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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
CONCLUSIONS: Melatonin combined with erastin exhibits synergistic anticancer effects without adverse reactions. Herein, this combination might become a promising alternative strategy for oral cancer treatment.PMID:37131152 | PMC:PMC10155313 | DOI:10.1186/s11658-023-00449-6
Source: Cellular and Molecular Biology Letters - May 2, 2023 Category: Biochemistry Authors: Leilei Wang Chuan Wang Xuan Li Zhuoying Tao Wangyong Zhu Yuxiong Su Wing Shan Choi Source Type: research
TWiV 1002: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, an...
Source: This Week in Virology - MP3 Edition - April 29, 2023 Category: Virology Authors: VIncent Racaniello Source Type: podcasts
Management of Poisonings and Intoxications
Clin J Am Soc Nephrol. 2023 Jan 13. doi: 10.2215/CJN.0000000000000057. Online ahead of print.ABSTRACTPoisoning occurs after exposure to any of a number of substances, including medicines, which can result in severe toxicity including death. The nephrologist may be involved in poisonings that cause kidney disease and for targeted treatments. The overall approach to the poisoned patient involves the initial acute resuscitation and performing a risk assessment, whereby the exposure is considered in terms of the anticipated severity and in the context of the patient's status and treatments that may be required. Time-critical i...
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 25, 2023 Category: Urology & Nephrology Authors: Marc Ghannoum Darren M Roberts Source Type: research
ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells
Chem Biol Interact. 2023 Apr 19:110502. doi: 10.1016/j.cbi.2023.110502. Online ahead of print.ABSTRACTMicroplastics have become a serious environmental pollutant and subsequently have harmful effects on human health. Thus, the impacts of microplastics on human cells need to be explored. In the present study, the cytotoxic effects at the subcellular-organelle levels to polystyrene nanoplastics (PS-NPs, diameter 21.5 ± 2.7 nm) were investigated in the human hepatocellular carcinoma (HepG2) cell line. The cell viability exposed to PS-NPs at the concentrations of 6.25, 12.5, 25 and 50 μg/mL for 24 h diminished in a concentra...
Source: Chemico-Biological Interactions - April 21, 2023 Category: Molecular Biology Authors: Yunjing Li Menghao Guo Shuyan Niu Mengting Shang Xiaoru Chang Zuoyi Sun Rui Zhang Xin Shen Yuying Xue Source Type: research
Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux
Ecotoxicol Environ Saf. 2023 Apr 20;257:114942. doi: 10.1016/j.ecoenv.2023.114942. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is a stable mycotoxin that contaminates animal feed on a large scale and causes severe damage to intestinal cells, induces inflammation and stimulates autophagy. Transient receptor potential mucolipin subfamily 1 (TRPML1) is a regulatory factor of autophagy, but the underlying mechanisms of TRPML1-mediated autophagy in AFB1 intestine toxicity remain elucidated. In the present study, AFB1 (0, 5, 10 μg/mL) was shown to reduce cell viability, increase reactive oxygen species (ROS) accumulation ...
Source: Ecotoxicology and Environmental Safety - April 20, 2023 Category: Environmental Health Authors: Xinyi Cheng Jiahua Liang Dan Wu Xiaoquan Guo Huabin Cao Caiying Zhang Ping Liu Ruiming Hu Guoliang Hu Yu Zhuang Source Type: research
ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells
Chem Biol Interact. 2023 Apr 19:110502. doi: 10.1016/j.cbi.2023.110502. Online ahead of print.ABSTRACTMicroplastics have become a serious environmental pollutant and subsequently have harmful effects on human health. Thus, the impacts of microplastics on human cells need to be explored. In the present study, the cytotoxic effects at the subcellular-organelle levels to polystyrene nanoplastics (PS-NPs, diameter 21.5 ± 2.7 nm) were investigated in the human hepatocellular carcinoma (HepG2) cell line. The cell viability exposed to PS-NPs at the concentrations of 6.25, 12.5, 25 and 50 μg/mL for 24 h diminished in a concentra...
Source: Chemico-Biological Interactions - April 19, 2023 Category: Molecular Biology Authors: Yunjing Li Menghao Guo Shuyan Niu Mengting Shang Xiaoru Chang Zuoyi Sun Rui Zhang Xin Shen Yuying Xue Source Type: research
Evaluation of cigarette smoke-induced oxidative stress and inflammation in BEAS-2B cells based on a lung microfluidic chip
Food Chem Toxicol. 2023 Apr 14;176:113787. doi: 10.1016/j.fct.2023.113787. Online ahead of print.ABSTRACTOxidative stress and inflammation induced by cigarette smoking are associated with the pathology process of various chronic respiratory diseases, including asthma, emphysema, chronic obstructive pulmonary disease and cancer. Compared with conventional cell culture techniques, microfluidic chips can provide a continuous nutrient supply, mimic the in vivo physiological microenvironment of the cells, and conduct an integrated and flexible analysis of cell status and functions. Here, we designed and fabricated a bionic-lung...
Source: Food and Chemical Toxicology - April 16, 2023 Category: Food Science Authors: Jingxian Xue Zezhi Li Xiang Li Chenfeng Hua Pingping Shang Junwei Zhao Kejian Liu Fuwei Xie Source Type: research
Bleomycin Overdose in a Patient with Stage II Hodgkin Lymphoma: A Case Report of a Medication Error
Br J Clin Pharmacol. 2023 Apr 14. doi: 10.1111/bcp.15744. Online ahead of print.ABSTRACTBleomycin is an antibiotic with cytotoxic properties that is commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in the dosage nomenclature of bleomycin appears universally, which increases the risk of medication errors. However, to the best of our knowledge, no such cases have been reported. Herein, we present a rare case report of a medication error caused by a bleomycin overdose. At the third cycle of chemotherapy, a 25-year-old patient with Stage II Hodgkin Lymphoma received a ten times hig...
Source: Clinical Lung Cancer - April 15, 2023 Category: Cancer & Oncology Authors: M D Zhang Jieting Xue Shuyi Chen Xiaolin M D Yang Hai Source Type: research
Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats
This study provided a novel direction for studying the occurrence of hypospadias and may provide a hypospadias predictive marker in the future.PMID:37059017 | DOI:10.1016/j.ecoenv.2023.114892
Source: Ecotoxicology and Environmental Safety - April 14, 2023 Category: Environmental Health Authors: Shan Hua Fei Shi Zhiwen Xie Lei Wu Mengqiao Dai Yongqing Zhang Xinyu Xu Yiping Zhu Juntao Jiang Source Type: research
Hydrogen sulfide protects Sertoli cells against toxicant Acrolein-induced cell injury
Food Chem Toxicol. 2023 Apr 12:113784. doi: 10.1016/j.fct.2023.113784. Online ahead of print.ABSTRACTAcrolein (ACR), a highly toxic α,β-unsaturated aldehyde, is considered to be a common mediator behind the reproductive injury induced by various factors. However, the understanding of its reproductive toxicity and prevention in reproductive system is limited. Given that Sertoli cells provide the first-line defense against various toxicants and that dysfunction of Sertoli cell causes impaired spermatogenesis, we, therefore, examined ACR cytotoxicity in Sertoli cells and tested whether hydrogen sulfide (H2S), a gaseous medi...
Source: Food and Chemical Toxicology - April 14, 2023 Category: Food Science Authors: Zhimin Mao Haitao Li Xiu-Ling Zhao Xu-Hui Zeng Source Type: research
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway
In this study, HepG2 cells were treated with 0.0625, 0.125, 0.25, 0.5 and 1 mM Dibutyl phthalate (DBP) for 48 h to investigate mitochondrial toxicity. The results showed that DBP caused mitochondrial damage, autophagy, apoptosis and necroptosis; Transcriptomics analysis identified that MAPK and PI3K were significant factors in the cytotoxic changes induced by DBP; N-Acetyl-L-cysteine (NAC), SIRT1 activator, ERK inhibitor, p38 inhibitor and ERK siRNA treatments counteracted the changes of SIRT1/PGC-1α and Nrf2 pathway-related proteins, autophagy and necroptotic apoptosis proteins induced by DBP. While PI3K and Nrf2 inhibit...
Source: Food and Chemical Toxicology - April 14, 2023 Category: Food Science Authors: Huan Liu Linjing Xu Lizi Zhou Wenna Han Zhongyi Li Chunhong Liu Source Type: research
