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GSE248167 Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model
In conclusion, our novel TIDE-based subtyping method can serve as a powerful clinical tool for BC and pan-cancer patients, and potentially guiding personalized therapy decisions for selecting potential beneficiaries and excluding resistant patients of ICB therapy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Mosaic RASopathies concept: different skin lesions, same systemic manifestations?
Conclusion This review delineates genotype/phenotype correlations of syndromic epidermal nevi with somatic RAS and BRAF pathogenic variants and may help improve their follow-up. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - April 19, 2024 Category: Genetics & Stem Cells Authors: Morren, M.-A., Fodstad, H., Brems, H., Bedoni, N., Guenova, E., Jacot-Guillarmod, M., Busiah, K., Giuliano, F., Gilliet, M., Atallah, I. Tags: Genotype-phenotype correlations Source Type: research

Gene of the month: the uroplakins
Uroplakins are a family of membrane-spanning proteins highly specific to the urothelium. There are four uroplakin proteins in humans. These are encoded by the following UPK genes: UPK1A, UPK1B, UPK2 and UPK3. Uroplakin proteins span the apical membrane of umbrella cells of the urothelium, where they associate into urothelial plaques. This provides a barrier function to prevent passage of urine across the urothelium in the renal pelvis, ureters, and bladder. Uroplakins are also involved in developmental processes such as nephrogenesis. The specific localisation of uroplakins within the urothelium means that they are often e...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Sivakumaar, K., Griffin, J., Schofield, E., Catto, J. W. F., Jubber, I. Tags: Gene of the month Source Type: research

Human malignancies associated with persistent HPV infection
Oncologist. 2024 Apr 17:oyae071. doi: 10.1093/oncolo/oyae071. Online ahead of print.ABSTRACTHuman papillomavirus (HPV)-associated malignancies account for ~5% of human cancers worldwide. Thirteen, or more, HPV types are oncogenic, but infection with these viruses is common and usually cleared within 2 years. Only infections that become persistent are associated with the development of cancer, often occurring several decades later. These cancers mostly arise in 6 different anatomical regions: 5 are anogenital (anus, cervix, penis, vagina, and vulva) and the sixth is the oropharynx. Oncogenic HPVs promote cellular proliferat...
Source: The Oncologist - April 17, 2024 Category: Cancer & Oncology Authors: Alison A McBride Source Type: research

The feasibility and outcomes of metabolic and bariatric surgery prior to neoplastic therapy
CONCLUSIONS: This study highlights the potential feasibility of employing MBS prior to neoplastic therapy in patients with low-grade, less aggressive neoplasms in the context of obesity. This underscores the importance of providing a personalized, case-to-case multidisciplinary approach in the management of these patients.PMID:38594091 | DOI:10.1016/j.soard.2024.02.008 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 9, 2024 Category: Surgery Authors: Chetan Parmar Kamal Abi Mosleh Pauline Aeschbacher Thorvardur R Halfdanarson Travis J McKenzie Raul J Rosenthal Omar M Ghanem BRIDGE Study Group Source Type: research

Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies
Aging (Albany NY). 2024 Mar 27;16. doi: 10.18632/aging.205689. Online ahead of print.ABSTRACTProgrammed death-1 and its ligand-1 (PD-1/PD-L1), immune checkpoints proteins, play a crucial role in anti-tumor responses. A large number of studies have evaluated the relationships of PD-1/PD-L1 polymorphisms with risk of cancer, but evidence for the associations remains inconsistent. Therefore, we performed a meta-analysis to examine the associations between PD-1/PD-L1 single nucleotide polymorphisms (SNPs) and cancer predisposition. Results showed that PD-1.3 and PD-L1 rs17718883 were significantly correlated with overall cance...
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Maoquan Yang Yan Liu Shuangshuang Zheng Peizhen Geng Tianhao He Linan Lu Yikuan Feng Qiqi Jiang Source Type: research

Extra-prostatic extension (EPE) grading system: Correlation with MRI features and integration of capsular enhancement sign (CES) for "enhanced" detection of T3a lesions
CONCLUSION: CES in the setting of multiparametric MRI can increase diagnostic accuracy for the prediction of extra-capsular disease.ADVANCES IN KNOWLEDGE: This study highlights the potential of contrast media in prostate cancer local staging.PMID:38544291 | DOI:10.1093/bjr/tqae065 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - March 28, 2024 Category: Radiology Authors: Federica Martini Maria Pigati Matilde Mattiauda Marta Ponzano Nataniele Piol Simona Pigozzi Bruno Spina Giuseppe Cittadini Veronica Giasotto Jeries Paolo Zawaideh Source Type: research

Transitional dynamics in oncology clinical trials: evaluating the impact of Clinical Trials Act on cooperative groups
CONCLUSION: the number of multicentre clinical trials in oncology gradually decreased after the Clinical Trials Act's enforcement, which underscores the need for comprehensive amendment of the Clinical Trials Act to streamline the operational process.PMID:38535873 | DOI:10.1093/jjco/hyae034 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Kenichi Nakamura Koji Takeda Akiko M Saito Miho Kato Shinya Sato Satoshi Nakagawa Yasuyuki Kawamoto Eiji Oki Isamu Okamoto Hiroaki Okamoto Hiroshi Katayama Junki Mizusawa Harumi Kaba Taro Shibata Haruhiko Fukuda Source Type: research

Multivariate Statistical Evaluation of 20 Metals/Metalloid Levels in the Serum of Patients with Prostate Gland Diseases
This study elucidates the imbalances of the elements with BPH/PC patients and healthy subjects. For multiple comparisons, Bonferroni test was applied and principal component analysis was performed for measuring the multiple metals/metalloid exposure. Mean concentrations of Al, Cr, Pb, Cd, Na, Ni and K were found higher significantly (p < 0.05) in the serum of BPH patients compared with healthy controls, while average levels of Sb, Al, Cd, As, Mn, Sr, K and Pb were significantly (p < 0.05) elevated in PC patients than controls. The correlation patterns revealed significantly different mutual associations amo...
Source: Indian Journal of Clinical Biochemistry - March 25, 2024 Category: Biochemistry Source Type: research

Testing the external validity of the POUT III trial (adjuvant platnium-based chemotherapy in upper tract urothelial carcinoma) in a North American cohort
CONCLUSIONS: While the primary disease stage was similar, the rate of advanced nodal disease was significantly higher in NCDB, which might be explained partially by the more extensive lymph node dissection performed in the latter. These differences warrant caution when applying the POUT III findings to North American patients.PMID:38522975 | DOI:10.1016/j.urolonc.2024.01.035 (Source: Urologic Oncology)
Source: Urologic Oncology - March 24, 2024 Category: Urology & Nephrology Authors: Nicholas James Corsi Alex Stephens Marco Finati Taylor Malchow Chase Morrison Matthew Davis Keinnan Hares Matthew P Corsi Sohrab Arora Giuseppe Chiarelli Giuseppe Ottone Cirulli Riccardo Autorino Akshay Sood Craig Rogers Firas Abdollah Source Type: research