Prognostic value of primary tumor surgery in seminoma patients with distant metastasis at diagnosis: a population-based study.
Abstract The aims of this study were to determine the prognostic value of primary tumor surgery and identify optimal candidates for such surgery among patients with seminoma and distant metastasis at diagnosis. We identified 521 patients with seminoma and distant metastasis at diagnosis between 2004 and 2014 from the Surveillance, Epidemiology, and End Results database. Among these patients, 434 had undergone surgery, whereas 87 had not. The prognostic value of primary tumor surgery was assessed by Kaplan-Meier methods, log-rank analyses, and multivariate Cox's proportional hazards model. Survival curves and fores...
Source: Asian Journal of Andrology - February 4, 2020 Category: Urology & Nephrology Authors: Jin SM, Wei JM, Wu JL, Wang BH, Gan HL, Xu PH, Wan FN, Gu WJ, Wei Y, Yang C, Shen YJ, Ye DW Tags: Asian J Androl Source Type: research

How do we define "castration" in men on androgen deprivation therapy?
How do we define "castration" in men on androgen deprivation therapy? Asian J Androl. 2020 Jan 21;: Authors: Itty S, Getzenberg RH Abstract Androgen deprivation therapy (ADT) is the mainstay for the treatment of advanced prostate cancer. Since the clinical evolution from surgical orchiectomy, we have typically used ADT and orchiectomy to be synonymous terms for castration. The goal of this study is to determine if, in contemporary medical practice, surgical and chemical castration provide for similar levels of diminishment of total and free testosterone. Further, what approaches should be us...
Source: Asian Journal of Andrology - January 21, 2020 Category: Urology & Nephrology Authors: Itty S, Getzenberg RH Tags: Asian J Androl Source Type: research

Fluorescent probes for the detection of reactive oxygen species in human spermatozoa.
Abstract Reactive oxygen species (ROS) production is a by-product of mitochondrial activity and is necessary for the acquisition of the capacitated state, a requirement for functional spermatozoa. However, an increase in oxidative stress, due to an abnormal production of ROS, has been shown to be related to loss of sperm function, highlighting the importance of an accurate detection of sperm ROS, given the specific nature of this cell. In this work, we tested a variety of commercially available fluorescent probes to detect ROS and reactive nitrogen species (RNS) in human sperm, to define their specificity. Using b...
Source: Asian Journal of Andrology - January 14, 2020 Category: Urology & Nephrology Authors: Escada-Rebelo S, Mora FG, Sousa AP, Almeida-Santos T, Paiva A, Ramalho-Santos J Tags: Asian J Androl Source Type: research

Erectile function after WST11 vascular-targeted photodynamic therapy for low-risk prostate cancer treatment.
Abstract Vascular-targeted photodynamic therapy (VTP) using padeliporfin is currently assessed as a low-risk prostate cancer (LRPCa) treatment. The aim of this study was to assess erectile function outcomes of VTP for LRPCa treatment. We prospectively included all patients treated with VTP for LRPCa. The primary endpoint was the post-treatment International Index of Erectile Function score (IIEF5 score) evolution (at 6 months, 12 months, and then every year for 5 years). Secondary endpoints were the need of erectile dysfunction (ED) treatment and its efficacy. Eighty-two men were included. The median follow-up was...
Source: Asian Journal of Andrology - January 14, 2020 Category: Urology & Nephrology Authors: Chelly S, Maulaz P, Bigot P, Azzouzi AR, Lebdai S Tags: Asian J Androl Source Type: research

Chromosome heteromorphisms: do they entail a reproductive risk for male carriers?
nco J PMID: 31929195 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - January 10, 2020 Category: Urology & Nephrology Authors: Anton E, Garcia-Guixé E, Ramos-Muntada M, Godo A, Sandalinas M, Blanco J Tags: Asian J Androl Source Type: research

Tissue expander capsule as an induced vascular bed to prefabricate an axial vascularized buccal mucosa-lined flap for tubularized posterior urethral reconstruction: preliminary results in an animal model.
Abstract Surgical repair of complex posterior urethral disruptions remains one of the most challenging problems in urology. The efficacy of using a tissue expander capsule as an induced vascular bed to prefabricate axial vascularized buccal mucosa-lined flaps for tubularized posterior urethral reconstruction in a rabbit model was tested. The experiments were performed in three stages. First, silicone tissue expanders were inserted into the groin to induce vascularized capsule pouch formation. Next, buccal mucosa grafts were transplanted into the newly formed capsular tissue supplied by axial vessels for buccal muc...
Source: Asian Journal of Andrology - January 10, 2020 Category: Urology & Nephrology Authors: Guo HL, Wang L, Jia ZM, Bao XQ, Huang YC, Zhou JM, Xie H, Yang XJ, Chen F Tags: Asian J Androl Source Type: research

Estradiol is an independent risk factor for organic erectile dysfunction in eugonadal young men.
Abstract Erectile dysfunction attributable to testosterone deficiency is less common in young males, and the effect of estradiol on erectile function in eugonadal young males is unclear. We analyzed data from 195 male participants, including 143 eugonadal patients with erectile dysfunction and 52 healthy men. To distinguish psychogenic and organic erectile dysfunction, penile rigidity was measured using the nocturnal penile tumescence rigidity test. Serum levels of sexual hormones were quantified by electrochemiluminescence, and penile vascular status was assessed by penile color Doppler ultrasound. Both serum est...
Source: Asian Journal of Andrology - January 10, 2020 Category: Urology & Nephrology Authors: Chen HR, Tian RH, Li P, Chen HX, Xia SJ, Li Z Tags: Asian J Androl Source Type: research

Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: results from a multicenter study in China.
Abstract To evaluate whether prostate volume (PV) would provide additional predictive utility to the prostate health index (phi) for predicting prostate cancer (PCa) or clinically significant prostate cancer, we designed a prospective, observational multicenter study in two prostate biopsy cohorts. Cohort 1 included 595 patients from three medical centers from 2012 to 2013, and Cohort 2 included 1025 patients from four medical centers from 2013 to 2014. Area under the receiver operating characteristic curves (AUC) and logistic regression models were used to evaluate the predictive performance of PV-based derivativ...
Source: Asian Journal of Andrology - January 10, 2020 Category: Urology & Nephrology Authors: Huang D, Wu YS, Ye DW, Qi J, Liu F, Helfand BT, Zheng SL, Ding Q, Xu DF, Na R, Xu JF, Sun YH Tags: Asian J Androl Source Type: research

Robot-assisted radical cystectomy and intracorporeal orthotopic neobladder: 1-year functional outcomes.
PMID: 31929193 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - January 7, 2020 Category: Urology & Nephrology Authors: Obrecht F, Youssef NA, Burkhardt O, Schregel C, Randazzo M, Padevit C, Wiklund P, John H Tags: Asian J Androl Source Type: research

Sexual health in Polish elderly men with coronary artery disease: importance, expectations, and reality.
Abstract Deterioration in overall health, hormonal disturbances, and erectile dysfunction (ED) contributes to limitations in sexual activity in the elderly, which is further limited by incorrect beliefs about the hazards of sexual activity in cardiac patients. We aimed to analyze the occurrence of ED in elderly men, their perception of the relevance of good sexual function, and their expectations of physicians. A cross-sectional study encompassed 731 patients with coronary artery disease (CAD) subjected to cardiac rehabilitation. Demographic data and data on modifiable risk factors and patient expectations were co...
Source: Asian Journal of Andrology - January 7, 2020 Category: Urology & Nephrology Authors: Rusiecki L, Zdrojowy R, Gebala J, Rabijewski M, Sobieszczańska M, Smoliński R, Pilecki W, Dziubek W, Janocha A, Womperski M, Kałka D Tags: Asian J Androl Source Type: research

National natural science foundation of China leads the comprehensive development of basic research in the field of male reproductive health in China.
PMID: 31898585 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - December 27, 2019 Category: Urology & Nephrology Authors: Liao SJ, Xu YY, Sun RJ, Lyu QY Tags: Asian J Androl Source Type: research

Real-time transrectal ultrasound-guided seminal vesiculoscopy for the treatment of patients with persistent hematospermia: A single-center, prospective, observational study.
This study aimed to describe endoscopic anatomy of the seminal tract and summarize our experience of transutricular seminal vesiculoscopy (TSV) guided by real-time transrectal ultrasonography (TRUS) in managing persistent hematospermia. A total of 281 consecutive patients with persistent hematospermia who underwent TSV with or without real-time TRUS were enrolled in this single-center, prospective, observational study. The median follow-up period was 36.5 (range: 8.0-97.5) months. TSV was successfully performed in 272 (96.8%) patients. The approach of a 4.5/6 F rigid vesiculoscope entering the seminal tract was categorized...
Source: Asian Journal of Andrology - December 27, 2019 Category: Urology & Nephrology Authors: Wang XS, Li M, Shao GF, Sun WD, Zhang XL, Xiao ZY, Ma Z, Yuan MZ, Guo LQ Tags: Asian J Androl Source Type: research

Transurethral resection of the prostate stricture management.
Abstract For more than nine decades, transurethral resection of the prostate remains the gold standard for the surgical treatment of lower urinary tract symptoms due to benign prostatic obstruction. The occurrence of urethral strictures after transurethral resection of the prostate is one of the major late complications and has been reported as the leading cause of iatrogenic urethral strictures in patients older than 45 years who underwent urethroplasty. Although several postulations have been proposed to explain the urethral stricture after transurethral resection of the prostate, the exact etiology of urethral ...
Source: Asian Journal of Andrology - December 20, 2019 Category: Urology & Nephrology Authors: Wang JW, Man LB Tags: Asian J Androl Source Type: research

Novel protective penile collar following inflatable penile prosthesis placement: The "Wang Collar".
We present a novel penile device after IPP placement, which we have found to improve patient satisfaction in the postoperative period. In addition, it eases the care of the patient by the perioperative staff. It is now our routine to use this device after IPP surgery. Further research is necessary to evaluate whether this device can decrease postoperative wound complications. PMID: 31854332 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - December 17, 2019 Category: Urology & Nephrology Authors: Borregales LD, Saavedra-Belaunde J, Wang R, Clavell-Hernández J Tags: Asian J Androl Source Type: research

Penile prosthesis implant in the special populations: diabetics, neurogenic conditions, fibrotic cases, concurrent urinary continence surgery, and salvage implants.
This article provides a critical review of relevant publications pertaining to PPI in men with diabetes, significant corporal fibrosis, spinal cord injury, concurrent continence surgery, and complex salvage cases. The discussion of each category of special populations includes a brief review of the surgical challenges and a practical action-based set of recommendations. While specific patient populations posed considerable challenges in PPI surgery, strict pre- and postoperative management coupled with safe surgical practice is a prerequisite to achieving excellent clinical outcomes and high patient satisfaction rate. ...
Source: Asian Journal of Andrology - December 3, 2019 Category: Urology & Nephrology Authors: Chung E Tags: Asian J Androl Source Type: research

Microsurgical subinguinal varicocelectomy with spermatic cord double traction and vein stripping.
Abstract We retrospectively reviewed data for 286 patients with varicocele who underwent microsurgical subinguinal varicocelectomy from March 2015 to May 2017 in Shanghai General Hospital (Shanghai, China). In this surgical approach, the testis was delivered, and the gubernacular and external cremasteric veins were stripped. In addition, the spermatic cord was delivered downward with continuous double traction away from the external ring. The remaining procedure was similar to the conventional approach. We followed patients for at least 3 months and evaluated postoperative semen parameters, pain symptoms, and comp...
Source: Asian Journal of Andrology - November 29, 2019 Category: Urology & Nephrology Authors: Tian RH, Zhao LY, Chen HX, Yang C, Li P, Huang YH, Wan Z, Zhi EL, Yao CC, Li Z Tags: Asian J Androl Source Type: research

Epidemiology regarding penile prosthetic surgery.
Abstract With the onset of a metabolic syndrome epidemic and the increasing life expectancy, erectile dysfunction (ED) has become a more common condition. As incidence and prevalence increase, the medical field is focused on providing more appropriate therapies. It is common knowledge that ED is a chronic condition that is also associated with a myriad of other disorders. Conditions such as aging, diabetes mellitus, hypertension, obesity, prostatic hypertrophy, and prostate cancer, among others, have a direct implication on the onset and progression of ED. Characterization and recognition of risk factors may help ...
Source: Asian Journal of Andrology - November 29, 2019 Category: Urology & Nephrology Authors: Saavedra-Belaunde JA, Clavell-Hernandez J, Wang R Tags: Asian J Androl Source Type: research

Artificial urinary sphincter surgery in the special populations: neurological, revision, concurrent penile prosthesis and female stress urinary incontinence groups.
This article provides a critical review of relevant publications pertaining to AUS surgery in specific high-risk groups such as men with spinal cord injury, revision cases, concurrent penile prosthesis implant, and female SUI. The discussion of each category includes a brief review of surgical challenge and a practical action-based set of recommendations. Our increased understandings of the pathophysiology of various SUI cases coupled with effective therapeutic strategies to enhance AUS surgery continue to improve clinical outcomes of many patients with SUI. PMID: 31793444 [PubMed - as supplied by publisher] (Source: ...
Source: Asian Journal of Andrology - November 29, 2019 Category: Urology & Nephrology Authors: Chung E Tags: Asian J Androl Source Type: research

Prokineticin 2 overexpression induces spermatocyte apoptosis in varicocele in rats.
Abstract Varicocele is one of the most important causes of male infertility, as this condition leads to a decline in sperm quality. It is generally believed that the presence of varicocele induces an increase in reactive oxygen species levels, leading to oxidative stress and sperm apoptosis; however, the specific pathogenic mechanisms affecting spermatogenesis remain elusive. Prokineticin 2 (PK2), a secretory protein, is associated with multiple biological processes, including cell migration, proliferation, and apoptosis. In the testis, PK2 is expressed in spermatocytes under normal physiological conditions. To in...
Source: Asian Journal of Andrology - November 19, 2019 Category: Urology & Nephrology Authors: Li Y, Zhou T, Su YF, Hu ZY, Wei JJ, Wang W, Liu CY, Zhao K, Zhang HP Tags: Asian J Androl Source Type: research

The modern testicular prosthesis: patient selection and counseling, surgical technique, and outcomes.
Abstract The testicular prosthesis can be an afterthought for providers when performing an orchiectomy for testicular cancer, torsion, atrophic testis, or trauma. However, data suggest that patients find the offer of a testicular prosthesis and counseling regarding placement to be extremely important from both a pragmatic and a psychosocial perspective. Only two-thirds of men undergoing orchiectomy are offered an implant at the time of orchiectomy and of those offered about one-third move forward with prosthesis placement. The relatively low acceptance rate is in stark contrast with high patient satisfaction and l...
Source: Asian Journal of Andrology - November 19, 2019 Category: Urology & Nephrology Authors: Hayon S, Michael J, Coward RM Tags: Asian J Androl Source Type: research

Management of urethral atrophy after implantation of artificial urinary sphincter: what are the weaknesses?
This article aims to present and summarize the current literature on the management of complications of AUS, especially urethral atrophy. We conducted a literature search on PubMed from January 1990 to December 2018 on AUS complications and their management. We review the various potential complications and their management. AUS complications are either mechanical or nonmechanical complications. Mechanical complications usually involve malfunction of the AUS. Nonmechanical complications include infection, urethral atrophy, cuff erosion, and stricture. Challenges exist especially in the management of urethral atrophy, with ...
Source: Asian Journal of Andrology - November 15, 2019 Category: Urology & Nephrology Authors: Heah NH, Tan RBW Tags: Asian J Androl Source Type: research

Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea.
This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of -300 mmHg), and anti-LOX + VD. Penile length was measured by a modified VD method and verified on exposed length data. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure (MAP) ratio were recorded to assess erectile function. For corpus cavernosum, LOX activity and concentrations of pyridinoline, desmosine, hydroxyp...
Source: Asian Journal of Andrology - November 15, 2019 Category: Urology & Nephrology Authors: Li T, Fu FD, Wu CJ, Qin F, Wang R, Yuan JH Tags: Asian J Androl Source Type: research

Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis.
In this study, the relationship of PRPS2 with hypospermatogenesis and spermatogenic cell apoptosis was investigated. The results showed that PRPS2 depletion increased the number of apoptotic spermatogenic cells in vitro. PRPS2 was downregulated in a mouse model of hypospermatogenesis. When PRPS2 expression was knocked down in mouse testes, hypospermatogenesis and accelerated apoptosis of spermatogenic cells were noted. E2F transcription factor 1 (E2F1) was confirmed as the target gene of PRPS2 and played a key role in cell apoptosis by regulating the P53/Bcl-xl/Bcl-2/Caspase 6/Caspase 9 apoptosis pathway. Therefore, these ...
Source: Asian Journal of Andrology - November 15, 2019 Category: Urology & Nephrology Authors: Lei B, Xie LX, Zhang SB, Wan B, Zhong LR, Zhou XM, Mao XM, Shu FP Tags: Asian J Androl Source Type: research

Biomedical engineering and erectile restoration: design considerations for urologic prosthetics.
Abstract For patients with moderate-to-severe erectile dysfunction, implantable penile prostheses continue to be a viable treatment. Medical device developers apply design controls during the development cycle to ensure that a product performs as intended in the final use environment. This process relies heavily on the principles of systems engineering and documents every facet of performance, unmet need, and risk. To better understand design philosophy, it is important to frame benchmarked performance outcomes in the context of the ideal state. Careful consideration of erectile anatomy and physiology, including f...
Source: Asian Journal of Andrology - November 12, 2019 Category: Urology & Nephrology Authors: Lund JJ Tags: Asian J Androl Source Type: research

Association between 5 α-reductase inhibitors therapy and incidence, cancer-specific mortality, and progression of prostate cancer: evidence from a meta-analysis.
Association between 5α-reductase inhibitors therapy and incidence, cancer-specific mortality, and progression of prostate cancer: evidence from a meta-analysis. Asian J Androl. 2019 Nov 08;: Authors: Luo LM, Yang RD, Wang JM, Zhao SK, Liu YZ, Zhu ZG, Xiang Q, Zhao ZG Abstract 5α-reductase inhibitors (5-ARI) are widely employed for the treatment of benign prostatic hyperplasia. It has been noted that 5-ARI exhibit the potential to attenuate the risk of prostate cancer, but consistent agreement has not been achieved. Moreover, the effect of 5-ARI on cancer-specific mortality and progression ...
Source: Asian Journal of Andrology - November 8, 2019 Category: Urology & Nephrology Authors: Luo LM, Yang RD, Wang JM, Zhao SK, Liu YZ, Zhu ZG, Xiang Q, Zhao ZG Tags: Asian J Androl Source Type: research

Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer.
Abstract Intraductal carcinoma of the prostate (IDC-P) is an aggressive pathological pattern of prostate cancer (PCa). We investigated the association of IDC-P in prostate biopsy (PBx) with several pathological features after radical prostatectomy (RP) and its prognostic value in high-risk PCa. A total of 418 patients with high-risk PCa after RP were included in this study. IDC-P and its architectural patterns were identified according to the 2016 World Health Organization Classification. Chi-squared test and logistic regression were used to investigate the correlation between IDC-P and post-RP pathological featur...
Source: Asian Journal of Andrology - November 8, 2019 Category: Urology & Nephrology Authors: Zhu S, Zhao JG, Chen JR, Liu ZH, Sun GX, Wang ZP, Ni YC, Dai JD, Shen PF, Zeng H Tags: Asian J Androl Source Type: research

Fundamentals of prosthetic urology.
Abstract The field of prosthetic urology demonstrates the striking impact that simple devices can have on quality of life. Penile prosthesis and artificial urinary sphincter implantation are the cornerstone procedures on which this specialty focuses. Modern research largely concentrates on decreasing the rates of complication and infection, as the current devices offer superior rates of satisfaction when revision is not necessary. These techniques are also able to salvage sexual function and continence in more difficult patient populations including female-to-male transgender individuals, those with ischemic priap...
Source: Asian Journal of Andrology - November 1, 2019 Category: Urology & Nephrology Authors: Akula KP, Raheem OA Tags: Asian J Androl Source Type: research

Damaged male germ cells induce epididymitis in mice.
Abstract Epididymitis can be caused by infectious and noninfectious etiological factors. While microbial infections are responsible for infectious epididymitis, the etiological factors contributing to noninfectious epididymitis remain to be defined. The present study demonstrated that damaged male germ cells (DMGCs) induce epididymitis in mice. Intraperitoneal injection of the alkylating agent busulfan damaged murine male germ cells. Epididymitis was observed in mice 4 weeks after the injection of busulfan and was characterized by massive macrophage infiltration. Epididymitis was coincident with an accumulation of...
Source: Asian Journal of Andrology - November 1, 2019 Category: Urology & Nephrology Authors: Liu WH, Wang F, Yu XQ, Wu H, Gong ML, Chen R, Zhang WJ, Han RQ, Liu AJ, Chen YM, Han DS Tags: Asian J Androl Source Type: research

Efficacy and safety of low-intensity shockwave therapy plus tadalafil 5 mg once daily in men with type 2 diabetes mellitus and erectile dysfunction: a matched-pair comparison study.
Abstract Low-intensity extracorporeal shockwave therapy (LiESWT) represents a promising treatment for patients with erectile dysfunction (ED). We investigated the efficacy of LiESWT combined with tadalafil 5 mg once daily in men with type 2 diabetes mellitus (T2DM) and ED and compared LiESWT protocols administering different number of shockwaves. We performed a retrospective matched-pair comparison using data from a prospectively maintained database. Seventy-eight patients who received tadalafil 5 mg once daily for 12 weeks + LiESWT performed with an electrohydraulic source for 3 weeks (Group A) were matched 1:1 t...
Source: Asian Journal of Andrology - November 1, 2019 Category: Urology & Nephrology Authors: Verze P, Capece M, Creta M, La Rocca R, Persico F, Spirito L, Cardi A, Mirone V Tags: Asian J Androl Source Type: research

Seminal plasma miR-210-3p induces spermatogenic cell apoptosis by activating caspase-3 in patients with varicocele.
This study included 102 patients whose semen quality was normal when they were diagnosed with varicocele. A 2-year follow-up for included patients was performed, and they were divided into Group A (semen quality became abnormal) and Group B (semen quality remained normal) according to the results of semen analysis during the follow-up. Semen parameters and seminal plasma miR-210-3p expression were investigated by semen analysis and quantitative real-time polymerase chain reaction, respectively. In vitro experiments with GC-2 cells were performed to explore the role of miR-210-3p in spermatogenic cells. The results of quant...
Source: Asian Journal of Andrology - October 25, 2019 Category: Urology & Nephrology Authors: Xu YW, Ou NJ, Song YX, Wang XH, Kang JQ, Yang YJ, Chen YG, Liu XQ Tags: Asian J Androl Source Type: research

A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility.
Abstract Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio. In this subset of patients, and particularly in those with hypogonadism, elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic-pituitary-testicular axis by suppressing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) production and impaired spermatogenesis. Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase end...
Source: Asian Journal of Andrology - October 15, 2019 Category: Urology & Nephrology Authors: Giudice FD, Busetto GM, De Berardinis E, Sperduti I, Ferro M, Maggi M, Gross MS, Sciarra A, Eisenberg ML Tags: Asian J Androl Source Type: research

Influence of in vitro capacitation time on structural and functional human sperm parameters.
Gómez-Torres MJ Abstract A cascade of dramatic physiological events is linked to the sperm acrosome reaction and binding to the oocyte's zona pellucida during human sperm capacitation. However, structural and functional sperm changes during capacitation currently remain poorly defined. Here, we performed a multibiomarker approach based on the utilization of sperm concentration, motility, viability, morphology, acrosome reaction, tyrosine phosphorylation, DNA fragmentation, and lectin-binding sites to analyze the impact caused by swim-up selection times (uncapacitated, 1 h capacitated, and 4 h capacitated) ...
Source: Asian Journal of Andrology - October 15, 2019 Category: Urology & Nephrology Authors: Sàez-Espinosa P, Huerta-Retamal N, Robles-Gómez L, Avilés M, Aizpurua J, Velasco I, Romero A, Gómez-Torres MJ Tags: Asian J Androl Source Type: research

Azoospermia: vasal agenesis.
PMID: 31621656 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 15, 2019 Category: Urology & Nephrology Authors: Fisher JS, Kim ED Tags: Asian J Androl Source Type: research

Prevalence of and risk factors for erectile dysfunction in young nondiabetic obese men: results from a regional study.
In this study, we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young (18-49 years) nondiabetic obese (body mass index [BMI] ≥ 30 kg m-2) men from primary care. Erectile function (International Index of Erectile Function [IIEF-5] questionnaire), quality of life (Aging Males' Symptoms [AMS scale]), and body composition analysis (Tanita MC-180MA) were determined. Total testosterone was determined using high-performance liquid chromatography-mass spectrometry. Multivariate logistic regression analysis was used to study the factors associated with ED. ED prevalence was 4...
Source: Asian Journal of Andrology - October 11, 2019 Category: Urology & Nephrology Authors: Molina-Vega M, Asenjo-Plaza M, Banderas-Donaire MJ, Hernández-Ollero MD, Rodríguez-Moreno S, Álvarez-Millán JJ, Cabezas-Sanchez P, Cardona-Díaz F, Alcaide-Torres J, Garrido-Sánchez L, Castellano-Castillo D, Tinahones FJ, Fernández-García JC Tags: Asian J Androl Source Type: research

Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility.
In conclusion, our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries, and SRR was higher in patients with AZFc deletion. PMID: 31603142 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 11, 2019 Category: Urology & Nephrology Authors: Iijima M, Shigehara K, Igarashi H, Kyono K, Suzuki Y, Tsuji Y, Kobori Y, Kobayashi H, Mizokami A Tags: Asian J Androl Source Type: research

The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer: a systematic review and meta-analysis.
Abstract The first-line treatment options for high-risk prostate cancer (PCa) are definitive external beam radiotherapy (EBRT) with or without androgen deprivation therapy (ADT) and radical prostatectomy (RP) with or without adjuvant therapies. However, few randomized trials have compared the survival outcomes of these two treatments. To systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT- or RP-based therapy, a comprehensive and up-to-date meta-analysis was performed. A systematic online search was conducted for randomized or observational studies that investigated biochemica...
Source: Asian Journal of Andrology - October 8, 2019 Category: Urology & Nephrology Authors: Cheng X, Wang ZH, Peng M, Huang ZC, Yi L, Li YJ, Yi L, Luo WZ, Chen JW, Wang YH Tags: Asian J Androl Source Type: research

Prosthetic urology: past, present, and future.
PMID: 31571641 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 1, 2019 Category: Urology & Nephrology Authors: Tsambarlis PN, G Hellstrom WJ Tags: Asian J Androl Source Type: research

Future considerations in prosthetic urology.
Abstract Since their popularization, genitourinary prosthetics have remained a gold-standard therapy for the treatment of erectile dysfunction and stress urinary incontinence and in cases of testicular loss or dysfunction. They have also represented an area of significant innovation, which has contributed to excellent long-term outcomes. Given this history, the objective of the current review was to provide a 5-10-year outlook on anticipated trends and developments in the field of genitourinary prosthetics. To accomplish this objective, a PubMed and patent search was performed of topics relating to penile and test...
Source: Asian Journal of Andrology - October 1, 2019 Category: Urology & Nephrology Authors: Trost L Tags: Asian J Androl Source Type: research

Establishing the lower limits of total serum testosterone among Chinese proven fertile men who received treatment of assisted reproductive technology.
Abstract Testosterone (T) plays a crucial role in spermatogenesis because extremely low levels of intratesticular T lead to correspondingly low serum levels of total T (tT), severe disorders of spermatogenesis, and male sterility. However, there is little consensus on the lower limits of serum tT in proven fertile men undergoing assisted reproductive technology treatments in Chinese or other Asian populations. We aimed to establish the reference range of serum tT based on a population of 868 fertile Chinese men undergoing in vitro fertilization or intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) ...
Source: Asian Journal of Andrology - September 27, 2019 Category: Urology & Nephrology Authors: Xu HY, Jiang H, Feng GS, Feng Y, Han Y, Tang WH, Zhang HX, Chen FH, Zhang HX, Liu DF, Li R, Qiao J Tags: Asian J Androl Source Type: research

Use of testicular sperm in couples with SCSA-defined high sperm DNA fragmentation and failed intracytoplasmic sperm injection using ejaculated sperm.
Abstract Sperm DNA fragmentation (SDF) has been linked with male infertility, and previous studies suggest that SDF can have negative influence on pregnancy outcomes with assisted reproduction. We performed a retrospective review of consecutive couples with a high SDF level that had intracytoplasmic sperm injection (ICSI) using testicular sperm (T-ICSI). We compared the T-ICSI outcomes to that of two control groups: 87 couples with failed first ICSI cycle and who had a second ICSI cycle using ejaculated sperm (Ej-ICSI), and 48 consecutive couples with high sperm chromatin structure assay (SCSA)-defined SDF (>15...
Source: Asian Journal of Andrology - September 27, 2019 Category: Urology & Nephrology Authors: Alharbi M, Hamouche F, Phillips S, Kadoch JI, Zini A Tags: Asian J Androl Source Type: research

A fertile male with a single sY86 deletion on the Y chromosome.
PMID: 31535627 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - September 17, 2019 Category: Urology & Nephrology Authors: Jia Y, Niu ZG, Li WY, Qin Q, Sun TT, Zhang F, Liu SR Tags: Asian J Androl Source Type: research

Testicular volume and clinical correlates of hypothalamic-pituitary-testicular function: A cross-sectional study in obese men.
Abstract The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic-pituitary-testicular (HPT) axis function. This was a cross-sectional substudy of a larger randomized controlled trial including obese men, body mass index (BMI) ≥30 kg m-2, with a total testosterone level
Source: Asian Journal of Andrology - September 17, 2019 Category: Urology & Nephrology Authors: Tang Fui MN, Hoermann R, Wittert G, Grossmann M Tags: Asian J Androl Source Type: research

Single-center experience with radium-223 in patients with castration-resistant prostate cancer and bone metastases.
PMID: 31535625 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - September 13, 2019 Category: Urology & Nephrology Authors: Kapoor A, Wong NC, Wang Y, Mukherjee S, Hotte S, Dayes I, Lukka H Tags: Asian J Androl Source Type: research

Low-intensity pulsed ultrasound for regenerating peripheral nerves: potential for penile nerve.
Abstract Peripheral nerve damage, such as that found after surgery or trauma, is a substantial clinical challenge. Much research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after injury. In recent years, low-intensity pulsed ultrasound (LIPUS) has been studied as a potential method of stimulating peripheral nerve regeneration. In this review, the physiology of peripheral nerve regeneration is reviewed, and the experiments employing LIPUS to improve peripheral nerve regeneration are discussed. Application of LIPUS following nerve surgery may promote nerve rege...
Source: Asian Journal of Andrology - September 13, 2019 Category: Urology & Nephrology Authors: Peng DY, Reed-Maldonado AB, Lin GT, Xia SJ, Lue TF Tags: Asian J Androl Source Type: research

Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis.
Abstract The apoptosis that occurs in the immature testis under physiological conditions is necessary for male germ cell development, whereas improper activation of apoptosis can impair spermatogenesis and cause defects in reproduction. We previously demonstrated that in mice, the makorin-2 (Mkrn 2) gene is expressed exclusively in the testis and its deletion leads to male infertility. To understand the potential molecular mechanism, in this study, we found that levels of apoptosis in the testis were abnormally high in the absence of Mkrn 2. To identify specific gene(s) involved, we performed digital gene expressi...
Source: Asian Journal of Andrology - September 6, 2019 Category: Urology & Nephrology Authors: Qian YC, Xie YX, Wang CS, Shi ZM, Jiang CF, Tang YY, Qian X, Wang L, Jiang BH Tags: Asian J Androl Source Type: research

Updates in penile prosthesis infections.
This article reviews the current state of knowledge surrounding penile prosthesis infections, with attention to the evidence for methods to prevent infection and best practices for device reimplantation. PMID: 31489848 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - September 6, 2019 Category: Urology & Nephrology Authors: Swanton AR, Munarriz RM, Gross MS Tags: Asian J Androl Source Type: research

Risk profiling in patients undergoing penile prosthesis implantation.
Abstract Penile prosthesis implantation is the gold standard of surgical therapy for patients with medication-refractory erectile dysfunction. However, this umbrella definition includes significant heterogeneity and associated risk profiles that should be candidly discussed and addressed perioperatively. Factors associated with operative success and patient satisfaction are often surgery specific; however, risk profiling via patient selection, preoperative optimization, proper device selection, and intraoperative consideration are highly correlated. Some examples of common risk profiles include comorbidity(ies) su...
Source: Asian Journal of Andrology - September 6, 2019 Category: Urology & Nephrology Authors: Huynh LM, Osman MM, Yafi FA Tags: Asian J Androl Source Type: research

Initial experience with a novel method for cognitive transperineal magnetic resonance imaging-targeted prostate biopsy.
Abstract A cognitive magnetic resonance imaging (MRI)-targeted prostate biopsy conducted by an experienced clinician enhances the detection rate of (high-grade) prostate cancer; however, this method is less successful in the hands of inexperienced surgeons. Therefore, an alternative method of conducting a cognitive MRI-targeted biopsy that can be successfully performed by the inexperienced clinicians should be developed. Ninety-six males suspected of prostate cancer were analyzed using systematic biopsy and cognitive MRI-targeted biopsy based on our novel three-dimensional matrix positioning method. Typically, the...
Source: Asian Journal of Andrology - August 27, 2019 Category: Urology & Nephrology Authors: Wang HF, Chen R, He BM, Qu M, Wang Y, Lin HZ, Yang QS, Gao X, Sun YH Tags: Asian J Androl Source Type: research

Pain management strategies in penile implantation.
Abstract The opioid epidemic continues to be a serious public health concern. Many have pointed to prescription drug misuse as a nidus for patients to become addicted to opioids and as such, urologists and other surgical subspecialists must critically define optimal pain management for the various procedures performed within their respective disciplines. Controlling pain following penile prosthesis implantation remains a unique challenge for urologists, given the increased pain patients commonly experience in the postoperative setting. Although most of the existing urological literature focuses on interventions pe...
Source: Asian Journal of Andrology - August 27, 2019 Category: Urology & Nephrology Authors: Ellis JL, Higgins AM, Simhan J Tags: Asian J Androl Source Type: research

Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis.
Abstract Mice deficient in the transcription factor pleomorphic adenoma gene 1 (PLAG1) exhibit reproductive issues that are characterized, in part, by decreased progressive sperm motility in the male. However, the underlying cause of this impairment is unknown. As epididymal transit is critical for sperm maturation and motility, the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mRNA were identified. Using X-gal staining and in situ hybridization, PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions o...
Source: Asian Journal of Andrology - August 23, 2019 Category: Urology & Nephrology Authors: Wong J, Juma AR, Tran SC, Gasperoni JG, Grommen SVH, De Groef B Tags: Asian J Androl Source Type: research