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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Protective effects and mechanisms of N-acetylcysteine on indomethacin-induced intestinal injury in a porcine model
This study aimed to investigate the effect of N-acetylcysteine (NAC) on indomethacin (IDMT)-induced intestinal injury in a piglet model and explore the underlying molecular mechanisms. Piglets were randomly divided into 3 treatment groups: (1) control group; (2) IDMT group; (3) NAC+IDMT group. The results showed that NAC administration significantly increased the average daily gain of piglets, attenuated the intestine hyperemia, and restored normal jejunal morphology. Further studies indicated that NAC administration significantly increased plasma citrulline concentration and jejunal villin expression, but decreased the co...
Source: Ecotoxicology and Environmental Safety - June 25, 2023 Category: Environmental Health Authors: Qian Zhang Wenkai Liu Qian Li Yitong Zeng Mengjun Wu Tao Wu Shuangshuang Guo Lei Wang Di Zhao Dan Yi Yongqing Hou Source Type: research
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS < sup > E < /sup >
Xenobiotica. 2023 Jun 19:1-29. doi: 10.1080/00498254.2023.2227976. Online ahead of print.ABSTRACT1. Compound Kushen injection (CKI) is a kind of sterilized water-soluble traditional Chinese medicine preparation that has been used for the clinical treatment of a variety of cancers (hepatocellular carcinoma, lung cancer, etc.) for nineteen years. However, to date, the metabolism-related study on CKI in vivo has not been conducted.2. An integrated analytical strategy was established to investigate the metabolic profile of alkaloids of CKI in rat plasma, urine and feces based on ultra-high performance liquid chromatography-ele...
Source: Xenobiotica - June 19, 2023 Category: Research Authors: Li Zhang Ruijuan Li Ting Zheng Huan Wu Yanyan Yin Source Type: research
Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion
CONCLUSIONS: This is the first large, robust study of the efficacy of IV NAC in respiratory diseases with abnormal mucus secretion. It provides new evidence for IV NAC administration in this indication in clinical situations where the IV route is preferred.PMID:37318485 | DOI:10.26355/eurrev_202306_32628
Source: Pharmacological Reviews - June 15, 2023 Category: Drugs & Pharmacology Authors: W Tang D Zhu F Wu J-F Xu J-P Yang Z-P Deng X-B Chen A Papi J-M Qu Source Type: research
Role of N-acetylcysteine in liver injury due to dengue fever
Trop Doct. 2023 Jun 13:494755231176317. doi: 10.1177/00494755231176317. Online ahead of print.ABSTRACTDengue fever (DF) is a common mosquito-borne viral infection which is endemic in Southeast Asia. Liver involvement may vary from asymptomatic elevation of liver enzymes to fulminant hepatitis. Although the valuable effects of N-acetylcysteine (NAC) in paracetamol toxicity and non-paracetamol liver failure have been extensively studied, its use in DF-associated hepatitis remains unclear. We made a literature search in an online format from libraries such as PubMed, Google Scholar, and EMBASE, and selected 33 articles includ...
Source: Tropical Doctor - June 14, 2023 Category: Tropical Medicine Authors: Monica Gupta Samiksha Gupta Dhriti Sood Akanksha Gupta Gautam Jesrani Source Type: research
Oxidative Stress Induced by Arsenite is Involved in YTHDF2 Phase Separation
Biol Trace Elem Res. 2023 Jun 13. doi: 10.1007/s12011-023-03728-7. Online ahead of print.ABSTRACTYTH N6-methyladenosine RNA binding protein 2 (YTHDF2) undergoes phase separation in response to the stimulation of high concentration of arsenite, suggesting that oxidative stress, the major mechanism of arsenite toxicity, may play a role in YTHDF2 phase separation. However, whether arsenite-induced oxidative stress is involved in phase separation of YTHDF2 has yet to be established. To explore the effect of arsenite-induced oxidative stress on YTHDF2 phase separation, the levels of oxidative stress, YTHDF2 phase separation, an...
Source: Biological Trace Element Research - June 13, 2023 Category: Biology Authors: Jin Man Qian Zhang Tianhe Zhao Donglei Sun Weilian Sun Keyan Long Zunzhen Zhang Source Type: research
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF- κB pathway in macrophages
In this study, the expression of NAT10 in macrophages was found to decrease during LPS-induced inflammation. NAT10 knockdown significantly reduced the generation of inflammatory factors, while NAT10 overexpression had the opposite effect. RNA sequencing revealed that the differentially expressed genes were enriched in the NF-κB signalling pathway and oxidative stress. Both the NF-κB inhibitor Bay11-7082 and the ROS scavenger N-acetyl-L-cysteine (NAC) could reverse the upregulation of inflammatory factors. NAC inhibited the phosphorylation of NF-κB, but Bay11-7082 had no effect on the production of ROS in NAT10-overexpre...
Source: Biochimica et Biophysica Acta - June 12, 2023 Category: Biochemistry Authors: Zhanqi Zhang Yiwen Zhang Yongjie Cai Di Li Jinlin He Zhihui Feng Qiong Xu Source Type: research
Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews
CONCLUSIONS: Despite a considerable increase in included evidence compared with the previous version of this overview, we identified no high-certainty evidence for the effectiveness of any therapy for CRPS. Until larger, high-quality trials are undertaken, formulating an evidence-based approach to managing CRPS will remain difficult. Current non-Cochrane systematic reviews of interventions for CRPS are of low methodological quality and should not be relied upon to provide an accurate and comprehensive summary of the evidence.PMID:37306570 | PMC:PMC10259367 | DOI:10.1002/14651858.CD009416.pub3
Source: Cochrane Database of Systematic Reviews - June 12, 2023 Category: General Medicine Authors: Michael C Ferraro Aidan G Cashin Benedict M Wand Keith M Smart Carolyn Berryman Louise Marston G Lorimer Moseley James H McAuley Neil E O'Connell Source Type: research
Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKC δ activation in the hippocampus of mice: Involvement of antioxidant potential
Food Chem Toxicol. 2023 Jun 10:113869. doi: 10.1016/j.fct.2023.113869. Online ahead of print.ABSTRACTAlthough the anticonvulsant effects of ginsenosides are recognized, little is known about their effects on the convulsive behaviors induced by the activation of L-type Ca2+ channels. Here, we investigated whether ginsenoside Re (GRe) modulates excitotoxicity induced by the L-type Ca2+ channel activator Bay k-8644. GRe significantly attenuated Bay k-8644-induced convulsive behaviors and hippocampal oxidative stress in mice. GRe-mediated antioxidant potential was more pronounced in the mitochondrial fraction than cytosolic fr...
Source: Food and Chemical Toxicology - June 12, 2023 Category: Food Science Authors: Ngoc Kim Cuong Tran Ji Hoon Jeong Naveen Sharma Yen Nhi Doan Nguyen Hoang-Yen Phi Tran Duy-Khanh Dang Jung Hoon Park Jae Kyung Byun Dezhong Jin Zeng Xiaoyan Sung Kwon Ko Seung-Yeol Nah Hyoung-Chun Kim Eun-Joo Shin Source Type: research
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF- κB pathway in macrophages
In this study, the expression of NAT10 in macrophages was found to decrease during LPS-induced inflammation. NAT10 knockdown significantly reduced the generation of inflammatory factors, while NAT10 overexpression had the opposite effect. RNA sequencing revealed that the differentially expressed genes were enriched in the NF-κB signalling pathway and oxidative stress. Both the NF-κB inhibitor Bay11-7082 and the ROS scavenger N-acetyl-L-cysteine (NAC) could reverse the upregulation of inflammatory factors. NAC inhibited the phosphorylation of NF-κB, but Bay11-7082 had no effect on the production of ROS in NAT10-overexpre...
Source: Cell Research - June 12, 2023 Category: Cytology Authors: Zhanqi Zhang Yiwen Zhang Yongjie Cai Di Li Jinlin He Zhihui Feng Qiong Xu Source Type: research
