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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway
Exp Neurol. 2023 May 29:114449. doi: 10.1016/j.expneurol.2023.114449. Online ahead of print.ABSTRACTHypoxic-ischemic encephalopathy (HIE) is an important factor leading to permanent damage of central nervous system (CNS) and even neonatal death. Long non-coding RNAs (lncRNAs) has been shown to get involved in the pathogenesis of nervous system diseases. LINC00938 is an intergenic lncRNA which is reported to be involved in neurodegenerative disease. However, the potential role of LINC00938 in nerve injury of neonatal HIE is undetermined. Here, we found that the expression of LINC00938 in the whole blood of neonates with HIE...
Source: Experimental Neurology - May 31, 2023 Category: Neurology Authors: Jing Zhao Meini Le Jie Li Qiong Huang Haocong Chen Wenyi Zhang Huiwen Mao Qing Sun Aiguo Li Yingmin Zhao Lingling Yu Mingjiang Yi Jie Wang Xinyuan Li Guangming Zhang Jun Ma Xiaohua Dong Source Type: research
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning
We reported a case of a 15-year- old girl referred to our Emergency Department 3 hours after ingestion of 10 g of paracetamol for suicidal purposes. She promptly started the administration of intravenous N-acetylcysteine (NAC) and the patient was discharged after 5 days of hospitalization in good clinical condition and with neuropsychiatric follow-up. Our case shows that the timing of the intravenous NAC administration is considered the most important factor in the prevention of acetaminophen-induced hepatic failure, despite high serum levels after acetaminophen ingestion.PMID:37247196 | DOI:10.23750/abm.v94iS1.13714
Source: Acta Bio-Medica : Atenei Parmensis - May 29, 2023 Category: General Medicine Authors: Serena Ferretti Antonietta Curatola Antonio Chiaretti Benedetta Graglia Antonio Gatto Lavinia Capossela Valeria Pansini Source Type: research
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
Free Radic Biol Med. 2023 May 26:S0891-5849(23)00429-X. doi: 10.1016/j.freeradbiomed.2023.05.013. Online ahead of print.ABSTRACTGrowing evidence suggests that the depletion of plasma NAD+ and glutathione (GSH) may play an important role in the development of metabolic disorders. The administration of Combined Metabolic Activators (CMA), consisting of GSH and NAD+ precursors, has been explored as a promising therapeutic strategy to target multiple altered pathways associated with the pathogenesis of the diseases. Although studies have examined the therapeutic effect of CMA that contains N-acetyl-l-cysteine (NAC) as a metabo...
Source: Free Radical Biology and Medicine - May 28, 2023 Category: Biology Authors: Hong Yang Xiangyu Li Han Jin Hasan Turkez Gurkan Ozturk Hamdi Levent Doganay Cheng Zhang Jens Nielsen Mathias Uhl én Jan Bor én Adil Mardinoglu Source Type: research
Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway
This study aimed to investigate the impact of metformin on OGC pyroptosis and the underlying mechanisms. The results showed that treating a human granulosa-like tumor cell line (KGN) with metformin significantly decreased LPS-induced expression of miR-670-3p, NOX2, NLRP3, ASC, cleaved caspase-1, and GSDMD-N. Cellular caspase-1 activity; ROS production; oxidative stress; and the secretion of IL-1β, IL-6, IL-18, and TNF-α were also diminished. These effects were amplified by adding N-acetyl-L-cysteine (NAC), a pharmacological inhibitor of ROS. In contrast, metformin's anti-pyroptosis and anti-inflammatory effects were robu...
Source: Aging - May 27, 2023 Category: Biomedical Science Authors: Li-Hua Zhou Hui Zou Jia-Yuan Hao Yong Huang Jia-Nan Zhang Xiao-Hong Xu Juan Li Source Type: research
Anti-Warburg effect via generation of ROS and inhibition of PKM2/ β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
Phytother Res. 2023 May 26. doi: 10.1002/ptr.7903. Online ahead of print.ABSTRACTTo elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells. MTT assay for cytotoxicity, RNA interference, cell cycle analysis for sub G1 population, nuclear and cytoplasmic extraction, lactate, Glucose and ATP assay by ELISA, Measurement of reactive oxygen species (ROS) generation, Western blotting, and immunoprecipitation assay were conducted in DU145 and PC3 prosta...
Source: Cell Research - May 26, 2023 Category: Cytology Authors: Ji-Na Pak Hyo-Jung Lee Deok Yong Sim Ji Eon Park Chi-Hoon Ahn Su-Yeon Park Jae-Ho Khil Bumsang Shim Bonglee Kim Sung-Hoon Kim Source Type: research
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway
CONCLUSIONS: In summary, AKF-PD can protect against ALF caused by APAP or LPS/D-Gal, in part, via regulating MKK4/JNK pathway. AKF-PD might be a novel candidate drug for ALF.PMID:37224750 | DOI:10.1016/j.biopha.2023.114844
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2023 Category: Drugs & Pharmacology Authors: Lei Gu Xin He Yanqiu Zhang Shenglan Li Jie Tang Ruixue Ma Xinyi Yang Hao Huang Yu Peng Yanyun Xie Zhangzhe Peng Jie Meng Gaoyun Hu Lijian Tao Xiaowei Liu Huixiang Yang Source Type: research
