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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus-Induced Mitochondrial Damage
CONCLUSIONS: Current study indicates that the mitochondrial fragmentation induced by hepatitis B virus infection can be reduced after antioxidant treatment pointing toward exploring better drug targets for the prevention of hepatitis B virus-induced mitochondrial frag- mentation and associated liver damage.PMID:37565795 | DOI:10.5152/tjg.2023.21290
Source: The Turkish Journal of Gastroenterology - August 11, 2023 Category: Gastroenterology Authors: Kehkshan Jabeen Aneela Javed Sobia Manzoor Shaheen Shahzad Source Type: research
Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes
This study found that a dose-dependent decrease in cell viability of CTX cells was observed with 150, 200, 250, 300 μmol/L Mn. The results of apoptosis-related protein assay showed that Mn decreased the expression of anti-apoptotic protein Bcl-2 and enhanced the expression of apoptosis-related proteins like Bax and Cleaved-Caspase3. In addition, treatment with Mn resulted in elevated ROS levels and increased phosphorylation levels of JNK. Conversely, phosphorylation of nuclear transcription factors FOXO3a, which regulates expression of transcription factors including Bim and PUMA, was decreased. Depletion of ROS by N-acet...
Source: Ecotoxicology and Environmental Safety - August 9, 2023 Category: Environmental Health Authors: Wan-He Li Zheng-Ting-Yan Xiang An-Xin Lu Su-Su Wang Chong-Huai Yan Source Type: research
Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid
This study suggests that the inactivation of the Atpif1 gene enhances glucose metabolism in neutrophils, resulting in increased bactericidal activity mediated by elevated levels of ROS and LA. Inhibiting ATPIF1 may be a potential approach to enhance antibacterial immunity.PMID:37558010 | DOI:10.1016/j.bbadis.2023.166820
Source: Biochimica et Biophysica Acta - August 9, 2023 Category: Biochemistry Authors: Genshen Zhong Ying Guo Xue Gong Meiqi Xu Qi Wang Minna Wu Xiaoying Zhang Yinming Liang Weidong Zhao Hui Wang Jianping Ye Source Type: research
Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes
This study found that a dose-dependent decrease in cell viability of CTX cells was observed with 150, 200, 250, 300 μmol/L Mn. The results of apoptosis-related protein assay showed that Mn decreased the expression of anti-apoptotic protein Bcl-2 and enhanced the expression of apoptosis-related proteins like Bax and Cleaved-Caspase3. In addition, treatment with Mn resulted in elevated ROS levels and increased phosphorylation levels of JNK. Conversely, phosphorylation of nuclear transcription factors FOXO3a, which regulates expression of transcription factors including Bim and PUMA, was decreased. Depletion of ROS by N-acet...
Source: Ecotoxicology and Environmental Safety - August 9, 2023 Category: Environmental Health Authors: Wan-He Li Zheng-Ting-Yan Xiang An-Xin Lu Su-Su Wang Chong-Huai Yan Source Type: research
Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid
This study suggests that the inactivation of the Atpif1 gene enhances glucose metabolism in neutrophils, resulting in increased bactericidal activity mediated by elevated levels of ROS and LA. Inhibiting ATPIF1 may be a potential approach to enhance antibacterial immunity.PMID:37558010 | DOI:10.1016/j.bbadis.2023.166820
Source: Biochimica et Biophysica Acta - August 9, 2023 Category: Biochemistry Authors: Genshen Zhong Ying Guo Xue Gong Meiqi Xu Qi Wang Minna Wu Xiaoying Zhang Yinming Liang Weidong Zhao Hui Wang Jianping Ye Source Type: research
ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine
In conclusion, thermochemotherapy inhibited pancreatic cell viability, migration and invasion, and promoted cell apoptosis by inducing excessive ROS production, which subsequently suppressed Sp1 expression and the downstream Cox-2.PMID:37545170 | DOI:10.1002/cbin.12073
Source: Cell Biology International - August 7, 2023 Category: Cytology Authors: Pan Xi Xiaojuan Ma Fuquan Hu Liang Li Huijuan Liu Jing Zhou Wenan Wu Source Type: research
N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate toxicity of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine in human placental villous trophoblast BeWo cells
Toxicology. 2023 Aug 4:153611. doi: 10.1016/j.tox.2023.153611. Online ahead of print.ABSTRACTTrichloroethylene (TCE) is a known human carcinogen with toxicity attributed to its metabolism. S-(1,2-Dichlorovinyl)-L-cysteine (DCVC) is a metabolite of TCE formed downstream in TCE glutathione (GSH) conjugation and is upstream of several toxic metabolites. Despite knowledge that DCVC stimulates reactive oxygen species (ROS) generation and apoptosis in placental cells, the extent to which these outcomes are attributable to DCVC metabolism is unknown. The current study used N-acetyl-L-cysteine (NAC) at 5mM and aminooxyacetic acid ...
Source: Toxicology - August 6, 2023 Category: Toxicology Authors: Anthony L Su Lawrence H Lash Rita Loch-Caruso Source Type: research
Organogold(III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs
J Inorg Biochem. 2023 Jul 29;247:112346. doi: 10.1016/j.jinorgbio.2023.112346. Online ahead of print.ABSTRACTThe limited chemical stability of gold(III)-based compounds in physiological environment has been a challenge in drug discovery, and organometallic chemistry might provide the solution to overcome this issue. In this work, four novel cationic organogold(III)-dithiocarbamate complexes of general structure [(C^N)AuIIIDTC]PF6 (C1a - C4a, DTC = dithiocarbamate, L1 - L4, C^N = 2-anilinopyridine) are presented, and compared to their coordination gold(III)-dithiocarbamate analogues [AuIIIDTCCl2] (C1b - C4b), as potential a...
Source: Journal of Inorganic Biochemistry - August 3, 2023 Category: Biochemistry Authors: Ana Luiza de Andrade Querino Alessandra Mara de Sousa Sophie R Thomas Geraldo Magela de Lima Dalton Dittz Angela Casini Rubens Lima do Monte-Neto Heveline Silva Source Type: research
N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation
This report focuses on the therapeutic effect of NAC in restoring erectile function using a hyperlipidemic rat model by preventing CCSMC phenotypic modulation and attenuating oxidative stress.PMID:37534881 | DOI:10.4103/aja202324
Source: Asian Journal of Andrology - August 3, 2023 Category: Urology & Nephrology Authors: Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei Source Type: research
N-Acetylcysteine amide (NACA) and dinaca inhibit H < sub > 2 < /sub > O < sub > 2 < /sub > -INDUCED cataract formation ex VIVO IN pig and rat lenses
Exp Eye Res. 2023 Aug 1:109610. doi: 10.1016/j.exer.2023.109610. Online ahead of print.ABSTRACTOxidative stress plays a central role in cataract formation suggesting that antioxidants might slow cataract progression. The anticataract activity of N-acetylcysteine amide (NACA) and (2 R, 2 R')-3,3'-disulfanediyl bis(2-acetamidopropanamide) (diNACA) and/or N-acetylcysteine (NAC), were evaluated in porcine and rat lens models. Cataractogenesis via oxidation was induced with H2O2 and/or glucose oxidase (GO). Porcine lenses were incubated in 0.1 mM, 1 mM, or 10 mM NAC, NACA or diNACA for 24 h. Lenses were then transferred to medi...
Source: Experimental Eye Research - August 3, 2023 Category: Opthalmology Authors: R M Martis A C Grey H Wu G M Wall P J Donaldson J C Lim Source Type: research
