Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus
This study aimed to measure KP metabolite levels in patients with SLE and investigate the relationship between disease activity, clinical findings, and KP. The study included 100 patients with SLE and 100 healthy controls. Serum tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), quinolinic acid (QA) concentrations were measured with tandem mass spectrometry. Serum KYN, KYNA, 3HAA, 3HK, and QA levels of the patients with SLE were significantly higher than the control group. Serum QA levels were elevated in patients with neurological involvement (four patie...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Duygu Eryavuz Onmaz Dilek Tezcan Sema Yilmaz Mustafa Onmaz Ali Unlu Source Type: research
Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer's disease therapeutics
Amino Acids. 2023 Nov 5. doi: 10.1007/s00726-023-03355-5. Online ahead of print.ABSTRACTDisruptions to iron metabolism and iron homeostasis have emerged as significant contributors to the development and progression of Alzheimer's disease (AD). Human transferrin plays a key part in maintaining iron equilibrium throughout the body, highlighting its importance in AD. Many plant-derived compounds and dietary constituents show promise for preventing AD. Polyphenols that are abundant in fruits, vegetables, teas, coffee, and herbs possess neuroprotective attributes. Resveratrol is a natural polyphenol present in various plant so...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Mohd Shahnawaz Khan Mohammad Furkan Moyad Shahwan Dharmendra Kumar Yadav Saleha Anwar Rizwan Hasan Khan Anas Shamsi Source Type: research
Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches
Amino Acids. 2023 Nov 2. doi: 10.1007/s00726-023-03350-w. Online ahead of print.ABSTRACTβ-Lactoglobulin is one of the proteins in milk possessing antioxidant activity. The peptides derived from β-Lactoglobulin exhibit higher antioxidant activities than the most commonly used antioxidant. Furthermore, the detailed structure-activity relationship of these antioxidant peptides has not been elucidated. Therefore, in the present work, two-dimensional quantitative structure-activity relationship (2D-QSAR) and three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed to investigate the str...
Source: Amino Acids - November 2, 2023 Category: Biochemistry Authors: Fangfang Wang Menghao Wen Bo Zhou Source Type: research
Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches
Amino Acids. 2023 Nov 2. doi: 10.1007/s00726-023-03350-w. Online ahead of print.ABSTRACTβ-Lactoglobulin is one of the proteins in milk possessing antioxidant activity. The peptides derived from β-Lactoglobulin exhibit higher antioxidant activities than the most commonly used antioxidant. Furthermore, the detailed structure-activity relationship of these antioxidant peptides has not been elucidated. Therefore, in the present work, two-dimensional quantitative structure-activity relationship (2D-QSAR) and three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed to investigate the str...
Source: Amino Acids - November 2, 2023 Category: Biochemistry Authors: Fangfang Wang Menghao Wen Bo Zhou Source Type: research
Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches
Amino Acids. 2023 Nov 2. doi: 10.1007/s00726-023-03350-w. Online ahead of print.ABSTRACTβ-Lactoglobulin is one of the proteins in milk possessing antioxidant activity. The peptides derived from β-Lactoglobulin exhibit higher antioxidant activities than the most commonly used antioxidant. Furthermore, the detailed structure-activity relationship of these antioxidant peptides has not been elucidated. Therefore, in the present work, two-dimensional quantitative structure-activity relationship (2D-QSAR) and three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed to investigate the str...
Source: Amino Acids - November 2, 2023 Category: Biochemistry Authors: Fangfang Wang Menghao Wen Bo Zhou Source Type: research
Effect of lipopeptide extracted from Bacillus licheniformis on the expression of bap and luxI genes in multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa
Amino Acids. 2023 Oct 31. doi: 10.1007/s00726-023-03346-6. Online ahead of print.ABSTRACTRecently, opportunistic pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa have caused concern due to their ability to cause antibiotic resistance in weakened immune systems. As a result, researchers are always seeking efficient antimicrobial agents to tackle this issue. The hypothesis of the recent study was that probiotic products derived from bacteria would be effective in reducing drug resistance in other bacteria. This research aimed to investigate the antimicrobial properties of probiotic products from various bact...
Source: Amino Acids - November 1, 2023 Category: Biochemistry Authors: Farangis Ghanipour Razieh Nazari Seyed Soheil Aghaei Parvaneh Jafari Source Type: research
Effect of lipopeptide extracted from Bacillus licheniformis on the expression of bap and luxI genes in multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa
Amino Acids. 2023 Oct 31. doi: 10.1007/s00726-023-03346-6. Online ahead of print.ABSTRACTRecently, opportunistic pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa have caused concern due to their ability to cause antibiotic resistance in weakened immune systems. As a result, researchers are always seeking efficient antimicrobial agents to tackle this issue. The hypothesis of the recent study was that probiotic products derived from bacteria would be effective in reducing drug resistance in other bacteria. This research aimed to investigate the antimicrobial properties of probiotic products from various bact...
Source: Amino Acids - November 1, 2023 Category: Biochemistry Authors: Farangis Ghanipour Razieh Nazari Seyed Soheil Aghaei Parvaneh Jafari Source Type: research
Acetylcholine hydrolytic activity of fibrillated β-amyloid (1-40) peptide
In this study, we examined the catalytic activity of the fibrils formed by Aβ(1-40), the most abundant Aβ variant, on acetylcholine hydrolysis. Our findings reveal that Aβ(1-40) fibrils exhibit moderate enzymatic activity, indicating that natural peptide aggregates could serve as biocatalysts and provide new insights into the potential role of Aβ in neurological disorders.PMID:37904049 | DOI:10.1007/s00726-023-03349-3 (Source: Amino Acids)
Source: Amino Acids - October 31, 2023 Category: Biochemistry Authors: Ivan Sanchis Roque Spinelli Alvaro Siano Source Type: research
Acetylcholine hydrolytic activity of fibrillated β-amyloid (1-40) peptide
In this study, we examined the catalytic activity of the fibrils formed by Aβ(1-40), the most abundant Aβ variant, on acetylcholine hydrolysis. Our findings reveal that Aβ(1-40) fibrils exhibit moderate enzymatic activity, indicating that natural peptide aggregates could serve as biocatalysts and provide new insights into the potential role of Aβ in neurological disorders.PMID:37904049 | DOI:10.1007/s00726-023-03349-3 (Source: Amino Acids)
Source: Amino Acids - October 31, 2023 Category: Biochemistry Authors: Ivan Sanchis Roque Spinelli Alvaro Siano Source Type: research
Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry
Amino Acids. 2023 Oct 26. doi: 10.1007/s00726-023-03337-7. Online ahead of print.ABSTRACTSmall neuropeptides from the corpora cardiaca are responsible in cockroaches for the mobilisation of trehalose from the fat body into the haemolymph. Such hypertrehalosaemic hormones (HrTHs) belong to the large family of insect adipokinetic hormones (AKHs); a few HrTHs were previously sequenced from cockroaches, and from genomic and/or transcriptomic information one may predict the genes encoding HrTHs from more species. Definite elucidation of the primary structure of the mature peptide with putative modifications needs analytical che...
Source: Amino Acids - October 26, 2023 Category: Biochemistry Authors: Heather G Marco Simone K önig Gerd G äde Source Type: research
Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry
Amino Acids. 2023 Oct 26. doi: 10.1007/s00726-023-03337-7. Online ahead of print.ABSTRACTSmall neuropeptides from the corpora cardiaca are responsible in cockroaches for the mobilisation of trehalose from the fat body into the haemolymph. Such hypertrehalosaemic hormones (HrTHs) belong to the large family of insect adipokinetic hormones (AKHs); a few HrTHs were previously sequenced from cockroaches, and from genomic and/or transcriptomic information one may predict the genes encoding HrTHs from more species. Definite elucidation of the primary structure of the mature peptide with putative modifications needs analytical che...
Source: Amino Acids - October 26, 2023 Category: Biochemistry Authors: Heather G Marco Simone K önig Gerd G äde Source Type: research
Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry
Amino Acids. 2023 Oct 26. doi: 10.1007/s00726-023-03337-7. Online ahead of print.ABSTRACTSmall neuropeptides from the corpora cardiaca are responsible in cockroaches for the mobilisation of trehalose from the fat body into the haemolymph. Such hypertrehalosaemic hormones (HrTHs) belong to the large family of insect adipokinetic hormones (AKHs); a few HrTHs were previously sequenced from cockroaches, and from genomic and/or transcriptomic information one may predict the genes encoding HrTHs from more species. Definite elucidation of the primary structure of the mature peptide with putative modifications needs analytical che...
Source: Amino Acids - October 26, 2023 Category: Biochemistry Authors: Heather G Marco Simone K önig Gerd G äde Source Type: research
Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry
Amino Acids. 2023 Oct 26. doi: 10.1007/s00726-023-03337-7. Online ahead of print.ABSTRACTSmall neuropeptides from the corpora cardiaca are responsible in cockroaches for the mobilisation of trehalose from the fat body into the haemolymph. Such hypertrehalosaemic hormones (HrTHs) belong to the large family of insect adipokinetic hormones (AKHs); a few HrTHs were previously sequenced from cockroaches, and from genomic and/or transcriptomic information one may predict the genes encoding HrTHs from more species. Definite elucidation of the primary structure of the mature peptide with putative modifications needs analytical che...
Source: Amino Acids - October 26, 2023 Category: Biochemistry Authors: Heather G Marco Simone K önig Gerd G äde Source Type: research
Serum albumin acted as an effective carrier to improve the stability of bioactive flavonoid
Amino Acids. 2023 Oct 19. doi: 10.1007/s00726-023-03347-5. Online ahead of print.ABSTRACTThe health-improving functions of bioactive flavonoids in vitro and in vivo are often limited by their low stability, which could be counteracted by the application of proteins as carriers of flavonoids. Clarification of the mechanism of protein-ligand interaction is crucial for the encapsulation of bioactive components. Herein, common plasma proteins [i.e., bovine serum albumin (BSA), human serum albumin (HSA), human immunoglobulin G (IgG) and fibrinogen (FG)] were compared for their binding characteristics to quercetin, the main comp...
Source: Amino Acids - October 19, 2023 Category: Biochemistry Authors: Ya-Di Yang Naihao Lu Rong Tian Source Type: research
Serum albumin acted as an effective carrier to improve the stability of bioactive flavonoid
Amino Acids. 2023 Oct 19. doi: 10.1007/s00726-023-03347-5. Online ahead of print.ABSTRACTThe health-improving functions of bioactive flavonoids in vitro and in vivo are often limited by their low stability, which could be counteracted by the application of proteins as carriers of flavonoids. Clarification of the mechanism of protein-ligand interaction is crucial for the encapsulation of bioactive components. Herein, common plasma proteins [i.e., bovine serum albumin (BSA), human serum albumin (HSA), human immunoglobulin G (IgG) and fibrinogen (FG)] were compared for their binding characteristics to quercetin, the main comp...
Source: Amino Acids - October 19, 2023 Category: Biochemistry Authors: Ya-Di Yang Naihao Lu Rong Tian Source Type: research
