression on B cell subsets in EID might lead to longer depletion or less repopulation of B cells after the next infusion of ocrelizumab. Lastly, even though extending the ocrelizumab interval dosing alters B cell repopulation, it does not affect the clinical efficacy of ocrelizumab in our cohort of patients with MS.PMID:37752582 | DOI:10.1186/s12974-023-02900-z (Source: Cancer Control)
Source: Cancer Control - September 26, 2023 Category: Cancer & Oncology Authors: Carla Rodriguez-Mogeda Zo ë Y G J van Lierop Susanne M A van der Pol Loet Coenen Laura Hogenboom Alwin Kamermans Ernesto Rodriguez Jack van Horssen Zo é L E van Kempen Bernard M J Uitdehaag Charlotte E Teunissen Maarten E Witte Joep Killestein Helga E d Source Type: research

Diagnostic roles of PAX8 immunohistochemistry in ovarian tumors
CONCLUSION: PAX8 expression rate was significantly higher in serous ovarian tumors than in mucinous ovarian tumors. In addition, PAX8 expression rates were significantly higher in primary ovarian cancers than in metastatic carcinomas.PMID:37742476 | DOI:10.1016/j.prp.2023.154822 (Source: Cell Research)
Source: Cell Research - September 24, 2023 Category: Cytology Authors: Jooyoung Kim Nae Yu Kim Jung-Soo Pyo Kyeung-Whan Min Dong-Wook Kang Source Type: research

Diagnostic roles of PAX8 immunohistochemistry in ovarian tumors
CONCLUSION: PAX8 expression rate was significantly higher in serous ovarian tumors than in mucinous ovarian tumors. In addition, PAX8 expression rates were significantly higher in primary ovarian cancers than in metastatic carcinomas.PMID:37742476 | DOI:10.1016/j.prp.2023.154822 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - September 24, 2023 Category: Pathology Authors: Jooyoung Kim Nae Yu Kim Jung-Soo Pyo Kyeung-Whan Min Dong-Wook Kang Source Type: research