Trio-based genome sequencing identifies candidate causal genes in lifelong premature ejaculation.
PMID: 33106462 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 23, 2020 Category: Urology & Nephrology Authors: Wang DQ, Jiao YT, Ling L, Wang JX, Niu YH, Tang Z, Chen YW, Gong JN, Wang T, Liu JH, Ling Q Tags: Asian J Androl Source Type: research

Management of residual penile curvature after penile prosthesis placement.
Abstract Residual penile curvature is a common situation following the implantation of a penile prosthesis in patients with Peyronie's disease. Currently, there is a variety of options for the correction of residual curvature, including penile modeling, plication techniques, as well as tunical incision/excision with or without grafting. A literature search of PubMed and Medline databases was conducted from 1964 until 2020, using search terms for all articles in the English language. In this article, we provide a review of the techniques and the outcomes, according to the published literature. PMID: 33106463 [...
Source: Asian Journal of Andrology - October 23, 2020 Category: Urology & Nephrology Authors: Krakhotkin DV, Ralph DJ, Blecher GA, Chernylovskyi VA, Greco F, Bakurov EE, Bugaev RA Tags: Asian J Androl Source Type: research

Mosaic isodicentric Y chromosome harboring intact AZF region in a cryptozoospermic male with normal hormone levels.
PMID: 33106464 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 23, 2020 Category: Urology & Nephrology Authors: Xie SY, Tao DC, Yang Y Tags: Asian J Androl Source Type: research

A preliminary study of sperm identification in microdissection testicular sperm extraction samples with deep convolutional neural networks.
Abstract Sperm identification and selection is an essential task when processing human testicular samples for in vitro fertilization. Locating and identifying sperm cell(s) in human testicular biopsy samples is labor intensive and time consuming. We developed a new computer-aided sperm analysis (CASA) system, which utilizes deep learning for near human-level performance on testicular sperm extraction (TESE), trained on a custom dataset. The system automates the identification of sperm in testicular biopsy samples. A dataset of 702 de-identified images from testicular biopsy samples of 30 patients was collected. Ea...
Source: Asian Journal of Andrology - October 23, 2020 Category: Urology & Nephrology Authors: Wu DJ, Badamjav O, Reddy VV, Eisenberg M, Behr B Tags: Asian J Androl Source Type: research

Novel deletion mutations of the PIH1D3 gene in an infertile young man with primary ciliary dyskinesia and his cousin with Kartagener's syndrome.
PMID: 33106461 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 20, 2020 Category: Urology & Nephrology Authors: Huang C, Liu NC, Wang XB, Gu BH, Zhang JX, Li-Zhang, Li Z Tags: Asian J Androl Source Type: research

Characterization of progression-related alternative splicing events in testicular germ cell tumors.
Abstract Accumulating evidence supports the significance of aberrant alternative splicing (AS) events in cancer; however, genome-wide profiling of progression-free survival (PFS)-related AS events in testicular germ cell tumors (TGCT) has not been reported. Here, we analyzed high-throughput RNA-sequencing data and percent-spliced-in values for 150 patients with TGCT. Using univariate and multivariate Cox regression analysis and a least absolute shrinkage and selection operator method, we identified the top 15 AS events most closely associated with disease progression. A risk-associated AS score (ASS) for the 15 AS...
Source: Asian Journal of Andrology - October 2, 2020 Category: Urology & Nephrology Authors: Zhang CJ, Li ZT, Shen KJ, Chen L, Xu DF, Gao Y Tags: Asian J Androl Source Type: research

A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.
Abstract Oligoasthenoteratozoospermia (OAT) refers to the combination of various sperm abnormalities, including a decreased sperm count, reduced motility, and abnormal sperm morphology. Only a few genetic causes have been shown to be associated with OAT. Herein, we identified a novel homozygous frameshift mutation in meiosis-specific nuclear structural 1 (MNS1; NM_018365: c.603_604insG: p.Lys202Glufs*6) by whole-exome sequencing in an OAT proband from a consanguineous Chinese family. Subsequent variant screening identified four additional heterozygous MNS1 variants in 6/219 infertile individuals with oligoasthenos...
Source: Asian Journal of Andrology - October 2, 2020 Category: Urology & Nephrology Authors: Li Y, Wang WL, Tu CF, Meng LL, Hu TY, Du J, Lin G, Nie HC, Tan YQ Tags: Asian J Androl Source Type: research

Prevalence of gene mutations in a Chinese 46,XY disorders of sex development cohort detected by targeted next-generation sequencing.
Abstract 46,XY disorders of sex development (DSD) is characterized by incomplete masculinization genitalia, with gonadal dysplasia and with/without the presence of Müllerian structures. At least 30 genes related to 46,XY DSD have been found. However, the clinical phenotypes of patients with different gene mutations overlap, and accurate diagnosis relies on gene sequencing technology. Therefore, this study aims to determine the prevalence of pathogenic mutations in a Chinese cohort with 46,XY DSD by the targeted next-generation sequencing (NGS) technology. Eighty-seven 46,XY DSD patients were enrolled from the...
Source: Asian Journal of Andrology - September 24, 2020 Category: Urology & Nephrology Authors: Yu BQ, Liu ZX, Gao YJ, Wang X, Mao JF, Nie M, Wu XY Tags: Asian J Androl Source Type: research

The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair.
This study assessed semen quality and the sperm DNA fragmentation index (DFI) response to varicocele repair in men with ipsilateral testicular atrophy (TA) versus men with no testicular atrophy (NTA). Semen parameter values and DFI in both groups were compared preoperatively and postoperatively. The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate. There were 20 men in the TA group and 121 men in the NTA group with no difference in age, varicocele grade, or preoperative semen parameter values between the two groups. The NTA group had a higher preoperative DFI than the TA group. Both groups ...
Source: Asian Journal of Andrology - September 14, 2020 Category: Urology & Nephrology Authors: Kavoussi PK, Abdullah N, Gilkey MS, Hunn C, Machen GL, Chen SH, Kavoussi KM, Esqueda A, Wininger JD, Kavoussi SK Tags: Asian J Androl Source Type: research

Prostatic anatomical parameters correlate with clinical characteristics suggestive of benign prostatic hyperplasia.
Abstract We conducted the present study to assess the correlation of the prostatic anatomical parameters, especially the ratio of peripheral zone thickness and transitional zone thickness, with clinical and uroflowmetry characteristics suggestive of benign prostate hyperplasia (BPH). A total of 468 consecutive patients with a detailed medical history were identified. All patients were evaluated by scoring subjective symptoms with the International Prostate Symptom Score (IPSS) and quality of life (QoL). The prostatic anatomical parameters were measured using transrectal ultrasonography, and postvoid residual urine...
Source: Asian Journal of Andrology - September 10, 2020 Category: Urology & Nephrology Authors: Tian Y, Liu HM, Yang B, Yang XS, Sun ZL, Sun F, Luo GH, Xia SJ Tags: Asian J Androl Source Type: research

Sperm retrieval and intracytoplasmic sperm injection outcomes in men with cystic fibrosis disease versus congenital bilateral absence of the vas deferens.
Abstract Recent data suggest that cystic fibrosis transmembrane conductance regulator (CFTR) gene alterations negatively impact male fertility beyond obstruction. We sought to compare gene alterations, sperm retrieval rates, and intracytoplasmic sperm injection (ICSI) outcomes among men with cystic fibrosis (CF) disease and congenital bilateral absence of the vas deferens (CBAVD) only. We retrospectively evaluated all men who underwent surgical sperm retrieval at two academic, high-volume andrology centers from 2010 to 2018. Only men with documented CFTR alterations and obstructive azoospermia from either CBAVD or...
Source: Asian Journal of Andrology - September 10, 2020 Category: Urology & Nephrology Authors: McBride JA, Kohn TP, Mazur DJ, Lipshultz LI, Coward RM Tags: Asian J Androl Source Type: research

NC1-peptide derived from collagen α3 (IV) chain is a blood-tissue barrier regulator: lesson from the testis.
NC1-peptide derived from collagen α3 (IV) chain is a blood-tissue barrier regulator: lesson from the testis. Asian J Androl. 2020 Sep 08;: Authors: Liu SW, Li HT, Ge RS, Cheng CY Abstract Collagen α3 (IV) chains are one of the major constituent components of the basement membrane in the mammalian testis. Studies have shown that biologically active fragments, such as noncollagenase domain (NC1)-peptide, can be released from the C-terminal region of collagen α3 (IV) chains, possibly through the proteolytic action of metalloproteinase 9 (MMP9). NC1-peptide was shown to promote blood-tes...
Source: Asian Journal of Andrology - September 7, 2020 Category: Urology & Nephrology Authors: Liu SW, Li HT, Ge RS, Cheng CY Tags: Asian J Androl Source Type: research

Response of prostate cancer to addition of dutasteride after progression on abiraterone.
PMID: 32896838 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - September 7, 2020 Category: Urology & Nephrology Authors: Lian JP, Gao YY, Tang JJ, Chen X, Liu Y, Wu DL, Li ZF, Huang SS Tags: Asian J Androl Source Type: research

Mutational analysis of the GATA4 gene in Chinese men with nonobstructive azoospermia.
Abstract As a crucial transcription factor for spermatogenesis, GATA-binding protein 4 (GATA4) plays important roles in the functioning of Sertoli and Leydig cells. Conditional knockout of GATA4 in mice results in age-dependent testicular atrophy and loss of fertility. However, whether GATA4 is associated with human azoospermia has not been reported. Herein, we analyzed the GATA4 gene by direct sequencing of samples obtained from 184 Chinese men with idiopathic nonobstructive azoospermia (NOA). We identified a missense mutation (c.191G>A, p.G64E), nine single-nucleotide polymorphisms (SNPs), and one rare varian...
Source: Asian Journal of Andrology - August 27, 2020 Category: Urology & Nephrology Authors: Zhang X, Zhang TJ, Liu W, Ning YN, Bian YH, Cao YZ, Liu HB, Ma JL, Zhang HB Tags: Asian J Androl Source Type: research

Application and efficacy of reconstructing forked corpus spongiosum in distal/midshaft hypospadias repair.
Abstract We reviewed our experience in reconstructing forked corpus spongiosum (FCS) in distal/midshaft hypospadias repair and analyzed the efficacy of this surgical technique. From August 2013 to December 2018, 137 consecutive cases of distal/midshaft hypospadias operated by the same surgeon in Urology Department, Children's Hospital of Fudan University (Shanghai, China), were retrospectively analyzed. Sixty-four patients who underwent routine tubularized incised plate (TIP) or onlay island flap (ONLAY) surgery were included in the nonreconstructing group, and 73 patients who underwent reconstructing FCS during T...
Source: Asian Journal of Andrology - August 27, 2020 Category: Urology & Nephrology Authors: Zhang B, Bi YL, Ruan SS Tags: Asian J Androl Source Type: research

Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
Abstract Prohibitin (PHB), an evolutionarily conserved mitochondrial inner membrane protein, is highly expressed in cells that require strong mitochondrial function. Recently, we demonstrated that the deletion of Phb in spermatocytes results in impaired mitochondrial function. In addition, PHB expression in the mitochondrial sheath of human sperm has a significantly negative correlation with mitochondrial reactive oxygen species levels, but a positive one with mitochondrial membrane potential and sperm motility. These results suggest that mitochondrial PHB expression plays a role in sperm motility. However, the me...
Source: Asian Journal of Andrology - August 24, 2020 Category: Urology & Nephrology Authors: Li XH, Chai RR, Chen GW, Zhang LF, Tan-Tai WJ, Shi HJ, Martin-DeLeon PA, Wai-Sum O, Chen H Tags: Asian J Androl Source Type: research

Periprostatic fat thickness measured on MRI correlates with lower urinary tract symptoms, erectile function, and benign prostatic hyperplasia progression.
This study investigated the correlation between periprostatic fat thickness (PPFT) measured on magnetic resonance imaging and lower urinary tract symptoms, erectile function, and benign prostatic hyperplasia (BPH) progression. A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were included. Patients were divided into two groups according to the median value of PPFT: high (PPFT>4.35 mm) PPFT group and low (PPFT
Source: Asian Journal of Andrology - August 24, 2020 Category: Urology & Nephrology Authors: Zhang B, Chen X, Liu YH, Gan Y, Liu PH, Chen Z, Xia WP, Dai GY, Ru F, Jiang ZX, He Y Tags: Asian J Androl Source Type: research

Use of a male antioxidant nutraceutical is associated with superior live birth rates during IVF treatment.
Abstract Oxidative stress is prevalent among infertile men and is a significant cause of sperm DNA damage. Since sperm DNA damage may reduce embryo quality and increase miscarriage rates, it is possible that untreated sperm oxidative stress may impair in vitro fertilization (IVF) live birth rates. Given that the antioxidant Menevit is reported to reduce sperm DNA damage, it was hypothesized that men's consumption of this supplement may alter IVF outcomes. Therefore, a retrospective cohort study was conducted analyzing outcomes for couples undergoing their first fresh embryo transfer. Men were classified as control...
Source: Asian Journal of Andrology - August 6, 2020 Category: Urology & Nephrology Authors: Tremellen K, Woodman R, Hill A, Shehadeh H, Lane M, Zander-Fox D Tags: Asian J Androl Source Type: research

A novel screening strategy for clinically significant prostate cancer in elderly men over 75 years of age.
In this study, we found that raising the PSA cutoff to 12 ng ml-1 for CSPC in elderly individuals can significantly reduce unnecessary prostate biopsies. Furthermore, CSPC could be efficiently discovered by combining the four supplementary markers in patients with a PSA level of 4-12 ng ml-1. By performing this screening for elderly men over 75 years of age, unnecessary biopsies may be reduced and CSPC may be detected efficiently. PMID: 32769233 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - July 27, 2020 Category: Urology & Nephrology Authors: Iwamoto H, Izumi K, Kadomoto S, Makino T, Naito R, Yaegashi H, Shigehara K, Kadono Y, Mizokami A Tags: Asian J Androl Source Type: research

Clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection with fresh or cryopreserved sperm in patients with nonobstructive azoospermia.
Abstract We performed this study to evaluate the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI) treatment that used fresh or cryopreserved sperm in patients with nonobstructive azoospermia (NOA). A total of 338 NOA patients with 344 consecutive cycles received treatment in the reproductive medicine center of Peking University Third Hospital in Beijing, China, from January 2014 to December 2017. Fresh oocytes and fresh sperm were used in 222 patients with 234 cycles (Group A). Fresh oocytes and cryopreserved sperm were used in 116 patients with 11...
Source: Asian Journal of Andrology - July 27, 2020 Category: Urology & Nephrology Authors: Zhang HL, Mao JM, Liu DF, Zhao LM, Tang WH, Hong K, Zhang L, Lian Y, Lin HC, Jiang H Tags: Asian J Androl Source Type: research

The emerging role of prostate-specific membrane antigen (PSMA) PET-CT in patients with high-risk prostate cancer: moving the bar in high-risk prostate cancer.
PMID: 32719192 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - July 23, 2020 Category: Urology & Nephrology Authors: Aragon-Ching JB Tags: Asian J Androl Source Type: research

Clinical significance of EPHX2 deregulation in prostate cancer.
In conclusion, EPHX2 deregulation is significantly correlated with the clinical characteristics of PCa progression and may serve as a prognostic marker for PCa. PMID: 32687069 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - July 16, 2020 Category: Urology & Nephrology Authors: Liu MS, Zhao H, Xu CX, Xie PB, Wang W, Yang YY, Lee WH, Jin Y, Zhou HQ Tags: Asian J Androl Source Type: research

Establishment and internal validation of preoperative nomograms for predicting the possibility of testicular salvage in patients with testicular torsion.
In conclusion, this brief preoperative prediction tool will help clinicians to quickly determine the urgency of surgical exploration. PMID: 32687070 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - July 16, 2020 Category: Urology & Nephrology Authors: Zheng WX, Hou GD, Zhang W, Wei D, Gao XL, Chen MH, Huang LG, Yan F, Zhang G, Yu L, Liu F, Zhang B, Yuan JL Tags: Asian J Androl Source Type: research

Androgen deprivation therapy and side effects: are GnRH antagonists safer?
Abstract Androgen deprivation therapy (ADT) with gonadotropin-releasing hormone (GnRH) agonists and antagonists is the mainstay of advanced prostate cancer treatment. Both drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones (FSH), thereby lowering testosterone to castrate levels. This is associated with adverse events (AEs), including cardiovascular (CV) disorders, bone fractures, metabolic dysfunction, and impaired cognitive function. This literature review discusses these AEs, with a focus on CV and bone-related events. A hypothesis-generating meta-analysis of six clinical trial...
Source: Asian Journal of Andrology - July 9, 2020 Category: Urology & Nephrology Authors: Freedland SJ, Abrahamsson PA Tags: Asian J Androl Source Type: research

Next-generation sequencing: toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure.
In conclusion, NGS technology, by screening a specific custom-made panel of genes, could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA. PMID: 32655042 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - July 9, 2020 Category: Urology & Nephrology Authors: Cannarella R, Condorelli RA, Paolacci S, Barbagallo F, Guerri G, Bertelli M, La Vignera S, Calogero AE Tags: Asian J Androl Source Type: research

Preimplantation genetic testing for a new abnormal cleavage behavior.
PMID: 32643631 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - July 2, 2020 Category: Urology & Nephrology Authors: Li MZ, Bai HY, Xue X, Shi JZ Tags: Asian J Androl Source Type: research

Associations of preorchiectomy hormone levels to testicular germ cell tumor pathology, clinical stage, and size.
PMID: 32567579 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - June 18, 2020 Category: Urology & Nephrology Authors: Pineault KG, Cheaib JG, Herati AS, Pierorazio PM Tags: Asian J Androl Source Type: research

Improving native human sperm freezing protection by using a modified vitrification method.
In this study, a modified vitrification method for native spermatozoa was developed. A total of 28 semen samples were included; each sample was divided into three equal parts and assigned to fresh, slow freezing, and vitrification groups. Sperm vitality, motility, morphology, DNA integrity, and acrosome reaction were assessed for each of the groups. The results showed that vitrification achieves better results for several sperm protection parameters than slow freezing; vitrification achieves a higher recovery rate (P
Source: Asian Journal of Andrology - June 15, 2020 Category: Urology & Nephrology Authors: Zhou D, Wang XM, Li RX, Wang YZ, Chao YC, Liu ZZ, Huang ZH, Nie HC, Zhu WB, Tan YQ, Fan LQ Tags: Asian J Androl Source Type: research

Testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children aged < 3 years: 10-year experience with 1034 cases.
Testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children aged
Source: Asian Journal of Andrology - June 11, 2020 Category: Urology & Nephrology Authors: Chen L, Huang WH, Wang YJ, Zhang QL, Zhou CM, Cui X, Zhang JQ Tags: Asian J Androl Source Type: research

The presence of intraductal carcinoma of the prostate is closely associated with poor prognosis: a systematic review and meta-analysis.
Abstract We aimed to confirm the predictive ability of the presence of intraductal carcinoma of the prostate (IDC-P) for prognosis and the associations between IDC-P and clinicopathological parameters. Studies were identified in PubMed, Cochrane Library, EMBASE, Web of Science, and SCOPUS up to December 1, 2019. Hazard ratios (HRs) for survival data and odds ratios for clinicopathological data with 95% confidence intervals (CIs) were extracted. Heterogeneity was evaluated by the I[2] value, and quality was assessed by the Newcastle-Ottawa Scale criteria. A total of 4179 patients from 13 studies were included. The ...
Source: Asian Journal of Andrology - June 1, 2020 Category: Urology & Nephrology Authors: Zhang YC, Sun GL, Ma DL, Wei C, Shang HJ, Liu Z, Li R, Wang T, Wang SG, Liu JH, Liu XM Tags: Asian J Androl Source Type: research

The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates.
Abstract This was a cohort study of in vitro fertilization (IVF) subjects at the University of Utah, Salt Lake City (UT, USA) utilizing partner sperm. Cycles where both the hamster egg penetration test (HEPT) and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and morphology. The mean conventional and intracytoplasmic sperm injection (ICSI) fertilization rates were calculated in each group. We performed a univariate analysis on the primary outcome comparing clinically interesting subjects. We performed a cost-effectiveness anal...
Source: Asian Journal of Andrology - May 18, 2020 Category: Urology & Nephrology Authors: Ibrahim Y, Einerson B, Carrell DT, Emery BR, Johnstone E Tags: Asian J Androl Source Type: research

Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6.
Abstract Prostate cancer (PCa) is one of the most common malignancies in Western countries. Studies have shown that androgen contributes to the progression of PCa, but how androgen promotes PCa remains largely unknown. Here, we demonstrated that androgen suppressed the expression of miR-760 depending on the interaction between androgen and androgen receptor (AR). miR-760 was downregulated in prostate cancer tissues compared with normal tissues. Functional experiments showed that miR-760 downregulation promoted the proliferation and growth of LNCaP and 22rv1 cells. In contrast, miR-760 ectopic expression inhibited ...
Source: Asian Journal of Andrology - May 14, 2020 Category: Urology & Nephrology Authors: Wang S, Yang Y, Cao YD, Tang XX, Du P Tags: Asian J Androl Source Type: research

A novel approach: successful management of vasectomy reversal with a three-dimensional digital image microscope system.
PMID: 32394900 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - May 11, 2020 Category: Urology & Nephrology Authors: Li P, Zhi EL, Yao CC, Xia SJ, Li Z Tags: Asian J Androl Source Type: research

N-acetylcysteine maintains penile length and erectile function in bilateral cavernous nerve crush rat model by reducing penile fibrosis.
This study investigated the effect of NAC on maintaining the penile length and the erectile function after bilateral cavernous nerve crush (BCNC) and its underlying mechanism. Twenty-four male rats were randomly divided into three groups: control group, BCNC group, and BCNC + NAC group. NAC or equal volume of saline was daily administrated by intragastric gavage for 4 weeks. The initial and end penile lengths were measured. Intracavernosal pressure/mean arterial pressure (ICP/MAP) ratio was calculated to assess erectile function. Hematoxylin-eosin staining, Masson's trichrome staining, immunohistochemistry, and Western blo...
Source: Asian Journal of Andrology - May 11, 2020 Category: Urology & Nephrology Authors: Ma M, Wu CJ, Zhang P, Li T, Wei SZ, Yu BT, Qin F, Yuan JH Tags: Asian J Androl Source Type: research

The pelvic pop: an extremely rare case of internal penile fracture presenting with scrotal hematoma and review of the literature.
PMID: 32367836 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - May 4, 2020 Category: Urology & Nephrology Authors: Rezaee ME, Gross MS Tags: Asian J Androl Source Type: research

The association between the two more common genetic causes of spermatogenic failure: a 7-year retrospective study.
This study was to investigate the incidence and characteristics of chromosomal aberrations and Y chromosome microdeletions in infertile men, and to explore whether there was a correlation between the two genetic defects of spermatogenic failure. A 7-year retrospective study was conducted on 5465 infertile men with nonobstructive azoospermia or oligozoospermia. Karyotype analysis of peripheral blood lymphocytes was performed by standard G-banding techniques. Y chromosome microdeletions were screened by multiplex PCR amplification with six specific sequence-tagged site (STS) markers. Among the 5465 infertile men analyzed, 37...
Source: Asian Journal of Andrology - April 30, 2020 Category: Urology & Nephrology Authors: Li HG, Fan LH, Liu B, Qian YQ, Chen M, Sun YX, Dong MY Tags: Asian J Androl Source Type: research

Does intraoperative frozen section really predict significant positive surgical margins after robot-assisted laparoscopic prostatectomy? A retrospective study.
Abstract We investigated the relationship between positive surgical margin (PSM)-related factors and biochemical recurrence (BCR) and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate cancer. The study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral preservation. Intraoperative frozen sections of the periurethra, dorsal vein, and bladder neck were analyzed. The ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic regression. Of 271 patients, 108 (39....
Source: Asian Journal of Andrology - April 30, 2020 Category: Urology & Nephrology Authors: Choi SY, Chi BH, Kim TH, Lim B, Lee W, You D, Kim CS Tags: Asian J Androl Source Type: research

Serum vitamin D content is associated with semen parameters and serum testosterone levels in men.
Abstract The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels. This is a cross-sectional study conducted at Androscience, Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo, Brazil, with 508 male patients, aged 18-60 years, from 2007 to 2017. Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria. Patients were divided into normozoospermic group (NZG, n = 124) and a group with seminal abnormalities (SAG, n ...
Source: Asian Journal of Andrology - April 27, 2020 Category: Urology & Nephrology Authors: Ciccone IM, Costa EM, Pariz JR, Teixeira TA, Drevet JR, Gharagozloo P, Aitken RJ, Hallak J Tags: Asian J Androl Source Type: research

Kinematic analysis of penile reflexes in a rat model of spinal cord injury.
This study examined, using two-dimensional (2D) kinematic analysis, the relationship between the PDFR and degree of white matter sparing (WMS). Male Wistar rats received a T9 contusion with varying degrees of impactor forces. Weekly kinematic recordings of the PDFR were made 3-8 weeks postinjury. Sexual reflex components examined included maximum angle of penile dorsiflexion, total penile event duration, and penile ascent speed. Post hoc comparison between animals grouped based upon injury severity (moderate-severe: 13.33%-17.15% WMS vs moderate: 20.85%-33.50% WMS) indicated PDFR effects. Specifically, the numbers of anima...
Source: Asian Journal of Andrology - April 20, 2020 Category: Urology & Nephrology Authors: Steadman CJ, Vangoor SS, Hubscher CH Tags: Asian J Androl Source Type: research

Sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection.
This study examined 769 patients with nonobstructive azoospermia who underwent 347 cycles of micro-TESE-ICSI. Patients with azoospermia were classified into Group A (Klinefelter syndrome, n = 284, 125 cycles), Group B (azoospermia Y chromosome factor c [AZFc] microdeletion, n = 91, 64 cycles), Group C (cryptorchidism, n = 52, 39 cycles), Group D (previous mumps and bilateral orchitis, n = 23, 23 cycles), and Group E (idiopathic azoospermia, n = 319, 96 cycles). Clinical characteristics, SRR, embryonic development, and pregnancy outcomes of the patients were compared between all groups. Patients in Group D had the highest a...
Source: Asian Journal of Andrology - April 20, 2020 Category: Urology & Nephrology Authors: Zhang HL, Zhao LM, Mao JM, Liu DF, Tang WH, Lin HC, Zhang L, Lian Y, Hong K, Jiang H Tags: Asian J Androl Source Type: research

Sperm retrieval success and testicular histopathology in idiopathic nonobstructive azoospermia.
Abstract Prior studies have investigated sperm retrieval rates in men with nonobstructive azoospermia (NOA) secondary to specific etiologies, yet most cases of NOA are idiopathic. We compared sperm retrieval rates and testicular histopathology in idiopathic NOA (iNOA) and nonidiopathic NOA (niNOA). We performed a retrospective review of men with NOA who underwent microdissection testicular sperm extraction (microTESE) between 2000 and 2016. Men with no history of malignancy or cryptorchidism and negative genetic evaluation were considered idiopathic. Multivariable regression determined the association between idio...
Source: Asian Journal of Andrology - April 20, 2020 Category: Urology & Nephrology Authors: Das A, Halpern JA, Darves-Bornoz AL, Patel M, Wren J, Keeter MK, Brannigan RE Tags: Asian J Androl Source Type: research

Relationship of sperm plasma membrane and acrosomal integrities with sperm morphometry in Bos taurus.
acute;niz J Abstract To date, sperm morphometric studies have assessed whole sperm populations without considering sperm function. The aim of this study was to evaluate the relationship of sperm membrane and acrosomal integrity with sperm morphometry in liquid semen samples collected from bulls. To this end, sperm morphometry was performed on cryopreserved semen samples from 16 bulls by a combination of fluorescent dyes, including Hoechst 33343, carboxyfluorescein diacetate, and propidium iodide. This allowed discrimination of different subpopulations on the basis of sperm membrane and acrosomal integrity and anal...
Source: Asian Journal of Andrology - April 20, 2020 Category: Urology & Nephrology Authors: Palacín I, Santolaria P, Alquezar-Baeta C, Soler C, Silvestre MA, Yániz J Tags: Asian J Androl Source Type: research

Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
Abstract The mammalian epididymis not only plays a fundamental role in the maturation of spermatozoa, but also provides protection against various stressors. The foremost among these is the threat posed by oxidative stress, which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids, proteins, and nucleic acids. In mice, the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5 (GPX5) as a major luminal scavenger in the proximal caput epididymidal segment. Accordingly, the loss of GPX5-mediated protection leads t...
Source: Asian Journal of Andrology - April 6, 2020 Category: Urology & Nephrology Authors: Chu C, Yu L, Henry-Berger J, Ru YF, Kocer A, Champroux A, Li ZT, He M, Xie SS, Ma WB, Ni MJ, Ni ZM, Guo YL, Fei ZL, Gou LT, Liu Q, Sharma S, Zhou Y, Liu MF, Chen CD, Eamens AL, Nixon B, Zhou YC, Drevet JR, Zhang YL Tags: Asian J Androl Source Type: research

Comparative study of intracavernous pressure and cavernous pathology after bilateral cavernous nerve crushing and resection in rats.
This study aimed to compare the effects of bilateral cavernous nerve crushing (BCNC) and bilateral cavernous nerve resection (BCNR) on intracavernous pressure (ICP) and cavernous pathology in rats and to explore the optimal treatment time for the BCNC and BCNR models. Seventy-two male rats aged 12 weeks were randomly divided into three equal groups: Sham (both cavernous nerves exposed only), BCNC (BCN crushed for 2 min), and BCNR (5 mm of BCN resected). Erectile function was then measured at 1 week, 3 weeks, and 5 weeks after nerve injury, and penile tissues were harvested for histological and molecular analyses by immunoh...
Source: Asian Journal of Andrology - March 30, 2020 Category: Urology & Nephrology Authors: Li M, Yuan YM, Yang BC, Gu SJ, Li HX, Xin ZC, Fang D, Guan RL Tags: Asian J Androl Source Type: research

Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas.
Abstract Spermatogenesis is regulated by a complex network of posttranslation modifications. Sumoylation (a modification by small ubiquitin-like modifiers, or SUMO proteins) was identified as an important cellular event in different cell types. SUMO proteins are highly expressed in the testis, and their role during spermatogenesis has begun to be elucidated. Given the important role of sumoylation in the regulation of mitosis and cancer progression in other tissues, the aim of the current study was to identify the targets of SUMO in proliferating mouse spermatogonia and human seminoma tissues and to initially exam...
Source: Asian Journal of Andrology - March 26, 2020 Category: Urology & Nephrology Authors: Vigodner M, Lucas B, Kemeny S, Schwartz T, Levy R Tags: Asian J Androl Source Type: research

Comparison of ART outcomes in men with altered mRNA protamine 1/protamine 2 ratio undergoing intracytoplasmic sperm injection with ejaculated and testicular spermatozoa.
rua J Abstract Assisted reproductive technologies involving the use of spermatozoa and eggs for in vitro fertilization (IVF) have come as the solution for many infertile couples to become parents. However, in some cases, the use of ejaculated spermatozoa delivers poor IVF performance. Some studies have suggested the use of testicular spermatozoa in severe male infertility cases, but no guidelines regarding their utilization are currently available. In the present study, we found the mRNA protamine 1/protamine 2 (P1/P2) ratio to be a valuable biomarker of poor sperm function that could be used as a diagnostic key f...
Source: Asian Journal of Andrology - March 23, 2020 Category: Urology & Nephrology Authors: Sarasa J, Enciso M, García L, Leza A, Steger K, Aizpurua J Tags: Asian J Androl Source Type: research

MAGI-2 downregulation: a potential predictor of tumor progression and early recurrence in Han Chinese patients with prostate cancer.
The objective of this study was to investigate the expression of MAGI-2 at mRNA and protein levels. The prognostic value of MAGI-2 in Han Chinese patients with prostate cancer was also investigated. The expression data of MAGI-2 were assessed through database retrieval, analysis of sequencing data from our group, and tissue immunohistochemistry using digital scoring system (H-score). The clinical, pathological, and follow-up data were collected. The expression of MAGI-2 in prostate tumor tissues and prostate normal tissues was evaluated and compared. MAGI-2 expression was associated with clinical parameters including tumor...
Source: Asian Journal of Andrology - March 9, 2020 Category: Urology & Nephrology Authors: Cao Z, Ji J, Wang FB, Kong C, Xu H, Xu YL, Chen X, Yu YW, Sun YH Tags: Asian J Androl Source Type: research

When to pull the trigger in nonazoospermic infertile men undergoing intracytoplasmic sperm injection?
PMID: 32167076 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - March 5, 2020 Category: Urology & Nephrology Authors: Esteves SC, Lewis SE Tags: Asian J Androl Source Type: research

Transurethral vesiculoscope-assisted laser incision of the prostatic utricle to treat partial ejaculatory duct obstruction.
PMID: 32129190 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - March 2, 2020 Category: Urology & Nephrology Authors: Wang KN, Xie WL, Zheng L, Jiang T Tags: Asian J Androl Source Type: research

Artificial urinary sphincter: current status and future directions.
Abstract Urge urinary incontinence (UUI) is one of the most troublesome complications of surgery of the prostate whether for malignancy or benign conditions. For many decades, there have been attempts to reduce the morbidity of this outcome with variable results. Since its development in the 1970s, the artificial urinary sphincter (AUS) has been the "gold standard" for treatment of the most severe cases of UUI. Other attempts including injectable bulking agents, previous sphincter designs, and slings have been developed, but largely abandoned because of poor long-term efficacy and significant complicatio...
Source: Asian Journal of Andrology - February 29, 2020 Category: Urology & Nephrology Authors: Carson CC Tags: Asian J Androl Source Type: research