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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Copper metabolism in cell death and autophagy
Autophagy. 2023 Apr 16:1-21. doi: 10.1080/15548627.2023.2200554. Online ahead of print.ABSTRACTCopper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as apoptosis, paraptosis, pyroptosis, ferroptosis, and cuproptosis. Furthermore, copper ions can trigger macroautophagy/autophagy, a lysosome-dependent degradation pathway that plays a dual role in regulating the survival or death fate of cells under various stress conditions. Pathologic...
Source: Autophagy - April 14, 2023 Category: Cytology Authors: Qian Xue Rui Kang Daniel J Klionsky Daolin Tang Jinbao Liu Xin Chen Source Type: research
Hydrogen sulfide protects Sertoli cells against toxicant Acrolein-induced cell injury
Food Chem Toxicol. 2023 Apr 12:113784. doi: 10.1016/j.fct.2023.113784. Online ahead of print.ABSTRACTAcrolein (ACR), a highly toxic α,β-unsaturated aldehyde, is considered to be a common mediator behind the reproductive injury induced by various factors. However, the understanding of its reproductive toxicity and prevention in reproductive system is limited. Given that Sertoli cells provide the first-line defense against various toxicants and that dysfunction of Sertoli cell causes impaired spermatogenesis, we, therefore, examined ACR cytotoxicity in Sertoli cells and tested whether hydrogen sulfide (H2S), a gaseous medi...
Source: Food and Chemical Toxicology - April 14, 2023 Category: Food Science Authors: Zhimin Mao Haitao Li Xiu-Ling Zhao Xu-Hui Zeng Source Type: research
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway
In this study, HepG2 cells were treated with 0.0625, 0.125, 0.25, 0.5 and 1 mM Dibutyl phthalate (DBP) for 48 h to investigate mitochondrial toxicity. The results showed that DBP caused mitochondrial damage, autophagy, apoptosis and necroptosis; Transcriptomics analysis identified that MAPK and PI3K were significant factors in the cytotoxic changes induced by DBP; N-Acetyl-L-cysteine (NAC), SIRT1 activator, ERK inhibitor, p38 inhibitor and ERK siRNA treatments counteracted the changes of SIRT1/PGC-1α and Nrf2 pathway-related proteins, autophagy and necroptotic apoptosis proteins induced by DBP. While PI3K and Nrf2 inhibit...
Source: Food and Chemical Toxicology - April 14, 2023 Category: Food Science Authors: Huan Liu Linjing Xu Lizi Zhou Wenna Han Zhongyi Li Chunhong Liu Source Type: research
Acute administration of myeloid differentiation factor 2 inhibitor and N-acetyl cysteine attenuate brain damage in rats with cardiac ischemia/reperfusion injury
In conclusion, treatment with 2i-10 and a high dose of NAC at the onset of reperfusion alleviated brain inflammation and mitochondrial dysfunction, consequently reducing dendritic spine loss in rats with cardiac I/R injury.PMID:37054769 | DOI:10.1016/j.abb.2023.109598
Source: Archives of Biochemistry and Biophysics - April 13, 2023 Category: Biochemistry Authors: Jirapong Vongsfak Nattayaporn Apaijai Titikorn Chunchai Hiranya Pintana Busarin Arunsak Chayodom Maneechote Kodchanan Singhanat Di Wu Guang Liang Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research
N-acetylcysteine overcomes NF1 loss-driven resistance to PI3K α inhibition in breast cancer
Cell Rep Med. 2023 Apr 4:101002. doi: 10.1016/j.xcrm.2023.101002. Online ahead of print.ABSTRACTA genome-wide PiggyBac transposon-mediated screen and a resistance screen in a PIK3CAH1047R-mutated murine tumor model reveal NF1 loss in mammary tumors resistant to the phosphatidylinositol 3-kinase α (PI3Kα)-selective inhibitor alpelisib. Depletion of NF1 in PIK3CAH1047R breast cancer cell lines and a patient-derived organoid model shows that NF1 loss reduces sensitivity to PI3Kα inhibition and correlates with enhanced glycolysis and lower levels of reactive oxygen species (ROS). Unexpectedly, the antioxidant N-acetylcystei...
Source: Genomics Proteomics ... - April 12, 2023 Category: Genetics & Stem Cells Authors: Priska Auf der Maur Marcel P Trefny Zora Baumann Milica Vulin Ana Luisa Correia Maren Diepenbruck Nicolas Kramer Katrin Volkmann Bogdan-Tiberius Preca Pedro Ramos Cedric Leroy Tobias Eichlisberger Katarzyna Buczak Federica Zilli Ryoko Okamoto Roland Rad M Source Type: research
Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish
Free Radic Biol Med. 2023 Apr 7:S0891-5849(23)00372-6. doi: 10.1016/j.freeradbiomed.2023.04.002. Online ahead of print.ABSTRACTPremature ovarian failure (POF) is characterized as the ovarian dysfunction and defective oocyte development. In POF patients, ROS level is reported to be significantly higher than normal individuals. However, the involvement of oxidative stress in POF and the regulatory mechanisms underlying the antioxidative process in oocyte development remain largely unknown. Here, we discover that oxidation resistance 1a (Oxr1a), the ortholog of mammalian Oxr1, protects the oocytes of female zebrafish against ...
Source: Free Radical Biology and Medicine - April 9, 2023 Category: Biology Authors: Hao Xu Xiaoyu Mao Zhentao Nie Yun Li Source Type: research
Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition
In this study, C57BL/6J male mice were exposed to 0, 5, 50, and 200 mg/kg B.W. of TPHP for 30 d by oral, as well as TM3 cells were treated with 0, 50, 100, and 200 μM of TPHP for 24 h. Results showed that TPHP induced testes damage, including spermatogenesis disorders and testosterone synthesis inhibition. Meanwhile, TPHP can cause apoptosis in testicular Leydig cells and TM3 cells, as evidenced by the increased apoptosis rate and decreased Bcl-2/Bax ratio. Moreover, TPHP disrupted mitochondrial ultrastructure of testicular Leydig cells and TM3 cells, reduced healthy mitochondria content and depressed mitochondrial membra...
Source: Ecotoxicology and Environmental Safety - April 7, 2023 Category: Environmental Health Authors: Minxin Wang Jinyu Xu Zhengbo Zhao Lichao Gong Yu Su Zhichao Fang Pengfei Chen Yifan Liu Lianshuang Zhang Feibo Xu Source Type: research
