Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway
This study showed that taurine significantly ameliorated axonal damage of spinal cord (SC), based on morphological and functional analyses, in a rat model of DN induced by streptozotocin (STZ). Taurine was also found to induce neurite outgrowth in cultured cerebral cortex neurons with high glucose exposure. Moreover, taurine up-regulated the expression of nerve growth factor (NGF) and neurite outgrowth relative protein GAP-43 in rat DN model and cultured cortical neurons/VSC4.1 cells. Besides, taurine increased the activating phosphorylation signals of TrkA, Akt, and mTOR. Mechanistically, the neuroprotection by taurine wa...
Source: Amino Acids - April 18, 2024 Category: Biochemistry Authors: Yachen Wang Bihu Gao Xiaochi Chen Xiaoxia Shi Shuangyue Li Qing Zhang Cong Zhang Fengyuan Piao Source Type: research
Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage
This study is the first to reveal the relationship between taurine and astrocyte polarization and may provide a new strategy for SAH research and clinical treatment.PMID:38616233 | PMC:PMC11016520 | DOI:10.1007/s00726-024-03387-5 (Source: Amino Acids)
Source: Amino Acids - April 14, 2024 Category: Biochemistry Authors: Chunlei Yang Zhiwen Jiang Xinjie Gao Heng Yang Jiabin Su Ruiyuan Weng Wei Ni Yuxiang Gu Source Type: research
Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage
This study is the first to reveal the relationship between taurine and astrocyte polarization and may provide a new strategy for SAH research and clinical treatment.PMID:38616233 | PMC:PMC11016520 | DOI:10.1007/s00726-024-03387-5 (Source: Amino Acids)
Source: Amino Acids - April 14, 2024 Category: Biochemistry Authors: Chunlei Yang Zhiwen Jiang Xinjie Gao Heng Yang Jiabin Su Ruiyuan Weng Wei Ni Yuxiang Gu Source Type: research
Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage
This study is the first to reveal the relationship between taurine and astrocyte polarization and may provide a new strategy for SAH research and clinical treatment.PMID:38616233 | PMC:PMC11016520 | DOI:10.1007/s00726-024-03387-5 (Source: Amino Acids)
Source: Amino Acids - April 14, 2024 Category: Biochemistry Authors: Chunlei Yang Zhiwen Jiang Xinjie Gao Heng Yang Jiabin Su Ruiyuan Weng Wei Ni Yuxiang Gu Source Type: research
Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage
This study is the first to reveal the relationship between taurine and astrocyte polarization and may provide a new strategy for SAH research and clinical treatment.PMID:38616233 | DOI:10.1007/s00726-024-03387-5 (Source: Amino Acids)
Source: Amino Acids - April 14, 2024 Category: Biochemistry Authors: Chunlei Yang Zhiwen Jiang Xinjie Gao Heng Yang Jiabin Su Ruiyuan Weng Wei Ni Yuxiang Gu Source Type: research
Effects of cancer-induced cachexia and administration of L-glutathione on the intestinal mucosa in rat
This study evaluated the duodenal mucosa of rats with Walker-256 tumor administered with 1% L-glutathione, intending to evaluate the damage caused by cancer-associated cachexia in the gastrointestinal tract and the effects of antioxidant administration on mucosal protection. Twenty-four 55-day-old male Wistar rats were distributed into four groups: control (C); control administered with 1% L-glutathione (C-GSH); Walker-256 tumor (W) and Walker-256 tumor administered with 1% L-glutathione (W-GSH). After 14 days of treatment, the duodenum was harvested for morphometric analysis of the mucosa, proliferation, apoptosis, immuno...
Source: Amino Acids - April 12, 2024 Category: Biochemistry Authors: Sabrina Silva Sestak Fabiana Galv ão da Motta Lima Ana Paula de Oliveira Let ícia Ganem Rillo Paz Barateiro Fl ávia Cristina Vieira-Frez Sara Raquel Garcia de Souza Fl ávia Alessandra Guarnier Juliana Vanessa Colombo Martins Perles Jacqueline Nelisis Source Type: research
Effects of cancer-induced cachexia and administration of L-glutathione on the intestinal mucosa in rat
This study evaluated the duodenal mucosa of rats with Walker-256 tumor administered with 1% L-glutathione, intending to evaluate the damage caused by cancer-associated cachexia in the gastrointestinal tract and the effects of antioxidant administration on mucosal protection. Twenty-four 55-day-old male Wistar rats were distributed into four groups: control (C); control administered with 1% L-glutathione (C-GSH); Walker-256 tumor (W) and Walker-256 tumor administered with 1% L-glutathione (W-GSH). After 14 days of treatment, the duodenum was harvested for morphometric analysis of the mucosa, proliferation, apoptosis, immuno...
Source: Amino Acids - April 12, 2024 Category: Biochemistry Authors: Sabrina Silva Sestak Fabiana Galv ão da Motta Lima Ana Paula de Oliveira Let ícia Ganem Rillo Paz Barateiro Fl ávia Cristina Vieira-Frez Sara Raquel Garcia de Souza Fl ávia Alessandra Guarnier Juliana Vanessa Colombo Martins Perles Jacqueline Nelisis Source Type: research
Effects of cancer-induced cachexia and administration of L-glutathione on the intestinal mucosa in rat
This study evaluated the duodenal mucosa of rats with Walker-256 tumor administered with 1% L-glutathione, intending to evaluate the damage caused by cancer-associated cachexia in the gastrointestinal tract and the effects of antioxidant administration on mucosal protection. Twenty-four 55-day-old male Wistar rats were distributed into four groups: control (C); control administered with 1% L-glutathione (C-GSH); Walker-256 tumor (W) and Walker-256 tumor administered with 1% L-glutathione (W-GSH). After 14 days of treatment, the duodenum was harvested for morphometric analysis of the mucosa, proliferation, apoptosis, immuno...
Source: Amino Acids - April 12, 2024 Category: Biochemistry Authors: Sabrina Silva Sestak Fabiana Galv ão da Motta Lima Ana Paula de Oliveira Let ícia Ganem Rillo Paz Barateiro Fl ávia Cristina Vieira-Frez Sara Raquel Garcia de Souza Fl ávia Alessandra Guarnier Juliana Vanessa Colombo Martins Perles Jacqueline Nelisis Source Type: research
Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine
In this study, we aimed to determine the changes in the blood levels of L-theanine administered to mice and amino acid composition of the serum. L-theanine were administered to four-week-old Std-ddY male mice orally or via tail vein injection. L-theanine and other amino acids in serum prepared from blood collected at different time points post-dose were labeled with phenylisothiocyanate and quantified. The serum concentration of orally administered L-theanine peaked 15 min after administration. The area under the curve for tail vein injection revealed the bioavailability of L- theanine to be approximately 70%. L-theanine a...
Source: Amino Acids - April 7, 2024 Category: Biochemistry Authors: Shinnosuke Yamaura Koki Sadamori Reiko Konishi Takashi Majima Akira Mukai Kyosuke Uno Toshihiko Kinjo Koji Komori Nobuyuki Kuramoto Kou Kawada Source Type: research
Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine
In this study, we aimed to determine the changes in the blood levels of L-theanine administered to mice and amino acid composition of the serum. L-theanine were administered to four-week-old Std-ddY male mice orally or via tail vein injection. L-theanine and other amino acids in serum prepared from blood collected at different time points post-dose were labeled with phenylisothiocyanate and quantified. The serum concentration of orally administered L-theanine peaked 15 min after administration. The area under the curve for tail vein injection revealed the bioavailability of L- theanine to be approximately 70%. L-theanine a...
Source: Amino Acids - April 7, 2024 Category: Biochemistry Authors: Shinnosuke Yamaura Koki Sadamori Reiko Konishi Takashi Majima Akira Mukai Kyosuke Uno Toshihiko Kinjo Koji Komori Nobuyuki Kuramoto Kou Kawada Source Type: research
Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine
In this study, we aimed to determine the changes in the blood levels of L-theanine administered to mice and amino acid composition of the serum. L-theanine were administered to four-week-old Std-ddY male mice orally or via tail vein injection. L-theanine and other amino acids in serum prepared from blood collected at different time points post-dose were labeled with phenylisothiocyanate and quantified. The serum concentration of orally administered L-theanine peaked 15 min after administration. The area under the curve for tail vein injection revealed the bioavailability of L- theanine to be approximately 70%. L-theanine a...
Source: Amino Acids - April 7, 2024 Category: Biochemistry Authors: Shinnosuke Yamaura Koki Sadamori Reiko Konishi Takashi Majima Akira Mukai Kyosuke Uno Toshihiko Kinjo Koji Komori Nobuyuki Kuramoto Kou Kawada Source Type: research
Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine
In this study, we aimed to determine the changes in the blood levels of L-theanine administered to mice and amino acid composition of the serum. L-theanine were administered to four-week-old Std-ddY male mice orally or via tail vein injection. L-theanine and other amino acids in serum prepared from blood collected at different time points post-dose were labeled with phenylisothiocyanate and quantified. The serum concentration of orally administered L-theanine peaked 15 min after administration. The area under the curve for tail vein injection revealed the bioavailability of L- theanine to be approximately 70%. L-theanine a...
Source: Amino Acids - April 7, 2024 Category: Biochemistry Authors: Shinnosuke Yamaura Koki Sadamori Reiko Konishi Takashi Majima Akira Mukai Kyosuke Uno Toshihiko Kinjo Koji Komori Nobuyuki Kuramoto Kou Kawada Source Type: research
Antibacterial activity of a short de novo designed peptide against fish bacterial pathogens
Amino Acids. 2024 Apr 5;56(1):28. doi: 10.1007/s00726-024-03388-4.ABSTRACTIn the face of increasing antimicrobial resistance in aquaculture, researchers are exploring novel substitutes to customary antibiotics. One potential solution is the use of antimicrobial peptides (AMPs). We aimed to design and evaluate a novel, short, and compositionally simple AMP with potent activity against various bacterial pathogens in aquaculture. The resulting peptide, KK12YW, has an amphipathic nature and net charge of + 7. Molecular docking experiments disclosed that KK12YW has a strong affinity for aerolysin, a virulence protein produced b...
Source: Amino Acids - April 5, 2024 Category: Biochemistry Authors: Raja Aadil Hussain Bhat Victoria C Khangembam Vinita Pant Ritesh Shantilal Tandel Pramod Kumar Pandey Dimpal Thakuria Source Type: research
