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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
ROS inhibition increases KDM6A-mediated NOX2 transcription and promotes macrophages oxidative stress and M1 polarization
In this study, lipopolysaccharide (LPS) was used to stimulate macrophages to increase the ROS in cells, and N-acetylcysteine (NAC) was used to reduce ROS. Inflammatory factors such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) were used to evaluate the M1 polarization level of macrophages. Chip was used to detect the tri-methylation at lysine 27 of histone H3 (H3K27me3) level at the promoter site. It was found that the decrease of ROS in macrophages would also cause the increase of the H3K27me3 demethylase KDM6A and lead to the reduction of H3K27me3 in the NOX2 promoter, which wou...
Source: Cell Stress and Chaperones - May 4, 2023 Category: Cytology Authors: Yunxi Zhao Luyang Wang Mingwei Liu Anning Du Ming Qiu Huanyu Shu Lu Li Xiangqing Kong Wei Sun Source Type: research
Intravenous n-acetylcysteine to prevent cisplatin-induced hearing loss in children: a nonrandomized controlled phase 1 trial
CONCLUSION: NAC was safe at the RP2D with strong evidence for efficacy to prevent CIHL, warranting further development as a next-generation otoprotectant.TRIAL NUMBER: NCT02094625.PMID:37134194 | DOI:10.1158/1078-0432.CCR-23-0252
Source: Clinical Cancer Research - May 3, 2023 Category: Cancer & Oncology Authors: Etan Orgel Kristin R Knight Yueh-Yun Chi Jemily Malvar Teresa Rushing Victoria Mena Laurie S Eisenberg Shahrad R Rassekh Colin Jd Ross Erika N Scott Michael Neely Edward A Neuwelt Leslie L Muldoon David R Freyer Source Type: research
TCF12 regulates exosome release from epirubicin-treated CAFs to promote ER+ breast cancer cell chemoresistance
In this study, we showed that epirubicin (EPI) treatment triggered ROS which initiated autophagy in CAFs, TCF12 inhibited autophagy flux and further promoted exosome secretion. Inhibition of EPI-induced reactive oxygen species (ROS) production with N-acetyl-L-cysteine (NAC) or suppression of autophagic initiation with short interfering RNA (siRNA) against ATG5 blunted exosome release from CAFs. Furthermore, exosome secreted from EPI-treated CAFs not only prevented ROS accumulation in CAFs but also upregulated the CXCR4 and c-Myc protein levels in recipient ER+ breast cancer cells, thus promoting EPI resistance of tumor cel...
Source: Biochimica et Biophysica Acta - May 3, 2023 Category: Biochemistry Authors: Yuxiang Qiu Xing Wang Yan Sun Yan-E Du Guobing Yin Haojun Luo Siyang Wen Lei Lang Manran Liu Xi Tang Source Type: research
Elevated LDL (Low-Density Lipoprotein) Cholesterol Increases Microvascular Endothelial VWF (von Willebrand Factor) and Thromboinflammation After Myocardial Infarction
CONCLUSIONS: In reperfused myocardial infarction, elevated LDL cholesterol promotes thromboinflammation through excess microvascular endothelial VWF and platelet adhesion, resulting in less microvascular reflow and larger infarct size. In the presence of elevated LDL cholesterol, therapies that suppress endothelial-associated VWF can promote recovery of left ventricular function and protect against remodeling.PMID:37128919 | DOI:10.1161/ATVBAHA.122.318884
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2023 Category: Cardiology Authors: Koya Ozawa William Packwood Oleg Varlamov Matthew Muller Aris Xie Melinda D Wu Rue-Jen Abraham-Fan Jos é A López Jonathan R Lindner Source Type: research
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
CONCLUSIONS: Melatonin combined with erastin exhibits synergistic anticancer effects without adverse reactions. Herein, this combination might become a promising alternative strategy for oral cancer treatment.PMID:37131152 | PMC:PMC10155313 | DOI:10.1186/s11658-023-00449-6
Source: Mol Biol Cell - May 2, 2023 Category: Molecular Biology Authors: Leilei Wang Chuan Wang Xuan Li Zhuoying Tao Wangyong Zhu Yuxiong Su Wing Shan Choi Source Type: research
Elevated LDL (Low-Density Lipoprotein) Cholesterol Increases Microvascular Endothelial VWF (von Willebrand Factor) and Thromboinflammation After Myocardial Infarction
CONCLUSIONS: In reperfused myocardial infarction, elevated LDL cholesterol promotes thromboinflammation through excess microvascular endothelial VWF and platelet adhesion, resulting in less microvascular reflow and larger infarct size. In the presence of elevated LDL cholesterol, therapies that suppress endothelial-associated VWF can promote recovery of left ventricular function and protect against remodeling.PMID:37128919 | DOI:10.1161/ATVBAHA.122.318884
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2023 Category: Cardiology Authors: Koya Ozawa William Packwood Oleg Varlamov Matthew Muller Aris Xie Melinda D Wu Rue-Jen Abraham-Fan Jos é A López Jonathan R Lindner Source Type: research
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
CONCLUSIONS: Melatonin combined with erastin exhibits synergistic anticancer effects without adverse reactions. Herein, this combination might become a promising alternative strategy for oral cancer treatment.PMID:37131152 | PMC:PMC10155313 | DOI:10.1186/s11658-023-00449-6
Source: Cellular and Molecular Biology Letters - May 2, 2023 Category: Biochemistry Authors: Leilei Wang Chuan Wang Xuan Li Zhuoying Tao Wangyong Zhu Yuxiong Su Wing Shan Choi Source Type: research
