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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKC δ activation in the hippocampus of mice: Involvement of antioxidant potential
Food Chem Toxicol. 2023 Jun 10:113869. doi: 10.1016/j.fct.2023.113869. Online ahead of print.ABSTRACTAlthough the anticonvulsant effects of ginsenosides are recognized, little is known about their effects on the convulsive behaviors induced by the activation of L-type Ca2+ channels. Here, we investigated whether ginsenoside Re (GRe) modulates excitotoxicity induced by the L-type Ca2+ channel activator Bay k-8644. GRe significantly attenuated Bay k-8644-induced convulsive behaviors and hippocampal oxidative stress in mice. GRe-mediated antioxidant potential was more pronounced in the mitochondrial fraction than cytosolic fr...
Source: Food and Chemical Toxicology - June 12, 2023 Category: Food Science Authors: Ngoc Kim Cuong Tran Ji Hoon Jeong Naveen Sharma Yen Nhi Doan Nguyen Hoang-Yen Phi Tran Duy-Khanh Dang Jung Hoon Park Jae Kyung Byun Dezhong Jin Zeng Xiaoyan Sung Kwon Ko Seung-Yeol Nah Hyoung-Chun Kim Eun-Joo Shin Source Type: research
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF- κB pathway in macrophages
In this study, the expression of NAT10 in macrophages was found to decrease during LPS-induced inflammation. NAT10 knockdown significantly reduced the generation of inflammatory factors, while NAT10 overexpression had the opposite effect. RNA sequencing revealed that the differentially expressed genes were enriched in the NF-κB signalling pathway and oxidative stress. Both the NF-κB inhibitor Bay11-7082 and the ROS scavenger N-acetyl-L-cysteine (NAC) could reverse the upregulation of inflammatory factors. NAC inhibited the phosphorylation of NF-κB, but Bay11-7082 had no effect on the production of ROS in NAT10-overexpre...
Source: Biochimica et Biophysica Acta - June 12, 2023 Category: Biochemistry Authors: Zhanqi Zhang Yiwen Zhang Yongjie Cai Di Li Jinlin He Zhihui Feng Qiong Xu Source Type: research
Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKC δ activation in the hippocampus of mice: Involvement of antioxidant potential
Food Chem Toxicol. 2023 Jun 10:113869. doi: 10.1016/j.fct.2023.113869. Online ahead of print.ABSTRACTAlthough the anticonvulsant effects of ginsenosides are recognized, little is known about their effects on the convulsive behaviors induced by the activation of L-type Ca2+ channels. Here, we investigated whether ginsenoside Re (GRe) modulates excitotoxicity induced by the L-type Ca2+ channel activator Bay k-8644. GRe significantly attenuated Bay k-8644-induced convulsive behaviors and hippocampal oxidative stress in mice. GRe-mediated antioxidant potential was more pronounced in the mitochondrial fraction than cytosolic fr...
Source: Food and Chemical Toxicology - June 12, 2023 Category: Food Science Authors: Ngoc Kim Cuong Tran Ji Hoon Jeong Naveen Sharma Yen Nhi Doan Nguyen Hoang-Yen Phi Tran Duy-Khanh Dang Jung Hoon Park Jae Kyung Byun Dezhong Jin Zeng Xiaoyan Sung Kwon Ko Seung-Yeol Nah Hyoung-Chun Kim Eun-Joo Shin Source Type: research
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF- κB pathway in macrophages
In this study, the expression of NAT10 in macrophages was found to decrease during LPS-induced inflammation. NAT10 knockdown significantly reduced the generation of inflammatory factors, while NAT10 overexpression had the opposite effect. RNA sequencing revealed that the differentially expressed genes were enriched in the NF-κB signalling pathway and oxidative stress. Both the NF-κB inhibitor Bay11-7082 and the ROS scavenger N-acetyl-L-cysteine (NAC) could reverse the upregulation of inflammatory factors. NAC inhibited the phosphorylation of NF-κB, but Bay11-7082 had no effect on the production of ROS in NAT10-overexpre...
Source: Biochimica et Biophysica Acta - June 12, 2023 Category: Biochemistry Authors: Zhanqi Zhang Yiwen Zhang Yongjie Cai Di Li Jinlin He Zhihui Feng Qiong Xu Source Type: research
Reactive oxygen species-dependent transient induction of genotoxicity by retene in human liver HepG2 cells
In this study, the cytotoxicity and genotoxicity of retene were investigated in human HepG2 liver cells. Our data showed that retene had minimal effect on cell viability, but induced DNA strand breaks, micronuclei formation, and reactive oxygen species (ROS) formation in a dose- and time-dependent manner. Stronger effects were observed at earlier time points than at longer, indicating transient genotoxicity. Retene activated phosphorylation of Checkpoint kinase 1 (Chk1), an indicator of replication stress and chromosomal instability, which was in accordance with increased formation of micronuclei. A protective effect of th...
Source: Toxicology in Vitro - June 11, 2023 Category: Toxicology Authors: Caroline Scaramboni Maria Lucia Arruda Moura Campos Daniel Junqueira Dorta Danielle Palma de Oliveira Silvia Regina Batistuzzo de Medeiros Marcos Felipe de Oliveira Galv ão Kristian Dreij Source Type: research
Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation
In this study, we found for the first time that Cinchonine (Cin) can act as an autophagy suppressor and exert anti-tumor effects. Cin significantly inhibited the proliferation, migration, and invasion of cancer cells in vitro and the tumor growth and metastasis in vivo, without obvious toxic effects. We found that Cin suppressed the autophagic process by blocking autophagosome degradation through the inhibition of the maturation of lysosomal hydrolases. Cin-mediated autophagy inhibition resulted in the elevated ROS level and the accumulation of damaged mitochondria, which in turn promoted apoptosis. N-acetylcysteine, a pot...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2023 Category: Drugs & Pharmacology Authors: Huan Wang Yuting Shi Dannv Ma Mengqing Cao Yuchao Sun Xinyuan Jiang Zhiyong Xu Yongfang Wang Ying Yang Yueli Shi Kai Wang Source Type: research
Helicobacter pylori infection selectively attenuates endothelial function in male mice < em > via < /em > exosomes-mediated ROS production
CONCLUSIONS: H. pylori infection selectively impairs endothelial function in male mice due to exosome-mediated ROS formation.PMID:37274312 | PMC:PMC10233065 | DOI:10.3389/fcimb.2023.1142387
Source: Atherosclerosis - June 5, 2023 Category: Cardiology Authors: Linfang Zhang Xiujuan Xia Hao Wu Xuanyou Liu Qiang Zhu Meifang Wang Hong Hao Yuqi Cui De-Pei Li Shi-You Chen Luis A Martinez-Lemus Michael A Hill Canxia Xu Zhenguo Liu Source Type: research
FABP4 Regulates Cell Proliferation, Stemness, Apoptosis, and Glycolysis in Colorectal Cancer via Modulating ROS/ERK/mTOR Pathway
CONCLUSIONS: These results suggest that FABP4 depletion inhibits colorectal cancer progression by modulating cell growth, stemness, glycolysis and apoptosis. This regulation occurs through the ROS/ERK/mTOR pathway.PMID:37272103 | DOI:10.24976/Discov.Med.202335176.37
Source: Cancer Control - June 5, 2023 Category: Cancer & Oncology Authors: Yingchao Gao Yuanyuan Wang Xin Wang Jianwei Ma Ming Wei Na Li Zengren Zhao Source Type: research
Targeted Knockdown of Macrophage Migration Inhibitory Factor Enhances UVB Irradiation-Induced Apoptosis Via Increasing ROS Generation in Oral Squamous Cell Carcinoma
Conclusion: MIF knockdown combined with UVB irradiation significantly inhibited the proliferation of OSCC cells. MIF was involved in UVB-induced ROS generation and enhanced UVB irradiation-induced mitochondria-dependent apoptosis of OSCC cells by activating the MAPK pathway. This suggests that MIF-targeted therapy combined with UVB irradiation may be a novel approach for treating OSCC.PMID:37272017 | DOI:10.1177/15330338231163436
Source: Cancer Control - June 5, 2023 Category: Cancer & Oncology Authors: Tian Chen Qibing Chen Fen Li Manli Zeng Bingru Wang Shiyong Huang Shiming Chen Zezhang Tao Source Type: research
Efficacy of Acetylcysteine and Selenium in Aneurysmal Subarachnoid Hemorrhage Patients: A Prospective, Multicenter, Single Blind Randomized Controlled Trial
CONCLUSION: In conclusion, antioxidant treatment failed to show the reduction of PHE volume, mid-line shifting, vasospasm and hydrocephalus in acute SAH patients. A significant reduction in ICU stay was observed but need more optimal dosing schedule and precise outcome targets are required to clarify the clinical impacts of antioxidants in these patients.TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0004628.PMID:37270916 | DOI:10.3346/jkms.2023.38.e161
Source: J Korean Med Sci - June 4, 2023 Category: General Medicine Authors: Moinay Kim Hanwool Jeon Yeongu Chung Si Un Lee Wonhyoung Park Jung Cheol Park Jae Sung Ahn Seungjoo Lee Source Type: research
AMPK negatively regulates RANKL-induced osteoclast differentiation by controlling oxidative stress
This study aimed to clarify the mechanistic connection between AMPK and osteoclast differentiation, and the potential role of AMPK in the anti-resorptive effects of several phytochemicals. We found that receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL)-induced osteoclast differentiation, osteoclastic gene expression, and activation of mitogen-activated protein kinase (MAPK) and NF-κB were promoted in cells transfected with AMPK siRNA. AMPK knockdown led to defective synthesis of heme oxygenase-1, an antioxidant enzyme, and the upstream mediator, nuclear factor erythroid-2-related factor 2. Furthermore, ...
Source: Free Radical Biology and Medicine - June 3, 2023 Category: Biology Authors: Miori Tanaka Hirofumi Inoue Nobuyuki Takahashi Mariko Uehara Source Type: research
