Amino acid-stimulated insulin secretion: a path forward in type 2 diabetes
Amino Acids. 2023 Nov 15. doi: 10.1007/s00726-023-03352-8. Online ahead of print.ABSTRACTQualitative and quantitatively appropriate insulin secretion is essential for optimal control of blood glucose. Beta-cells of the pancreas produce and secrete insulin in response to glucose and non-glucose stimuli including amino acids. In this manuscript, we review the literature on amino acid-stimulated insulin secretion in oral and intravenous in vivo studies, in addition to the in vitro literature, and describe areas of consensus and gaps in understanding. We find promising evidence that the synergism of amino acid-stimulated insul...
Source: Amino Acids - November 15, 2023 Category: Biochemistry Authors: Jelena Kolic WenQing Grace Sun James D Johnson Nicola Guess Source Type: research
Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials
Amino Acids. 2023 Nov 10. doi: 10.1007/s00726-023-03354-6. Online ahead of print.ABSTRACTL-Arg is a nonessential amino acid but has many physiological roles. Accordingly, L-Arg has been used in various fields, but there is only limited information available about its safety upon overdose. Generally, the no-observed adverse effect level (NOAEL) is used when setting the upper amount for chemical substances. Recently, systematic reviews have been used to assess the safety as well as the effectiveness and usefulness of them. Therefore, we conducted an assessment of the safety of the oral intake of L-Arg in healthy subjects usi...
Source: Amino Acids - November 10, 2023 Category: Biochemistry Authors: Yui Kuramochi Mai Murata Akihide Sumino Hideko Sone Kohsuke Hayamizu Source Type: research
Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials
Amino Acids. 2023 Nov 10. doi: 10.1007/s00726-023-03354-6. Online ahead of print.ABSTRACTL-Arg is a nonessential amino acid but has many physiological roles. Accordingly, L-Arg has been used in various fields, but there is only limited information available about its safety upon overdose. Generally, the no-observed adverse effect level (NOAEL) is used when setting the upper amount for chemical substances. Recently, systematic reviews have been used to assess the safety as well as the effectiveness and usefulness of them. Therefore, we conducted an assessment of the safety of the oral intake of L-Arg in healthy subjects usi...
Source: Amino Acids - November 10, 2023 Category: Biochemistry Authors: Yui Kuramochi Mai Murata Akihide Sumino Hideko Sone Kohsuke Hayamizu Source Type: research
Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials
Amino Acids. 2023 Nov 10. doi: 10.1007/s00726-023-03354-6. Online ahead of print.ABSTRACTL-Arg is a nonessential amino acid but has many physiological roles. Accordingly, L-Arg has been used in various fields, but there is only limited information available about its safety upon overdose. Generally, the no-observed adverse effect level (NOAEL) is used when setting the upper amount for chemical substances. Recently, systematic reviews have been used to assess the safety as well as the effectiveness and usefulness of them. Therefore, we conducted an assessment of the safety of the oral intake of L-Arg in healthy subjects usi...
Source: Amino Acids - November 10, 2023 Category: Biochemistry Authors: Yui Kuramochi Mai Murata Akihide Sumino Hideko Sone Kohsuke Hayamizu Source Type: research
Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials
Amino Acids. 2023 Nov 10. doi: 10.1007/s00726-023-03354-6. Online ahead of print.ABSTRACTL-Arg is a nonessential amino acid but has many physiological roles. Accordingly, L-Arg has been used in various fields, but there is only limited information available about its safety upon overdose. Generally, the no-observed adverse effect level (NOAEL) is used when setting the upper amount for chemical substances. Recently, systematic reviews have been used to assess the safety as well as the effectiveness and usefulness of them. Therefore, we conducted an assessment of the safety of the oral intake of L-Arg in healthy subjects usi...
Source: Amino Acids - November 10, 2023 Category: Biochemistry Authors: Yui Kuramochi Mai Murata Akihide Sumino Hideko Sone Kohsuke Hayamizu Source Type: research
Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials
Amino Acids. 2023 Nov 10. doi: 10.1007/s00726-023-03354-6. Online ahead of print.ABSTRACTL-Arg is a nonessential amino acid but has many physiological roles. Accordingly, L-Arg has been used in various fields, but there is only limited information available about its safety upon overdose. Generally, the no-observed adverse effect level (NOAEL) is used when setting the upper amount for chemical substances. Recently, systematic reviews have been used to assess the safety as well as the effectiveness and usefulness of them. Therefore, we conducted an assessment of the safety of the oral intake of L-Arg in healthy subjects usi...
Source: Amino Acids - November 10, 2023 Category: Biochemistry Authors: Yui Kuramochi Mai Murata Akihide Sumino Hideko Sone Kohsuke Hayamizu Source Type: research
Potential of milk-derived bioactive peptides as antidiabetic, antihypertensive, and xanthine oxidase inhibitors: a comprehensive bibliometric analysis and updated review
In this study, reports of the activity of BPs isolated from milk with the potential glycemic control, antihypertensive activity, and inhibitors of uric acid formation were compiled. A systematic literature review and bibliometric analysis were conducted, using the PICO strategy for the research. The temporal analysis of publications revealed a growing interest in the investigation of bioactive peptides with potential antidiabetic, antihypertensive, and xanthine oxidase inhibitory activities, using dairy sources as products for their extraction. The literature analysis also revealed an increase in research involving non-bov...
Source: Amino Acids - November 8, 2023 Category: Biochemistry Authors: Emyr Hiago Bellaver Aniela Pinto Kempka Source Type: research
Potential of milk-derived bioactive peptides as antidiabetic, antihypertensive, and xanthine oxidase inhibitors: a comprehensive bibliometric analysis and updated review
In this study, reports of the activity of BPs isolated from milk with the potential glycemic control, antihypertensive activity, and inhibitors of uric acid formation were compiled. A systematic literature review and bibliometric analysis were conducted, using the PICO strategy for the research. The temporal analysis of publications revealed a growing interest in the investigation of bioactive peptides with potential antidiabetic, antihypertensive, and xanthine oxidase inhibitory activities, using dairy sources as products for their extraction. The literature analysis also revealed an increase in research involving non-bov...
Source: Amino Acids - November 8, 2023 Category: Biochemistry Authors: Emyr Hiago Bellaver Aniela Pinto Kempka Source Type: research
Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus
This study aimed to measure KP metabolite levels in patients with SLE and investigate the relationship between disease activity, clinical findings, and KP. The study included 100 patients with SLE and 100 healthy controls. Serum tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), quinolinic acid (QA) concentrations were measured with tandem mass spectrometry. Serum KYN, KYNA, 3HAA, 3HK, and QA levels of the patients with SLE were significantly higher than the control group. Serum QA levels were elevated in patients with neurological involvement (four patie...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Duygu Eryavuz Onmaz Dilek Tezcan Sema Yilmaz Mustafa Onmaz Ali Unlu Source Type: research
Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer's disease therapeutics
Amino Acids. 2023 Nov 5. doi: 10.1007/s00726-023-03355-5. Online ahead of print.ABSTRACTDisruptions to iron metabolism and iron homeostasis have emerged as significant contributors to the development and progression of Alzheimer's disease (AD). Human transferrin plays a key part in maintaining iron equilibrium throughout the body, highlighting its importance in AD. Many plant-derived compounds and dietary constituents show promise for preventing AD. Polyphenols that are abundant in fruits, vegetables, teas, coffee, and herbs possess neuroprotective attributes. Resveratrol is a natural polyphenol present in various plant so...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Mohd Shahnawaz Khan Mohammad Furkan Moyad Shahwan Dharmendra Kumar Yadav Saleha Anwar Rizwan Hasan Khan Anas Shamsi Source Type: research
Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus
This study aimed to measure KP metabolite levels in patients with SLE and investigate the relationship between disease activity, clinical findings, and KP. The study included 100 patients with SLE and 100 healthy controls. Serum tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), quinolinic acid (QA) concentrations were measured with tandem mass spectrometry. Serum KYN, KYNA, 3HAA, 3HK, and QA levels of the patients with SLE were significantly higher than the control group. Serum QA levels were elevated in patients with neurological involvement (four patie...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Duygu Eryavuz Onmaz Dilek Tezcan Sema Yilmaz Mustafa Onmaz Ali Unlu Source Type: research
Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer's disease therapeutics
Amino Acids. 2023 Nov 5. doi: 10.1007/s00726-023-03355-5. Online ahead of print.ABSTRACTDisruptions to iron metabolism and iron homeostasis have emerged as significant contributors to the development and progression of Alzheimer's disease (AD). Human transferrin plays a key part in maintaining iron equilibrium throughout the body, highlighting its importance in AD. Many plant-derived compounds and dietary constituents show promise for preventing AD. Polyphenols that are abundant in fruits, vegetables, teas, coffee, and herbs possess neuroprotective attributes. Resveratrol is a natural polyphenol present in various plant so...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Mohd Shahnawaz Khan Mohammad Furkan Moyad Shahwan Dharmendra Kumar Yadav Saleha Anwar Rizwan Hasan Khan Anas Shamsi Source Type: research
Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus
This study aimed to measure KP metabolite levels in patients with SLE and investigate the relationship between disease activity, clinical findings, and KP. The study included 100 patients with SLE and 100 healthy controls. Serum tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), quinolinic acid (QA) concentrations were measured with tandem mass spectrometry. Serum KYN, KYNA, 3HAA, 3HK, and QA levels of the patients with SLE were significantly higher than the control group. Serum QA levels were elevated in patients with neurological involvement (four patie...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Duygu Eryavuz Onmaz Dilek Tezcan Sema Yilmaz Mustafa Onmaz Ali Unlu Source Type: research
Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer's disease therapeutics
Amino Acids. 2023 Nov 5. doi: 10.1007/s00726-023-03355-5. Online ahead of print.ABSTRACTDisruptions to iron metabolism and iron homeostasis have emerged as significant contributors to the development and progression of Alzheimer's disease (AD). Human transferrin plays a key part in maintaining iron equilibrium throughout the body, highlighting its importance in AD. Many plant-derived compounds and dietary constituents show promise for preventing AD. Polyphenols that are abundant in fruits, vegetables, teas, coffee, and herbs possess neuroprotective attributes. Resveratrol is a natural polyphenol present in various plant so...
Source: Amino Acids - November 5, 2023 Category: Biochemistry Authors: Mohd Shahnawaz Khan Mohammad Furkan Moyad Shahwan Dharmendra Kumar Yadav Saleha Anwar Rizwan Hasan Khan Anas Shamsi Source Type: research
Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches
Amino Acids. 2023 Nov 2. doi: 10.1007/s00726-023-03350-w. Online ahead of print.ABSTRACTβ-Lactoglobulin is one of the proteins in milk possessing antioxidant activity. The peptides derived from β-Lactoglobulin exhibit higher antioxidant activities than the most commonly used antioxidant. Furthermore, the detailed structure-activity relationship of these antioxidant peptides has not been elucidated. Therefore, in the present work, two-dimensional quantitative structure-activity relationship (2D-QSAR) and three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed to investigate the str...
Source: Amino Acids - November 2, 2023 Category: Biochemistry Authors: Fangfang Wang Menghao Wen Bo Zhou Source Type: research
