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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Role of ROS-mediated PERK/ATF4 signaling activation in extracorporeal tube formation injury of human umbilical vein endothelial cells induced by cooking oil fume PM < sub > 2.5 < /sub > exposure
This study aimed to investigate the role of ROS-mediated PERK/ATF4 signaling activation in COF-PM2.5-inhibited extracorporeal tube formation in human umbilical vein endothelial cells (HUVECs). HUVECs were treated with 100 μg/mL COF-PM2.5 at different times, with or without 100 nM PERK activity inhibitor GSK2606414 (GSK) or 200 μM antioxidant N-acetylcysteine (NAC) pretreatment. Our results showed that COF-PM2.5 exposure can inhibit extracorporeal tube formation and down-regulate VEGFR2 expression in HUVECs. Furthermore, our data indicated that COF-PM2.5 exposure can activate the PERK/ATF4 signaling in HUVECs. Mechanistic...
Source: Ecotoxicology and Environmental Safety - August 23, 2023 Category: Environmental Health Authors: Shu Sun Chao Zhang Qi Zhang Changlian Li Dan Huang Rui Ding Jiyu Cao Jiahu Hao Source Type: research
Oxidative stress as a key event in 2,6-dichloro-1,4-benzoquinone-induced neurodevelopmental toxicity
Ecotoxicol Environ Saf. 2023 Aug 18;263:115357. doi: 10.1016/j.ecoenv.2023.115357. Online ahead of print.ABSTRACT2,6-dichloro-1,4-benzoquinone (DCBQ) has been identified as an emerging disinfection byproducts (DBPs) in drinking water and has the potential to induce neurodevelopmental toxicity. However, there is rarely a comprehensive toxicological evaluation of the neurodevelopmental toxicity of DCBQ. Here, neural differentiating SH-SY5Y cells were used as an in vitro model. Our results have found that DCBQ has decreased cell viability and neural differentiation, generated higher level of reactive oxygen species (ROS), inc...
Source: Ecotoxicology and Environmental Safety - August 20, 2023 Category: Environmental Health Authors: Ting Liu Xin Chen Wanling Li Xu Zhang Gaihua Wang Jun Wang Lanqian Liang Fan Yang Juan Li Jinhua Li Source Type: research
Hexachlorocyclohexane impairs human sperm motility by affecting lysine glutarylation and mitochondrial functions
In conclusion, we propose that HCH inhibits sperm Kglu, leading to the disruption of mitochondrial energy metabolism, which in turn adversely affects sperm motility.PMID:37595880 | DOI:10.1016/j.fct.2023.113991
Source: Food and Chemical Toxicology - August 18, 2023 Category: Food Science Authors: Liu Yang Guangquan Mei Yebin Yang Jiajun Cui Shenglin Peng Zhen Peng Yimin Cheng Source Type: research
Copper nanoclusters electrochemiluminescence with tunable near-infrared emission wavelength for ultrasensitive detection of matrix metalloproteinase-2
Biosens Bioelectron. 2023 Aug 9;238:115580. doi: 10.1016/j.bios.2023.115580. Online ahead of print.ABSTRACTHerein, the methionine (Met)/N-acetyl-L-cysteine (NAC) templated copper nanoclusters (Met/NAC-Cu NCs) with tunable near-infrared region (NIR) electrochemiluminescence (ECL) emission wavelength was firstly synthesized as emitter for the ultrasensitive detection of matrix metalloproteinase-2 (MMP-2). Significantly, the NAC played the role of template and reductant of cupric to acquire Cu NCs, and the surface defect regulator Met was used to connect NAC through -S-S- bond, which could heighten the surface defect of Cu NC...
Source: Biosensors and Bioelectronics - August 18, 2023 Category: Biotechnology Authors: Xiaochun Zhu Yuxi Song Xiaofeng Wang Ying Zhou Yaqin Chai Ruo Yuan Source Type: research
Tranexamic acid improves psoriasis-like skin inflammation: Evidence from in vivo and in vitro studies
Biomed Pharmacother. 2023 Aug 11;166:115307. doi: 10.1016/j.biopha.2023.115307. Online ahead of print.ABSTRACTThe chronic disease psoriasis is associated with severe inflammation and abnormal keratinocyte propagation in the skin. Tranexamic acid (TXA), a plasmin inhibitor, is used to cure serious bleeding. We investigated whether TXA ointment mitigated Imiquimod (IMQ)-induced psoriasis-like inflammation. Furthermore, this study investigated the effect of noncytotoxic concentrations of TXA on IL-17-induced human keratinocyte (HaCaT) cells to determine the status of proliferative psoriatic keratinocytes. We found that TXA re...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 13, 2023 Category: Drugs & Pharmacology Authors: Jhih-Hsuan Hseu Chon-I Chan Chithravel Vadivalagan Siang-Jyun Chen Hung-Rong Yen You-Cheng Hseu Hsin-Ling Yang Po-Yuan Wu Source Type: research
Glucose Deprivation Induces Cancer Cell Death through Failure of ROS Regulation
Conclusion is clear that glucose deprivation-induced cell death is independent from ATP depletion-induced cell death.PMID:37569345 | DOI:10.3390/ijms241511969
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Mingyu Kang Joon H Kang In A Sim Do Y Seong Suji Han Hyonchol Jang Ho Lee Sang W Kang Soo-Youl Kim Source Type: research
Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus-Induced Mitochondrial Damage
CONCLUSIONS: Current study indicates that the mitochondrial fragmentation induced by hepatitis B virus infection can be reduced after antioxidant treatment pointing toward exploring better drug targets for the prevention of hepatitis B virus-induced mitochondrial frag- mentation and associated liver damage.PMID:37565795 | DOI:10.5152/tjg.2023.21290
Source: The Turkish Journal of Gastroenterology - August 11, 2023 Category: Gastroenterology Authors: Kehkshan Jabeen Aneela Javed Sobia Manzoor Shaheen Shahzad Source Type: research
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2
In this study, the mRNA of Control group, Ang II group, ATH-1 group and Losartan group mice were sequenced by high-throughput sequencing technology. The results showed that the differentially expressed genes (DEGs) were significantly enriched in cell response to oxidative stress, regulation of reactive oxygen species metabolism and calmodulin binding. Then, the oxidation level of mouse hearts and H9c2 cardiomyocytes in each group and the expression of key proteins of CaMKII/HDAC/MEF2C and ERK1/2 signaling pathways were detected to preliminarily verify the positive effect of ATH-1. At the same time, the effect of ATH-1 was ...
Source: European Journal of Pharmacology - August 11, 2023 Category: Drugs & Pharmacology Authors: Xi Zheng Fuxiang Su Ming Lei Jingyuan Li Chenyang Zhang Yujia Zhang Ming Wei Wei Li Sichong Chen Yunzhu Liu Qinghua Gao Liying Hao Source Type: research
Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus-Induced Mitochondrial Damage
CONCLUSIONS: Current study indicates that the mitochondrial fragmentation induced by hepatitis B virus infection can be reduced after antioxidant treatment pointing toward exploring better drug targets for the prevention of hepatitis B virus-induced mitochondrial frag- mentation and associated liver damage.PMID:37565795 | DOI:10.5152/tjg.2023.21290
Source: The Turkish Journal of Gastroenterology - August 11, 2023 Category: Gastroenterology Authors: Kehkshan Jabeen Aneela Javed Sobia Manzoor Shaheen Shahzad Source Type: research
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2
In this study, the mRNA of Control group, Ang II group, ATH-1 group and Losartan group mice were sequenced by high-throughput sequencing technology. The results showed that the differentially expressed genes (DEGs) were significantly enriched in cell response to oxidative stress, regulation of reactive oxygen species metabolism and calmodulin binding. Then, the oxidation level of mouse hearts and H9c2 cardiomyocytes in each group and the expression of key proteins of CaMKII/HDAC/MEF2C and ERK1/2 signaling pathways were detected to preliminarily verify the positive effect of ATH-1. At the same time, the effect of ATH-1 was ...
Source: European Journal of Pharmacology - August 11, 2023 Category: Drugs & Pharmacology Authors: Xi Zheng Fuxiang Su Ming Lei Jingyuan Li Chenyang Zhang Yujia Zhang Ming Wei Wei Li Sichong Chen Yunzhu Liu Qinghua Gao Liying Hao Source Type: research
Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus-Induced Mitochondrial Damage
CONCLUSIONS: Current study indicates that the mitochondrial fragmentation induced by hepatitis B virus infection can be reduced after antioxidant treatment pointing toward exploring better drug targets for the prevention of hepatitis B virus-induced mitochondrial frag- mentation and associated liver damage.PMID:37565795 | DOI:10.5152/tjg.2023.21290
Source: The Turkish Journal of Gastroenterology - August 11, 2023 Category: Gastroenterology Authors: Kehkshan Jabeen Aneela Javed Sobia Manzoor Shaheen Shahzad Source Type: research
