Filtered By:
Drug: Acetylcysteine
This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 2370 results found since Jan 2013.
Evidence for the Metabolic Activation of Deferasirox < em > In Vitro < /em > and < em > In Vivo < /em >
Chem Res Toxicol. 2023 Jul 12. doi: 10.1021/acs.chemrestox.2c00416. Online ahead of print.ABSTRACTDeferasirox (DFS) is used for the treatment of iron accumulation caused by the need for long-term blood transfusions, such as thalassemia or other rare anemia. Liver injury due to exposure to DFS has been documented, and the toxic mechanisms of DFS are unknown. The present study aimed to investigate the reactive metabolites of DFS in vitro and in vivo to help us understand the mechanisms of DFS hepatotoxicity. Two hydroxylated metabolites (5-OH and 5'-OH) were identified during incubation of DFS-supplemented rat liver microsom...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Mengdie Su Yanjia Zhao Mei Li Chenyang Jia He Liu Yue Zhang Weiwei Li Ying Peng Jiang Zheng Source Type: research
Structural characterisation and pH-dependent preference of pyrrole cross-link isoforms from reactions of oxoenal with cysteine and lysine side chains as model systems
In this study, we subjected 5,5-diethoxy-4-oxopent-2-enal (DOPE), a model amino acids cross-linking reagent, to reactions with N-acetylcysteine (Ac-Cys) and Nα-acetyllysine (Ac-Lys), and identified three pyrrole cross-links. The compounds were isolated and their structures were rigorously determined by spectrometric and spectroscopic methods, including 2D NMR experiments. The use of 2D NMR spectroscopy was crucial to determine the position of the substituents in the pyrrole rings. The products were identified as 2,4-, 2,3-, and 2,5-substituted pyrroles. The data obtained from their structural characterisation can help sim...
Source: Amino Acids - July 11, 2023 Category: Biochemistry Authors: Malwina Mu ńko Karolina Ciesielska Marcin Hoffmann Donata Pluskota-Karwatka Source Type: research
Elucidation of the relationship between evodiamine-induced liver injury and CYP3A4-mediated metabolic activation by UPLC-MS/MS analysis
In this study, comprehensive hepatotoxicity evaluation was explored, which demonstrated that EVD caused hepatotoxicity in both time- and dose-dependent manners in mice. By application of UPLC-Q/TOF-MS/MS, two GSH conjugates (GM1 and GM2) derived from reactive metabolites of EVD were identified, in microsomal incubation systems exposed to EVD with glutathione (GSH) as trapping agents. CYP3A4 was proved to be the main metabolic enzyme. Correspondingly, the N-acetyl-L-cysteine conjugate derived from the degradation of GM2 was detected in the urine of mice after exposure to EVD. For the first time, the iminoquinone intermediat...
Source: Analytical and Bioanalytical Chemistry - July 11, 2023 Category: Chemistry Authors: Ting Peng Jinqiu Rao Tingting Zhang Yuan Wang Na Li Qing Gao Xinchi Feng Zhaohui Song Kai Wang Feng Qiu Source Type: research
Activation of transient receptor potential channels is involved in reactive oxygen species (ROS)-dependent regulation of blood flow by (-)-epicatechin tetramer cinnamtannin A2
Biochem Pharmacol. 2023 Jul 8;214:115682. doi: 10.1016/j.bcp.2023.115682. Online ahead of print.ABSTRACTIntervention trials confirmed that blood flow-mediated dilatation increases significantly after intake of astringent (-)-epicatechin (EC) oligomers (procyanidins)-rich foods, but the mechanism remains unclear. We have previously found that procyanidins can activate the sympathetic nervous and subsequently increase blood flow. Here, we examined whether procyanidin-derived reactive oxygen species (ROS) activate transient receptor potential (TRP) channels in gastrointestinal sensory nerves and consequently induce sympathoex...
Source: Biochemical Pharmacology - July 10, 2023 Category: Drugs & Pharmacology Authors: Taiki Fushimi Chie Hirahata Kento Hiroki Yasuyuki Fujii Vittorio Calabrese Yoshitomo Suhara Naomi Osakabe Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
Bisphenol A Regulates the TNFR1 Pathway and Excessive ROS Mediated by miR-26a-5p/ADAM17 Axis to Aggravate Selenium Deficiency-Induced Necroptosis in Broiler Veins
This study lays a data foundation for future ecological and health risk assessments of nutrient deficiencies and environmental toxic pollution.PMID:37422542 | DOI:10.1007/s12011-023-03756-3
Source: Atherosclerosis - July 8, 2023 Category: Cardiology Authors: Xue Fan Yixuan Wang Jintao Zhang Hongjin Lin Zhikun Bai Shu Li Source Type: research
