TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Healthcare worker deaths (Guardian) Children and adolescent disease severity (JAMA) Physical inactivity and increased disease risk (BMJ) Expansion of P...
Source: This Week in Virology - MP3 Edition - April 17, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 743: Shape-shifting viruses
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pleomorphic virus particles and cell entry (Nat Micro) Letters read on TWiV 743 Timestamps by Jolene. Thanks! Weekly Picks Dickson – A tiny particle’s w...
Source: This Week in Virology - MP3 Edition - April 15, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 742: De-fusing COVID-19
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature) Letters read on TWiV 742 Timestamps by Jolene. Thanks! Weekly Picks Brianne – COVI...
Source: This Week in Virology - MP3 Edition - April 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 741: COVID-19 clinical update #57 with Dr. Daniel Griffin
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children with MIS-C (JAMA) Transmission with masks (Op For Inf Dis) Accuracy of diagnostic tests (Am J Inf Cont) Long COVID in hospitalized patients (BMJ) Neurological and psychiatric outcomes o...
Source: This Week in Virology - MP3 Edition - April 10, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 740: Complementation will get you everywhere
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here) Research position in Spindler labo...
Source: This Week in Virology - MP3 Edition - April 8, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Arturo Casadevall Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Victory for Scientific Pragmatism (New Atlantis) Convalescent plasma levels and risk of COVID-19 death (NEJM) COVI...
Source: This Week in Virology - MP3 Edition - April 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer mRNA vaccine is 100% effective in 12-15 year olds (Pfizer) Cue at-home PCR test receives FDA EUA (Cue) DxTerity COVID-19 ...
Source: This Week in Virology - MP3 Edition - April 3, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 737: SARS-CoV-2 in NYC wastewater
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: John Dennehy, Davida Smyth, and Monica Trujillo Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Protocol for detecting SARS-CoV-2 RNA in wastewater (medRx...
Source: This Week in Virology - MP3 Edition - April 1, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 736: Rhapsody in T with Alessandro Sette
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Alessandro Sette Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Little impact of SARS-CoV-2 variants on T cell reactivity (bioRxiv) NIDO 2021 Sym...
Source: This Week in Virology - MP3 Edition - March 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 735: COVID-19 clinical update #55 with Dr. Daniel Griffin
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in primary and secondary schools (MMWR) Low transmission in elementary schools (MMWR) COVID-19 testing guidance (CDC...
Source: This Week in Virology - MP3 Edition - March 26, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 735: COVID-19 clinical update #735 with Dr. Daniel Griffin
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in primary and secondary schools (MMWR) Low transmission in elementary schools (MMWR) COVID-19 testing guidance (CDC...
Source: This Week in Virology - MP3 Edition - March 26, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 734: Weiss hath no furin like a virus scorned
Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection. Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CoV pathogenesis in CNS (J Neuro Pharm) SARS-CoV-2 induces dsRNA-mediated innate responses (bioRxiv) Screen of FDA-approved drugs (J Viral) Letters...
Source: This Week in Virology - MP3 Edition - March 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 733: COVID-19 clinical update #54 with Dr. Daniel Griffin
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effectiveness of 3 ft vs 6 ft (CID) Effect of physical distancing, masks, eye protection (Lancet) Vaccine second dose completion ...
Source: This Week in Virology - MP3 Edition - March 20, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 732: Citizen science with Forest Rohwer and Maria-Isabel Rojas
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Forest on TWiV 391 Swabbing surfaces in San Diego (10News) Nido21 meeting Molnupiravir in phase 2a (Fierce Biotech) Letters read on TWiV 732 Timestamps by Jolene. Thanks! Weekly P...
Source: This Week in Virology - MP3 Edition - March 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 731: The kids aren't alright
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK. Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ebolavirus disease outbreak continues in Africa (ProMedMail) List of Ebolavirus outbreaks (Wikipedia) Ebolavirus genome sequences from Guinea (virological) Bias in reporting on childho...
Source: This Week in Virology - MP3 Edition - March 14, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 730: COVID-19 clinical update #53 with Dr. Daniel Griffin
In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 seroprevalence in (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - March 13, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 729: A floret of spikes with Matt Frieman
Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Matt Frieman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Phase 1-2 trial of Novavax protein vaccine (NEJM) MERS-CoV spike nanoparticle vaccine in mice (Vaccine) Novavax phase 3 press release When you’ve been fully vaccinated (CDC) Letters read on...
Source: This Week in Virology - MP3 Edition - March 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 728: Cover your nose and mouse
TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mavis Agbandje-McKenna dies (UF) Mavis on TWiV 448 Maximizing mask fit (MMWR) Genomic and subgenomic RNA in COVID-19 patien...
Source: This Week in Virology - MP3 Edition - March 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin
In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 attack rates in children and adults (Clin Inf Dis) Documents for J&J COVID-19 vaccine review (FDA) Convalescent plasma and clin...
Source: This Week in Virology - MP3 Edition - March 6, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 726: Molecular animator Janet Iwasa
Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler Guest: Janet Iwasa Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The Animation Lab SARS-CoV-2 animation Documents for J&J COVID-19 vaccine review (FDA) Phase III data (pdf) Slide presentation of data (pdf) Addendum (pdf) Summary of v-Safe...
Source: This Week in Virology - MP3 Edition - March 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 725: Eva Harris and Janet Smith clip flavivirus wings
Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediated endothelial dysfunction (Science) Broadly protective antibody against NS1 (Science) Letters...
Source: This Week in Virology - MP3 Edition - February 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin
In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Updated NYC mask guidance (NYC Health) Two masks recommended (CDC) Effectiveness of testing in nursing homes (Clin Inf Dis) Vaccine reactogenicity and...
Source: This Week in Virology - MP3 Edition - February 27, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 723: COVID-19 palliative care with Ginger Campbell, MD
Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Ginger Campbell, MD Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Brain Science Podcast Dr. Campbell’s video on palliative care (YouTube) Resources on palliative care (WHO) Interviews with Paul Offit (one, two) Being Mortal by Atul Gawande Letters read on TWiV 723 Timestamps by Jolene. Thanks! Week...
Source: This Week in Virology - MP3 Edition - February 25, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 722: More coronaviruses in the pipeline
The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 in Manaus (Lancet) SARS-CoV-2 related viruses in Southeast Asian bats (Nat Comm) Increased Ct following COVID-19 vaccination (medRxiv) Letters rea...
Source: This Week in Virology - MP3 Edition - February 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 721: COVID-19 clinical update #50 with Dr. Daniel Griffin
In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance on school openings (CDC) Calcifediol Treatment and COVID-19 (Lancet preprints) Zinc and vitamin C for COVID-19 (JAMA) Early anti...
Source: This Week in Virology - MP3 Edition - February 20, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 720: With vaccines, Offit is on it
Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine education center Letters read on TWiV 720 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Life ...
Source: This Week in Virology - MP3 Edition - February 14, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 719: COVID-19 clinical update #49 with Dr. Daniel Griffin
In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 in Brazil (Lancet) Pfizer vaccine reduces viral load (medRxiv) EUA for bamlanivimab plus etes...
Source: This Week in Virology - MP3 Edition - February 13, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 718: Recombining vaccine schedules
TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode AZD1222 single dose efficacy and booster timing (Lancet preprint) Safety and efficacy of Sputnik V vaccine (Lancet) Proofreading exonuclease regulates CoV recombination (PLoS Path) Letters read on TWiV 718...
Source: This Week in Virology - MP3 Edition - February 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 717: Paul and Theodora, pandemic explorers
Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Paul Bieniasz and Theodora Hatziioannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evolution of antibody immunity to SARS-CoV-2 (bioRxiv) mRNA vaccine elicited antibody to variants (bioR...
Source: This Week in Virology - MP3 Edition - February 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 716: COVID-19 clinical update #48 with Dr. Daniel Griffin
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Resistance of variants to mAb neutralization (bioRxiv) Sa...
Source: This Week in Virology - MP3 Edition - February 6, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 715: Fauci ouchy
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TMPRSS2 is why hydroxychloroquine failed (PLoS Path) Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) Letters read on TWiV 715 Timestamps by Jolene. Thanks! Weekly Picks Brianne – How the Body Reacts to Viruses Rich – How do wombats...
Source: This Week in Virology - MP3 Edition - February 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 714: The shape of spike with Jason McLellan
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Guest: Jason McLellan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prefusion spike structure (Science) Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer Novavax COVID-19 vacc...
Source: This Week in Virology - MP3 Edition - January 31, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 713: COVID-19 clinical update #47 with Dr. Daniel Griffin
In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Novavax vaccine phase 3 results (Novavax) J&J vaccine phase 3 results (J&J) COVID-19 and transmission in K-12 schools (MMWR) Lilly mAb therapy (NEJM) Regeneron mAb prophylaxis ...
Source: This Week in Virology - MP3 Edition - January 30, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 712: Deutscher Virus Wahnsinn
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode German Society for Virology Ticks in Germany and TBEV (Sci Rep) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - January 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 711: The New Heal
The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biden’s COVID-19 strategy (pdf) CDC evaluation of BinaxNOW antigen test (MMWR) FDA instructions for BinaxNOW test (pdf) Adam Neely on Sea Shanties (YouTube) Letters read on TWiV 711 Timestamps by Jolene. Than...
Source: This Week in Virology - MP3 Edition - January 24, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 710: COVID-19 clinical update #46 with Dr. Daniel Griffin
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evaluation of Abbott BinaxNOW (MMWR) Lilly mAb in nursing ho...
Source: This Week in Virology - MP3 Edition - January 23, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 709: COVID cherry picking
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode President’s science advisor to Cabinet (NY Times) Letter from Biden to Lander (pdf) Weekly flu (CDC) Weekly NY flu (NYDOH) WHO study on SARS-CoV-2 origins (WHO) Letters read on TWiV 709 Time...
Source: This Week in Virology - MP3 Edition - January 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 708: Alpaca llama full of nanobodies
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times) Phase 1/2 results of Sinovac inactivated vaccine (Lancet) beta-propiolactone (Wikipedia) Multiv...
Source: This Week in Virology - MP3 Edition - January 17, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 707: COVID-19 clinical update #45 with Dr. Daniel Griffin
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytokine release syndrome (CID) Letters read on TWiV 707 Timestamps by Jolene. Thanks! Intro music...
Source: This Week in Virology - MP3 Edition - January 16, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 706: Do as Dr. Fauci says
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poems are at Twiverse 2020 US traffic deaths (Car & Driver) National Vaccine Injury Compensation Program (HRSA) Jet injector (Wikipedia) Letters read on TWiV 706 Timestamps by Jolene. Thanks! Weekly Picks Brianne – We Know Almost Nothing About Giant Viruses Rich – Th...
Source: This Week in Virology - MP3 Edition - January 14, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 705: Rocky Mountain COVID with Emily Travanty
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Emily Travanty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode VOC detected in Colorado (WaPo) US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) Human CoV evolves to escape immunity (bioRxiv) Timestamps by Jolene. Thanks! Weekly Picks Dickson &n...
Source: This Week in Virology - MP3 Edition - January 10, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 704: COVID-19 clinical update #44 with Dr. Daniel Griffin
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Argentine study on plasma therapy (NEJM) Ct values and clinical outcome (Open Forum Inf Dis) Bamlanivimab fact sheet (FDA pdf) Cognitive defects in recov...
Source: This Week in Virology - MP3 Edition - January 9, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 703: Does dose matter?
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that higher Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position Follow authorized vaccine dosing schedule (FDA) Mina suggests one vaccine dose (NY Times) UK decision doc...
Source: This Week in Virology - MP3 Edition - January 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 702: Year of the Pandemic
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poems are at Twiverse This little virus went to market (TWiV 581) Host genetics initiative TWiV 628  Inborn errors of immunity & seri...
Source: This Week in Virology - MP3 Edition - January 3, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 701: COVID-19 clinical update #43 with Dr. Daniel Griffin
In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Attributes and predictors of long COVID-19 (medRxiv) Letters read on TWiV 701 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - January 2, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 700: 'Twas COVID and the aerosols
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position PHE update #2 (pdf) South African variant (medRxiv) CDC cautious in conclusions on variant Afucosylated IgG and severe CO...
Source: This Week in Virology - MP3 Edition - December 31, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 699: Arboviruses at ASTMH
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode RNAi in arbovirus-vector interactions (Viruses) Arbovirus emergence via bridge vectors (Sci Rep) Rift Va...
Source: This Week in Virology - MP3 Edition - December 27, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Phased allocation of COVID-19 vaccines (ACIP slides) How CDC is making COVID-19 vaccine recommendations (CDC) Letters read on TWiV 698 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virol...
Source: This Week in Virology - MP3 Edition - December 26, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 697: The sky is NOT falling
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG meeting minutes (pdf) NERVTAG Preliminary genomic characterization of UK variant (virological....
Source: This Week in Virology - MP3 Edition - December 24, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 696: Tear down that SARS-CoV-2 manuscript
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 laboratory assistant manager position FDA authorizes EUA for Moderna mRNA vaccine (FDA) COVID-19 is...
Source: This Week in Virology - MP3 Edition - December 20, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts