Transitional Cell Carcinoma Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

GSE215920 Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma [Bulk RNA-seq]
Contributors : Marzia Scortegagna ; Ze'ev A RonaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor microenvironment components, including T and myeloid cells, play important roles in lung adenocarcinoma (LADC) progression and response to therapy. Here, we identify a role for Siah1a/2 ubiquitin ligases in controlling alveolar macrophage (AM) differentiation and urethane-induced LADC. Genetic ablation of Siah1a/2 in AMs enriched their immature state, coinciding with increased pro-tumorigenic and inflammatory gene signatures and abundance of Siah1a/2 substrates NRF2 and B-catenin. U...
Source: GEO: Gene Expression Omnibus - May 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE215992 Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma [scRNA-seq]
Contributors : Marzia Scortegagna ; Ze'ev A RonaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor microenvironment components, including T and myeloid cells, play important roles in lung adenocarcinoma (LADC) progression and response to therapy. Here, we identify a role for Siah1a/2 ubiquitin ligases in controlling alveolar macrophage (AM) differentiation and urethane-induced LADC. Genetic ablation of Siah1a/2 in AMs enriched their immature state, coinciding with increased pro-tumorigenic and inflammatory gene signatures and abundance of Siah1a/2 substrates NRF2 and B-catenin. U...
Source: GEO: Gene Expression Omnibus - May 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Transcriptome analysis identifies oncogenic tissue remodeling during progression from common nevi to early melanoma
Am J Pathol. 2023 May 3:S0002-9440(23)00134-7. doi: 10.1016/j.ajpath.2023.03.016. Online ahead of print.ABSTRACTEarly detection and treatment of melanoma, the most aggressive skin cancer, improves the median 5-year survival rate of patients from 25% to 99%. Melanoma development involves a stepwise process during which genetic changes drive histological alterations within nevi and surrounding tissue. Here, we perform a comprehensive analysis of publicly available gene expression datasets of melanoma, common or congenital nevi (CN), and dysplastic nevi (DN), and assess molecular & genetic pathways leading to early melano...
Source: The American Journal of Pathology - May 5, 2023 Category: Pathology Authors: Amin Zia Yoav Litvin Ronnie Voskoboynik Amit Klein Catherine Shachaf Source Type: research

Transcriptome analysis identifies oncogenic tissue remodeling during progression from common nevi to early melanoma
Am J Pathol. 2023 May 3:S0002-9440(23)00134-7. doi: 10.1016/j.ajpath.2023.03.016. Online ahead of print.ABSTRACTEarly detection and treatment of melanoma, the most aggressive skin cancer, improves the median 5-year survival rate of patients from 25% to 99%. Melanoma development involves a stepwise process during which genetic changes drive histological alterations within nevi and surrounding tissue. Here, we perform a comprehensive analysis of publicly available gene expression datasets of melanoma, common or congenital nevi (CN), and dysplastic nevi (DN), and assess molecular & genetic pathways leading to early melano...
Source: Am J Pathol - May 5, 2023 Category: Pathology Authors: Amin Zia Yoav Litvin Ronnie Voskoboynik Amit Klein Catherine Shachaf Source Type: research

Transcriptome Analysis Identifies Oncogenic Tissue Remodeling during Progression from Common Nevi to Early Melanoma
Am J Pathol. 2023 May 3:S0002-9440(23)00134-7. doi: 10.1016/j.ajpath.2023.03.016. Online ahead of print.ABSTRACTEarly detection and treatment of melanoma, the most aggressive skin cancer, improves the median 5-year survival rate of patients from 25% to 99%. Melanoma development involves a stepwise process during which genetic changes drive histologic alterations within nevi and surrounding tissue. Here, we perform a comprehensive analysis of publicly available gene expression data sets of melanoma, common or congenital nevi (CN), and dysplastic nevi (DN), and assess molecular and genetic pathways leading to early melanoma....
Source: Am J Pathol - May 5, 2023 Category: Pathology Authors: Amin Zia Yoav Litvin Ronnie Voskoboynik Amit Klein Catherine Shachaf Source Type: research

Transcriptome Analysis Identifies Oncogenic Tissue Remodeling during Progression from Common Nevi to Early Melanoma
Am J Pathol. 2023 May 3:S0002-9440(23)00134-7. doi: 10.1016/j.ajpath.2023.03.016. Online ahead of print.ABSTRACTEarly detection and treatment of melanoma, the most aggressive skin cancer, improves the median 5-year survival rate of patients from 25% to 99%. Melanoma development involves a stepwise process during which genetic changes drive histologic alterations within nevi and surrounding tissue. Here, we perform a comprehensive analysis of publicly available gene expression data sets of melanoma, common or congenital nevi (CN), and dysplastic nevi (DN), and assess molecular and genetic pathways leading to early melanoma....
Source: The American Journal of Pathology - May 5, 2023 Category: Pathology Authors: Amin Zia Yoav Litvin Ronnie Voskoboynik Amit Klein Catherine Shachaf Source Type: research

GSE231679 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [in_vivo_RNA_seq]
Contributors : Alyssa M Kaiser ; Laura D AttardiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells, we observed graded effects...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE231678 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [in_vitro_RNA_seq]
Contributors : Alyssa M Kaiser ; Kathryn T Bieging-Rolett ; Laura D AttardiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells,...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE231677 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [in_vivo_ATAC_seq2]
Contributors : Alyssa M Kaiser ; Laura D AttardiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells, we observed ...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE231676 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [in_vivo_ATAC_seq1]
Contributors : Alyssa M Kaiser ; Laura D AttardiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells, we observed ...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE231675 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [scRNA-Seq]
Contributors : Alyssa M Kaiser ; Kathryn J Hanson ; Laura D AttardiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells, we obse...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE231674 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [10x single cell multiomics RNA-Seq]
Contributors : Alyssa M Kaiser ; Kathryn J Hanson ; Laura D AttardiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells, we obse...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE231671 p53 governs an alveolar type 1 differentiation program in lung cancer suppression [10x_multiome_ATAC]
Contributors : Alyssa M Kaiser ; Kathryn J Hanson ; Laura D AttardiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) ...
Source: GEO: Gene Expression Omnibus - May 4, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research