TWiV 807: The shot yearned 'round the world with Chadi Saad-Roy and Caroline Wagner
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Brianne Barker Guests: Chadi Saad-Roy and Caroline Wagner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine nationalism and control of the pandemic (Science) Vaccine sharing app Dynamics of SARS-CoV-2 simulation Dynamics...
Source: This Week in Virology - MP3 Edition - September 19, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 806: COVID-19 clinical update #80 with Dr. Daniel Griffin
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Updated mask guidance (CDC) Transmission to masked and unmasked (MMWR) Daily testing in schools (...
Source: This Week in Virology - MP3 Edition - September 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 805: Delta and boosters
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls Vaccine boosters not needed (Lancet) Delta variant replication and immune evasion (Nature) Epidemiologically linked COVID-19 outbreaks (MMWR) Letters read on TWiV 805 Time...
Source: This Week in Virology - MP3 Edition - September 16, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 804: A tangled web of viruses with Mya Breitbart
Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more. Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier Guest: Mya Breitbart Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viruses of spinybacked orbweavers (J Gen Virol) Viruses of terrestrial arthropods (PeerJ) Pepper mild mottle virus in sewage (PLoS Path) Environmental DNA in marine community (Nat Comm) Viral community of freshwater spr...
Source: This Week in Virology - MP3 Edition - September 12, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 803: COVID-19 clinical update #79 with Dr. Daniel Griffin
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease. Hosts: Daniel Griffin and Vincent Racaniello   Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Overlooked shortcomings of observational s...
Source: This Week in Virology - MP3 Edition - September 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 802: Another epitope with Shane Crotty
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls SARS-CoV-2 immune memory 8 months post-infection (Science) SARS-CoV-2 T cell epitopes (Cell Host Microbe) ...
Source: This Week in Virology - MP3 Edition - September 9, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 801: We can hear the coffin
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls COVID-19 excess mortality (eLife) Tracking pandemic death toll (eLife) COVID-19 vaccines and delta varian...
Source: This Week in Virology - MP3 Edition - September 5, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 800: COVID-19 clinical update #78 with Dr. Daniel Griffin
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Do not take veterinary ivermectin (FDA) Ivermectin sid...
Source: This Week in Virology - MP3 Edition - September 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 799: A very model of a modern TWiV
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Neutralizing antibodies predict protection against symptomatic COVID-19 (Nat Med) Host and vector importance for Ross River virus (eLife) Coronavirus in t...
Source: This Week in Virology - MP3 Edition - September 2, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 798: Rats, more coronaviruses!
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biden preliminary report on virus origins (NY Times) Window on SARS-CoV-2 origins closing (Nature) WHO Committee members on TWiV 760 Origins of SARS-CoV-2 review (Cell) Comirnaty? ...
Source: This Week in Virology - MP3 Edition - August 29, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 797: COVID-19 clinical update #77 with Dr. Daniel Griffin
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron&...
Source: This Week in Virology - MP3 Edition - August 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 796: The vary hungry spike with Paul and Theodora
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Paul Bieniasz and Theodora Hatiziiouannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High genetic barrier for SARS-CoV-2 antibod...
Source: This Week in Virology - MP3 Edition - August 22, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 795: COVID-19 clinical update #76 with Dr. Daniel Griffin
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Goo...
Source: This Week in Virology - MP3 Edition - August 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 794: PAMS spray SARS-CoV-2
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Halls (ASV) Arboviral illness, US, 2019 (MMWR) Estimating SARS-CoV-2 infectiousness (Science) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Climate Reports | United Nations Brianne – Astronomy Picture o...
Source: This Week in Virology - MP3 Edition - August 15, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 793: COVID-19 clinical update with Dr. Daniel Griffin
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine effectiveness against transmission (Euro Surve...
Source: This Week in Virology - MP3 Edition - August 14, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 792: Transmission with Jeffrey Shaman
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Jeffrey Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant in India (medRxiv) Letters read on TWiV 792 Timestamps by Jolene. Thanks! Weekly Picks Bria...
Source: This Week in Virology - MP3 Edition - August 12, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 791: A mad virologists' T party
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell induction by mRNA vaccine (Nature) T cell depleted macaques recover from SARS-CoV-2 infection (mBio) ...
Source: This Week in Virology - MP3 Edition - August 8, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 790: COVID-19 clinical update #74 with Dr. Daniel Griffin
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of nfection and impact on quality of life 1-6 months after illness. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Outbreak in Barnstable County, MA&n...
Source: This Week in Virology - MP3 Edition - August 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 789: Does delta mean a change?
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence (one, two, three) Disease protection by non-neutralizing antibodies (Cell) Timestamps by Jolene. Tha...
Source: This Week in Virology - MP3 Edition - August 5, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 788: neuroCOVID with Kiran Thakur, MD
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Kiran Thakur Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccinated people (NEJM) Letters read on TWiV 788 Timestamps by Jolene. Thanks! Weekly Picks Dickson &...
Source: This Week in Virology - MP3 Edition - August 1, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 787: COVID-19 clinical update #73 with Dr. Daniel Griffin
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podca...
Source: This Week in Virology - MP3 Edition - July 31, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 786: You make mucus and you move it
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) Letters read on TWiV 786 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science o...
Source: This Week in Virology - MP3 Edition - July 29, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 785: COVID-19 Q & A with Dr. Daniel Griffin
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Letters read on TWiV 785 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - July 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 784: Virtually live from ASV
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker Guests: Joseph Hyzer and Moriah Szpara Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Genome of HSV1 from multip...
Source: This Week in Virology - MP3 Edition - July 25, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 783: COVID-19 clinical update #72 with Dr. Daniel Griffin
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of&nbs...
Source: This Week in Virology - MP3 Edition - July 23, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 782: An antibody for all sarbecoviruses
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immune responses after heterologous COVID-19 vaccine boost (Nat Med) Undiagnosed SARS-CoV-2 infections in US (Sci Transl Med) Broadly neutralizing sa...
Source: This Week in Virology - MP3 Edition - July 22, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 781: My genome is left to tell the tale
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 on dogs and cats (Viruses) Maternal to neonatal transfer of SARS-CoV-2 antibodies (J Clin Investîmes) R...
Source: This Week in Virology - MP3 Edition - July 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 780: COVID-19 clinical update #71 with Dr. Daniel Griffin
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode School and child care gui...
Source: This Week in Virology - MP3 Edition - July 17, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 779: Evolving boosterism
TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vaccine boosts variant B and T cell responses (Science) Directed evolution of virus-like nucleo...
Source: This Week in Virology - MP3 Edition - July 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 778: COVID-19 clinical update #70 with Dr. Daniel Griffin
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induce serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy of portable air cleaners (MMWR) Ad26.COV2.S elicited neutralization of variants (bioRxiv) Prevention of COVI...
Source: This Week in Virology - MP3 Edition - July 10, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 777: SARS-CoV-2 fitness with Ron Fouchier
Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Ron Fouchier Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ron Fouchier on TWiV 177, 291, 557 Mutations driving H5N1 airborne transmission in ferrets (Cell) SARS-CoV an...
Source: This Week in Virology - MP3 Edition - July 8, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 776: Yes! We have no pangolins
TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Animal sales from Wuhan markets before COVID-19 (Sci Rep) Dengue control by Wolbachia-infected mosquitoes (NEJM) Fatal dengue in Florida (NEJM) Letters read on TWiV 776 Timestamps by Jolene. Thanks! Weekly Picks Brianne – You Know...
Source: This Week in Virology - MP3 Edition - July 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 775: COVID-19 clinical update #69 with Dr. Daniel Griffin
In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Po...
Source: This Week in Virology - MP3 Edition - July 3, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guests: Kristian Andersen and Robert Garry Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Andersen laboratory Recovery of deleted deep sequencing data (bioRxiv) Animal sales from Wuhan wet markets (Sci Rep) Danielle Anderson on Wuhan Lab (Bloomberg) Timestamps by Jol...
Source: This Week in Virology - MP3 Edition - July 1, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 773: Laurie Garrett, pandemic prophet
Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Laurie Garrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lauriegarrett.com The Coming Plague Betrayal of Trust Trump sabotaged coronavirus response (Foreign Policy) ASV Vaccine Town Hall Timestamps by Jolene. Th...
Source: This Week in Virology - MP3 Edition - June 27, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 772: COVID-19 clinical update #68 with Dr. Daniel Griffin
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!...
Source: This Week in Virology - MP3 Edition - June 26, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 771: Borna hundred million years ago
A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2. Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 100 million year old bornavirus infections (PNAS) Bornaviruses across geological timescales (PNAS) Bornaviruses previously on TWiV 303, 347, 548 Novel bat SARS-CoV-2 related cor...
Source: This Week in Virology - MP3 Edition - June 20, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 770: COVID-19 clinical update #67 with Dr. Daniel Griffin
In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a...
Source: This Week in Virology - MP3 Edition - June 19, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 769: MIS-C and leaky gut
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 769 (68 MB .mp3, 114 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 Novavax vaccine efficacy reported (Novavax) H3N2 glycosylation in eggs (TWiV 480) Prevent...
Source: This Week in Virology - MP3 Edition - June 17, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 768: Can nanobody stop these variants?
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall Spread of SARS-CoV-2 variant in summer 2020 (Nature) Nanobodies neutralize SARS-CoV-2 variants (Nature) Letters read on TWiV 768 Timestamps by Jole...
Source: This Week in Virology - MP3 Edition - June 13, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 767: COVID-19 clinical update #66 with Dr. Daniel Griffin
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS,&nbs...
Source: This Week in Virology - MP3 Edition - June 12, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 766: The CORONA project with David Fajgenbaum
David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: David Fajgenbaum Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CORONA project Center for Cytokine Storm Treatment & Laboratory Castleman Disease Collaborative Network Chasing M...
Source: This Week in Virology - MP3 Edition - June 10, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 765: Potpourri of COVID-19
TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Updated nomenclature of SARS-CoV-2 variants (WHO) Pfizer-BioNTech vaccine effective against alpha variant...
Source: This Week in Virology - MP3 Edition - June 6, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 764: COVID-19 clinical update #65 with Dr. Daniel Griffin
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of vaccines and NPIs (JAMA) Guidance on summer camps (CDC) Antibody test...
Source: This Week in Virology - MP3 Edition - June 5, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 763: Cap-snatch fever
TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cap-snatching makes new ORFs (Cell) Cap-snatching leads to novel proteins (Cell) Letters read on TWiV 763 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Flat pasta that turns into shapes here and here Rich – Ad Fontes Media Bias Chart (wiki) Vincent – Marti...
Source: This Week in Virology - MP3 Edition - June 3, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 762: SARS-CoV-2 origins with Robert Garry
Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Robert Garry Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The proximal origin of SARS-CoV-2 (Nature) Two early genome lineages in Wuhan markets (virological.org) Insights from spike proteins ...
Source: This Week in Virology - MP3 Edition - May 30, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 761: COVID-19 clinical update #64 with Dr. Daniel Griffin
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance on child camps and day care (NY State) Mitigation and schools (medRxiv) Masks in elementary schools (MMWR) T...
Source: This Week in Virology - MP3 Edition - May 29, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea K ølsen Fischer, Marion Koopmans
Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Peter on TWiV 615, 623 Thea on TWiV 576 Marion on TWiV 413, 548 WHO report on orig...
Source: This Week in Virology - MP3 Edition - May 27, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 759: Pork dogs and an evolutionary pickle
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls 15:10 Porcine deltacoronavirus in Haitian children (medRxiv) Canine coronavirus from Malaysian pneumonia patient (Clin Inf Dis) No shift, measles (TWiV 340) Th...
Source: This Week in Virology - MP3 Edition - May 23, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 758: COVID-19 clinical update #63 with Dr. Daniel Griffin
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in child care facilities (MMWR) mRNA vaccine effectiveness (MMWR) Excelsior...
Source: This Week in Virology - MP3 Edition - May 22, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts