Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Amino Acids. 2023 Aug 15. doi: 10.1007/s00726-023-03311-3. Online ahead of print.ABSTRACTGut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between microbiota and epithelium in the metabolism of amino acids with neuroactive properties remains unclear in the colon of piglets. To investigate the microbial and epithelial metabolism, metagenomics and mucosal metabolomics were performed using colonic samples from 12 ileum-canulated piglets subjected to a 25-day infusion with saline or antibiotics. We categorized 23 metabolites derived from the ...
Source: Amino Acids - August 15, 2023 Category: Biochemistry Authors: Ziyu Liu Chunlong Mu Weiyun Zhu Source Type: research
Research progress on the role of cationic amino acid transporter (CAT) family members in malignant tumors and immune microenvironment
Amino Acids. 2023 Aug 12. doi: 10.1007/s00726-023-03313-1. Online ahead of print.ABSTRACTAmino acids are essential for the survival of all living organisms and living cells. Amino acid transporters mediate the transport and absorption of amino acids, and the dysfunction of these proteins can induce human diseases. Cationic amino acid transporters (CAT family, SLC7A1-4, and SLC7A14) are considered to be a group of transmembrane transporters, of which SLC7A1-3 are essential for arginine transport in mammals. Numerous studies have shown that CAT family-mediated arginine transport is involved in signal crosstalk between malign...
Source: Amino Acids - August 12, 2023 Category: Biochemistry Authors: Shijing You Xiahui Han Yuance Xu Qin Yao Source Type: research
Research progress on the role of cationic amino acid transporter (CAT) family members in malignant tumors and immune microenvironment
Amino Acids. 2023 Aug 12. doi: 10.1007/s00726-023-03313-1. Online ahead of print.ABSTRACTAmino acids are essential for the survival of all living organisms and living cells. Amino acid transporters mediate the transport and absorption of amino acids, and the dysfunction of these proteins can induce human diseases. Cationic amino acid transporters (CAT family, SLC7A1-4, and SLC7A14) are considered to be a group of transmembrane transporters, of which SLC7A1-3 are essential for arginine transport in mammals. Numerous studies have shown that CAT family-mediated arginine transport is involved in signal crosstalk between malign...
Source: Amino Acids - August 12, 2023 Category: Biochemistry Authors: Shijing You Xiahui Han Yuance Xu Qin Yao Source Type: research
Research progress on the role of cationic amino acid transporter (CAT) family members in malignant tumors and immune microenvironment
Amino Acids. 2023 Aug 12. doi: 10.1007/s00726-023-03313-1. Online ahead of print.ABSTRACTAmino acids are essential for the survival of all living organisms and living cells. Amino acid transporters mediate the transport and absorption of amino acids, and the dysfunction of these proteins can induce human diseases. Cationic amino acid transporters (CAT family, SLC7A1-4, and SLC7A14) are considered to be a group of transmembrane transporters, of which SLC7A1-3 are essential for arginine transport in mammals. Numerous studies have shown that CAT family-mediated arginine transport is involved in signal crosstalk between malign...
Source: Amino Acids - August 12, 2023 Category: Biochemistry Authors: Shijing You Xiahui Han Yuance Xu Qin Yao Source Type: research
Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)
Amino Acids. 2023 Aug 7. doi: 10.1007/s00726-023-03312-2. Online ahead of print.ABSTRACTThe amphibian family Leptodactylidae is divided into three sub-families: Leiuperinae, Leptodactylinae, and Paratelmatobiinae. Host-defense peptides (HDPs) present in the skins of frogs belonging to the Leptodactylinae have been studied extensively, but information is limited regarding peptides from Leiuperinae species. Peptidomic analysis of norepinephrine-stimulated skin secretions from the Tungara frog Engystomops pustulosus (Leiuperinae) collected in Trinidad led to the isolation and structural characterization of previously undescri...
Source: Amino Acids - August 7, 2023 Category: Biochemistry Authors: J Michael Conlon Laure Guilhaudis Samir Attoub Laurent Coquet J érôme Leprince Thierry Jouenne Milena Mechkarska Source Type: research
Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)
Amino Acids. 2023 Aug 7. doi: 10.1007/s00726-023-03312-2. Online ahead of print.ABSTRACTThe amphibian family Leptodactylidae is divided into three sub-families: Leiuperinae, Leptodactylinae, and Paratelmatobiinae. Host-defense peptides (HDPs) present in the skins of frogs belonging to the Leptodactylinae have been studied extensively, but information is limited regarding peptides from Leiuperinae species. Peptidomic analysis of norepinephrine-stimulated skin secretions from the Tungara frog Engystomops pustulosus (Leiuperinae) collected in Trinidad led to the isolation and structural characterization of previously undescri...
Source: Amino Acids - August 7, 2023 Category: Biochemistry Authors: J Michael Conlon Laure Guilhaudis Samir Attoub Laurent Coquet J érôme Leprince Thierry Jouenne Milena Mechkarska Source Type: research
Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)
Amino Acids. 2023 Aug 7. doi: 10.1007/s00726-023-03312-2. Online ahead of print.ABSTRACTThe amphibian family Leptodactylidae is divided into three sub-families: Leiuperinae, Leptodactylinae, and Paratelmatobiinae. Host-defense peptides (HDPs) present in the skins of frogs belonging to the Leptodactylinae have been studied extensively, but information is limited regarding peptides from Leiuperinae species. Peptidomic analysis of norepinephrine-stimulated skin secretions from the Tungara frog Engystomops pustulosus (Leiuperinae) collected in Trinidad led to the isolation and structural characterization of previously undescri...
Source: Amino Acids - August 7, 2023 Category: Biochemistry Authors: J Michael Conlon Laure Guilhaudis Samir Attoub Laurent Coquet J érôme Leprince Thierry Jouenne Milena Mechkarska Source Type: research
Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)
Amino Acids. 2023 Aug 7. doi: 10.1007/s00726-023-03312-2. Online ahead of print.ABSTRACTThe amphibian family Leptodactylidae is divided into three sub-families: Leiuperinae, Leptodactylinae, and Paratelmatobiinae. Host-defense peptides (HDPs) present in the skins of frogs belonging to the Leptodactylinae have been studied extensively, but information is limited regarding peptides from Leiuperinae species. Peptidomic analysis of norepinephrine-stimulated skin secretions from the Tungara frog Engystomops pustulosus (Leiuperinae) collected in Trinidad led to the isolation and structural characterization of previously undescri...
Source: Amino Acids - August 7, 2023 Category: Biochemistry Authors: J Michael Conlon Laure Guilhaudis Samir Attoub Laurent Coquet J érôme Leprince Thierry Jouenne Milena Mechkarska Source Type: research
Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)
Amino Acids. 2023 Aug 7. doi: 10.1007/s00726-023-03312-2. Online ahead of print.ABSTRACTThe amphibian family Leptodactylidae is divided into three sub-families: Leiuperinae, Leptodactylinae, and Paratelmatobiinae. Host-defense peptides (HDPs) present in the skins of frogs belonging to the Leptodactylinae have been studied extensively, but information is limited regarding peptides from Leiuperinae species. Peptidomic analysis of norepinephrine-stimulated skin secretions from the Tungara frog Engystomops pustulosus (Leiuperinae) collected in Trinidad led to the isolation and structural characterization of previously undescri...
Source: Amino Acids - August 7, 2023 Category: Biochemistry Authors: J Michael Conlon Laure Guilhaudis Samir Attoub Laurent Coquet J érôme Leprince Thierry Jouenne Milena Mechkarska Source Type: research
Optimizing the synthesis of dimeric peptides: influence of the reaction medium and effects that modulate kinetics and reaction yield
Amino Acids. 2023 Aug 6. doi: 10.1007/s00726-023-03309-x. Online ahead of print.ABSTRACTPeptides are remarkably interesting alternatives to several applications. In particular, antimicrobial sequences have raised major interest of the scientific community due to the resistance acquired by commonly used antibiotics. Amongst these, some dimeric peptides have shown very promising characteristics as strong biological activities and resistance against degradation by peptidases. However, despite such promising characteristics, a relatively small number of studies address dimeric peptides, mainly due to the synthesis-related obst...
Source: Amino Acids - August 6, 2023 Category: Biochemistry Authors: Carlos F R C Guimar ães Amanda S F élix Tiago A S Brand ão Marcelo P Bemquerer Dorila Pil ó-Veloso Rodrigo M Verly Jarbas M Resende Source Type: research
Comparison of homocitrulline and carbamylated albumin as biomarkers of carbamylation reactions in hemodialyzed patients
Amino Acids. 2023 Aug 2. doi: 10.1007/s00726-023-03306-0. Online ahead of print.ABSTRACTTo describe the association between levels of homocitrulline (HCit) and the degree of albumin carbamylation in a cohort of hemodialyzed patients. Plasma total and protein-bound HCit concentrations in samples from hemodialyzed patients included in NICOREN trial were determined by LC-MS/MS at baseline and after 24 weeks of treatment with either sevelamer or nicotinamide. HCit concentrations at all timepoints and in both groups were positively and significantly correlated with the degree of albumin carbamylation. Plasma concentrations of t...
Source: Amino Acids - August 2, 2023 Category: Biochemistry Authors: Aurelie Lenglet St éphane Jaisson Philippe Gillery Souleiman El Balkhi Sophie Liabeuf Ziad A Massy Source Type: research
