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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Structure-guided approach to modify the substrate specificity of the protein human deglycase-1 (hDJ-1)
Biochem Biophys Res Commun. 2023 Sep 1;679:122-128. doi: 10.1016/j.bbrc.2023.08.058. Online ahead of print.ABSTRACTGlycation is a non-enzymatic reaction wherein sugars or dicarbonyls such as methylglyoxal (MGO) and glyoxal (GO) react with proteins, leading to protein inactivation. The hydrolysing enzyme human deglycase-1 (hDJ-1) is reported to decrease glycative stress by deglycating the modified proteins, specifically at cysteine, lysine, and arginine sites. This specificity of hDJ-1 is thought to be regulated by its active site cysteine residue (Cys106). Structural analysis of hDJ-1 by molecular docking and simulation st...
Source: Biochemical and Biophysical Research communications - September 9, 2023 Category: Biochemistry Authors: Sera A Fernandes Subrata Dasgupta Rashmi S Tupe Ejaj K Pathan Source Type: research
N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury
This study aimed to evaluate whether N-acetylcysteine (NAC) has hepatoprotective effects against ADR-induced hepatotoxicity in rats. In addition, it was aimed to determine how Meteorin-Like (MtrnL), which has pleiotropic effects on immunology, inflammation, and metabolism, is affected by ADR and/or NAC applications in liver tissue. 28 rats were randomly assigned to one of four equal groups in the study: control (no treatment), NAC (150 mg/kg/day of NAC intraperitoneally (i.p), ADR (15 mg/kg only on the first day of the experiment), and ADR + NAC (ADR 15 mg/kg on the first day of the experiment + 150 mg/kg/day NAC i.p). Aft...
Source: Cell Stress and Chaperones - September 5, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Ahmet Tektemur Tuncay Kulo ğlu Source Type: research
Metallothionein Gene Deficiency Facilitates the Differentiation of C2C12 Myoblasts into Slow-Twitch Myotubes
In this study, we investigated the effect of MT1 and MT2 gene knock-out using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) system in an in vitro skeletal muscle differentiation model (C2C12 cell line). MT deficiency promoted myogenic differentiation and myotube formation in C2C12 cells. Muscle-specific transcription factors MyoD and myogenin were found to be upregulated at the late stage of myotube differentiation in MTKO cells. Furthermore, the fast-twitch myosin heavy chain (MyHC) protein expression was similar in MTKO and mock-transfected myotubes, but ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yoshito Kadota Ryo Yamanokuchi Nodoka Ohnishi Mami Matsuoka Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis
In this study, NUF251 stimulated intracellular superoxide radical production in mouse macrophage RAW264.7 cells, which was reduced by N-acetylcysteine. This result suggests that NUF251 infection causes oxidative stress. To evaluate the regulatory mechanism of Jfsod1 at transcriptional levels under oxidative stress induced by NUF251 infection, we cloned and determined the nucleotide sequence (1124 bp) of the 5'-flanking region of the Jfsod1 gene. The sequence analysis demonstrated that the binding sites for the transcription factors C/EBPα and NF-IL6 involved in the transcriptional regulation of the mammalian sod1 gene exi...
Source: Biochimie - September 4, 2023 Category: Biochemistry Authors: Xiao-Mi Sun Asami Yoshida Takuya Ishii Yan-Rong Jiang Yi-Li Gao Mikinori Ueno Katsuya Hirasaka Kiyoshi Osatomi Source Type: research
Metallothionein Gene Deficiency Facilitates the Differentiation of C2C12 Myoblasts into Slow-Twitch Myotubes
In this study, we investigated the effect of MT1 and MT2 gene knock-out using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) system in an in vitro skeletal muscle differentiation model (C2C12 cell line). MT deficiency promoted myogenic differentiation and myotube formation in C2C12 cells. Muscle-specific transcription factors MyoD and myogenin were found to be upregulated at the late stage of myotube differentiation in MTKO cells. Furthermore, the fast-twitch myosin heavy chain (MyHC) protein expression was similar in MTKO and mock-transfected myotubes, but ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yoshito Kadota Ryo Yamanokuchi Nodoka Ohnishi Mami Matsuoka Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis
In this study, NUF251 stimulated intracellular superoxide radical production in mouse macrophage RAW264.7 cells, which was reduced by N-acetylcysteine. This result suggests that NUF251 infection causes oxidative stress. To evaluate the regulatory mechanism of Jfsod1 at transcriptional levels under oxidative stress induced by NUF251 infection, we cloned and determined the nucleotide sequence (1124 bp) of the 5'-flanking region of the Jfsod1 gene. The sequence analysis demonstrated that the binding sites for the transcription factors C/EBPα and NF-IL6 involved in the transcriptional regulation of the mammalian sod1 gene exi...
Source: Biochimie - September 4, 2023 Category: Biochemistry Authors: Xiao-Mi Sun Asami Yoshida Takuya Ishii Yan-Rong Jiang Yi-Li Gao Mikinori Ueno Katsuya Hirasaka Kiyoshi Osatomi Source Type: research
A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis
In conclusion, gestational Sb exposure disrupted oxidative stress homeostasis, thereby impairing growth and development.PMID:37666440 | DOI:10.1016/j.freeradbiomed.2023.09.002
Source: Free Radical Biology and Medicine - September 4, 2023 Category: Biology Authors: Xiaoke Wang Peiyao Zhou Ziyang Zhang Qiuru Huang Xia Chen Li Ji Xinmeng Cheng Yi Shi Shali Yu Juan Tang Chi Sun Xinyuan Zhao Jun Yu Source Type: research
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis
In this study, NUF251 stimulated intracellular superoxide radical production in mouse macrophage RAW264.7 cells, which was reduced by N-acetylcysteine. This result suggests that NUF251 infection causes oxidative stress. To evaluate the regulatory mechanism of Jfsod1 at transcriptional levels under oxidative stress induced by NUF251 infection, we cloned and determined the nucleotide sequence (1124 bp) of the 5'-flanking region of the Jfsod1 gene. The sequence analysis demonstrated that the binding sites for the transcription factors C/EBPα and NF-IL6 involved in the transcriptional regulation of the mammalian sod1 gene exi...
Source: Biochimie - September 4, 2023 Category: Biochemistry Authors: Xiao-Mi Sun Asami Yoshida Takuya Ishii Yan-Rong Jiang Yi-Li Gao Mikinori Ueno Katsuya Hirasaka Kiyoshi Osatomi Source Type: research
A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis
In conclusion, gestational Sb exposure disrupted oxidative stress homeostasis, thereby impairing growth and development.PMID:37666440 | DOI:10.1016/j.freeradbiomed.2023.09.002
Source: Free Radical Biology and Medicine - September 4, 2023 Category: Biology Authors: Xiaoke Wang Peiyao Zhou Ziyang Zhang Qiuru Huang Xia Chen Li Ji Xinmeng Cheng Yi Shi Shali Yu Juan Tang Chi Sun Xinyuan Zhao Jun Yu Source Type: research
Metallothionein Gene Deficiency Facilitates the Differentiation of C2C12 Myoblasts into Slow-Twitch Myotubes
In this study, we investigated the effect of MT1 and MT2 gene knock-out using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) system in an in vitro skeletal muscle differentiation model (C2C12 cell line). MT deficiency promoted myogenic differentiation and myotube formation in C2C12 cells. Muscle-specific transcription factors MyoD and myogenin were found to be upregulated at the late stage of myotube differentiation in MTKO cells. Furthermore, the fast-twitch myosin heavy chain (MyHC) protein expression was similar in MTKO and mock-transfected myotubes, but ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yoshito Kadota Ryo Yamanokuchi Nodoka Ohnishi Mami Matsuoka Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research
Antioxidants stimulate BACH1-dependent tumor angiogenesis
J Clin Invest. 2023 Aug 31:e169671. doi: 10.1172/JCI169671. Online ahead of print.ABSTRACTLung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs); but growing evidence indicate that transcriptional programs beyond HIFs control tumor angiogenesis. Here we show that the redox-sensitive transcription factor BTB and CNC homology 1 (BACH1) controls the transcription of a broad range of angiogenesis genes. BACH1 is stabilized by lowering reactive oxygen species levels; consequently, angiogenesis gene expression in lung cancer cells, tu...
Source: Clinical Lung Cancer - August 31, 2023 Category: Cancer & Oncology Authors: Ting Wang Yongqiang Dong Zhiqiang Huang Guoqing Zhang Ying Zhao Haidong Yao Jianjiang Hu Elin T üksammel Huan Cai Ning Liang Xiufeng Xu Xijie Yang Sarah Schmidt Xi Qiao Susanne Schlisio Staffan Str ömblad Hong Qian Changtao Jiang Eckardt Treuter Martin Source Type: research
Aflatoxin B1-induced early developmental hepatotoxicity in larvae zebrafish
Chemosphere. 2023 Aug 25:139940. doi: 10.1016/j.chemosphere.2023.139940. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is a ubiquitous mycotoxin that causes oxidative damage in various organs. At present, the research studies on AFB1 are primarily focused on its effects on the terrestrial environment and animals. However, its toxicity mechanism in aquatic environments and aquatic animals has not been largely explored. Thus, in this study, zebrafish was used as a model to study the toxicity mechanism of AFB1 on the liver of developing larvae. The results showed that AFB1 exposure inhibited liver development and promoted...
Source: Chemosphere - August 27, 2023 Category: Chemistry Authors: Chi Feng Hongxia Bai Xu Chang Zhixuan Wu Wu Dong Qianqian Ma Jingfeng Yang Source Type: research
