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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia
Autophagy. 2023 Jul 13:1-15. doi: 10.1080/15548627.2023.2230839. Online ahead of print.ABSTRACTThe selective autophagic degradation of mitochondria via mitophagy is essential for preserving mitochondrial homeostasis and, thereby, disease maintenance and progression in acute myeloid leukemia (AML). Mitophagy is orchestrated by a variety of mitophagy receptors whose interplay is not well understood. Here, we established a pairwise multiplexed CRISPR screen targeting mitophagy receptors to elucidate redundancies and gain a deeper understanding of the functional interactome governing mitophagy in AML. We identified OPTN (optin...
Source: Autophagy - July 13, 2023 Category: Cytology Authors: Laura M Meyer Sebastian E Koschade Jonas B Vischedyk Marlyn Thoelken Andrea Gubas Martin Wegner Marion Basoglu Stefan Knapp Manuel Kaulich Stefan Eimer Shabnam Shaid Christian H Brandts Source Type: research
N-acetylcysteine Treatment Attenuates Hemodialysis Access-related Limb Pathophysiology in Mice with Chronic Kidney Disease
The objective of this study was to determine if treatment with N-acetylcysteine (NAC) could reduce access-related limb dysfunction in mice. Male and female C57BL6J mice were fed an adenine supplemented diet to induce chronic kidney disease prior to surgical creation of an arteriovenous fistula (AVF) in the iliac vascular bundle. AVF creation significantly increased peak aortic and infrarenal vena cava blood flow velocities, but NAC treatment had no significant impact indicating that fistula maturation was not impacted by NAC treatment. Hindlimb muscle and paw perfusion recovery and muscle capillary density in the AVF limb ...
Source: American Journal of Physiology. Renal Physiology - July 13, 2023 Category: Physiology Authors: Kyoungrae Kim Tomas A Cort Eric M Kunz Jack Moerschel Victoria R Palzkill Gengfu Dong Chatick N Moparthy Erik M Anderson Brian Fazzone Kerri A O'Malley Scott T Robinson Scott A Berceli Terence E Ryan Salvatore T Scali Source Type: research
