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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours
ConclusionsThese results suggest that targeting the Nrf2/GSH antioxidant system may present a novel therapeutic strategy to combat chemoresistance in rhabdoid tumours.
Source: Journal of Cancer Research and Clinical Oncology - July 28, 2023 Category: Cancer & Oncology Source Type: research
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study
CONCLUSION: The results of this study support the significant hepatoprotective effect of SLB nanoliposomes against acetaminophen-induced toxicity depending on the route of administration.PMID:37506470 | DOI:10.1016/j.bbrc.2023.07.045
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Fatemeh Gheybi Alireza Khooei Azam Hoseinian Maham Doagooyan Kebria Houshangi Mahmoud Reza Jaafari Arash Papi Zahra Khoddamipour Amirhossein Sahebkar Seyedeh Hoda Alavizadeh Source Type: research
Durable cellulose paper by grafting thiol groups and controlling silver deposition for ultrahigh electromagnetic interference shielding
Int J Biol Macromol. 2023 Jul 25:125972. doi: 10.1016/j.ijbiomac.2023.125972. Online ahead of print.ABSTRACTElectromagnetic interference (EMI) shielding paper with durability and high effectiveness is of significant importance to long-term service for preventing EMI pollution. Herein, we report a practical method for preparing cellulose paper/Ag composite with outstanding durable and ultrahigh EMI shielding performance by electroless silver plating. The silver deposition process, the surface morphology, the silver content and conductivity of the composite can be controlled by varying the amount of N-acetyl-L-cysteine (NAC)...
Source: International Journal of Biological Macromolecules - July 27, 2023 Category: Biochemistry Authors: Duoduo He Liying Qian Xingyu Chen Beihai He Junrong Li Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner
In this study, we examined the effect of varying doses and exposure times of hesperetin on MCF-7 and MDA-MB-231 cancer cells, as well as MCF-10A normal cells. By using MTT assay, real-time PCR, western blot, and flow cytometry, we determined the effects of Hst on cell viability, ROS levels, and markers of cell death. Furthermore, molecular docking was used to identify Hst targets that might be involved in ROS-dependent cell death. According to the results, different concentrations of Hst induced different modes of cell death at specific ROS levels. Paraptosis occurred in all cell lines at concentration ranges of IC35 to IC...
Source: Chemico-Biological Interactions - July 24, 2023 Category: Molecular Biology Authors: Mohammad Rasoul Samandari-Bahraseman Babak Khorsand Sara Zareei Massoud Amanlou Hanieh Rostamabadi Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway
This study tested the hypothesis that pyroptosis underlies the relationship between hyperuricemia and atherosclerosis, using ApoE-/- mice (a model of atherosclerosis), human umbilical vein endothelial cells (HUVECs), and human atherosclerotic arterial samples. We found that hyperuricemia can aggravate the aortic atherosclerotic plaque-load in ApoE-/- mice and promote endothelial cell pyroptosis. Additionally, hyperuricemia can increase the levels of serum inflammatory factors (including IL-1β and IL-18). Exposure to lipopolysaccharide plus a high concentration of soluble uric acid (≥12 mg/dL) induced cell pyroptosis in ...
Source: Atherosclerosis - July 21, 2023 Category: Cardiology Authors: Bin He Qiangqiang Nie Feng Wang Xuming Wang Yun Zhou Cheng Wang Jing Guo Xueqiang Fan Zhidong Ye Peng Liu Jianyan Wen Source Type: research
3,5,6-Trichloro-2-pyridinol confirms ototoxicity in mouse cochlear organotypic cultures and induces cytotoxicity in HEI-OC1 cells
Toxicol Appl Pharmacol. 2023 Jul 16:116612. doi: 10.1016/j.taap.2023.116612. Online ahead of print.ABSTRACTThe metabolite of organophosphate pesticide chlorpyrifos (CPF), 3,5,6-Trichloro-2-pyridinol (TCP), is persistent and mobile toxic in soil and water environments, exhibiting cytotoxic, genotoxic and neurotoxic properties. However, little is known about its effects on the peripheral auditory system. Herein, we investigated the effects of TCP exposure on mouse postnatal day 3 (P3) cochlear culture and an auditory cell line HEI-OC1 to elucidate the underlying molecular mechanisms of ototoxicity. The damage of TCP to outer...
Source: Toxicology and Applied Pharmacology - July 18, 2023 Category: Toxicology Authors: Mao Huang Mingshan Zou Shuangshuang Mao Wenqi Xu Yu Hong Haiyan Wang Fei Gui Lei Yang Fuzhi Lian Rong Chen Source Type: research
Copper induced intestinal inflammation response through oxidative stress induced endoplasmic reticulum stress in Takifugu fasciatus
In conclusion, our in vivo and in vitro studies have confirmed that oxidative stress triggers the ERS pathway, which is involved in the intestinal inflammatory response. Our study provides new insights into the relationship among Cu-induced oxidative stress, ERS, and inflammatory responses in fish, as well as for the healthy culture of fish in aqueous environments.PMID:37453186 | DOI:10.1016/j.aquatox.2023.106634
Source: Aquatic Toxicology - July 15, 2023 Category: Toxicology Authors: Sisi Ma Yuxi Liu Cheng Zhao Peng Chu Shaowu Yin Tao Wang Source Type: research
N-acetylcysteine Treatment Attenuates Hemodialysis Access-related Limb Pathophysiology in Mice with Chronic Kidney Disease
The objective of this study was to determine if treatment with N-acetylcysteine (NAC) could reduce access-related limb dysfunction in mice. Male and female C57BL6J mice were fed an adenine supplemented diet to induce chronic kidney disease prior to surgical creation of an arteriovenous fistula (AVF) in the iliac vascular bundle. AVF creation significantly increased peak aortic and infrarenal vena cava blood flow velocities, but NAC treatment had no significant impact indicating that fistula maturation was not impacted by NAC treatment. Hindlimb muscle and paw perfusion recovery and muscle capillary density in the AVF limb ...
Source: American Journal of Physiology. Renal Physiology - July 13, 2023 Category: Physiology Authors: Kyoungrae Kim Tomas A Cort Eric M Kunz Jack Moerschel Victoria R Palzkill Gengfu Dong Chatick N Moparthy Erik M Anderson Brian Fazzone Kerri A O'Malley Scott T Robinson Scott A Berceli Terence E Ryan Salvatore T Scali Source Type: research
