Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03316-y. Online ahead of print.ABSTRACTCancer malignancies may broadly be described as heterogeneous disorders manifested by uncontrolled cellular growth/division and proliferation. Tumor cells utilize metabolic reprogramming to accomplish the upregulated nutritional requirements for sustaining their uncontrolled growth, proliferation, and survival. Metabolic reprogramming also called altered or dysregulated metabolism undergoes modification in normal metabolic pathways for anabolic precursor's generation that serves to continue biomass formation that sustains the growth, p...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Dalong Liu Yun Wang Xiaojiang Li Yan Wang Zhiqiang Zhang Zhifeng Wang Xudong Zhang Source Type: research
Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03318-w. Online ahead of print.ABSTRACTGuanidino compounds such as dimethylarginines (SDMA, ADMA) and L-homoarginine ((L-)hArg) can interfere with bioavailability and function of the main NO-donor L-arginine (L-Arg). High ADMA and SDMA but low L-hArg concentrations have been associated with cardio- and cerebrovascular events and mortality in adults. The role of guanidino compounds in paediatric patients remains less clear. We, therefore, compared guanidino compound levels in plasma samples of 57 individuals with chronic kidney disease (CKD) and 141 individuals without CKD f...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Florence Baach Boglarka Meyer Jun Oh Susanne Lezius Rainer B öger Edzard Schwedhelm Chi-Un Choe Axel Neu Source Type: research
Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03316-y. Online ahead of print.ABSTRACTCancer malignancies may broadly be described as heterogeneous disorders manifested by uncontrolled cellular growth/division and proliferation. Tumor cells utilize metabolic reprogramming to accomplish the upregulated nutritional requirements for sustaining their uncontrolled growth, proliferation, and survival. Metabolic reprogramming also called altered or dysregulated metabolism undergoes modification in normal metabolic pathways for anabolic precursor's generation that serves to continue biomass formation that sustains the growth, p...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Dalong Liu Yun Wang Xiaojiang Li Yan Wang Zhiqiang Zhang Zhifeng Wang Xudong Zhang Source Type: research
Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03318-w. Online ahead of print.ABSTRACTGuanidino compounds such as dimethylarginines (SDMA, ADMA) and L-homoarginine ((L-)hArg) can interfere with bioavailability and function of the main NO-donor L-arginine (L-Arg). High ADMA and SDMA but low L-hArg concentrations have been associated with cardio- and cerebrovascular events and mortality in adults. The role of guanidino compounds in paediatric patients remains less clear. We, therefore, compared guanidino compound levels in plasma samples of 57 individuals with chronic kidney disease (CKD) and 141 individuals without CKD f...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Florence Baach Boglarka Meyer Jun Oh Susanne Lezius Rainer B öger Edzard Schwedhelm Chi-Un Choe Axel Neu Source Type: research
Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03316-y. Online ahead of print.ABSTRACTCancer malignancies may broadly be described as heterogeneous disorders manifested by uncontrolled cellular growth/division and proliferation. Tumor cells utilize metabolic reprogramming to accomplish the upregulated nutritional requirements for sustaining their uncontrolled growth, proliferation, and survival. Metabolic reprogramming also called altered or dysregulated metabolism undergoes modification in normal metabolic pathways for anabolic precursor's generation that serves to continue biomass formation that sustains the growth, p...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Dalong Liu Yun Wang Xiaojiang Li Yan Wang Zhiqiang Zhang Zhifeng Wang Xudong Zhang Source Type: research
Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03318-w. Online ahead of print.ABSTRACTGuanidino compounds such as dimethylarginines (SDMA, ADMA) and L-homoarginine ((L-)hArg) can interfere with bioavailability and function of the main NO-donor L-arginine (L-Arg). High ADMA and SDMA but low L-hArg concentrations have been associated with cardio- and cerebrovascular events and mortality in adults. The role of guanidino compounds in paediatric patients remains less clear. We, therefore, compared guanidino compound levels in plasma samples of 57 individuals with chronic kidney disease (CKD) and 141 individuals without CKD f...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Florence Baach Boglarka Meyer Jun Oh Susanne Lezius Rainer B öger Edzard Schwedhelm Chi-Un Choe Axel Neu Source Type: research
Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03316-y. Online ahead of print.ABSTRACTCancer malignancies may broadly be described as heterogeneous disorders manifested by uncontrolled cellular growth/division and proliferation. Tumor cells utilize metabolic reprogramming to accomplish the upregulated nutritional requirements for sustaining their uncontrolled growth, proliferation, and survival. Metabolic reprogramming also called altered or dysregulated metabolism undergoes modification in normal metabolic pathways for anabolic precursor's generation that serves to continue biomass formation that sustains the growth, p...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Dalong Liu Yun Wang Xiaojiang Li Yan Wang Zhiqiang Zhang Zhifeng Wang Xudong Zhang Source Type: research
Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence
Amino Acids. 2023 Aug 30. doi: 10.1007/s00726-023-03318-w. Online ahead of print.ABSTRACTGuanidino compounds such as dimethylarginines (SDMA, ADMA) and L-homoarginine ((L-)hArg) can interfere with bioavailability and function of the main NO-donor L-arginine (L-Arg). High ADMA and SDMA but low L-hArg concentrations have been associated with cardio- and cerebrovascular events and mortality in adults. The role of guanidino compounds in paediatric patients remains less clear. We, therefore, compared guanidino compound levels in plasma samples of 57 individuals with chronic kidney disease (CKD) and 141 individuals without CKD f...
Source: Amino Acids - August 30, 2023 Category: Biochemistry Authors: Florence Baach Boglarka Meyer Jun Oh Susanne Lezius Rainer B öger Edzard Schwedhelm Chi-Un Choe Axel Neu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
