Serum albumin acted as an effective carrier to improve the stability of bioactive flavonoid
Amino Acids. 2023 Oct 19. doi: 10.1007/s00726-023-03347-5. Online ahead of print.ABSTRACTThe health-improving functions of bioactive flavonoids in vitro and in vivo are often limited by their low stability, which could be counteracted by the application of proteins as carriers of flavonoids. Clarification of the mechanism of protein-ligand interaction is crucial for the encapsulation of bioactive components. Herein, common plasma proteins [i.e., bovine serum albumin (BSA), human serum albumin (HSA), human immunoglobulin G (IgG) and fibrinogen (FG)] were compared for their binding characteristics to quercetin, the main comp...
Source: Amino Acids - October 19, 2023 Category: Biochemistry Authors: Ya-Di Yang Naihao Lu Rong Tian Source Type: research
Cross species review of the physiological role of D-serine in translationally relevant behaviors
Amino Acids. 2023 Oct 13. doi: 10.1007/s00726-023-03338-6. Online ahead of print.ABSTRACTBridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences. Therefore, i...
Source: Amino Acids - October 13, 2023 Category: Biochemistry Authors: Dena Arizanovska Jada A Emodogo Anna P Lally Caroline B Palavicino-Maggio Daniel J Liebl Oluwarotimi O Folorunso Source Type: research
Cross species review of the physiological role of D-serine in translationally relevant behaviors
Amino Acids. 2023 Oct 13. doi: 10.1007/s00726-023-03338-6. Online ahead of print.ABSTRACTBridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences. Therefore, i...
Source: Amino Acids - October 13, 2023 Category: Biochemistry Authors: Dena Arizanovska Jada A Emodogo Anna P Lally Caroline B Palavicino-Maggio Daniel J Liebl Oluwarotimi O Folorunso Source Type: research
Cross species review of the physiological role of D-serine in translationally relevant behaviors
Amino Acids. 2023 Oct 13. doi: 10.1007/s00726-023-03338-6. Online ahead of print.ABSTRACTBridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences. Therefore, i...
Source: Amino Acids - October 13, 2023 Category: Biochemistry Authors: Dena Arizanovska Jada A Emodogo Anna P Lally Caroline B Palavicino-Maggio Daniel J Liebl Oluwarotimi O Folorunso Source Type: research
Cross species review of the physiological role of D-serine in translationally relevant behaviors
Amino Acids. 2023 Oct 13. doi: 10.1007/s00726-023-03338-6. Online ahead of print.ABSTRACTBridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences. Therefore, i...
Source: Amino Acids - October 13, 2023 Category: Biochemistry Authors: Dena Arizanovska Jada A Emodogo Anna P Lally Caroline B Palavicino-Maggio Daniel J Liebl Oluwarotimi O Folorunso Source Type: research
Cross species review of the physiological role of D-serine in translationally relevant behaviors
Amino Acids. 2023 Oct 13. doi: 10.1007/s00726-023-03338-6. Online ahead of print.ABSTRACTBridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences. Therefore, i...
Source: Amino Acids - October 13, 2023 Category: Biochemistry Authors: Dena Arizanovska Jada A Emodogo Anna P Lally Caroline B Palavicino-Maggio Daniel J Liebl Oluwarotimi O Folorunso Source Type: research
Mucosal-associated invariant T cells display both pathogenic and protective roles in patients with inflammatory bowel diseases
Amino Acids. 2023 Oct 11. doi: 10.1007/s00726-023-03344-8. Online ahead of print.ABSTRACTAn important subtype of the innate-like T lymphocytes is mucosal-associated invariant T (MAIT) cells expressing a semi-invariant T cell receptor α (TCR-α) chain. MAIT cells could be activated mainly by TCR engagement or cytokines. They have been found to have essential roles in various immune mediated. There have been growing preclinical and clinical findings that show an association between MAIT cells and the physiopathology of inflammatory bowel diseases (IBD). Of note, published reports demonstrate contradictory findings regarding...
Source: Amino Acids - October 11, 2023 Category: Biochemistry Authors: Lei Wei Zhigang Chen Qiang Lv Source Type: research
Mucosal-associated invariant T cells display both pathogenic and protective roles in patients with inflammatory bowel diseases
Amino Acids. 2023 Oct 11. doi: 10.1007/s00726-023-03344-8. Online ahead of print.ABSTRACTAn important subtype of the innate-like T lymphocytes is mucosal-associated invariant T (MAIT) cells expressing a semi-invariant T cell receptor α (TCR-α) chain. MAIT cells could be activated mainly by TCR engagement or cytokines. They have been found to have essential roles in various immune mediated. There have been growing preclinical and clinical findings that show an association between MAIT cells and the physiopathology of inflammatory bowel diseases (IBD). Of note, published reports demonstrate contradictory findings regarding...
Source: Amino Acids - October 11, 2023 Category: Biochemistry Authors: Lei Wei Zhigang Chen Qiang Lv Source Type: research
Mucosal-associated invariant T cells display both pathogenic and protective roles in patients with inflammatory bowel diseases
Amino Acids. 2023 Oct 11. doi: 10.1007/s00726-023-03344-8. Online ahead of print.ABSTRACTAn important subtype of the innate-like T lymphocytes is mucosal-associated invariant T (MAIT) cells expressing a semi-invariant T cell receptor α (TCR-α) chain. MAIT cells could be activated mainly by TCR engagement or cytokines. They have been found to have essential roles in various immune mediated. There have been growing preclinical and clinical findings that show an association between MAIT cells and the physiopathology of inflammatory bowel diseases (IBD). Of note, published reports demonstrate contradictory findings regarding...
Source: Amino Acids - October 11, 2023 Category: Biochemistry Authors: Lei Wei Zhigang Chen Qiang Lv Source Type: research
Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism
Amino Acids. 2023 Oct 9. doi: 10.1007/s00726-023-03334-w. Online ahead of print.ABSTRACTApart from cancer, metabolic reprogramming is also prevalent in other diseases, such as bacterial infections. Bacterial infections can affect a variety of cells, tissues, organs, and bodies, leading to a series of clinical diseases. Common Pathogenic bacteria include Helicobacter pylori, Salmonella enterica, Mycobacterium tuberculosis, Staphylococcus aureus, and so on. Amino acids are important and essential nutrients in bacterial physiology and support not only their proliferation but also their evasion of host immune defenses. Many pa...
Source: Amino Acids - October 9, 2023 Category: Biochemistry Authors: Xiao-Yue Li Zi-Xin Zeng Zhi-Xing Cheng Yi-Lin Wang Liang-Jun Yuan Zhi-Yong Zhai Wei Gong Source Type: research
The possibilities of LOXL4 as a prognostic marker for carcinomas
Amino Acids. 2023 Oct 9. doi: 10.1007/s00726-023-03343-9. Online ahead of print.ABSTRACTLysyl oxidase-like 4 (LOXL4), a member of lysyl oxidase family, is a copper and lysine tyrosylquinone-dependent amine oxidase that serves the role of catalyzing the cross-linking of elastin and collagen in the extracellular matrix. Numerous studies have shown a significant association between LOXL4 expression levels and tumor proliferation, migration, invasion and patients' prognosis and overall survival in different types of tumors. Here we review their relationship and the molecular pathogenesis behind them, aiming to explore the poss...
Source: Amino Acids - October 9, 2023 Category: Biochemistry Authors: Jiaming Wang Chaojian Chen Jiayi Huang Ziman Xie Xiaoxue Chen Ziqi Zheng Enmin Li Haiying Zou Source Type: research
Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells
Amino Acids. 2023 Oct 9. doi: 10.1007/s00726-023-03345-7. Online ahead of print.ABSTRACTHepatic stellate cell (HSC) activation is the key process in hepatic fibrosis (HF) development. Targeted death of HSCs could be effective in the prevention and treatment of HF. Phosphatidylethanolamine-binding protein (PEBP)1 can trigger ferroptosis by mediating peroxide production, but how it modulates HSC ferroptosis is not known. We screened natural small molecules that could bind with PEBP1, and investigated the mechanism by which it promotes HSC ferroptosis. The maximum binding energy of berberine with PEBP1 was - 8.51 kcal/mol, in...
Source: Amino Acids - October 9, 2023 Category: Biochemistry Authors: Zhongping Xie Yu Zhou Min Lin Caihua Huang Source Type: research
Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism
Amino Acids. 2023 Oct 9. doi: 10.1007/s00726-023-03334-w. Online ahead of print.ABSTRACTApart from cancer, metabolic reprogramming is also prevalent in other diseases, such as bacterial infections. Bacterial infections can affect a variety of cells, tissues, organs, and bodies, leading to a series of clinical diseases. Common Pathogenic bacteria include Helicobacter pylori, Salmonella enterica, Mycobacterium tuberculosis, Staphylococcus aureus, and so on. Amino acids are important and essential nutrients in bacterial physiology and support not only their proliferation but also their evasion of host immune defenses. Many pa...
Source: Amino Acids - October 9, 2023 Category: Biochemistry Authors: Xiao-Yue Li Zi-Xin Zeng Zhi-Xing Cheng Yi-Lin Wang Liang-Jun Yuan Zhi-Yong Zhai Wei Gong Source Type: research
The possibilities of LOXL4 as a prognostic marker for carcinomas
Amino Acids. 2023 Oct 9. doi: 10.1007/s00726-023-03343-9. Online ahead of print.ABSTRACTLysyl oxidase-like 4 (LOXL4), a member of lysyl oxidase family, is a copper and lysine tyrosylquinone-dependent amine oxidase that serves the role of catalyzing the cross-linking of elastin and collagen in the extracellular matrix. Numerous studies have shown a significant association between LOXL4 expression levels and tumor proliferation, migration, invasion and patients' prognosis and overall survival in different types of tumors. Here we review their relationship and the molecular pathogenesis behind them, aiming to explore the poss...
Source: Amino Acids - October 9, 2023 Category: Biochemistry Authors: Jiaming Wang Chaojian Chen Jiayi Huang Ziman Xie Xiaoxue Chen Ziqi Zheng Enmin Li Haiying Zou Source Type: research
Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells
Amino Acids. 2023 Oct 9. doi: 10.1007/s00726-023-03345-7. Online ahead of print.ABSTRACTHepatic stellate cell (HSC) activation is the key process in hepatic fibrosis (HF) development. Targeted death of HSCs could be effective in the prevention and treatment of HF. Phosphatidylethanolamine-binding protein (PEBP)1 can trigger ferroptosis by mediating peroxide production, but how it modulates HSC ferroptosis is not known. We screened natural small molecules that could bind with PEBP1, and investigated the mechanism by which it promotes HSC ferroptosis. The maximum binding energy of berberine with PEBP1 was - 8.51 kcal/mol, in...
Source: Amino Acids - October 9, 2023 Category: Biochemistry Authors: Zhongping Xie Yu Zhou Min Lin Caihua Huang Source Type: research
