Myeloid-derived suppressor cells from tumour-bearing mice induce the population expansion of CD19 < sup > hi < /sup > Fc γRIIb < sup > hi < /sup > regulatory B cells via PD-L1

Immunology. 2024 Feb 8. doi: 10.1111/imm.13763. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) increase in number and gain immunosuppressive functions in tumours and many other pathological conditions. MDSCs are characterized by their strong T-cell immunosuppressive capacity. The effects that MDSCs may have on B cells, especially within the tumour microenvironment, are less well understood. Here, we report that either monocytic MDSCs or polymorphonuclear MDSCs can promote increases in interleukin (IL)-10-expressing CD19hi FcγRIIbhi regulatory B cells in vitro and in vivo. Splenic transitional-1, -2, and -3 cells and marginal zone B cells, but not follicular B cells, differentiate into IL-10-expressing CD19hi FcγRIIbhi regulatory B cells. The adoptive transfer of CD19hi FcγRIIbhi regulatory B cells via tail vein injection can promote subcutaneous 3LL tumour growth in mice. The expression of programmed death-ligand 1 on MDSCs was found to be strongly associated with CD19hi FcγRIIbhi regulatory B cell population expansion. Furthermore, the frequency of circulating CD19+ FcγRIIhi regulatory B cells was significantly increased in advanced-stage lung cancer patients. Our results unveil a critical role of MDSCs in regulatory B-cell differentiation and population expansion in lung cancer patients.PMID:38332630 | DOI:10.1111/imm.13763

Source: Immunology - February 9, 2024 Category: Allergy & Immunology Authors: Wenyan Chen Xiaomin Ning Yang Liu Tingting Shen Mengru Liu Hui Yin Yue Ding Jingwen Zhou Rui Yin Liangliang Cai Yuhan Wu Li Qian Source Type: research