Phenolic compounds as potential adenosine deaminase inhibitors: molecular docking and dynamics simulation coupled with MM-GBSA calculations
This study provides insights into the possible inhibitory potential of these phenolic compounds against ADA.PMID:37517044 | DOI:10.1007/s00726-023-03310-4 (Source: Amino Acids)
Source: Amino Acids - July 30, 2023 Category: Biochemistry Authors: Abdullahi Ibrahim Uba Nicholas Joseph Paradis Chun Wu Gokhan Zengin Source Type: research
Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects
In this study, we investigated the status of amino acids, their post-translational modifications (PTM), major nitric oxide (NO) metabolites and of malondialdehyde (MDA) as a biomarker of oxidative stress in serum and urine samples of long COVID (LoCo, n = 124) and ex COVID (ExCo, n = 24) human subjects collected in 2022. Amino acids and metabolites were measured by gas chromatography-mass spectrometry (GC-MS) methods using stable-isotope labelled analogs as internal standards. There were no differences with respect to circulating and excretory arginine and asymmetric dimethylarginine (ADMA). LoCo participants excreted high...
Source: Amino Acids - July 29, 2023 Category: Biochemistry Authors: Marie Mikuteit Svetlana Baskal Sandra Klawitter Alexandra Dopfer-Jablonka Georg M N Behrens Frank M üller Dominik Schr öder Frank Klawonn Sandra Steffens Dimitrios Tsikas Source Type: research
Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects
In this study, we investigated the status of amino acids, their post-translational modifications (PTM), major nitric oxide (NO) metabolites and of malondialdehyde (MDA) as a biomarker of oxidative stress in serum and urine samples of long COVID (LoCo, n = 124) and ex COVID (ExCo, n = 24) human subjects collected in 2022. Amino acids and metabolites were measured by gas chromatography-mass spectrometry (GC-MS) methods using stable-isotope labelled analogs as internal standards. There were no differences with respect to circulating and excretory arginine and asymmetric dimethylarginine (ADMA). LoCo participants excreted high...
Source: Amino Acids - July 29, 2023 Category: Biochemistry Authors: Marie Mikuteit Svetlana Baskal Sandra Klawitter Alexandra Dopfer-Jablonka Georg M N Behrens Frank M üller Dominik Schr öder Frank Klawonn Sandra Steffens Dimitrios Tsikas Source Type: research
CSC01 shows promise as a potential inhibitor of the oncogenic G13D mutant of KRAS: an in silico approach
Amino Acids. 2023 Jul 27. doi: 10.1007/s00726-023-03304-2. Online ahead of print.ABSTRACTAbout 30% of malignant tumors include KRAS mutations, which are frequently required for the development and maintenance of malignancies. KRAS is now a top-priority cancer target as a result. After years of research, it is now understood that the oncogenic KRAS-G12C can be targeted. However, many other forms, such as the G13D mutant, are yet to be addressed. Here, we used a receptor-based pharmacophore modeling technique to generate potential inhibitors of the KRAS-G13D oncogenic mutant. Using a comprehensive virtual screening workflow ...
Source: Amino Acids - July 27, 2023 Category: Biochemistry Authors: Olanrewaju Ayodeji Durojaye Umer Ejaz Henrietta Onyinye Uzoeto Adeola Abraham Fadahunsi Adebayo Oluwole Opabunmi Daniel Emmanuel Ekpo Divine Mensah Sedzro Mukhtar Oluwaseun Idris Source Type: research
CSC01 shows promise as a potential inhibitor of the oncogenic G13D mutant of KRAS: an in silico approach
Amino Acids. 2023 Jul 27. doi: 10.1007/s00726-023-03304-2. Online ahead of print.ABSTRACTAbout 30% of malignant tumors include KRAS mutations, which are frequently required for the development and maintenance of malignancies. KRAS is now a top-priority cancer target as a result. After years of research, it is now understood that the oncogenic KRAS-G12C can be targeted. However, many other forms, such as the G13D mutant, are yet to be addressed. Here, we used a receptor-based pharmacophore modeling technique to generate potential inhibitors of the KRAS-G13D oncogenic mutant. Using a comprehensive virtual screening workflow ...
Source: Amino Acids - July 27, 2023 Category: Biochemistry Authors: Olanrewaju Ayodeji Durojaye Umer Ejaz Henrietta Onyinye Uzoeto Adeola Abraham Fadahunsi Adebayo Oluwole Opabunmi Daniel Emmanuel Ekpo Divine Mensah Sedzro Mukhtar Oluwaseun Idris Source Type: research
Common alterations in plasma free amino acid profiles and gut microbiota-derived tryptophan metabolites of five types of cancer patients
This study provides evidence that common alterations of the metabolites mentioned above suggest their role in the pathogenesis of each cancer patient. It was suggested that multivariate models based on PFAA profiles and tryptophan metabolites might be applicable in the screening of cancer patients.PMID:37490156 | DOI:10.1007/s00726-023-03308-y (Source: Amino Acids)
Source: Amino Acids - July 25, 2023 Category: Biochemistry Authors: Ahad Hussain Li Xie Guozhe Deng Xuejun Kang Source Type: research
Common alterations in plasma free amino acid profiles and gut microbiota-derived tryptophan metabolites of five types of cancer patients
This study provides evidence that common alterations of the metabolites mentioned above suggest their role in the pathogenesis of each cancer patient. It was suggested that multivariate models based on PFAA profiles and tryptophan metabolites might be applicable in the screening of cancer patients.PMID:37490156 | DOI:10.1007/s00726-023-03308-y (Source: Amino Acids)
Source: Amino Acids - July 25, 2023 Category: Biochemistry Authors: Ahad Hussain Li Xie Guozhe Deng Xuejun Kang Source Type: research
Common alterations in plasma free amino acid profiles and gut microbiota-derived tryptophan metabolites of five types of cancer patients
This study provides evidence that common alterations of the metabolites mentioned above suggest their role in the pathogenesis of each cancer patient. It was suggested that multivariate models based on PFAA profiles and tryptophan metabolites might be applicable in the screening of cancer patients.PMID:37490156 | DOI:10.1007/s00726-023-03308-y (Source: Amino Acids)
Source: Amino Acids - July 25, 2023 Category: Biochemistry Authors: Ahad Hussain Li Xie Guozhe Deng Xuejun Kang Source Type: research
Serum amino acid profiles in patients with myasthenia gravis
In conclusion, amino acids may be involved in mechanisms underlying myasthenia gravis pathogenesis as well as may be potential biomarkers in MG patients diagnosis. However, considering the multifactorial, heterogenous and complex nature of this disease, validation on a larger study sample in further research is required before application into diagnostic practice.PMID:37474707 | DOI:10.1007/s00726-023-03303-3 (Source: Amino Acids)
Source: Amino Acids - July 20, 2023 Category: Biochemistry Authors: Piotr Ko śliński Łukasz Rzepiński Emilia Daghir-Wojtkowiak Marcin Koba Zdzis ław Maciejek Source Type: research
Serum amino acid profiles in patients with myasthenia gravis
In conclusion, amino acids may be involved in mechanisms underlying myasthenia gravis pathogenesis as well as may be potential biomarkers in MG patients diagnosis. However, considering the multifactorial, heterogenous and complex nature of this disease, validation on a larger study sample in further research is required before application into diagnostic practice.PMID:37474707 | DOI:10.1007/s00726-023-03303-3 (Source: Amino Acids)
Source: Amino Acids - July 20, 2023 Category: Biochemistry Authors: Piotr Ko śliński Łukasz Rzepiński Emilia Daghir-Wojtkowiak Marcin Koba Zdzis ław Maciejek Source Type: research
Serum amino acid profiles in patients with myasthenia gravis
In conclusion, amino acids may be involved in mechanisms underlying myasthenia gravis pathogenesis as well as may be potential biomarkers in MG patients diagnosis. However, considering the multifactorial, heterogenous and complex nature of this disease, validation on a larger study sample in further research is required before application into diagnostic practice.PMID:37474707 | DOI:10.1007/s00726-023-03303-3 (Source: Amino Acids)
Source: Amino Acids - July 20, 2023 Category: Biochemistry Authors: Piotr Ko śliński Łukasz Rzepiński Emilia Daghir-Wojtkowiak Marcin Koba Zdzis ław Maciejek Source Type: research
Serum amino acid profiles in patients with myasthenia gravis
In conclusion, amino acids may be involved in mechanisms underlying myasthenia gravis pathogenesis as well as may be potential biomarkers in MG patients diagnosis. However, considering the multifactorial, heterogenous and complex nature of this disease, validation on a larger study sample in further research is required before application into diagnostic practice.PMID:37474707 | DOI:10.1007/s00726-023-03303-3 (Source: Amino Acids)
Source: Amino Acids - July 20, 2023 Category: Biochemistry Authors: Piotr Ko śliński Łukasz Rzepiński Emilia Daghir-Wojtkowiak Marcin Koba Zdzis ław Maciejek Source Type: research
Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy
Amino Acids. 2023 Jul 14. doi: 10.1007/s00726-023-03301-5. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) can promote the occurrence of end-stage renal disease (ESRD). The injury of renal tubular epithelial cells is a significant reason for the occurrence of ESRD. A recent research demonstrated that ferroptosis was associated with renal tubular injury in DN. Ferroptosis is a kind of cell death brought on by the buildup of iron ions and lipid peroxidation brought on by ROS. Because carnosine (CAR) is a scavenger of iron ions and reactive oxygen species, we investigated whether CAR can improve DN by regulating ferro...
Source: Amino Acids - July 14, 2023 Category: Biochemistry Authors: Song Zhang Yuanyuan Li Xueqi Liu Shanshan Guo Ling Jiang Yuebo Huang Yonggui Wu Source Type: research
Influence of amino acid and N-terminal protection residue structures on peptide p-nitroanilide adsorption on polystyrene-based support
Amino Acids. 2023 Jul 14. doi: 10.1007/s00726-023-03302-4. Online ahead of print.ABSTRACTPolystyrene-based support Bio-Beads® SM-2 was employed for desalting peptide-p-nitroanilides from Oxone®. Neither tosyl, 9-fluorenyl(methoxycarbonyl), p-nitroanilide groups nor indolyl or p-hydroxyphenyl side-chains of Trp and Tyr ensured an efficient adsorption of peptide-p-nitroanilides onto Bio-Beads® SM-2. Only unsubstituted phenyl-containing protection groups (carbobenzoxy or benzoyl) and Phe residues provided the adsorption of peptides on Bio-Beads® SM-2 and their efficient desalting. This support is well suitable for multipl...
Source: Amino Acids - July 14, 2023 Category: Biochemistry Authors: Alena V Kolesnichenko Nathalia A Kazmina Alexey A Chistov Roman G Vakhrenev Ekaterina F Kolesanova Source Type: research
Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy
Amino Acids. 2023 Jul 14. doi: 10.1007/s00726-023-03301-5. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) can promote the occurrence of end-stage renal disease (ESRD). The injury of renal tubular epithelial cells is a significant reason for the occurrence of ESRD. A recent research demonstrated that ferroptosis was associated with renal tubular injury in DN. Ferroptosis is a kind of cell death brought on by the buildup of iron ions and lipid peroxidation brought on by ROS. Because carnosine (CAR) is a scavenger of iron ions and reactive oxygen species, we investigated whether CAR can improve DN by regulating ferro...
Source: Amino Acids - July 14, 2023 Category: Biochemistry Authors: Song Zhang Yuanyuan Li Xueqi Liu Shanshan Guo Ling Jiang Yuebo Huang Yonggui Wu Source Type: research
