Stem cell therapy: a potential for the perils of pancreatitis.
Abstract Acute and chronic pancreatitis carry a significant disease burden and there is no definite treatment that exists for either. They are associated with local and systemic inflammation and lead to numerous complications. Stem cell therapy has been explored for other disease processes and is a topic of research that has gained momentum with regards to implications for acute and chronic pancreatitis. They not only carry the potential to aid in regeneration but also prevent pancreatic injury as well as injury of other organs and hence the resultant complications. Stem cells appear to have immunomodulatory prope...
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Chela H, Romana BS, Madabattula M, Albarrak AA, Yousef MH, Samiullah S, Tahan V Tags: Turk J Gastroenterol Source Type: research

Acute gastric injury after ingestion of substrate with hyperosmolar glucose and benzoate inversely related with small intestinal bacterial overgrowth.
CONCLUSION: Highly concentrated glucose might provoke acute gastric injury, which could predict the absence of SIBO. PMID: 32721913 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Kim YJ, Paik CN, Lee JM, Kim DB, Yang JM Tags: Turk J Gastroenterol Source Type: research

Effect of visceral fat tissue on superior mesenteric artery configuration: Is it superior to BMI?
FE Abstract BACKGROUND/AIMS: To determine the effect of visceral fat volume measured via computed tomography (CT) images of umbilical slices on superior mesenteric artery (SMA) configuration, as compared with body mass index (BMI). In addition, this study aims to determine the effect of lumbar lordosis angle (LLA) on SMA configuration. MATERIALS AND METHODS: The study included 310 patients who underwent abdominal CT. On CT images, the aortomesenteric angle (AMA), the distance between SMA and aorta at three levels, and LLA were measured. Visceral fat volume was measured using three consecutive images obtained...
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Bahadir Ülger FE Tags: Turk J Gastroenterol Source Type: research

Gastric and small intestinal traditional serrated adenomas: a detailed morphologic and immunohistochemical analysis.
CONCLUSION: Our results showed that the presence of eosinophilic cells with pencillate nuclei commonly accompanied by ECF and slit-like serration are the defining features of gastric and small intestinal TSAs. They frequently harbor neoplastic foci, particularly in gastric location where serrated dysplasia seems to be more common. PMID: 32721915 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Kiremitçi S, Cansız Ersöz C, Savaş B, Ensari A Tags: Turk J Gastroenterol Source Type: research

Antiplatelet agents'-ticagrelol and eptifibatide-safety in experimental colitis in mice.
CONCLUSION: The antiplatelet agents ticagrelor and eptifibatide were safe in DSS colitis mice, suggesting their potential in humans suffering from ulcerative colitis, and supporting future safety studies. PMID: 32721916 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Petrovic SS, Vasiljevska MM, Obradovic SD, Tarabar DK, Doder RB, Majstorovic IJ, Petrovic MD, Magic ZM, Cikota BM, Perisic NJ, Brcerevic IA, Manojlovic NS, Rancic NK Tags: Turk J Gastroenterol Source Type: research

Bone marrow mesenchymal stem cells differentiate into intestinal epithelioid cells through the ERK1/2 pathway.
CONCLUSION: rBMSCs differentiate into intestinal epithelium after co-culture with mIEC-6 by regulation of the ERK1/2 signaling pathway. Further research is needed to elucidate the network of mechanisms. PMID: 32721917 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Jiang T, Shi ML, Xia G, Yang YN, Xu JM, Lei YJ, Tang YM, Yang JH Tags: Turk J Gastroenterol Source Type: research

Symptomatic response to GERDOFF ® in patients with gastro-esophageal reflux disease and poor response to alginates: an exploratory, post-market, open-label study.
Symptomatic response to GERDOFF® in patients with gastro-esophageal reflux disease and poor response to alginates: an exploratory, post-market, open-label study. Turk J Gastroenterol. 2020 Jun;31(6):466-473 Authors: Boarino V, Raguzzi I, Marocchi M, Merighi A Abstract BACKGROUND/AIMS: A novel medical device based on hyaluronic acid, chondroitin sulphate plus aluminum hydroxide (GERDOFF®, melt-in-mouth tablets) showed efficacy in reducing GER-related symptoms. This exploratory, open-label study evaluated symptomatic effects of a 14-day treatment with GERDOFF® in GERD patients. MATERIAL...
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Boarino V, Raguzzi I, Marocchi M, Merighi A Tags: Turk J Gastroenterol Source Type: research

Desmopressin acetate decreases blood loss in patients with massive hemorrhage undergoing gastrointestinal surgery.
This study was to investigate whether DDAVP can decrease blood loss in patients with massive hemorrhage undergoing gastrointestinal surgery. MATERIALS AND METHODS: A multiple-centers, double-blind clinical trial was conducted, patients who underwent gastrointestinal surgery were recruited from 3 hospitals, randomly assigned to two different groups. Patients in the treatment group received desmopressin 0.3 ug/kg,30 min once a day after surgery, patients in the control group received 50 ml saline for 30 min. The primary outcome was the changes of hemoglobin at 24 hours after the surgery. And the secondary outcomes inclu...
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Wang LC, Hu YF, Chen L, Xing R, Lin XF, Kou QY Tags: Turk J Gastroenterol Source Type: research

The Turkish version of the childhood bladder and bowel dysfunction questionnaire (CBBDQ): Cross-cultural adaptation, reliability and construct validity.
This study was designed for the translation the CBBDQ into Turkish and the cultural adaptation of CBBDQ for the use among 5-12-year-old children. Moreover, another aim of this study was that the determination of the reliability and construct validity of the Turkish version. The main hypothesis of our study was that the translation and cultural adaptation of the CBBDQ into Turkish language, so that Turkish parents could understand it. Additionally, we estimated that the Turkish version would have eventual internal consistency and test-retest reliability and admissible construct validity. MATERIALS AND METHODS: The CBBD...
Source: The Turkish Journal of Gastroenterology - June 1, 2020 Category: Gastroenterology Authors: Aydın G, van Engelenburg-van Lonkhuyzen ML, Baktır S, Kaya Mutlu E, Mutlu C, de Bie RA Tags: Turk J Gastroenterol Source Type: research

The COVID-19 pandemic: Clinical practice advice for gastroenterologists, hepatologists, and liver transplant specialists.
akoğlu S, Karasu Z, İdilman R Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a novel acute infectious disease that has rapidly reached staggering pandemic proportions. This review addresses gastroenterologists, hepatologists, liver transplant (LT) specialists, and health-care professionals working in the field of liver diseases and liver transplantation. It has been written based on a limited number of publications, recommendations of national and international liver and organ transplantation societies, and experiences of patients with COV...
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Kabaçam G, Dayangaç M, Üçbilek E, Erçin CN, Günsar F, Akyıldız M, Akarsu M, Demir M, Kaymakoğlu S, Karasu Z, İdilman R Tags: Turk J Gastroenterol Source Type: research

The role of FAS gene variants in inflammatory bowel disease.
Abstract BACKGROUND/AIMS: The analysis of genes thought to be important in inflammatory bowel disease (IBD) has shown that more than half of IBD-related genes are also associated with other autoimmune diseases. The aim of this study was to detect a possible association between the polymorphisms of the (-670 A/G, -1377 G/A) fFas cell surface death receptor (FAS) gene promoter and susceptibility to IBD in the Turkish population. MATERIALS AND METHODS: In total, 125 patients with IBD, including 73 ulcerative colitis and 52 Crohn's disease and also 101 healthy controls without any pathological signs of IBD were c...
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Demir A, Kahraman R, Candan G, Ergen A Tags: Turk J Gastroenterol Source Type: research

Clinical usefulness of esophagogastric junction distensibility measurement in patients with achalasia before and after peroral endoscopic myotomy.
This study aimed to determine the clinical efficacy of measuring the esophagogastric junction (EGJ) distensibility index (DI) in patients with achalasia before and after peroral endoscopic myotomy (POEM). MATERIALS AND METHODS: Retrospective data were collected from 195 patients who underwent POEM from November 2014 to November 2017 at our clinic. The Eckardt score, high-resolution manometry, and EGJ distensibility were measured before and six months after POEM. Treatment failure was defined as a postprocedure Eckardt score>3 or patients who underwent repeat POEM. RESULTS: The DI (mm2/mmHg) before and after PO...
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Chang J, Yoo IK, Günay S, Paköz ZB, Cho JY Tags: Turk J Gastroenterol Source Type: research

Prognostic significance of early complete response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy: Multicentric study of Turkish Society for Radiation Oncology Group (TROD).
, Göçen F, Yalman D Abstract BACKGROUND/AIMS: To assess the effect of various parameters on the oncologic outcomes, including the time interval between therapy and surgery (S) in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy (CRT). MATERIALS AND METHODS: The data of 914 LARC patients who received preoperative CRT between 1994 and 2015 were collected retrospectively. Patients received 45-50.4 Gy RT with 5FU based chemotherapy (CT). They all underwent radical resection followed by maintenance CT. Clinical and pathologic variables were compared between the pC...
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Kılıç D, Sert F, Görken İB, Arıcan Alıcıkuş Z, Aktürk N, Kaytan Sağlam E, Kizir A, Özkök S, Yılmaz HT, Göçen F, Yalman D Tags: Turk J Gastroenterol Source Type: research

Polidocanol versus phenol in oil injection sclerotherapy in treatment of internal hemorrhoids: A randomized controlled trial.
CONCLUSION: 3% polidocanol is safe and more effective than 5% phenol in oil when used as injection sclerotherapy in the treatment of first and second-degree internal hemorrhoids. PMID: 32519957 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Mishra S, Sahoo AK, Elamurugan TP, Jagdish S Tags: Turk J Gastroenterol Source Type: research

The impact of direct-acting antiviral treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients: temporary? permanent?
Altıntaş E Abstract BACKGROUND/AIMS: In previous studies that investigated the impact of direct-acting antiviral (DAA) treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients have been compared to baseline values with either end of treatment or post-treatment values. The results are inconsistent. We evaluated patients throughout the treatment and after treatment. MATERIALS AND METHODS: 121 patients were included in the study. 93 patients were treated with sofosbuvir/ledipasvir±Ribavirin (RBV), and 28 patients were treated with ombitasvir/paritaprevir/ritonavir+dasabuvir&...
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Özdoğan O, Yaraş S, Ateş F, Üçbilek E, Sezgin O, Altıntaş E Tags: Turk J Gastroenterol Source Type: research

Can family physicians have a role in eradication of hepatitis c infection?
CONCLUSION: Family physicians have gaps in their knowledge of the screening, natural history and treatment of HCV infection. The results of this study show that HCV training plans for family physicians should cover all aspects of the infection, and emphasize the necessity for the establishment of guideline-based screening recommendations. PMID: 32519959 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Şahin AR, Erdoğan A, Gisi K, İspiroğlu M, Ateş S, Okyay RA, Nazik S, Kantarçeken B Tags: Turk J Gastroenterol Source Type: research

Human dental follicle mesenchymal stem cells alleviate T cell response in inflamed tissue of Crohn's patients.
il; T Abstract BACKGROUND/AIMS: Crohn's Disease (CD) is a chronic inflammatory condition characterized by various abnormalities that lead to overly aggressive T-cell responses. Our in vitro experiments aimed to investigate the potential use of Dental Follicle Mesenchymal Stem Cells (DF-MSCs) to suppress the exaggerated immune response in inflamed and non-inflamed tissue of Crohn's Disease (CD). MATERIAL AND METHODS: Dental follicle tissues were obtained from extracted third molar teeth of 3 healthy volunteers who have no abscess or inflammatory diseases. Eleven patients included the experiment who had been di...
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Zibandeh N, Genc D, Duran Y, Banzragch M, Sokwala S, Goker K, Atug O, Akkoç T Tags: Turk J Gastroenterol Source Type: research

A tiny lesion arising within Barrett's esophagus.
PMID: 32519961 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Pugliese F, Bonato G, Dioscoridi L, Cintolo M, Aquilano MC, Forti E, Giannetti A, Italia A, Mutignani M Tags: Turk J Gastroenterol Source Type: research

The first report of colonic involvement of angioimmunoblastic T-cell lymphoma.
lbül H PMID: 32519962 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Authors: Turan İ, Özsan N, Doğanavşargil B, Davulcu EA, Bülbül H Tags: Turk J Gastroenterol Source Type: research

Predictors of endoscopic recurrence in resected patients with Crohn's disease in a long-term follow-up cohort: History of multiple previous resections and residual synchronous disease in the remnant intestine.
CONCLUSION: In a retrospective long-term follow-up cohort of resected patients with CD, having multiple resections for CD and the presence of any residual synchronous disease after ileocolonic resection were identified as risk factors for endoscopic recurrence; the latter was never reported in previous studies. PMID: 32412898 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Erzin Y, Şişman G, Hatemi İ, Baca B, Hamzaoglu İ, Dirican A, Korman U, Çelik AF Tags: Turk J Gastroenterol Source Type: research

Recovery from hemorrhoids and anal fissure without surgery.
In this study, we hypothesize that increasing patients' awareness of hidden risk factors could reduce the rate of HD and AF. MATERIALS AND METHODS: A questionnaire-based controlled study was planned. After power analysis, patients with HD (n=60) and AF (n=60) were enrolled consecutively into the study group and compared with the control group (n=60) of healthy individuals. The survey was designed to assess the participants' toilet and dietary habits and anxiety risk. Odds ratios were calculated and a binary logistic regression model was constructed to identify associated factors. RESULTS: Hard stools, spending mo...
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Şişik A, Başak F, Hasbahçeci M, Acar A, Kılıç A, Özel Y, Baş G Tags: Turk J Gastroenterol Source Type: research

Probiotics and dietary intervention modulate the colonic mucosa-associated microbiota in high-fat diet populations.
CONCLUSION: The results of this study suggested that the addition of probiotics and dietary intervention could improve the composition of the colonic mucosal microbiota in high-fat diet populations. PMID: 32412900 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Qian L, Huang J, Qin H Tags: Turk J Gastroenterol Source Type: research

Real-world efficacy, safety, and clinical outcomes of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin combination therapy in patients with hepatitis C virus genotype 1 or 4 infection: The Turkey experience experience.
CONCLUSION: The present real-life data of Turkey for the OBV/PTV/r ± DSV ± RBV treatment of patients with HCV genotype 1b, 1a, or 4 infection from 862 patients demonstrated high efficacy and a safety profile. PMID: 32412901 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Aygen B, Demirtürk N, Yıldız O, Çelen MK, Çelik İ, Barut Ş, Ural O, Batırel A, Mıstık R, Şimşek F, Asan A, Ersöz G, Türker N, Bilgin H, Kınıklı S, Karakeçili F, Zararsız G, Turkish Society Of Clinical Microbiology And Infectious Disease Tags: Turk J Gastroenterol Source Type: research

Endoscopic retrograde cholangiography via a permanent access loop.
CONCLUSION: PAL-mediated ERC procedure is a technique with high technical and clinical success and low complication rate in patients who require frequent percutaneous procedures and those with difficult access to the biliary tract. PMID: 32412902 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Kaplan M, Dişibeyaz S, Ödemiş B, Parlak E, Öztaş E, Gökbulut V Tags: Turk J Gastroenterol Source Type: research

Validity and reliability analysis of the Turkish version of pediatric nutritional risk score scale.
Günay İ Abstract BACKGROUND/AIMS: We aimed to perform the validity and reliability analysis of the Turkish version of the Pediatric Nutritional Risk Score (PNRS). MATERIALS AND METHODS: The study group consisted of 149 patients aged between 1 month and 18 years who were admitted to the hospital for at least 48 h. The patients' age, gender, anthropometric measurements, length of stay, admission diagnosis, daily body weights, food consumption, and pain status were recorded. Backward and forward translations into Turkish were done. PNRS was performed by two different physicians. The consistency of the PNRS...
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Taşcı O, Bekem Soylu Ö, Kıran Taşcı E, Eser E, Oruçoğlu B, Günay İ Tags: Turk J Gastroenterol Source Type: research

Esmolol inhibits inflammation and apoptosis in the intestinal tissue via the overexpression of NF- κB-p65 in the early stage sepsis rats.
CONCLUSION: Esmolol can suppress inflammation and apoptosis in the intestinal tissue via the overexpression of NF-kappa B-p65 in the early stage sepsis rats. kappa BEarly-stage use of esmolol might be an ideal treatment method for sepsis. PMID: 32412904 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Guo CA, Ma L, Su XL, Wang YZ, Zhen LL, Zhang B, An H, Liu HB Tags: Turk J Gastroenterol Source Type: research

Puborectalis muscle and External Anal Sphincter: a functional unit?
PMID: 32412905 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Andromanakos N, Filippou D, Karandreas N, Kostakis A Tags: Turk J Gastroenterol Source Type: research

Hepatitis B virus reactivation during direct-acting antiviral agent-based therapy for chronic Hepatitis C.
S, Karabay O PMID: 32412906 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Güçlü E, Alan S, Karabay O Tags: Turk J Gastroenterol Source Type: research

Is there any evidence implying the use of a different criterion for protective anti-HBs titer after HBV vaccination in immunosuppressed patients?
r R PMID: 32412907 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - April 1, 2020 Category: Gastroenterology Authors: Hasanoğu İ, Güner R Tags: Turk J Gastroenterol Source Type: research

Does periampullary diverticulum affect ERCP cannulation and post-procedure complications? an up-to-date meta-analysis.
Abstract Research conclusions differ on the impact of periampullary diverticulum (PAD) on endoscopic retrograde cholangiopancreatography (ERCP). An up-to-date meta-analysis evaluated the role of PAD in ERCP, especially in terms of cannulation failure and early complications. A comprehensive literature search was performed. All statistical analyses were carried out with the Review Manager 5.3 software. Horizontal lines represented a 95% confidence interval (CI) and the area of each square in forest plots. Twenty-six studies including 23 826 patients with or without PAD who underwent ERCP were evaluated. PAD was ass...
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Yue P, Mu P, Li F, Lin Y, Liu Y, Meng W, Zhou W, Li X Tags: Turk J Gastroenterol Source Type: research

Epstein-Barr virus infection in patients with chronic gastritis without Helicobacter pylori infection.
CONCLUSION: EBV was detected in 12% of the cases with gastritis without H. pylori infection. Endoscopic follow-up may be appropriate for patients with gastritis, who have atrophy without intestinal metaplasia and are H. pylori negative but EBV positive. PMID: 32343232 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Dursun N, Hacıhasanoğlu E, Okçu O, Paşaoğlu E, Leblebici C Tags: Turk J Gastroenterol Source Type: research

Implication of alterations in Parkin gene among North Indian patients with colorectal cancer.
Abstract BACKGROUND/AIMS: Alterations in Parkin (PRKN) have been described in many cancers; however, the molecular mechanism that contributes to loss of Parkin expression in colorectal cancer (CRC) remains unclear. The aim of this study was to investigate the involvement of PRKN mutation and loss of heterozygosity (LOH) in loss of Parkin expression. To understand the role of PRKN in cancer progression, we also evaluated the association of Parkin expression with clinicopathological parameters in North Indian population. MATERIALS AND METHODS: We studied 219 CRC samples and their adjacent normal tissues (contro...
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Tiwari RR, Wahabi K, Perwez A, Bhat ZI, Hasan SS, Saluja SS, Rizvi MA Tags: Turk J Gastroenterol Source Type: research

Sociodemographic characteristics and clinical risk factors of Helicobacter pylori infection and antibiotic resistance in the Eastern Black Sea region of Turkey.
CONCLUSION: An understanding of the risk factors for H. pylori positivity and antibiotic resistance in an extended anamnesis may affect treatment choice and facilitate H. pylori eradication. In regions where antibiotic resistance rates are elevated, performing antibiotic susceptibility tests may lead to effective eradication treatment. PMID: 32343234 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Erkut M, Uzun DY, Kaklıkkaya N, Fidan S, Yoğun Y, Coşar AM, Akyıldız E, Topbaş M, Özgür O, Arslan M Tags: Turk J Gastroenterol Source Type: research

High-dose dual therapy is effective as first-line treatment for Helicobacter pylori infection.
CONCLUSION: High-dose dual therapy with rabeprazole and amoxicillin was highly effective and well tolerated as a first-line therapy for H. pylori eradication. PMID: 32343235 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Öztürk K, Kurt Ö, Çelebi G, Şarlak H, Karakaya MF, Demirci H, Kılınç A, Uygun A Tags: Turk J Gastroenterol Source Type: research

Real-life experience of ledipasvir and sofosbuvir single-tablet regimen among chronic hepatitis C patients in Turkey.
CONCLUSION: In conclusion, LDV/SOF±ribavirin yielded very high SVR12 rates, without any safety or tolerability concern in Turkey. The effectiveness of the LDV/SOF treatment was not affected by the patient demographics or medical characteristics such as fibrosis level, cirrhosis status, previous treatment status, HCV-RNA level or HCV genotype. PMID: 32343236 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Yamazhan T, Turan İ, Ersöz G, Günşar F, Pullukçu H, Danış N, Ünal NG, Vardar R, Oruç N, Tekin F, Taşbakan M, Sipahi OR, Akarca US Tags: Turk J Gastroenterol Source Type: research

Viral hepatitis B and C infections increase the risks of intrahepatic and extrahepatic cholangiocarcinoma: Evidence from a systematic review and meta-analysis.
CONCLUSION: The HBV and HCV infections significantly increased the risk of CCA, as well as ICC and ECC. The involvement of AFP, CA19-9, and lymph nodes may play an important role in the diagnosis of CCA. PMID: 32343237 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Tan JH, Zhou WY, Zhou L, Cao RC, Zhang GW Tags: Turk J Gastroenterol Source Type: research

Histopathological features of incidental appendectomy specimens obtained from living liver donors.
CONCLUSION: This study showed that a careful inspection of the abdominal cavity was useful, and appendectomy should be performed when required. In addition, even if the macroscopic appearance of the appendectomy specimens is normal, histopathological evaluations facilitate an early diagnosis of numerous unusual appendiceal diseases. PMID: 32343238 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Akbulut S, Koç C, Sarıcı B, Özcan M, Şamdancı E, Yılmaz S Tags: Turk J Gastroenterol Source Type: research

Effects and mechanism of Lanthanum Citrate on the proliferation and apoptosis of hepatocellular carcinoma cell line SMMC-7721.
CONCLUSION: Lanthanum citrate inhibits proliferation and promotes apoptosis in HCC SMMC-7721 cells by suppressing the Hh signaling pathway. PMID: 32343239 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Chen B, Hu Z, Chen B, Li B Tags: Turk J Gastroenterol Source Type: research

An unusual colonoscopic complication of inflammatory bowel disease.
Çiçek B, Baba F PMID: 32343240 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Türkel Küçükmetin N, Çiçek B, Baba F Tags: Turk J Gastroenterol Source Type: research

Isolated lipstick-like ulceration of the ileocecal valve: A hallmark of cytomegalovirus colitis.
PMID: 32343241 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Daniel F, Ghaoui N, Karaoui WR, Sabatto BZ, Khalifeh I, El-Cheikh J Tags: Turk J Gastroenterol Source Type: research

Endoscopic resection of giant esophageal fibrovascular polyp.
PMID: 32343242 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Khamaysi I, Asbeh YA Tags: Turk J Gastroenterol Source Type: research

Adenocarcinoma coexisting with signet ring cell carcinoma in nonampullary duodenum.
PMID: 32343243 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - March 1, 2020 Category: Gastroenterology Authors: Lee TH, Wang JH, Lee YH, Ko SY, Ma CH, Kim BH Tags: Turk J Gastroenterol Source Type: research

Covering the Cover.
l; İ PMID: 32141814 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Ergenç İ Tags: Turk J Gastroenterol Source Type: research

Bezoar in upper gastrointestinal endoscopy: A single center experience.
CONCLUSION: The findings of this study indicated that bezoars are more common among subjects with history of gastrointestinal surgery, diabetes mellitus, or psychiatric disorders; bezoars are closely related to peptic ulcer and reflux esophagitis; and they can be successfully treated with endoscopy. PMID: 32141815 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Gökbulut V, Kaplan M, Kaçar S, Akdoğan Kayhan M, Coşkun O, Kayaçetin E Tags: Turk J Gastroenterol Source Type: research

Prognostic value of the 2017 World Health Organization Classification System for gastric neuroendocrine tumors: A single-center experience.
In this study, the prognostic value of the World Health Organization (WHO) 2017 grading system and the effect of surgery on survival in low grade neuroendocrine tumors were investigated. MATERIALS AND METHODS: G-NETs who were diagnosed between January 2000 and May 2017 were included in the study. Patients' demographic characteristics, treatment details, and survival data were obtained from medical charts. Pathological samples were re-classified according to the WHO 2017 grading system. RESULTS: Of the total 94 evaluated patients, 50 (53.2%) were classified with G1 NETs, 37(39.4%) with G2 NETs, 4(4.2%) with well-d...
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Karakaş Y, Laçin Ş, Kurtulan O, Esin E, Sunar V, Sökmensüer C, Kılıçkap S, Yalçin Ş Tags: Turk J Gastroenterol Source Type: research

Vitamin D decreases CD40L gene expression in ulcerative colitis patients: A randomized, double-blinded, placebo-controlled trial.
Abstract BACKGROUND/AIMS: The interaction of CD40 ligand (CD40L) and CD40 triggers the induction of pro-inflammatory cytokines. It has been proposed that vitamin D deficiency might be an important factor, which causes or aggregates the autoimmune situations. The aim of the present study was to assess the effect of vitamin D on CD40L gene expression in patients with ulcerative colitis (UC). MATERIALS AND METHODS: Ninety mild-to-moderate UC patients were randomized to receive a single injection of 7.5 mg cholecalciferol or 1 mL normal saline. At baseline and 90 days following the intervention, RNA samples from ...
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Sharifi A, Vahedi H, Honarvar MR, Amiriani T, Nikniaz Z, Rad EY, Hosseinzadeh-Attar MJ Tags: Turk J Gastroenterol Source Type: research

The Role of 18F-FDG PET/CT in staging of gallbladder carcinomas.
CONCLUSION: In our study, distant metastases and age were observed to be crucial prognostic factors in patients with gallbladder carcinoma (GBC). In addition, we believe that 18F-FDG PET/CT imaging will help to stage the GBC, detect nodal and distant metastasis, and evaluate the metabolic state of gallbladder lesions. PMID: 32141818 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Arslan E, Aksoy T, Dursun N, Gürsu RU, Sevinç MM, Çermik TF Tags: Turk J Gastroenterol Source Type: research

Serum resolvin D1 levels as a marker of inflammation in constipation dominant irritable bowel syndrome.
The objective of this study is to determine the role of circulating resolvin D1 (RvD1) in patients with constipation subtype of irritable bowel syndrome (IBS-C) and evaluate the relationship between abdominal pain severity and RvD1 levels. MATERIALS AND METHODS: This research included 55 patients with IBS-C and 36 healthy controls. Controls were selected from patients who applied to our department with similar complaints as IBS but were not diagnosed with any type of pathology after further investigations. All participants underwent complete blood count, C-reactive protein (CRP), and RvD1 levels measurements. We also ...
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Karatay E, Utku ÖG Tags: Turk J Gastroenterol Source Type: research

Functional constipation as a neglected condition in laryngectomized patients.
This study aims to determine whether surgical or concurrent chemoradiotherapy treatments matter in the development of functional constipation in patients with advanced-stage laryngeal cancer. MATERIALS AND METHODS: Patients without presurgical constipation (according to Rome IV) who were treated with either surgery (n=30) or chemoradiation (n=25) were evaluated for constipation development. Interim evaluation and recommendations were made on the 3rd month. On the 3rd and 6th months, the frequency of constipation between groups was compared using the Rome IV criteria and European Organization for Research and Treatment...
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Şirin G, Şirin S Tags: Turk J Gastroenterol Source Type: research

Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data.
CONCLUSION: Our study showed that although genotype 1b dominance continues, the distribution and prevalence of HCV genotypes are changing in our region mainly due to migration and increase in the frequency of patients with non-traditional risk factors such as intravenous drug use. Monitoring the epidemiology of HCV genotypes may provide guidance in treatment decisions. PMID: 32141821 [PubMed - as supplied by publisher] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 1, 2020 Category: Gastroenterology Authors: Çetin Duran A, Kaya Çetinkaya Ö, Sayıner AA, Şeydaoğlu G, Özkarataş E, Abacıoğlu H Tags: Turk J Gastroenterol Source Type: research