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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis
Anal Sci. 2023 Aug 26. doi: 10.1007/s44211-023-00415-4. Online ahead of print.ABSTRACTA new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated, while validation was carried out in the linearity detection range (0.0075-0.02%). As a result, excellent linearity (R2 > 0.99) and pre...
Source: Anal Sci - August 26, 2023 Category: Chemistry Authors: Hung-Yu Chen Richie L C Chen Bo-Chuan Hsieh Tzong-Jih Cheng Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
Potential Use of Antioxidant Compounds for the Treatment of Inflammatory Bowel Disease
Pharmaceuticals (Basel). 2023 Aug 14;16(8):1150. doi: 10.3390/ph16081150.ABSTRACTSince inflammatory bowel diseases (IBDs) are chronic, the development of new effective therapeutics to combat them does not lose relevance. Oxidative stress is one of the main pathological processes that determines the progression of IBD. In this regard, antioxidant therapy seems to be a promising approach. The role of oxidative stress in the development and progression of IBD is considered in detail in this review. The main cause of oxidative stress in IBD is an inadequate response of leukocytes to dysbiosis and food components in the intesti...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Alexander V Blagov Varvara A Orekhova Vasily N Sukhorukov Alexandra A Melnichenko Alexander N Orekhov Source Type: research
Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis
Anal Sci. 2023 Aug 26. doi: 10.1007/s44211-023-00415-4. Online ahead of print.ABSTRACTA new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated, while validation was carried out in the linearity detection range (0.0075-0.02%). As a result, excellent linearity (R2 > 0.99) and pre...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - August 26, 2023 Category: Chemistry Authors: Hung-Yu Chen Richie L C Chen Bo-Chuan Hsieh Tzong-Jih Cheng Source Type: research
Potential Use of Antioxidant Compounds for the Treatment of Inflammatory Bowel Disease
Pharmaceuticals (Basel). 2023 Aug 14;16(8):1150. doi: 10.3390/ph16081150.ABSTRACTSince inflammatory bowel diseases (IBDs) are chronic, the development of new effective therapeutics to combat them does not lose relevance. Oxidative stress is one of the main pathological processes that determines the progression of IBD. In this regard, antioxidant therapy seems to be a promising approach. The role of oxidative stress in the development and progression of IBD is considered in detail in this review. The main cause of oxidative stress in IBD is an inadequate response of leukocytes to dysbiosis and food components in the intesti...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Alexander V Blagov Varvara A Orekhova Vasily N Sukhorukov Alexandra A Melnichenko Alexander N Orekhov Source Type: research
Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis
Anal Sci. 2023 Aug 26. doi: 10.1007/s44211-023-00415-4. Online ahead of print.ABSTRACTA new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated, while validation was carried out in the linearity detection range (0.0075-0.02%). As a result, excellent linearity (R2 > 0.99) and pre...
Source: Anal Sci - August 26, 2023 Category: Chemistry Authors: Hung-Yu Chen Richie L C Chen Bo-Chuan Hsieh Tzong-Jih Cheng Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis
Anal Sci. 2023 Aug 26. doi: 10.1007/s44211-023-00415-4. Online ahead of print.ABSTRACTA new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated, while validation was carried out in the linearity detection range (0.0075-0.02%). As a result, excellent linearity (R2 > 0.99) and pre...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - August 26, 2023 Category: Chemistry Authors: Hung-Yu Chen Richie L C Chen Bo-Chuan Hsieh Tzong-Jih Cheng Source Type: research
Efficacy of treatment with N-acetylcysteine inhalation for AECOPD: A propensity-score-matched cohort study
CONCLUSION: NAC inhalation is associated with an improved clinical outcome. A further study should be conducted to confirm the clinical usefulness of NAC inhalation in AECOPD patients.PMID:37621062 | DOI:10.1111/crj.13690
Source: Respiratory Care - August 25, 2023 Category: Respiratory Medicine Authors: Hengyi Chen Hui Zhou Chen Luo Kaican Zong Yingya Fu Wen Li Chunyan Luo Guojuan Xue E Jiang Yang Duan Tinglan Luo Yangzhi Jiang Source Type: research
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
Eur J Pharmacol. 2023 Aug 23:176004. doi: 10.1016/j.ejphar.2023.176004. Online ahead of print.ABSTRACTSmall molecule drugs are of significant importance in the treatment of non-small cell lung cancer (NSCLC). Here, we explored biological effects of the PI3K/mTOR inhibitor VS-5584 on NSCLC. Our findings indicated that VS-5584 administration resulted in a dose-dependent inhibition of NSCLC cell proliferation, as well as the induction of apoptosis and cycle arrest. Additionally, we observed a significant increase in intracellular reactive oxygen species (ROS) levels following VS-5584 treatment. The use of the ROS inhibitor N-...
Source: European Journal of Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Senxia Zhao Yibin Li Gang Li Juanping Ye Rong Wang Xiaoting Zhang Fei Li Chang Gao Junbiao Li Jie Jiang Yanjun Mi Source Type: research
Acrolein induces mitochondrial dysfunction and insulin resistance in muscle and adipose tissues in vitro and in vivo
This study demonstrated that acrolein increased oxidative stress and inhibited mitochondrial respiration in differentiated C2C12 myotubes and differentiated 3T3-L1 adipocytes. As a result, insulin signaling pathways were inhibited, leading to reduced glucose uptake. Treatment with acrolein scavengers, N-acetylcysteine, or carnosine ameliorated mitochondrial dysfunction and inhibited insulin signaling. Additionally, an increase in acrolein expression correlated with mitochondrial dysfunction in the muscle and adipose tissues of diabetic mice. These findings suggest that acrolein-induced mitochondrial dysfunction contributes...
Source: Environmental Pollution - August 25, 2023 Category: Environmental Health Authors: Jia-Yu Jhuo Zhen-Jie Tong Pei-Hsuan Ku Hsiao-Wei Cheng Hsiang-Tsui Wang Source Type: research
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) protects hair cells from cisplatin-induced ototoxicity in vitro: possible relation to the activities of p38 MAPK signaling pathway
Arch Toxicol. 2023 Aug 22. doi: 10.1007/s00204-023-03588-z. Online ahead of print.ABSTRACTThe 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) gene encodes rate-limiting enzyme in cholesterol biosynthesis, which is related to cell proliferation and mitochondrial function. The present study was designed to explore the expression of HMGCR in murine cochlear hair cells and HEI-OC1 cells and the possible mechanisms underpinning the actions of HMGCR in cisplatin-induced ototoxicity, with special attention given to p38 mitogen-activated protein kinase (MAPK) activities in vitro. The expressions of HMGCR, p-p38, ...
Source: Archives of Toxicology - August 23, 2023 Category: Toxicology Authors: Yanan Li Huiming Yang Huiming Nong Fan Wang Yajie Wang Yue Xu Junhong Zhang Hao Zhao Zhixin Cao Qianqian Yang Jianfeng Li Source Type: research
