Investigation of encapsulated water wire within self-assembled hydrophilic nanochannels, in a modified γ < sup > 4 < /sup > -amino acid crystals: Tracking thermally induced changes of intermolecular interactions within a crystalline hydrate
Amino Acids. 2024 Feb 5;56(1):9. doi: 10.1007/s00726-023-03372-4.ABSTRACTNanostructures formed by the self-assembly of modified/unmodified amino acids have the potential to be useful in several biological/nonbiological applications. In that regard, the greater conformational space provided by γ-amino acids, owing to their additional backbone torsional degrees of freedom and enhanced proteolytic stability, compared to their α-counterparts, should be explored. Though, modified single amino acid-based nanomaterials such as nanobelts or hydrogels are developed by utilizing the monosubstituted γ-amino acids derived from the ...
Source: Amino Acids - February 5, 2024 Category: Biochemistry Authors: Krishnayan Basuroy Jose de Jesus Velazquez-Garcia Simone Techert Source Type: research

Investigating metabolic dysregulation in serum of triple transgenic Alzheimer's disease male mice: implications for pathogenesis and potential biomarkers
This study provides novel insights into the dysregulation of several key metabolites and metabolic pathways in AD, presenting potential avenues for future research and the development of peripheral biomarkers.PMID:38315232 | PMC:PMC10844422 | DOI:10.1007/s00726-023-03375-1 (Source: Amino Acids)
Source: Amino Acids - February 5, 2024 Category: Biochemistry Authors: Hongbin Zhuang Xueshan Cao Xiaoxiao Tang Yongdong Zou Hongbo Yang Zhiyuan Liang Xi Yan Xiaolu Chen Xingui Feng Liming Shen Source Type: research

The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults
Amino Acids. 2024 Feb 5;56(1):8. doi: 10.1007/s00726-023-03377-z.ABSTRACTPlant-derived proteins are generally believed to possess lesser anabolic properties when compared with animal-derived proteins. This is, at least partly, attributed to the lower leucine content of most plant-derived proteins. Corn protein has a leucine content that is highest among most plant-derived proteins and it even exceeds the levels observed in animal-derived proteins such as whey protein. Therefore, this study aimed to compare muscle protein synthesis rates following the ingestion of 30 g corn protein and a 30 g blend of corn plus milk protein...
Source: Amino Acids - February 5, 2024 Category: Biochemistry Authors: Philippe J M Pinckaers Michelle E G Weijzen Lisanne H P Houben Antoine H Zorenc Imre W K Kouw Lisette C P G M de Groot Lex B Verdijk Tim Snijders Luc J C van Loon Source Type: research

The dual role of autophagy in the regulation of cancer treatment
This article provides a summary of the recent advances regarding the dual and different mechanisms of autophagy-mediated therapeutic efficacy in cancer.PMID:38310598 | PMC:PMC10838838 | DOI:10.1007/s00726-023-03364-4 (Source: Amino Acids)
Source: Amino Acids - February 4, 2024 Category: Biochemistry Authors: Louis Boafo Kwantwi Source Type: research

D-Amino acids differentially trigger an inflammatory environment in vitro
Amino Acids. 2024 Feb 3;56(1):6. doi: 10.1007/s00726-023-03360-8.ABSTRACTStudies in vivo have demonstrated that the accumulation of D-amino acids (D-AAs) is associated with age-related diseases and increased immune activation. However, the underlying mechanism(s) of these observations are not well defined. The metabolism of D-AAs by D-amino oxidase (DAO) produces hydrogen peroxide (H2O2), a reactive oxygen species involved in several physiological processes including immune response, cell differentiation, and proliferation. Excessive levels of H2O2 contribute to oxidative stress and eventual cell death, a characteristic of...
Source: Amino Acids - February 3, 2024 Category: Biochemistry Authors: Siew Hwei Yap Cheng Siang Lee Nur Diyana Zulkifli Darshinie Suresh Kenji Hamase Kumitaa Theva Das Reena Rajasuriar Kok Hoong Leong Source Type: research

Molecular properties of linear amino acids in water
Amino Acids. 2024 Feb 1;56(1):5. doi: 10.1007/s00726-023-03365-3.ABSTRACTFour linear amino acids of increased separation of the carboxyl and amino groups, namely glycine (aminoacetic acid), β-alanine (3-aminopropanoic acid), GABA (4-aminobutanoic acid) and DAVA (5-aminopentanoic acid), have been studied by quantum chemical ab initio and DFT methods including the solvent effect in order to get electronic structure and molecular descriptors, such as ionisation energy, electron affinity, molecular electronegativity, chemical hardness, electrophilicity index, dipole moment, quadrupole moment and dipole polarizability. Thermod...
Source: Amino Acids - February 1, 2024 Category: Biochemistry Authors: Roman Bo ča Richard Imrich Juraj Štofko Be áta Vranovičová Cyril Rajn ák Source Type: research

Amino acid distribution in blood following high-intensity interval exercise: a preliminary study
This study investigated the effect of high-intensity interval exercise on total and individual amino acid concentrations in red blood cells (RBCs) and plasma. Seven males (31 ± 13 yr) provided venous blood samples at rest, immediately and 15 min and 30 min following an 8-min high-intensity exercise bout. The exercise bout was 16 × 15 s cycle efforts at 0.4N/kg of body mass and 90 rpm, interspersed with 15 s passive recovery. Total and individual amino acid concentrations of RBC and plasma and blood cell parameters were analysed. No significant differences for total amino acid concentrations between RBC and plasma were fo...
Source: Amino Acids - February 1, 2024 Category: Biochemistry Authors: Nattai Borges Thomas M Doering Grace Murphy Margaret Macdonald Richard H Dunstan Source Type: research

Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents
This study aims to assess the potential of these radiolabeled peptides as targeting agents for breast cancer. The three peptides were synthesized using the Fmoc strategy, purified via reversed-phase high-performance liquid chromatography (RP-HPLC), and characterized through mass spectrometry. Iodine-131 (131I) radiolabeling was performed using the chloramine T method, exhibiting high radiochemical yield and stability for [131I]I-YIKVAV and [131I]I-YIGSR. Conversely, [131I]I-KAFDITYVRLKF demonstrated low radiochemical yield and stability and was excluded from the biological studies. The lipophilicity of the compounds ranged...
Source: Amino Acids - January 29, 2024 Category: Biochemistry Authors: Fernanda Ferreira Mendon ça Danielle Vieira Sobral Ana Claudia Ranucci Durante Ana Cl áudia Camargo Miranda Jorge Mejia Daniele de Paula Faria Fabio Luiz Navarro Marques Marycel Figols de Barboza Leonardo Lima Fuscaldi Luciana Malavolta Source Type: research

Heat shock interferes with the amino acid metabolism of bovine cumulus-oocyte complexes in vitro: a multistep analysis
This study aimed to determine how heat shock (HS) during in vitro maturation affected the ability of the bovine cumulus-oocyte complexes (COCs) to develop, as well as their metabolism of amino acids (AAs). In this study, COCs were in vitro matured for 23 h at 38.5 °C (control; n = 322), 39.5 °C (mild HS (MHS); n = 290), or 40.5 °C (severe HS (SHS); n = 245). In comparison to the control group, the MHS and SHS groups significantly decreased the percentage of metaphase-II oocytes, as well as cumulus cell expansion and viability. The SHS decreased the rates of cleavage and blastocyst formation in comparison to the control ...
Source: Amino Acids - January 29, 2024 Category: Biochemistry Authors: Hayder Radhi Hussein Mzedawee Rasoul Kowsar Reza Moradi-Hajidavaloo Roya Shiasi-Sardoabi Khaled Sadeghi Mohammad Hossein Nasr-Esfahani Mehdi Hajian Source Type: research

Structure determination needs to go viral
Amino Acids. 2024 Jan 29;56(1):3. doi: 10.1007/s00726-023-03374-2.ABSTRACTViral diseases are expected to cause new epidemics in the future, therefore, it is essential to assess how viral diversity is represented in terms of deposited protein structures. Here, data were collected from the Protein Data Bank to screen the available structures of viruses of interest to WHO. Excluding SARS-CoV-2 and HIV-1, less than 50 structures were found per year, indicating a lack of diversity. Efforts to determine viral structures are needed to increase preparedness for future public health challenges.PMID:38286913 | PMC:PMC10824879 | DOI:...
Source: Amino Acids - January 29, 2024 Category: Biochemistry Authors: Matheus de Bastos Balbe E Gutierres Conrado Pedebos Paula Bacaicoa-Caruso Rodrigo Ligabue-Braun Source Type: research

Publisher's Note: Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
Amino Acids. 2023 Dec;55(12):1727. doi: 10.1007/s00726-023-03358-2.NO ABSTRACTPMID:38040960 | DOI:10.1007/s00726-023-03358-2 (Source: Amino Acids)
Source: Amino Acids - December 1, 2023 Category: Biochemistry Source Type: research

Publisher's Note: Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
Amino Acids. 2023 Dec;55(12):1727. doi: 10.1007/s00726-023-03358-2.NO ABSTRACTPMID:38040960 | DOI:10.1007/s00726-023-03358-2 (Source: Amino Acids)
Source: Amino Acids - December 1, 2023 Category: Biochemistry Source Type: research

Publisher's Note: Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
Amino Acids. 2023 Dec;55(12):1727. doi: 10.1007/s00726-023-03358-2.NO ABSTRACTPMID:38040960 | DOI:10.1007/s00726-023-03358-2 (Source: Amino Acids)
Source: Amino Acids - December 1, 2023 Category: Biochemistry Source Type: research

Publisher's Note: Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
Amino Acids. 2023 Dec;55(12):1727. doi: 10.1007/s00726-023-03358-2.NO ABSTRACTPMID:38040960 | DOI:10.1007/s00726-023-03358-2 (Source: Amino Acids)
Source: Amino Acids - December 1, 2023 Category: Biochemistry Source Type: research

Publisher's Note: Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
Amino Acids. 2023 Dec;55(12):1727. doi: 10.1007/s00726-023-03358-2.NO ABSTRACTPMID:38040960 | DOI:10.1007/s00726-023-03358-2 (Source: Amino Acids)
Source: Amino Acids - December 1, 2023 Category: Biochemistry Source Type: research