The renoprotective effects of taurine against diabetic nephropathy via the p38 MAPK and TGF- β/Smad2/3 signaling pathways
Amino Acids. 2023 Oct 7. doi: 10.1007/s00726-023-03342-w. Online ahead of print.ABSTRACTDiabetic nephropathy (DN), a severe diabetes complication, causes kidney morphological and structural changes due to extracellular matrix accumulation. This accumulation is caused mainly by oxidative stress. Semi-essential amino acid derivative taurine has powerful antioxidant and antifibrotic effects. The aim of this study was to investigate the renoprotective effects of taurine through its possible roles in oxidative stress, extracellular matrix proteins, and the signaling pathways associated with the accumulation of extracellular mat...
Source: Amino Acids - October 7, 2023 Category: Biochemistry Authors: Cemre Ural Asli Celik Seda Ozbal Ensari Guneli Sevki Arslan Bekir Ugur Ergur Caner Cavdar G ül Akdoğan Zahide Cavdar Source Type: research
The renoprotective effects of taurine against diabetic nephropathy via the p38 MAPK and TGF- β/Smad2/3 signaling pathways
Amino Acids. 2023 Oct 7. doi: 10.1007/s00726-023-03342-w. Online ahead of print.ABSTRACTDiabetic nephropathy (DN), a severe diabetes complication, causes kidney morphological and structural changes due to extracellular matrix accumulation. This accumulation is caused mainly by oxidative stress. Semi-essential amino acid derivative taurine has powerful antioxidant and antifibrotic effects. The aim of this study was to investigate the renoprotective effects of taurine through its possible roles in oxidative stress, extracellular matrix proteins, and the signaling pathways associated with the accumulation of extracellular mat...
Source: Amino Acids - October 7, 2023 Category: Biochemistry Authors: Cemre Ural Asli Celik Seda Ozbal Ensari Guneli Sevki Arslan Bekir Ugur Ergur Caner Cavdar G ül Akdoğan Zahide Cavdar Source Type: research
Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells
This study confirms that bromelain and ficin mixture could be effective in improving the symptoms of CeD.PMID:37803248 | DOI:10.1007/s00726-023-03333-x (Source: Amino Acids)
Source: Amino Acids - October 6, 2023 Category: Biochemistry Authors: Masoumeh Sadat Mousavi Maleki Hooman Aghamirza Moghim Ali Abadi Behrooz Vaziri Ali Akbar Shabani Ghazaleh Ghavami Hamid Madanchi Soroush Sardari Source Type: research
Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells
This study confirms that bromelain and ficin mixture could be effective in improving the symptoms of CeD.PMID:37803248 | DOI:10.1007/s00726-023-03333-x (Source: Amino Acids)
Source: Amino Acids - October 6, 2023 Category: Biochemistry Authors: Masoumeh Sadat Mousavi Maleki Hooman Aghamirza Moghim Ali Abadi Behrooz Vaziri Ali Akbar Shabani Ghazaleh Ghavami Hamid Madanchi Soroush Sardari Source Type: research
Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine
Amino Acids. 2023 Oct 5. doi: 10.1007/s00726-023-03314-0. Online ahead of print.ABSTRACTTellurium (Te) containing amino acids and their derivatives have the potential to participate in biological processes, which are currently being studied extensively to understand the function of Te in biological and pharmacological activities. Here, we are reporting the synthesis of two novel Te-containing unnatural amino acids; 1,3-Tellurazolidine-4-carboxylic acid [Te{CH2CH(COOH)NHCH2}] 5, and 4,4'-(1,2-Ditellurdiyl)bis(2-aminobutanoic acid), i.e., tellurohomocystine [TeCH2CH2CH(NH2)COOH]2 7, synthesized from tellurocystine, and L-met...
Source: Amino Acids - October 5, 2023 Category: Biochemistry Authors: Abhishek Tripathi Amreen Khan Rohit Srivastava Source Type: research
Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine
Amino Acids. 2023 Oct 5. doi: 10.1007/s00726-023-03314-0. Online ahead of print.ABSTRACTTellurium (Te) containing amino acids and their derivatives have the potential to participate in biological processes, which are currently being studied extensively to understand the function of Te in biological and pharmacological activities. Here, we are reporting the synthesis of two novel Te-containing unnatural amino acids; 1,3-Tellurazolidine-4-carboxylic acid [Te{CH2CH(COOH)NHCH2}] 5, and 4,4'-(1,2-Ditellurdiyl)bis(2-aminobutanoic acid), i.e., tellurohomocystine [TeCH2CH2CH(NH2)COOH]2 7, synthesized from tellurocystine, and L-met...
Source: Amino Acids - October 5, 2023 Category: Biochemistry Authors: Abhishek Tripathi Amreen Khan Rohit Srivastava Source Type: research
Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis
Amino Acids. 2023 Oct 4. doi: 10.1007/s00726-023-03341-x. Online ahead of print.ABSTRACTExcessive melanogenesis leads to hyperpigmentation, which is one of the common skin conditions in humans. Existing whitening cosmetics cannot meet market needs due to their inherent limitations. Thus, the development of novel skin-whitening agents continues to be a challenge. The peptide OA-VI12 from the skin of amphibians at high altitude has attracted attention due to its remarkable anti light damage activity. However, whether OA-VI12 has the skin-whitening effect of inhibiting melanogenesis is still. Mouse melanoma cells (B16) were u...
Source: Amino Acids - October 4, 2023 Category: Biochemistry Authors: Junsong Wang Yilin Li Chengan Feng Haoyu Wang Jiayi Li Naixin Liu Zhe Fu Yinglei Wang Yutong Wu Yixiang Liu Yingxuan Zhang Saige Yin Li He Ying Wang Xinwang Yang Source Type: research
Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis
Amino Acids. 2023 Oct 4. doi: 10.1007/s00726-023-03341-x. Online ahead of print.ABSTRACTExcessive melanogenesis leads to hyperpigmentation, which is one of the common skin conditions in humans. Existing whitening cosmetics cannot meet market needs due to their inherent limitations. Thus, the development of novel skin-whitening agents continues to be a challenge. The peptide OA-VI12 from the skin of amphibians at high altitude has attracted attention due to its remarkable anti light damage activity. However, whether OA-VI12 has the skin-whitening effect of inhibiting melanogenesis is still. Mouse melanoma cells (B16) were u...
Source: Amino Acids - October 4, 2023 Category: Biochemistry Authors: Junsong Wang Yilin Li Chengan Feng Haoyu Wang Jiayi Li Naixin Liu Zhe Fu Yinglei Wang Yutong Wu Yixiang Liu Yingxuan Zhang Saige Yin Li He Ying Wang Xinwang Yang Source Type: research
Effects of L-ascorbic acid (C < sub > 6 < /sub > H < sub > 8 < /sub > O < sub > 6 < /sub > : Vit-C) on collagen amino acids: DFT study
This study aimed to investigate the mechanism of action of vitamin C in terms of thermodynamics and structure of the reaction. The calculations are performed using density function theory (DFT) by the base set of B3LYP/6-311++G (p,d). The results show that the presence of vitamin C is effective in the formation of collagen protein for this interaction and the mechanism of amino acid sequence (Gly-Hyp-Pro) is better in the formation of collagen protein in the presence of vitamin C. The presence of Vit-C in the formation and direction of hydroxyproline (Hyp) causes its separation from the prolyl 5-hydroxylase enzyme. In the ...
Source: Amino Acids - October 2, 2023 Category: Biochemistry Authors: Uliana Y Chugaeva Mahmoud Raouf Natalia S Morozova Leila Mahdavian Source Type: research
Effects of L-ascorbic acid (C < sub > 6 < /sub > H < sub > 8 < /sub > O < sub > 6 < /sub > : Vit-C) on collagen amino acids: DFT study
This study aimed to investigate the mechanism of action of vitamin C in terms of thermodynamics and structure of the reaction. The calculations are performed using density function theory (DFT) by the base set of B3LYP/6-311++G (p,d). The results show that the presence of vitamin C is effective in the formation of collagen protein for this interaction and the mechanism of amino acid sequence (Gly-Hyp-Pro) is better in the formation of collagen protein in the presence of vitamin C. The presence of Vit-C in the formation and direction of hydroxyproline (Hyp) causes its separation from the prolyl 5-hydroxylase enzyme. In the ...
Source: Amino Acids - October 2, 2023 Category: Biochemistry Authors: Uliana Y Chugaeva Mahmoud Raouf Natalia S Morozova Leila Mahdavian Source Type: research
An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts
Amino Acids. 2023 Sep 28. doi: 10.1007/s00726-023-03340-y. Online ahead of print.ABSTRACTIn the human body, the skin is one of the organs most affected by the aging process. Nutritional approaches aimed to counteract the age-induced decline of extracellular matrix (ECM) deposition could be a valuable tool to decrease the degenerative processes underlying skin aging. Here, we investigated the ability of a six-amino acid plus hyaluronic acid (6AAH) formulation enriched with tricarboxylic acid (TCA) intermediates to stimulate ECM gene expression. To this aim, human BJ fibroblasts were treated with 6AAH alone or plus succinate...
Source: Amino Acids - September 28, 2023 Category: Biochemistry Authors: Maurizio Ragni Luca Canciani Letizia Spataro Chiara Ruocco Alessandra Valerio Enzo Nisoli Source Type: research
An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts
Amino Acids. 2023 Sep 28. doi: 10.1007/s00726-023-03340-y. Online ahead of print.ABSTRACTIn the human body, the skin is one of the organs most affected by the aging process. Nutritional approaches aimed to counteract the age-induced decline of extracellular matrix (ECM) deposition could be a valuable tool to decrease the degenerative processes underlying skin aging. Here, we investigated the ability of a six-amino acid plus hyaluronic acid (6AAH) formulation enriched with tricarboxylic acid (TCA) intermediates to stimulate ECM gene expression. To this aim, human BJ fibroblasts were treated with 6AAH alone or plus succinate...
Source: Amino Acids - September 28, 2023 Category: Biochemistry Authors: Maurizio Ragni Luca Canciani Letizia Spataro Chiara Ruocco Alessandra Valerio Enzo Nisoli Source Type: research
An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts
Amino Acids. 2023 Sep 28. doi: 10.1007/s00726-023-03340-y. Online ahead of print.ABSTRACTIn the human body, the skin is one of the organs most affected by the aging process. Nutritional approaches aimed to counteract the age-induced decline of extracellular matrix (ECM) deposition could be a valuable tool to decrease the degenerative processes underlying skin aging. Here, we investigated the ability of a six-amino acid plus hyaluronic acid (6AAH) formulation enriched with tricarboxylic acid (TCA) intermediates to stimulate ECM gene expression. To this aim, human BJ fibroblasts were treated with 6AAH alone or plus succinate...
Source: Amino Acids - September 28, 2023 Category: Biochemistry Authors: Maurizio Ragni Luca Canciani Letizia Spataro Chiara Ruocco Alessandra Valerio Enzo Nisoli Source Type: research
An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts
Amino Acids. 2023 Sep 28. doi: 10.1007/s00726-023-03340-y. Online ahead of print.ABSTRACTIn the human body, the skin is one of the organs most affected by the aging process. Nutritional approaches aimed to counteract the age-induced decline of extracellular matrix (ECM) deposition could be a valuable tool to decrease the degenerative processes underlying skin aging. Here, we investigated the ability of a six-amino acid plus hyaluronic acid (6AAH) formulation enriched with tricarboxylic acid (TCA) intermediates to stimulate ECM gene expression. To this aim, human BJ fibroblasts were treated with 6AAH alone or plus succinate...
Source: Amino Acids - September 28, 2023 Category: Biochemistry Authors: Maurizio Ragni Luca Canciani Letizia Spataro Chiara Ruocco Alessandra Valerio Enzo Nisoli Source Type: research
Sodium pyruvate improves the plasma amino acid profile in rats with L-arginine-induced acute pancreatitis
This study investigated the effect of sodium pyruvate on pancreatic morphology and plasma amino acid levels in rats with acute pancreatitis. Acute pancreatitis in rats was induced by administration of L-arginine (5 g/kg) Experimental treatment group received sodium pyruvate (1 g/kg) for 4 days. On day 8 of the experiment, animals were killed, blood was collected and plasma amino acid concentration was determined with high-performance liquid chromatography. Histological examination showed large areas of fibrosis in the pancreas of animals treated with L-arginine irrespectively of sodium pyruvate administration. Sodium pyruv...
Source: Amino Acids - September 27, 2023 Category: Biochemistry Authors: Anastasiia M Zub Roman D Ostapiv Bohdan O Manko Volodymyr V Manko Source Type: research
