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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
Bisphenol A Regulates the TNFR1 Pathway and Excessive ROS Mediated by miR-26a-5p/ADAM17 Axis to Aggravate Selenium Deficiency-Induced Necroptosis in Broiler Veins
This study lays a data foundation for future ecological and health risk assessments of nutrient deficiencies and environmental toxic pollution.PMID:37422542 | DOI:10.1007/s12011-023-03756-3
Source: Biological Trace Element Research - July 8, 2023 Category: Biology Authors: Xue Fan Yixuan Wang Jintao Zhang Hongjin Lin Zhikun Bai Shu Li Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
Bisphenol A Regulates the TNFR1 Pathway and Excessive ROS Mediated by miR-26a-5p/ADAM17 Axis to Aggravate Selenium Deficiency-Induced Necroptosis in Broiler Veins
This study lays a data foundation for future ecological and health risk assessments of nutrient deficiencies and environmental toxic pollution.PMID:37422542 | DOI:10.1007/s12011-023-03756-3
Source: Atherosclerosis - July 8, 2023 Category: Cardiology Authors: Xue Fan Yixuan Wang Jintao Zhang Hongjin Lin Zhikun Bai Shu Li Source Type: research
Network pharmacology and in vitro experiments reveal that Noscapine induces ROS-mediated apoptosis and cell cycle arrest via PI3K/Akt/FoxO3a signaling pathway in human bladder cancer cells
CONCLUSIONS: Noscapine induces ROS-mediated apoptosis and cell cycle arrest via PI3K/Akt/FoxO3a signaling pathway in human BLCA cells.PMID:37415366 | DOI:10.2174/1568009623666230706153936
Source: Current Cancer Drug Targets - July 7, 2023 Category: Cancer & Oncology Authors: Yao Su Lin Chen Jin Yang Source Type: research
Effect of MetioNac ® in patients with metabolic syndrome who are at risk of metabolic dysfunction associated fatty liver disease: a randomized controlled trial
CONCLUSION: supplementation with MetioNac® may be protective against hyperlipidemia, insulin resistance, and overweight among metabolic syndrome patients. Further studies on this issue are needed in a larger population.PMID:37409712 | DOI:10.20960/nh.04635
Source: Nutricion Hospitalaria - July 6, 2023 Category: Nutrition Authors: Elena Garicano Vilar Sara Sanz Rojo Sara L ópez Oliva Silvia Mart ínez Ana Terr én Lora Ismael San Mauro Martin Source Type: research
