TWiV 638: Do, there is no try
Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Viviana Simon, Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - July 12, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 637: Clearing the fog of ignorance
In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China approves COVID-19 vaccine for military (CNN) Ad5-vectored COVID-19 vaccine phase I results (Lancet) US pays $1.6 billion for Novavax vaccine (NY Times...
Source: This Week in Virology - MP3 Edition - July 9, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 636: Georgia State viral
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development. Host: Vincent Racaniello Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mutant Ebolavirus lacks virulence (Cell Rep) Blocking Ebolavirus replication by depleting nucleoside pools (Antiviral Res) Herd immunity against bad actor molecules (PloS Path) Bacteria prevent and cure rotaviru...
Source: This Week in Virology - MP3 Edition - July 7, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 635: Mask hysteria
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectious SARS-CoV-2 in nasopharynx of youth (Emerg Inf Dis) SARS-CoV-2 viral load by patient age (Hosp Charité) Viral l...
Source: This Week in Virology - MP3 Edition - July 5, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 634: 1000 hours of the sunlight of TWiV
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New swine flu with pandemic potential (BBC, PNAS) Oral SARS-CoV-2 vaccine candidate (ClinicalOmics) Operation Warp Speed (HHS) ACTIV (NIH) Development and licensure of COVID-19 vacci...
Source: This Week in Virology - MP3 Edition - July 2, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 633: Singapore viral
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccine infections (Nat Med) RNA recognition by RIG-I and MDA5 (Nucl Acids Res) Timestamps by Jolene. ...
Source: This Week in Virology - MP3 Edition - June 30, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 632: Countering a miasma of anti-think
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dexamethasone for COVID-19 (medRxiv) Proning trial for COVID-19 (Lancet) Tocilizumab for COVID-19 cytokine storm (Chest) Global causes of death Vesicular stomatitis in horses (Pr...
Source: This Week in Virology - MP3 Edition - June 28, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 631: Lots of eggs in the spike basket
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Probability of symptoms and severe COVID-19 (aRxiv) Cellular immune response without seroconversion (medRxiv) Image credit Letters read on TWiV 631 Timestamps by Jolene. Thanks! Intro music is ...
Source: This Week in Virology - MP3 Edition - June 25, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 630: Singapore Environmental Health Institute
From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission. Host: Vincent Racaniello Guest: Lee Ching Ng Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - June 24, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 629: Coronavirus update, pandemic sitrep
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dexamethasone reduces COVID-19 deaths (U Oxford) Assessment of asymptomatic COVID-19 (Nature ...
Source: This Week in Virology - MP3 Edition - June 21, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 628: Physical distance for COVID-19
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) Hamster SARS-CoV-2 model (Nature) COVID-19 host genetic initiative Image credit Letters read on...
Source: This Week in Virology - MP3 Edition - June 18, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 627: Singapore National Centre for Infectious Diseases
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host: Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National Centre for Infectious Diseases National Public Health Laboratory Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv (Source: This Wee...
Source: This Week in Virology - MP3 Edition - June 17, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 626: Ralph Baric and fancy ferrets
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Mouse-adapted SARS-CoV-2 model (bioRxiv) SARS-CoV-2 mRNA vaccine (bioRxiv) ASM resources for #shutdownstem President Obama on sustaining momentum for change (...
Source: This Week in Virology - MP3 Edition - June 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 625: Fred Murphy, virologist for all seasons
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Hosts: Vincent Racaniello and Rich Condit Guest: Frederick A. Murphy Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Link for this episode Foundations of Virology/Virus images (UTMB) Intro music is by Ronald Jenkees Send your virology questions and comments to ...
Source: This Week in Virology - MP3 Edition - June 11, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 624: SeXX matters with Sabra Klein
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SeXX matters in infectious disease pathogenesis (PLoS Path) Sex and gender impact immune...
Source: This Week in Virology - MP3 Edition - June 7, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 623: Bats and coronaviruses with Peter Daszak
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bats are reservoirs of SARSr-CoV (Science) Bat SARSr-CoV that binds ACE2 (Nature) Rich gene pool of bat SARSr-CoV (PLoS Path) Bat SARSr-...
Source: This Week in Virology - MP3 Edition - June 4, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 622: Nonhuman primate model for COVID-19 with Emmie de Wit
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques ...
Source: This Week in Virology - MP3 Edition - June 2, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 621: An era of COVID-19 poppycock
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety of Ad5 vectored COVID-19 vaccine (Lancet) Analysis...
Source: This Week in Virology - MP3 Edition - May 31, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 620: Antibodies and T cells in COVID-19 patients
Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in humans (Nat Med) Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microb...
Source: This Week in Virology - MP3 Edition - May 29, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 619: Recombination led to emergence of SARS-CoV-2
Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv) Bat CoV with cleavage site insertion (Curr Biol) Timestamps by Jolene. Thanks! Intro music i...
Source: This Week in Virology - MP3 Edition - May 27, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 618: Nipah virus at 20
From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - May 26, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 617: Coronavirus Times
Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scientists denounce end to CoV grant (NY Times) ASMBMB denounces end to CoV grant (pdf) For TETRIS, ...
Source: This Week in Virology - MP3 Edition - May 24, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 616: Singing about coronavirus
Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I results Liposomes and lipid nanoparticles (Exelead) Cigarette smoke increases ACE2 (Dev Cell) Letter...
Source: This Week in Virology - MP3 Edition - May 21, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 615: Peter Daszak of EcoHealth Alliance
Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - May 19, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 614: COVID Tetris - Test, trace, isolate
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Triple therapy for COVID-19 (Lancet) Virology podcast goes viral (Thalia Gigerenzer) Paul Stays Home...
Source: This Week in Virology - MP3 Edition - May 17, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 613: Jenner, vaccines, and COVID-19
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccin...
Source: This Week in Virology - MP3 Edition - May 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 614: Jenner, vaccines, and COVID-19
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccin...
Source: This Week in Virology - MP3 Edition - May 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 612: CEPI, preventing the next pandemic
From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts: Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - May 12, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 611: Corona and crowns
Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode OSHA guidance for dentistry COVID0-19 challenges for dentistry (J Dent Res) COVID-19 and dentistry (Int J Env Res Pub Health) Mouthrinses for dentistry (J Clin Med) Disingenuous plandemic documentary (Big ...
Source: This Week in Virology - MP3 Edition - May 10, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 610: Coronavirus FAQ
The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology-based tests for SARS-CoV-2 (Center for Health Security) ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) Global COVID-19 CFR (CEBM) Debunking transmissio...
Source: This Week in Virology - MP3 Edition - May 7, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 609: A coronavirus chronology with Susan Weiss
Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) CoV and antagonism of RNAse L (mBio) Exoribonuclease needed for MHV innate antag...
Source: This Week in Virology - MP3 Edition - May 3, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 608: Daniel Griffin's COVID-19 clinical report
Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions. Hosts: Vincent Racaniello and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pulmonary embolism in COVID-19 (Emerg Inf Dis) Patch Study Remdesivir in adults with severe COVID-19 (Lancet) ACTT remdesivir trial (NIAID) Commentary on remdesivir trials (Lancet) FDA expected to issue remdesivir EUA (Contaigon Live) Recovered COVID-19 pati...
Source: This Week in Virology - MP3 Edition - May 1, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 607: Coronavirus epidemiology with Jeff Shaman
Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months. Hosts: Vincent Racaniello and Rich Condit Guest: Jeff Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 findings and simulations (Shaman Lab) Reconciling diverse estimates of infection rates (pdf) Undocumented SARS-CoV-2 infections (Science) Simulations of SA...
Source: This Week in Virology - MP3 Edition - April 29, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 606: Evidence-based science and medicine for COVID-19
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) Saliva is more sensitve than nasopharyngeal swab (medRxiv) NY serologica...
Source: This Week in Virology - MP3 Edition - April 26, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 605: READDI for the next pandemic
Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Ralph Baric, Mark Heise, and Nat Moorman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - April 23, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease (pdf) OPV for COVID-19 (pdf) Enteroviruses to prevent human infections (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (...
Source: This Week in Virology - MP3 Edition - April 21, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 603: Cloudy with a chance of coronavirus
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) SARS-CoV-2 screening before delivery (NEJM) SARS-CoV-2 seroprevalence in Santa Cla...
Source: This Week in Virology - MP3 Edition - April 19, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 602: Coronavirus immunology with Stanley Perlman
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenk...
Source: This Week in Virology - MP3 Edition - April 16, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 601: Das coronavirus with Christian Drosten
Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comment...
Source: This Week in Virology - MP3 Edition - April 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 600: SARS-CoV-2 - enter the Coronials
Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 32 nucleotide deletion in ths SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 382 nt deletion in genome of SARS-CoV-2 (bioRxiv_ Recombination and mutation leading to SARS-CoV-2 (bioRxiv) Letters read on TWiV 600 Timesta...
Source: This Week in Virology - MP3 Edition - April 12, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 599: Coronavirus update - we need a plan
Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Doris Cully Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) Tiger at NY zoo positive for SARS-CoV-2 (NY Times) IL-6 level predict...
Source: This Week in Virology - MP3 Edition - April 8, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 598: Who was that masked man? Coronavirus update with Daniel Griffin
Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Restricted dispensing of Plaquenil in NY state Virology of COVID-19 patients (Nature) Susceptibility of domestic animals t...
Source: This Week in Virology - MP3 Edition - April 5, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 597: A lot of immunology and some COVID-19 with Jon Yewdell
Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2. Hosts: Vincent Racaniello and Rich Condit Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - April 3, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 596: COVID-19 - an ounce of prevention
TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Emergency use of hydroxychloroquine (FDA) Trial of hydroxycholorquine in COVID-19 patients (China, France) COVID-19 in critically ill patients, Seattle (NE...
Source: This Week in Virology - MP3 Edition - April 2, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 595: Coronavirus update - Daniel Griffin MD in the parking lot
Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tocilizumab (Wiki) Nares swab for SARS-CoV-2 (Star Trib) US SARS-CoV-2 epidemic curve (CDC) Cleaning and disinfecting (CDC) Cleaning fru...
Source: This Week in Virology - MP3 Edition - March 29, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV Special: Conversation with a COVID-19 patient, Ian Lipkin
Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more. Hosts: Vincent Racaniello Guest: W. Ian Lipkin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Center for Infection and Immunity Control the Contagion videos Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - March 28, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV Special: Coronavirus update with Mark Denison, MD
Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics. Hosts: Vincent Racaniello Guest: Mark Denison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - March 26, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 594: Coronavirus update - Shelter in place
A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus test kit Rapid SARS-CoV-2 serological assay (medRxiv) Is Dr. Fauci in trouble? (NY Times) FDA approves emergency use of c...
Source: This Week in Virology - MP3 Edition - March 25, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 593: Coronavirus update - flatten the curve
Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pregnancy and COVID-19 papers (1, 2, 3, 4, 5) Second dog i...
Source: This Week in Virology - MP3 Edition - March 22, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 592: Coronavirus update - dangerous curve ahead
Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Ori Lieberman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Scary modeling (Imperial College London) Avigan vs SARS-CoV-2 (NHK) SARS-CoV-2 mRNA vaccine (Clinical Trials) SARS-CoV-2 stability (NEJM) Pediatric COVID-19 (one, two) SARS-CoV-2 asymptomatic infection (one, two) CDC...
Source: This Week in Virology - MP3 Edition - March 19, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts